WO2002018921A2 - Method and system for real-time fluorescent determination of trace elements - Google Patents
Method and system for real-time fluorescent determination of trace elements Download PDFInfo
- Publication number
- WO2002018921A2 WO2002018921A2 PCT/US2001/026892 US0126892W WO0218921A2 WO 2002018921 A2 WO2002018921 A2 WO 2002018921A2 US 0126892 W US0126892 W US 0126892W WO 0218921 A2 WO0218921 A2 WO 0218921A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- samples
- radiation
- range
- fluorescence
- moving
- Prior art date
Links
- 239000011573 trace mineral Substances 0.000 title claims abstract description 30
- 235000013619 trace mineral Nutrition 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims description 23
- 230000005855 radiation Effects 0.000 claims abstract description 94
- 238000004891 communication Methods 0.000 claims abstract description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 238000010249 in-situ analysis Methods 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 description 22
- 238000001917 fluorescence detection Methods 0.000 description 20
- 238000009472 formulation Methods 0.000 description 14
- 239000003814 drug Substances 0.000 description 13
- 239000000203 mixture Substances 0.000 description 13
- 230000005540 biological transmission Effects 0.000 description 10
- 238000007689 inspection Methods 0.000 description 9
- 238000001514 detection method Methods 0.000 description 7
- 239000011888 foil Substances 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- 238000002189 fluorescence spectrum Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000002775 capsule Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006862 quantum yield reaction Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000012921 fluorescence analysis Methods 0.000 description 1
- 239000013022 formulation composition Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/95—Investigating the presence of flaws or contamination characterised by the material or shape of the object to be examined
- G01N21/9508—Capsules; Tablets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
- G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
- G01N23/043—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material using fluoroscopic examination, with visual observation or video transmission of fluoroscopic images
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0339—Holders for solids, powders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N2021/845—Objects on a conveyor
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002523593A JP2004507759A (en) | 2000-08-29 | 2001-08-29 | Method and system for real-time fluorescence measurement of trace elements |
CA002420665A CA2420665A1 (en) | 2000-08-29 | 2001-08-29 | Method and system for real-time fluorescent determination of trace elements |
IL15425601A IL154256A0 (en) | 2000-08-29 | 2001-08-29 | Method and system for real-time fluorescent determination of trace elements |
AU2001286884A AU2001286884B2 (en) | 2000-08-29 | 2001-08-29 | Method and system for real-time fluorescent determination of trace elements |
DE60126959T DE60126959T2 (en) | 2000-08-29 | 2001-08-29 | METHOD AND DEVICE FOR REAL-TIME FLUORESCENCE DETERMINATION OF TRACE ELEMENTS |
US10/363,294 US7277168B2 (en) | 2000-08-29 | 2001-08-29 | Method and system for real-time fluorescent determination of trace elements |
AU8688401A AU8688401A (en) | 2000-08-29 | 2001-08-29 | Method and system for real-time fluorescent determination of trace elements |
EP01966362A EP1314021B1 (en) | 2000-08-29 | 2001-08-29 | Method and system for real-time fluorescent determination of trace elements |
IL154256A IL154256A (en) | 2000-08-29 | 2003-02-03 | Method and system for real-time fluorescent determination of trace elements |
US11/531,469 US7456952B2 (en) | 2000-08-29 | 2006-09-13 | System for real-time fluorescent determination of trace elements |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22867300P | 2000-08-29 | 2000-08-29 | |
US60/228,673 | 2000-08-29 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10363294 A-371-Of-International | 2001-08-29 | ||
US11/531,469 Continuation US7456952B2 (en) | 2000-08-29 | 2006-09-13 | System for real-time fluorescent determination of trace elements |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002018921A2 true WO2002018921A2 (en) | 2002-03-07 |
WO2002018921A3 WO2002018921A3 (en) | 2003-01-30 |
Family
ID=22858146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/026892 WO2002018921A2 (en) | 2000-08-29 | 2001-08-29 | Method and system for real-time fluorescent determination of trace elements |
Country Status (11)
Country | Link |
---|---|
US (2) | US7277168B2 (en) |
EP (1) | EP1314021B1 (en) |
JP (1) | JP2004507759A (en) |
AT (1) | ATE355516T1 (en) |
AU (2) | AU2001286884B2 (en) |
CA (1) | CA2420665A1 (en) |
DE (1) | DE60126959T2 (en) |
ES (1) | ES2282286T3 (en) |
IL (2) | IL154256A0 (en) |
WO (1) | WO2002018921A2 (en) |
ZA (1) | ZA200300895B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008042565A2 (en) | 2006-09-29 | 2008-04-10 | Glaxo Group Limited | Method and system for rapid phase luminescense spectroscopy analysis |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040126450A1 (en) * | 2002-12-30 | 2004-07-01 | Barkans Anthony Christian | Method for using electromagnetic radiation to destroy data stored on a data storage device fabricated with a conductive layer |
JP2008512666A (en) * | 2004-09-10 | 2008-04-24 | ワラック オサケ ユキチュア | Instruments and methods compatible with optical measurements of amplified luminescent proximity homogeneity assay (Amplified Luminescent Proximity Homogenous Assay) |
WO2006036522A1 (en) * | 2004-09-28 | 2006-04-06 | Glaxo Group Limited | Luminescense sensor apparatus and method |
US7924414B2 (en) * | 2006-05-10 | 2011-04-12 | Abb Schweiz Ag | Non-hazardous bulk material analyzer system |
US8841570B2 (en) * | 2010-10-13 | 2014-09-23 | Paramount Farms International Llc | System and method for aflatoxin detection |
US8967851B1 (en) | 2011-01-19 | 2015-03-03 | Kemeny Associates | Spectral monitoring of ingredient blending |
US20230322977A1 (en) | 2022-04-11 | 2023-10-12 | Independence Oilfield Chemicals Llc | Aqueous formulations |
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US5085510A (en) * | 1990-08-28 | 1992-02-04 | Pfizer Inc. | Pharmaceutical tablet vision inspection system |
US5257302A (en) * | 1987-08-31 | 1993-10-26 | Ngk Insulators, Ltd. | Fluorescent X-ray analyzing system |
US5296911A (en) * | 1992-07-16 | 1994-03-22 | Schiapparelli Biosystems, Inc. | Optical test system for a chemical analyzer |
US5663997A (en) * | 1995-01-27 | 1997-09-02 | Asoma Instruments, Inc. | Glass composition determination method and apparatus |
WO2000006078A2 (en) * | 1998-07-30 | 2000-02-10 | Systems & Electronics | Pharmaceutical pill recognition and verification system |
JP2000186915A (en) * | 1998-12-21 | 2000-07-04 | Yuki Gijutsu Sogo:Kk | Visual inspection method and visual inspection device in tablet blister package line |
Family Cites Families (25)
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DE2807060A1 (en) | 1978-02-18 | 1979-08-23 | Bosch Gmbh Robert | DEVICE FOR SCANNING PACKS OF TABLET STRIPS |
JPS5896247A (en) * | 1981-12-03 | 1983-06-08 | Hitachi Ltd | Detector for welded part |
US4577110A (en) * | 1983-04-11 | 1986-03-18 | Biochem Sensors, Inc. | Optical apparatus and method for measuring the characteristics of materials by their fluorescence |
US4866283A (en) * | 1988-08-12 | 1989-09-12 | Southwest Research Institute | Optical inspection of food products |
US5000569A (en) * | 1988-12-28 | 1991-03-19 | Lamb-Weston, Inc. | Light reflection defect detection apparatus and method using pulsed light-emitting semiconductor devices of different wavelengths |
DK96989D0 (en) * | 1989-02-28 | 1989-02-28 | Faxe Kalkbrud Aktieselskabet | PROCEDURE FOR MONITORING BIOLOGICAL PROCESSES |
JPH04340445A (en) * | 1991-05-17 | 1992-11-26 | Scala Kk | Method for discriminating false medicine |
JPH06288925A (en) * | 1993-04-01 | 1994-10-18 | Toshiba Eng Co Ltd | Automatic inspection area setter |
FR2709472B1 (en) * | 1993-09-01 | 1996-02-23 | Paradigma | Method and device for controlling products;, in particular pharmaceutical wafers, during transfer and machine thus equipped. |
DE29604552U1 (en) * | 1995-05-05 | 1996-05-23 | Truetzschler Gmbh & Co Kg | Device in a spinning preparation facility (blow room) for the detection and removal of foreign substances, e.g. Pieces of fabric, ribbons, cords, pieces of film, in or out of fiber material |
JPH08334469A (en) * | 1995-06-09 | 1996-12-17 | Lion Eng Kk | Detector for package such as tablet |
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US5946083A (en) * | 1997-10-01 | 1999-08-31 | Texas Instruments Incorporated | Fixed optic sensor system and distributed sensor network |
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JP3494561B2 (en) * | 1997-10-13 | 2004-02-09 | シーケーディ株式会社 | Tablet appearance inspection method and tablet appearance inspection device |
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-
2001
- 2001-08-29 IL IL15425601A patent/IL154256A0/en active IP Right Grant
- 2001-08-29 AU AU2001286884A patent/AU2001286884B2/en not_active Ceased
- 2001-08-29 JP JP2002523593A patent/JP2004507759A/en active Pending
- 2001-08-29 AT AT01966362T patent/ATE355516T1/en not_active IP Right Cessation
- 2001-08-29 EP EP01966362A patent/EP1314021B1/en not_active Expired - Lifetime
- 2001-08-29 WO PCT/US2001/026892 patent/WO2002018921A2/en active IP Right Grant
- 2001-08-29 US US10/363,294 patent/US7277168B2/en not_active Expired - Fee Related
- 2001-08-29 ES ES01966362T patent/ES2282286T3/en not_active Expired - Lifetime
- 2001-08-29 DE DE60126959T patent/DE60126959T2/en not_active Expired - Lifetime
- 2001-08-29 AU AU8688401A patent/AU8688401A/en active Pending
- 2001-08-29 CA CA002420665A patent/CA2420665A1/en not_active Abandoned
-
2003
- 2003-01-31 ZA ZA200300895A patent/ZA200300895B/en unknown
- 2003-02-03 IL IL154256A patent/IL154256A/en not_active IP Right Cessation
-
2006
- 2006-09-13 US US11/531,469 patent/US7456952B2/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5257302A (en) * | 1987-08-31 | 1993-10-26 | Ngk Insulators, Ltd. | Fluorescent X-ray analyzing system |
US5085510A (en) * | 1990-08-28 | 1992-02-04 | Pfizer Inc. | Pharmaceutical tablet vision inspection system |
US5296911A (en) * | 1992-07-16 | 1994-03-22 | Schiapparelli Biosystems, Inc. | Optical test system for a chemical analyzer |
US5663997A (en) * | 1995-01-27 | 1997-09-02 | Asoma Instruments, Inc. | Glass composition determination method and apparatus |
WO2000006078A2 (en) * | 1998-07-30 | 2000-02-10 | Systems & Electronics | Pharmaceutical pill recognition and verification system |
JP2000186915A (en) * | 1998-12-21 | 2000-07-04 | Yuki Gijutsu Sogo:Kk | Visual inspection method and visual inspection device in tablet blister package line |
Non-Patent Citations (2)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 10, 17 November 2000 (2000-11-17) & JP 2000 186915 A (YUKI GIJUTSU SOGO:KK;FRONTEC CORP; EISAI CO LTD), 4 July 2000 (2000-07-04) * |
See also references of EP1314021A2 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008042565A2 (en) | 2006-09-29 | 2008-04-10 | Glaxo Group Limited | Method and system for rapid phase luminescense spectroscopy analysis |
WO2008042565A3 (en) * | 2006-09-29 | 2008-07-03 | Glaxo Group Ltd | Method and system for rapid phase luminescense spectroscopy analysis |
Also Published As
Publication number | Publication date |
---|---|
ATE355516T1 (en) | 2006-03-15 |
DE60126959T2 (en) | 2007-11-08 |
US7456952B2 (en) | 2008-11-25 |
IL154256A0 (en) | 2003-09-17 |
AU2001286884B2 (en) | 2004-12-09 |
AU8688401A (en) | 2002-03-13 |
DE60126959D1 (en) | 2007-04-12 |
US20040027567A1 (en) | 2004-02-12 |
ZA200300895B (en) | 2004-02-09 |
CA2420665A1 (en) | 2002-03-07 |
IL154256A (en) | 2008-11-26 |
US20070091308A1 (en) | 2007-04-26 |
EP1314021A2 (en) | 2003-05-28 |
US7277168B2 (en) | 2007-10-02 |
JP2004507759A (en) | 2004-03-11 |
ES2282286T3 (en) | 2007-10-16 |
EP1314021B1 (en) | 2007-02-28 |
WO2002018921A3 (en) | 2003-01-30 |
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