WO2002016941A3 - A combinatorial method for rapid screening of drug delivery formulations - Google Patents

A combinatorial method for rapid screening of drug delivery formulations Download PDF

Info

Publication number
WO2002016941A3
WO2002016941A3 PCT/US2001/026473 US0126473W WO0216941A3 WO 2002016941 A3 WO2002016941 A3 WO 2002016941A3 US 0126473 W US0126473 W US 0126473W WO 0216941 A3 WO0216941 A3 WO 0216941A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
rapid screening
formulations
substance
well
Prior art date
Application number
PCT/US2001/026473
Other languages
French (fr)
Other versions
WO2002016941A2 (en
Inventor
Samir Mitragotri
Pankaj Karande
Original Assignee
Univ California
Samir Mitragotri
Pankaj Karande
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Samir Mitragotri, Pankaj Karande filed Critical Univ California
Priority to AU2001286725A priority Critical patent/AU2001286725A1/en
Priority to US10/344,961 priority patent/US20040023841A1/en
Publication of WO2002016941A2 publication Critical patent/WO2002016941A2/en
Publication of WO2002016941A3 publication Critical patent/WO2002016941A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays

Abstract

This invention describes a novel method for rapid screening of formulations for drug delivery, which uses a high throughput array to screen multiple samples. This method monitors the depletion of a test substance from a donor well, the migration of the substance into a test membrane, and/or the migration of the substance through a membrane into a receptor well. It can be used to discover new formulations as well as to optimize the existing formulations for delivering drugs via transdermal, oral, or injectable routes.
PCT/US2001/026473 2000-08-23 2001-08-23 A combinatorial method for rapid screening of drug delivery formulations WO2002016941A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001286725A AU2001286725A1 (en) 2000-08-23 2001-08-23 A combinatorial method for rapid screening of drug delivery formulations
US10/344,961 US20040023841A1 (en) 2001-08-23 2001-08-23 Combinatorial method for rapid screening of drug delivery formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22745300P 2000-08-23 2000-08-23
US60/227,453 2000-08-23

Publications (2)

Publication Number Publication Date
WO2002016941A2 WO2002016941A2 (en) 2002-02-28
WO2002016941A3 true WO2002016941A3 (en) 2003-01-03

Family

ID=22853172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026473 WO2002016941A2 (en) 2000-08-23 2001-08-23 A combinatorial method for rapid screening of drug delivery formulations

Country Status (2)

Country Link
AU (1) AU2001286725A1 (en)
WO (1) WO2002016941A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852526B2 (en) 2000-07-14 2005-02-08 Transform Pharmaceuticals, Inc. Transdermal assay with magnetic clamp
IL153468A0 (en) 2000-07-14 2003-07-06 Transform Pharmaceuticals Inc System and method for optimizing tissue barrier transfer of compounds
US7172859B2 (en) 2000-07-14 2007-02-06 Transform Pharmaceuticals, Inc. System and method for optimizing tissue barrier transfer of compounds
EP1556501A4 (en) * 2002-10-28 2009-04-08 Transform Pharmaceuticals Inc Transdermal assay with magnetic clamp
US7449307B2 (en) 2002-10-28 2008-11-11 Transform Pharmaceuticals, Inc. Raised surface assay plate
WO2005009510A2 (en) * 2003-07-23 2005-02-03 The Regents Of The University Of California Penetration enhancer combinations for transdermal delivery
US7635452B2 (en) * 2003-09-24 2009-12-22 3M Innovative Properties Company System, kit, and method for measuring membrane diffusion
US20050065062A1 (en) * 2003-09-24 2005-03-24 3M Innovative Properties Company Method of formulating a pharmaceutical composition
CN103323496B (en) * 2013-05-24 2018-12-18 中国人民解放军第二五一医院 High-throughput percutaneous corrosion and absorption detecting plate
CN103308564A (en) * 2013-06-03 2013-09-18 拉芳家化股份有限公司 Method for detecting percutaneous absorption efficiency of active component of cosmetic
CN113514370A (en) * 2021-04-14 2021-10-19 广州健康元呼吸药物工程技术有限公司 Device and method for determining one-way permeability of drug-loaded non-vascular stent drug

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260210A (en) * 1989-09-27 1993-11-09 Rubin Lee L Blood-brain barrier model
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260210A (en) * 1989-09-27 1993-11-09 Rubin Lee L Blood-brain barrier model
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TANG HUA ET AL: "Theoretical description of transdermal transport of hydrophilic permeants: Application to low-frequency sonophoresis.", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 90, no. 5, May 2001 (2001-05-01), pages 545 - 568, XP001096081, ISSN: 0022-3549 *

Also Published As

Publication number Publication date
AU2001286725A1 (en) 2002-03-04
WO2002016941A2 (en) 2002-02-28

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