WO2002014319A3 - Heterocyclic compounds useful as inhibitors of tyrosine kinases - Google Patents

Heterocyclic compounds useful as inhibitors of tyrosine kinases Download PDF

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Publication number
WO2002014319A3
WO2002014319A3 PCT/US2001/024390 US0124390W WO0214319A3 WO 2002014319 A3 WO2002014319 A3 WO 2002014319A3 US 0124390 W US0124390 W US 0124390W WO 0214319 A3 WO0214319 A3 WO 0214319A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
inhibitors
useful
tyrosine kinases
diseases
Prior art date
Application number
PCT/US2001/024390
Other languages
French (fr)
Other versions
WO2002014319A2 (en
Inventor
Roger John Snow
Donghong A Gao
Daniel R Goldberg
Abdelhakim Hammach
Daniel Kuzmich
Tina Marie Morwick
Neil Moss
Iii Anthony S Prokopowicz
Robert D Selliah
Hidenori Takahashi
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Priority to JP2002519459A priority Critical patent/JP5000068B2/en
Priority to MXPA03001306A priority patent/MXPA03001306A/en
Priority to DE60132702T priority patent/DE60132702T2/en
Priority to EP01957425A priority patent/EP1309596B1/en
Priority to CA002417635A priority patent/CA2417635C/en
Publication of WO2002014319A2 publication Critical patent/WO2002014319A2/en
Publication of WO2002014319A3 publication Critical patent/WO2002014319A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Disclosed are novel compounds of formula (I) (see formula I as described in specification) wherein Ar1, X, Y, P, Q and Het are defined herein, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are pharmaceutical compositions comprising these compounds, processes for preparing these compounds and novel intermediate compounds useful in these processes.
PCT/US2001/024390 2000-08-11 2001-08-02 Heterocyclic compounds useful as inhibitors of tyrosine kinases WO2002014319A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2002519459A JP5000068B2 (en) 2000-08-11 2001-08-02 Heterocyclic compounds useful as inhibitors of tyrosine kinases
MXPA03001306A MXPA03001306A (en) 2000-08-11 2001-08-02 Heterocyclic compounds useful as inhibitors of tyrosine kinases.
DE60132702T DE60132702T2 (en) 2000-08-11 2001-08-02 Heterocyclic compounds as inhibitors of tyrosine kinases
EP01957425A EP1309596B1 (en) 2000-08-11 2001-08-02 Heterocyclic compounds useful as inhibitors of tyrosine kinases
CA002417635A CA2417635C (en) 2000-08-11 2001-08-02 Heterocyclic compounds useful as inhibitors of tyrosine kinases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22472400P 2000-08-11 2000-08-11
US60/224,724 2000-08-11

Publications (2)

Publication Number Publication Date
WO2002014319A2 WO2002014319A2 (en) 2002-02-21
WO2002014319A3 true WO2002014319A3 (en) 2002-08-01

Family

ID=22841899

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024390 WO2002014319A2 (en) 2000-08-11 2001-08-02 Heterocyclic compounds useful as inhibitors of tyrosine kinases

Country Status (9)

Country Link
US (2) US6489328B2 (en)
EP (1) EP1309596B1 (en)
JP (1) JP5000068B2 (en)
AT (1) ATE385498T1 (en)
CA (1) CA2417635C (en)
DE (1) DE60132702T2 (en)
ES (1) ES2299501T3 (en)
MX (1) MXPA03001306A (en)
WO (1) WO2002014319A2 (en)

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JP2005536533A (en) * 2002-08-08 2005-12-02 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Substituted benzimidazole compounds
US7135484B2 (en) * 2002-08-14 2006-11-14 Abbott Laboratories Azabicyclic compounds are central nervous system active agents
MXPA05001726A (en) * 2002-08-14 2005-05-27 Abbott Lab Azabicyclic compounds are central nervous system active agents.
WO2004030635A2 (en) * 2002-10-03 2004-04-15 Targegen, Inc. Vasculostatic agents and methods of use thereof
US20050282814A1 (en) * 2002-10-03 2005-12-22 Targegen, Inc. Vasculostatic agents and methods of use thereof
AU2004240772B2 (en) * 2003-05-22 2011-04-28 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazoline derivatives,process for their preparation and their use as kinase inhibitors
US20050096332A1 (en) * 2003-10-30 2005-05-05 Boehringer Ingelheim International Gmbh Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
GB0401334D0 (en) * 2004-01-21 2004-02-25 Novartis Ag Organic compounds
EP1809614B1 (en) * 2004-04-08 2014-05-07 TargeGen, Inc. Benzotriazine inhibitors of kinases
CA2578283A1 (en) 2004-08-25 2006-03-02 Targegen, Inc. Heterocyclic compounds and methods of use
ES2400287T3 (en) * 2005-03-14 2013-04-08 High Point Pharmaceuticals, Llc Benzazole derivatives, compositions and methods of use as beta-secretase inhibitors
WO2006101783A2 (en) * 2005-03-15 2006-09-28 Irm Llc Compounds and compositions as protein kinase inhibitors
TWI370820B (en) 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
US8541457B2 (en) * 2005-06-03 2013-09-24 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
BRPI0606172A2 (en) * 2005-06-08 2009-06-02 Targegen Inc methods and compositions for treating eye disorders
US8604042B2 (en) 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
JP5191391B2 (en) 2005-11-01 2013-05-08 ターゲジェン インコーポレーティッド Bi-aryl meta-pyrimidine inhibitors of kinases
US8133900B2 (en) 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
WO2007127366A2 (en) * 2006-04-25 2007-11-08 Targegen, Inc. Kinase inhibitors and methods of use thereof
WO2008063668A1 (en) 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
WO2012060847A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
CN103249306A (en) * 2010-11-28 2013-08-14 Mapi医药公司 Intermediate compounds and processes for the preparation of quinoline derivatives such as laquinimod sodium
CN103298816A (en) 2010-12-17 2013-09-11 内尔维阿诺医学科学有限公司 Substituted pyrazolo-quinazoline derivatives as kinase inhibitors
KR101934651B1 (en) * 2017-10-19 2019-01-02 가톨릭대학교 산학협력단 Composition for Preventing or Treating TNF-mediated Disease Comprising Novel Derivatives and Method for Inhibiting TNF-activity with the Same

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EP0322746A1 (en) * 1987-12-30 1989-07-05 Orion Corporation Limited Heterocyclic compounds
WO1998028281A1 (en) * 1996-12-23 1998-07-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
WO1999024035A1 (en) * 1997-11-10 1999-05-20 Bristol-Myers Squibb Company Benzothiazole protein tyrosine kinase inhibitors

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US4176184A (en) * 1977-07-21 1979-11-27 Boehringer Ingelheim Gmbh Imidazoisoquinoline-diones and salts thereof
EP0322746A1 (en) * 1987-12-30 1989-07-05 Orion Corporation Limited Heterocyclic compounds
WO1998028281A1 (en) * 1996-12-23 1998-07-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
WO1999024035A1 (en) * 1997-11-10 1999-05-20 Bristol-Myers Squibb Company Benzothiazole protein tyrosine kinase inhibitors

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Also Published As

Publication number Publication date
WO2002014319A2 (en) 2002-02-21
CA2417635C (en) 2008-02-05
US6844435B2 (en) 2005-01-18
US20030207902A1 (en) 2003-11-06
ATE385498T1 (en) 2008-02-15
DE60132702D1 (en) 2008-03-20
JP5000068B2 (en) 2012-08-15
JP2004506636A (en) 2004-03-04
EP1309596B1 (en) 2008-02-06
CA2417635A1 (en) 2002-02-21
EP1309596A2 (en) 2003-05-14
DE60132702T2 (en) 2009-03-19
US20020119975A1 (en) 2002-08-29
MXPA03001306A (en) 2003-10-15
ES2299501T3 (en) 2008-06-01
US6489328B2 (en) 2002-12-03

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