WO2002012854A3 - Systems and methods for providing information concerning chromophores in physiological media - Google Patents

Systems and methods for providing information concerning chromophores in physiological media Download PDF

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Publication number
WO2002012854A3
WO2002012854A3 PCT/US2001/024301 US0124301W WO0212854A3 WO 2002012854 A3 WO2002012854 A3 WO 2002012854A3 US 0124301 W US0124301 W US 0124301W WO 0212854 A3 WO0212854 A3 WO 0212854A3
Authority
WO
WIPO (PCT)
Prior art keywords
chromophores
medium
methods
systems
radiation
Prior art date
Application number
PCT/US2001/024301
Other languages
French (fr)
Other versions
WO2002012854A2 (en
WO2002012854A9 (en
Inventor
Xuefeng Cheng
Xiaorong Xu
Shuoming Zhou
Lai Wang
Ming Wang
Feng Li
Guobao Hu
Original Assignee
Photonify Technologies Inc
Xuefeng Cheng
Xiaorong Xu
Shuoming Zhou
Lai Wang
Ming Wang
Feng Li
Guobao Hu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/664,972 external-priority patent/US6597931B1/en
Priority claimed from US09/778,614 external-priority patent/US6801648B2/en
Priority claimed from US09/778,617 external-priority patent/US20020033454A1/en
Priority claimed from US09/778,613 external-priority patent/US20020035317A1/en
Priority claimed from US09/778,618 external-priority patent/US6516209B2/en
Priority claimed from US09/877,515 external-priority patent/US6587703B2/en
Priority to CA2417917A priority Critical patent/CA2417917C/en
Priority to EP01959449A priority patent/EP1307135A4/en
Application filed by Photonify Technologies Inc, Xuefeng Cheng, Xiaorong Xu, Shuoming Zhou, Lai Wang, Ming Wang, Feng Li, Guobao Hu filed Critical Photonify Technologies Inc
Priority to JP2002517488A priority patent/JP4846181B2/en
Priority to AU2001281005A priority patent/AU2001281005A1/en
Publication of WO2002012854A2 publication Critical patent/WO2002012854A2/en
Publication of WO2002012854A9 publication Critical patent/WO2002012854A9/en
Publication of WO2002012854A3 publication Critical patent/WO2002012854A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/043—Arrangements of multiple sensors of the same type in a linear array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/413—Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G01N2021/3144—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths for oxymetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid

Abstract

The present invention generally relates to systems and methods for providing information about chromophores in physiological media. More particularly, the invention relates to non-invasive systems and methods for determining absolute values of oxygenated and/or deoxygenated hemoglobins and their ratios in a physiological medium. The system generally includes a portable probe having a source module (122) for irradiating into the medium electromagnetic radiation, a detector module (124) detecting radiation from a target area in the medium, and a processing module (140) determining the absolute values of the chromophore concentrations and the ratios thereof based on input and output parameters of the source and detector modules. In one aspect, the invention provides a solution for unknown parameters of the chromophores in a medium using a novel processing algorithm. In another aspect, the invention concerns a portable unit for performing the requisite measurements, which unit includes a movable member having one or more radiation sources and one or more radiation detectors, and an actuator designed to cause the member to move along predetermined curvilinear paths. Properties of the chromophores are measured for individual voxels defined along each motion path, and/or cross-voxels defined at the intersection of voxels along different motion paths. These measured values are then used in a preferred embodiment to generate two- or three-dimensional images of the distribution of chromophores or their properties. In other aspects, the invention includes various patterns for the optimal distribution of sources and detectors for the optical probe, and self-calibrating operation of the probe substantially in real-time.
PCT/US2001/024301 2000-08-04 2001-08-03 Systems and methods for providing information concerning chromophores in physiological media WO2002012854A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2001281005A AU2001281005A1 (en) 2000-08-04 2001-08-03 Systems and methods for providing information concerning chromophores in physiological media
JP2002517488A JP4846181B2 (en) 2000-08-04 2001-08-03 System and method for providing information about chromophores in physiological media
CA2417917A CA2417917C (en) 2000-08-04 2001-08-03 Systems and methods for providing information concerning chromophores in physiological media
EP01959449A EP1307135A4 (en) 2000-08-04 2001-08-03 Systems and methods for providing information concerning chromophores in physiological media

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US22281600P 2000-08-04 2000-08-04
US22307400P 2000-08-04 2000-08-04
US60/222,816 2000-08-04
US60/223,074 2000-08-04
US09/664,972 2000-09-18
US09/664,972 US6597931B1 (en) 2000-09-18 2000-09-18 System and method for absolute oxygen saturation
US09/778,618 US6516209B2 (en) 2000-08-04 2001-02-06 Self-calibrating optical imaging system
US09/778,613 US20020035317A1 (en) 2000-08-04 2001-02-06 Optical imaging system with movable scanning unit
US09/778,613 2001-02-06
US09/778,617 US20020033454A1 (en) 2000-08-04 2001-02-06 Optical imaging system with direct image construction
US09/778,618 2001-02-06
US09/778,614 US6801648B2 (en) 2000-08-04 2001-02-06 Optical imaging system with symmetric optical probe
US09/778,614 2001-02-06
US09/778,617 2001-02-06
US09/877,515 2001-06-07
US09/877,515 US6587703B2 (en) 2000-09-18 2001-06-07 System and method for measuring absolute oxygen saturation

Publications (3)

Publication Number Publication Date
WO2002012854A2 WO2002012854A2 (en) 2002-02-14
WO2002012854A9 WO2002012854A9 (en) 2002-10-17
WO2002012854A3 true WO2002012854A3 (en) 2002-12-19

Family

ID=27575220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024301 WO2002012854A2 (en) 2000-08-04 2001-08-03 Systems and methods for providing information concerning chromophores in physiological media

Country Status (4)

Country Link
EP (1) EP1307135A4 (en)
AU (1) AU2001281005A1 (en)
CA (1) CA2417917C (en)
WO (1) WO2002012854A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9588033B2 (en) 2011-04-15 2017-03-07 Roche Diagnostics Hematology, Inc. Measuring volume and constituents of cells

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7551950B2 (en) 2004-06-29 2009-06-23 O2 Medtech, Inc,. Optical apparatus and method of use for non-invasive tomographic scan of biological tissues
US8249696B2 (en) 2007-12-19 2012-08-21 Depuy Spine, Inc. Smart pedicle tool
EP3570743A4 (en) * 2017-01-18 2020-11-11 Optican Systems Inc. Handheld probe and system for imaging human tissue
WO2020239922A1 (en) * 2019-05-28 2020-12-03 Universität Zürich Optical apparatus comprising two self-calibrated optical measurement sets
CN111929655B (en) * 2020-09-08 2023-07-14 中国电子科技集团公司第三十八研究所 Method and system for tracking road target of millimeter wave radar of automobile

Citations (7)

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Publication number Priority date Publication date Assignee Title
US5676143A (en) * 1992-11-09 1997-10-14 Boehringer Mannheim Gmbh Apparatus for analytical determination of glucose in a biological matrix
US5803909A (en) * 1994-10-06 1998-09-08 Hitachi, Ltd. Optical system for measuring metabolism in a body and imaging method
US5987346A (en) * 1993-02-26 1999-11-16 Benaron; David A. Device and method for classification of tissue
US6078833A (en) * 1998-03-25 2000-06-20 I.S.S. (Usa) Inc. Self referencing photosensor
US6088605A (en) * 1996-02-23 2000-07-11 Diasense, Inc. Method and apparatus for non-invasive blood glucose sensing
US6104945A (en) * 1995-08-01 2000-08-15 Medispectra, Inc. Spectral volume microprobe arrays
US6151518A (en) * 1998-03-03 2000-11-21 Fuji Photo Film Co., Ltd. Instrument for measuring concentrations of constituent parts of blood

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
JPH06103257B2 (en) * 1988-12-19 1994-12-14 大塚電子株式会社 Method and apparatus for measuring absorption coefficient of substance using light scattering
JP3433498B2 (en) * 1993-06-02 2003-08-04 浜松ホトニクス株式会社 Method and apparatus for measuring internal information of scattering medium

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5676143A (en) * 1992-11-09 1997-10-14 Boehringer Mannheim Gmbh Apparatus for analytical determination of glucose in a biological matrix
US5987346A (en) * 1993-02-26 1999-11-16 Benaron; David A. Device and method for classification of tissue
US5803909A (en) * 1994-10-06 1998-09-08 Hitachi, Ltd. Optical system for measuring metabolism in a body and imaging method
US6104945A (en) * 1995-08-01 2000-08-15 Medispectra, Inc. Spectral volume microprobe arrays
US6088605A (en) * 1996-02-23 2000-07-11 Diasense, Inc. Method and apparatus for non-invasive blood glucose sensing
US6151518A (en) * 1998-03-03 2000-11-21 Fuji Photo Film Co., Ltd. Instrument for measuring concentrations of constituent parts of blood
US6078833A (en) * 1998-03-25 2000-06-20 I.S.S. (Usa) Inc. Self referencing photosensor

Non-Patent Citations (1)

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Title
See also references of EP1307135A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9588033B2 (en) 2011-04-15 2017-03-07 Roche Diagnostics Hematology, Inc. Measuring volume and constituents of cells

Also Published As

Publication number Publication date
WO2002012854A2 (en) 2002-02-14
EP1307135A2 (en) 2003-05-07
AU2001281005A1 (en) 2002-02-18
CA2417917C (en) 2014-10-14
CA2417917A1 (en) 2002-02-14
EP1307135A4 (en) 2006-05-31
WO2002012854A9 (en) 2002-10-17

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