WO2002007870A3 - Use of combinatorial chemistry to optimize multi-step synthesis - Google Patents

Use of combinatorial chemistry to optimize multi-step synthesis Download PDF

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Publication number
WO2002007870A3
WO2002007870A3 PCT/US2001/022128 US0122128W WO0207870A3 WO 2002007870 A3 WO2002007870 A3 WO 2002007870A3 US 0122128 W US0122128 W US 0122128W WO 0207870 A3 WO0207870 A3 WO 0207870A3
Authority
WO
WIPO (PCT)
Prior art keywords
reaction conditions
catalysts
reactions
conditions
optimum
Prior art date
Application number
PCT/US2001/022128
Other languages
French (fr)
Other versions
WO2002007870A2 (en
Inventor
Dennis J O'rear
Charles L Kibby
Georgieanna L Scheuerman
Original Assignee
Chevron Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chevron Usa Inc filed Critical Chevron Usa Inc
Priority to AU2001278915A priority Critical patent/AU2001278915A1/en
Priority to EP01957146A priority patent/EP1315562A2/en
Publication of WO2002007870A2 publication Critical patent/WO2002007870A2/en
Publication of WO2002007870A3 publication Critical patent/WO2002007870A3/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/0033—Optimalisation processes, i.e. processes with adaptive control systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10G—CRACKING HYDROCARBON OILS; PRODUCTION OF LIQUID HYDROCARBON MIXTURES, e.g. BY DESTRUCTIVE HYDROGENATION, OLIGOMERISATION, POLYMERISATION; RECOVERY OF HYDROCARBON OILS FROM OIL-SHALE, OIL-SAND, OR GASES; REFINING MIXTURES MAINLY CONSISTING OF HYDROCARBONS; REFORMING OF NAPHTHA; MINERAL WAXES
    • C10G2/00—Production of liquid hydrocarbon mixtures of undefined composition from oxides of carbon
    • C10G2/30—Production of liquid hydrocarbon mixtures of undefined composition from oxides of carbon from carbon monoxide with hydrogen
    • C10G2/32—Production of liquid hydrocarbon mixtures of undefined composition from oxides of carbon from carbon monoxide with hydrogen with the use of catalysts
    • C10G2/33—Production of liquid hydrocarbon mixtures of undefined composition from oxides of carbon from carbon monoxide with hydrogen with the use of catalysts characterised by the catalyst used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00698—Measurement and control of process parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00745—Inorganic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00745—Inorganic compounds
    • B01J2219/00747—Catalysts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00745—Inorganic compounds
    • B01J2219/0075—Metal based compounds
    • B01J2219/00754—Metal oxides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/08—Methods of screening libraries by measuring catalytic activity
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/18—Libraries containing only inorganic compounds or inorganic materials
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Abstract

Methods for discovering optimum catalysts and/or reaction conditions for performing multi-step reactions, in particular multi-step catalytic reactions, are disclosed. A combinatorial approach is used to identify optimum catalysts and/or reaction conditions for performing the reactions. The reactions are performed in the voids of a suitable reactor capable of handling conditions of elevated temperature and pressure, and also that can handle a plurality of simultaneous or substantially simultaneous reactions. The methods can advantageously be used to generate a database of combinations of catalyst systems and/or reaction conditions that provide various product streams, such that as market conditions vary and/or product requirements change, conditions suitable for forming desired products can be identified with little or no downtime. The catalysts can be evaluate using varied reaction conditions, which can provide a) a combinatorial library of product streams and a database including the combination of catalysts and reaction conditions to provide each product stream and/or b) the optimum combination of catalysts and reaction conditions for obtaining a desired product stream.
PCT/US2001/022128 2000-07-24 2001-07-13 Use of combinatorial chemistry to optimize multi-step synthesis WO2002007870A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001278915A AU2001278915A1 (en) 2000-07-24 2001-07-13 Use of combinatorial chemistry to optimize multi-step synthesis
EP01957146A EP1315562A2 (en) 2000-07-24 2001-07-13 Use of combinatorial chemistry to optimize multi-step synthesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62521600A 2000-07-24 2000-07-24
US09/625,216 2000-07-24

Publications (2)

Publication Number Publication Date
WO2002007870A2 WO2002007870A2 (en) 2002-01-31
WO2002007870A3 true WO2002007870A3 (en) 2002-07-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022128 WO2002007870A2 (en) 2000-07-24 2001-07-13 Use of combinatorial chemistry to optimize multi-step synthesis

Country Status (3)

Country Link
EP (1) EP1315562A2 (en)
AU (1) AU2001278915A1 (en)
WO (1) WO2002007870A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1641730B1 (en) 2003-05-08 2014-07-30 Valent Technologies, LLC Recombined molecules and preparation thereof
US20050095714A1 (en) * 2003-10-31 2005-05-05 Wollenberg Robert H. High throughput preparation of lubricating oil compositions for combinatorial libraries
US7579192B2 (en) * 2003-10-31 2009-08-25 Chevron Oronite Company Llc High throughput screening methods for lubricating oil compositions
US7150182B2 (en) 2003-10-31 2006-12-19 Chevron Oronite Company, Llc High throughput screening methods for lubricating oil compositions
US7462490B2 (en) * 2003-10-31 2008-12-09 Chevron Oronite Company Llc Combinatorial lubricating oil composition libraries

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4099923A (en) * 1977-01-17 1978-07-11 The Standard Oil Company Automatic catalytic screening unit
WO1996011878A1 (en) * 1994-10-18 1996-04-25 The Regents Of The University Of California The combinatorial synthesis of novel materials
US6030917A (en) * 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
WO2000032308A2 (en) * 1998-12-04 2000-06-08 Symyx Technologies, Inc. Continuous feed parallel reactor
US6214195B1 (en) * 1998-09-14 2001-04-10 Nanomaterials Research Corporation Method and device for transforming chemical compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4099923A (en) * 1977-01-17 1978-07-11 The Standard Oil Company Automatic catalytic screening unit
WO1996011878A1 (en) * 1994-10-18 1996-04-25 The Regents Of The University Of California The combinatorial synthesis of novel materials
US6030917A (en) * 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US6214195B1 (en) * 1998-09-14 2001-04-10 Nanomaterials Research Corporation Method and device for transforming chemical compositions
WO2000032308A2 (en) * 1998-12-04 2000-06-08 Symyx Technologies, Inc. Continuous feed parallel reactor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AKPORIAYE ET AL.: "Combinatorial approach to the hydrothermal synthesis of zeolites", ANGEW. CHEM. INT. ED., vol. 37, no. 5, March 1998 (1998-03-01), pages 609 - 611, XP000982283 *
KLEIN ET AL.: "Combinatorial material libraries on the microgram scale with an example of hydrothermal synthesis", ANGEW. CHEM. INT. ED., vol. 37, no. 24, December 1998 (1998-12-01), pages 3369 - 3372, XP000982281 *
PITTMAN ET AL.: "Sequential multistep reactions catalyzed by polymer-anchored homogeneous catalysts", J. AM. CHEM. SOC., vol. 97, no. 7, April 1975 (1975-04-01), pages 1749 - 1754, XP002948880 *

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Publication number Publication date
EP1315562A2 (en) 2003-06-04
WO2002007870A2 (en) 2002-01-31
AU2001278915A1 (en) 2002-02-05

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