WO2002005890A3 - Microdevice and method of manufacturing a microdevice - Google Patents

Microdevice and method of manufacturing a microdevice Download PDF

Info

Publication number
WO2002005890A3
WO2002005890A3 PCT/US2001/021791 US0121791W WO0205890A3 WO 2002005890 A3 WO2002005890 A3 WO 2002005890A3 US 0121791 W US0121791 W US 0121791W WO 0205890 A3 WO0205890 A3 WO 0205890A3
Authority
WO
WIPO (PCT)
Prior art keywords
microdevice
support
skin
penetrating member
skin penetrating
Prior art date
Application number
PCT/US2001/021791
Other languages
French (fr)
Other versions
WO2002005890A2 (en
Inventor
Alexander G Lastovich
John D Evans
Ronald J Pettis
Original Assignee
Alexander G Lastovich
John D Evans
Ronald J Pettis
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexander G Lastovich, John D Evans, Ronald J Pettis, Becton Dickinson Co filed Critical Alexander G Lastovich
Priority to DE60124917T priority Critical patent/DE60124917T2/en
Priority to JP2002511820A priority patent/JP4892166B2/en
Priority to AU2001273340A priority patent/AU2001273340A1/en
Priority to EP01952607A priority patent/EP1301237B1/en
Publication of WO2002005890A2 publication Critical patent/WO2002005890A2/en
Publication of WO2002005890A3 publication Critical patent/WO2002005890A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Micromachines (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

A device for monitoring, sampling or delivering a substance though the skin of a patient includes a support and a microdevice having at least one skin penetrating member. The support has a substantially flat bottom surface with the skin penetrating member extending beyond the bottom surface. An outlet port extends through the support to the bottom surface at a location between the skin penetrating member and the outer edge of the support for drawing a vacuum to enhance penetration of the skin. The device is produced by positioning the microdevice in a recess formed in the support and applying a bonding agent to wick into a gap formed between the microdevice and the wall of the recess.
PCT/US2001/021791 2000-07-14 2001-07-11 Microdevice and method of manufacturing a microdevice WO2002005890A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE60124917T DE60124917T2 (en) 2000-07-14 2001-07-11 MICRO-DEVICE AND METHOD OF MANUFACTURE
JP2002511820A JP4892166B2 (en) 2000-07-14 2001-07-11 Micro device and method for manufacturing the same
AU2001273340A AU2001273340A1 (en) 2000-07-14 2001-07-11 Microdevice and method of manufacturing a microdevice
EP01952607A EP1301237B1 (en) 2000-07-14 2001-07-11 Microdevice and method of manufacturing a microdevice

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/616,771 2000-07-14
US09/616,771 US6440096B1 (en) 2000-07-14 2000-07-14 Microdevice and method of manufacturing a microdevice

Publications (2)

Publication Number Publication Date
WO2002005890A2 WO2002005890A2 (en) 2002-01-24
WO2002005890A3 true WO2002005890A3 (en) 2002-04-25

Family

ID=24470876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021791 WO2002005890A2 (en) 2000-07-14 2001-07-11 Microdevice and method of manufacturing a microdevice

Country Status (8)

Country Link
US (2) US6440096B1 (en)
EP (1) EP1301237B1 (en)
JP (1) JP4892166B2 (en)
AT (1) ATE346645T1 (en)
AU (1) AU2001273340A1 (en)
DE (1) DE60124917T2 (en)
ES (1) ES2276805T3 (en)
WO (1) WO2002005890A2 (en)

Families Citing this family (264)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US9717451B2 (en) * 2000-06-08 2017-08-01 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6607513B1 (en) * 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6749575B2 (en) * 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
WO2002045771A2 (en) * 2000-11-09 2002-06-13 Biovalve Technologies, Inc. Microneedle adapter
US9302903B2 (en) * 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
MXPA03009603A (en) * 2001-04-20 2004-12-06 Johnson & Johnson Microprojection array having a beneficial agent containing coating.
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
WO2002100476A2 (en) * 2001-06-08 2002-12-19 Becton, Dickinson And Company Device for manipulating a needle or abrader array
DK1432466T3 (en) * 2001-09-12 2012-12-03 Becton Dickinson Co Micro needle-based pen dispenser for drug delivery and method of use thereof
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US6830562B2 (en) 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
WO2003049610A1 (en) * 2001-12-06 2003-06-19 University Of Virginia Patent Foundation An apparatus for fluid transport and related method thereof
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
AU2003209645A1 (en) 2002-03-04 2003-09-16 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
BRPI0308319B1 (en) * 2002-03-11 2015-06-09 Beaver Visitec Int Us Inc Method for making a crystalline material cutting device and method for making a surgical blade of crystalline material
US7387742B2 (en) * 2002-03-11 2008-06-17 Becton, Dickinson And Company Silicon blades for surgical and non-surgical use
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
WO2004000389A2 (en) * 2002-06-25 2003-12-31 Sung-Yun Kwon Rapidly dissolving micro-perforator for drug delivery and other applications
CA2497154C (en) * 2002-08-29 2012-01-03 Becton, Dickinson And Company Substance delivery via a rotating microabrading surface
US20040051019A1 (en) 2002-09-02 2004-03-18 Mogensen Lasse Wesseltoft Apparatus for and a method of adjusting the length of an infusion tube
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
EP1590034B1 (en) * 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
DK200201823A (en) 2002-11-26 2004-05-27 Maersk Medical As Connection piece for a hose connection
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20090007436A1 (en) * 2003-03-10 2009-01-08 Daskal Vadim M Silicon blades for surgical and non-surgical use
US20050155955A1 (en) * 2003-03-10 2005-07-21 Daskal Vadim M. Method for reducing glare and creating matte finish of controlled density on a silicon surface
TW566423U (en) * 2003-04-23 2003-12-11 Ind Tech Res Inst Structure for miniature gripping clip
EP1633250A2 (en) * 2003-06-04 2006-03-15 Georgia Tech Research Corporation Drilling microneedle device
IL156374A0 (en) * 2003-06-10 2004-01-04 Danenberg Holdings 2000 Ltd N Method for removing a pigmented section of skin
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CA2530531A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
IL157696A0 (en) * 2003-09-01 2004-03-28 Hawk Medical Technologies Ltd Apparatus and method for removing a pigmented section of skin
JP2007514457A (en) * 2003-09-17 2007-06-07 ベクトン・ディキンソン・アンド・カンパニー System and method for creating straight and non-linear grooves using routers in silicon and other crystalline materials
US7956742B2 (en) 2003-10-30 2011-06-07 Motedata Inc. Method and system for storing, retrieving, and managing data for tags
US7388488B2 (en) * 2003-10-30 2008-06-17 Peter Lupoli Method and system for storing, retrieving, and managing data for tags
JP2007511318A (en) * 2003-11-18 2007-05-10 ナノ パス テクノロジーズ リミテッド Improved insertion system and method for sliding microneedles
US7998119B2 (en) * 2003-11-18 2011-08-16 Nano Pass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
EP1706171A1 (en) * 2003-12-29 2006-10-04 3M Innovative Properties Company Medical devices and kits including same
WO2005082593A1 (en) * 2004-02-17 2005-09-09 Avery Dennison Corporation Method of making microneedles
JP4500851B2 (en) * 2004-03-12 2010-07-14 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ Method and mold for use in manufacturing microneedles with side holes
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
CA2560784A1 (en) 2004-03-26 2005-10-06 Unomedical A/S Infusion set
JP4971133B2 (en) * 2004-04-01 2012-07-11 ザ ジェネラル ホスピタル コーポレイション Equipment for dermatological treatment
BRPI0509806A (en) * 2004-04-12 2007-09-18 Allergan Inc multi-site injection system
US7396484B2 (en) * 2004-04-30 2008-07-08 Becton, Dickinson And Company Methods of fabricating complex blade geometries from silicon wafers and strengthening blade geometries
AU2005244734A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2005123173A1 (en) * 2004-06-10 2005-12-29 3M Innovative Properties Company Patch application device and kit
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
ATE490037T1 (en) * 2004-08-16 2010-12-15 Functional Microstructures Ltd METHOD FOR PRODUCING A MICRONEEDLE OR A MICROIMPLANT
US7316665B2 (en) * 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
JP5015787B2 (en) 2004-11-18 2012-08-29 スリーエム イノベイティブ プロパティズ カンパニー Contact coating method of microneedle array
BRPI0517749A (en) 2004-11-18 2008-10-21 3M Innovative Properties Co application device for applying a micro-needle device to a skin surface, and method for using an application device
KR101224257B1 (en) * 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Masking method for coating a microneedle array
US9174035B2 (en) 2004-11-18 2015-11-03 3M Innovative Properties Company Microneedle array applicator and retainer
US8007466B2 (en) * 2004-11-18 2011-08-30 Nanopass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
MX2007006840A (en) 2004-12-10 2007-08-14 Unomedical As Cannula inserter.
WO2006064271A1 (en) * 2004-12-17 2006-06-22 Functional Microstructures Limited Microneedle device for transdermal transport of fluid
US7985199B2 (en) * 2005-03-17 2011-07-26 Unomedical A/S Gateway system
WO2006108185A1 (en) 2005-04-07 2006-10-12 3M Innovative Properties Company System and method for tool feedback sensing
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US8277415B2 (en) 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US20080097291A1 (en) * 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
US8137314B2 (en) * 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8512288B2 (en) 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7641649B2 (en) 2005-05-06 2010-01-05 Medtronic Minimed, Inc. Reservoir support and method for infusion device
US8840586B2 (en) * 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
EP1904158B1 (en) * 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
JP5144510B2 (en) 2005-06-27 2013-02-13 スリーエム イノベイティブ プロパティズ カンパニー Microneedle array application device
AU2006268713A1 (en) * 2005-07-13 2007-01-18 F. Hoffmann-La Roche Ag Benzimidazole derivatives as 5-HT6,5-HT24
BRPI0614477A2 (en) * 2005-08-01 2011-03-29 Hawk Medical Technologies Ltd use of salicylic acid for eradication of pigmentation in a skin area, eradication apparatus and method of using a skin piercing apparatus
CN101242869B (en) * 2005-09-02 2010-05-26 Iomai公司 Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
CN101687094B (en) * 2005-09-06 2012-09-26 谢拉杰克特股份有限公司 Solid solution perforator containing drug particle and/or drug-adsorbed particles
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
PT1762259E (en) 2005-09-12 2010-12-10 Unomedical As Inserter for an infusion set with a first and second spring units
US20070087029A1 (en) * 2005-10-14 2007-04-19 Pakala Syamasundar V Localized delivery to the lymphatic system
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
ES2327963T3 (en) 2005-12-23 2009-11-05 Unomedical A/S INJECTION DEVICE.
EP1971278A4 (en) * 2006-01-12 2009-12-23 Nano Pass Technologies Ltd Device for superficial abrasive treatment of the skin
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
EP2335754B1 (en) 2006-02-09 2013-12-18 DEKA Products Limited Partnership Patch-sized fluid delivery systems
WO2007098771A2 (en) 2006-02-28 2007-09-07 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
KR20090026760A (en) 2006-06-07 2009-03-13 우노메디컬 에이/에스 Inserter
KR20090028701A (en) 2006-06-09 2009-03-19 우노메디컬 에이/에스 Mounting pad
JP2009539508A (en) 2006-06-15 2009-11-19 シーガル アイピー ピーティーワイ リミテッド Delivery system and method
WO2008014791A1 (en) 2006-08-02 2008-02-07 Unomedical A/S Cannula and delivery device
EP1884223A1 (en) 2006-08-04 2008-02-06 IP Randwyck B.V. Wound-stimulating unit
US7455663B2 (en) * 2006-08-23 2008-11-25 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US7828764B2 (en) * 2006-08-23 2010-11-09 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US20080051765A1 (en) * 2006-08-23 2008-02-28 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7794434B2 (en) * 2006-08-23 2010-09-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7811262B2 (en) * 2006-08-23 2010-10-12 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
JP2010505471A (en) 2006-10-02 2010-02-25 エムキネティクス， インコーポレイテッド Method and apparatus for magnetic induction therapy
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
EP1917990A1 (en) 2006-10-31 2008-05-07 Unomedical A/S Infusion set
WO2008091602A2 (en) 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
WO2008130587A2 (en) 2007-04-16 2008-10-30 Corium International, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
JP5102350B2 (en) 2007-04-30 2012-12-19 メドトロニック ミニメド インコーポレイテッド Reservoir filling / bubble management / infusion medium delivery system and method using the system
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
JP2010530266A (en) 2007-06-20 2010-09-09 ウノメディカル アクティーゼルスカブ Catheter and catheter manufacturing method and apparatus
CN101808685A (en) 2007-07-03 2010-08-18 优诺医疗有限公司 Inserter having bistable equilibrium states
US8486003B2 (en) 2007-07-10 2013-07-16 Unomedical A/S Inserter having two springs
WO2009010396A1 (en) 2007-07-18 2009-01-22 Unomedical A/S Insertion device with pivoting action
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
FR2923151B1 (en) * 2007-11-02 2010-09-03 Commissariat Energie Atomique BLOOD SAMPLING DEVICE COMPRISING AT LEAST ONE FILTER.
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
GB0802447D0 (en) * 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
US10898643B2 (en) 2008-02-13 2021-01-26 Unomedical A/S Sealing between a cannula part and a fluid path
WO2009103759A1 (en) 2008-02-20 2009-08-27 Unomedical A/S Insertion device with horizontally moving part
CN102105108B (en) * 2008-05-21 2013-12-04 谢拉杰克特股份有限公司 Method of manufacturing solid solution peforator patches and uses thereof
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
AU2009331635A1 (en) 2008-12-22 2011-06-23 Unomedical A/S Medical device comprising adhesive pad
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US20120277629A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collection and/or manipulation of blood spots or other bodily fluids
EP2408372B1 (en) 2009-03-02 2019-01-09 Seventh Sense Biosystems, Inc. Devices associated with blood sampling
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
EP2459252B1 (en) 2009-07-30 2013-08-21 Unomedical A/S Inserter device with horizontal moving part
EP2724739B1 (en) 2009-07-30 2015-07-01 Tandem Diabetes Care, Inc. Portable infusion pump system
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
BR112012002804A2 (en) 2009-08-07 2016-05-31 Unomedical As sensor device and one or more cannulas
EP2493551A4 (en) 2009-10-26 2013-04-17 Emkinetics Inc Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
CN102770156B (en) 2009-12-16 2016-01-20 克洛恩泰克制药股份公司 Codon optimized hepatitis B virus core antigen (HBCAG)
WO2011075676A2 (en) 2009-12-18 2011-06-23 Knowlton Edward W A skin treatment and drug delivery device
KR20130018783A (en) 2010-03-30 2013-02-25 우노메디컬 에이/에스 Medical device
WO2011135531A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. MEDICAL DEVICES FOR DELIVERY OF siRNA
MX2012012567A (en) 2010-04-28 2012-11-21 Kimberly Clark Co Method for increasing permeability of an epithelial barrier.
ES2636673T3 (en) 2010-04-28 2017-10-06 Kimberly-Clark Worldwide, Inc. Device for the administration of rheumatoid arthritis medications
MX2012012317A (en) 2010-04-28 2012-11-21 Kimberly Clark Co Injection molded microneedle array and method for forming the microneedle array.
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
US20120016308A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure packaging for fluid devices
EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
EP2433663A1 (en) 2010-09-27 2012-03-28 Unomedical A/S Insertion system
US20120237975A1 (en) 2010-10-01 2012-09-20 Jason Schrum Engineered nucleic acids and methods of use thereof
EP2436412A1 (en) 2010-10-04 2012-04-04 Unomedical A/S A sprinkler cannula
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
EP2460553A1 (en) * 2010-12-02 2012-06-06 Debiotech S.A. Device for inserting needles
US10702684B2 (en) 2010-12-17 2020-07-07 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
US10368904B2 (en) 2013-12-06 2019-08-06 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11612410B2 (en) 2010-12-17 2023-03-28 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10485575B2 (en) 2010-12-17 2019-11-26 Srgi Holdings Llc Pixel array medical devices and methods
US11000310B2 (en) 2010-12-17 2021-05-11 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10661063B2 (en) 2010-12-17 2020-05-26 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
US10335190B2 (en) 2013-12-06 2019-07-02 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10736653B2 (en) 2013-12-06 2020-08-11 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11103275B2 (en) 2010-12-17 2021-08-31 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11278309B2 (en) 2010-12-17 2022-03-22 Srgi Holdings, Llc Pixel array medical systems, devices and methods
KR101993810B1 (en) 2011-01-28 2019-06-27 더 제너럴 하스피탈 코포레이션 An apparatus for cosmetic resurfacing of a skin tissue
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
ES2597081T3 (en) 2011-04-29 2017-01-13 Seventh Sense Biosystems, Inc. Delivery and / or reception of fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP2720740A1 (en) 2011-06-15 2014-04-23 ChronTech Pharma AB Injection needle and device
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2850624A1 (en) 2011-10-03 2013-04-11 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
EP2763723B1 (en) 2011-10-05 2016-04-13 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
AU2012328037B2 (en) 2011-10-27 2017-11-02 Sorrento Therapeutics, Inc. Transdermal delivery of high viscosity bioactive agents
KR20140079429A (en) 2011-10-27 2014-06-26 킴벌리-클라크 월드와이드, 인크. Implantable devices for delivery of bioactive agents
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
KR20140102759A (en) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 Modified nucleoside, nucleotide, and nucleic acid compositions
CA2868398A1 (en) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
JP6145249B2 (en) * 2012-05-25 2017-06-07 学校法人 関西大学 Hollow fine needle and method for producing the same
KR102140553B1 (en) * 2012-06-22 2020-08-03 도판 인사츠 가부시키가이샤 Needle-shaped body and manufacturing method for needle-shaped body
WO2014064534A2 (en) 2012-10-05 2014-05-01 Chrontech Pharma Ab Injection needle, device, immunogenic compositions and method of use
JP6144355B2 (en) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． Chemically modified mRNA
MX2015007227A (en) 2012-12-06 2016-02-18 Srgi Holdings Llc Pixel array medical devices and methods.
CN105073178B (en) 2012-12-21 2019-07-30 考里安国际公司 Microarray and its application method for therapeutic agent delivering
US10543127B2 (en) 2013-02-20 2020-01-28 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
WO2014164314A1 (en) 2013-03-12 2014-10-09 Corium International, Inc. Microprojection applicators
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
JP2016512754A (en) 2013-03-15 2016-05-09 コリウム インターナショナル， インコーポレイテッド Microarray, method of use and manufacturing for delivery of therapeutic agents
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
EP2968118B1 (en) 2013-03-15 2022-02-09 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
CN104056345B (en) * 2013-03-22 2017-04-19 北京神州汉方医药科技有限公司 Transdermal drug delivery device
AU2014262382A1 (en) * 2013-05-06 2015-11-19 Mupharma Pty Ltd Non-invasive agent applicator
BR112016002695B1 (en) 2013-08-09 2022-09-20 Cytrellis Biosystems, Inc DEVICE WITH AN ABLATIVE DEVICE, A REMOVAL DEVICE AND A POSITIONING DEVICE
CA2926322C (en) 2013-10-02 2022-10-18 Srgi Holdings, Llc Pixel array medical devices and methods
ES2827049T3 (en) 2013-10-02 2021-05-19 Srgi Holdings Llc Pixel Set Medical Devices
JP2016538829A (en) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Polynucleotide encoding low density lipoprotein receptor
US11229452B2 (en) 2013-12-06 2022-01-25 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11937846B2 (en) 2013-12-06 2024-03-26 Srgi Holdings Llc Pixel array medical systems, devices and methods
EP3082897A4 (en) 2013-12-19 2017-07-26 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
JP2017507732A (en) * 2014-03-10 2017-03-23 スリーエム イノベイティブ プロパティズ カンパニー Microneedle device
US20160279401A1 (en) * 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
CN106163594B (en) * 2014-04-14 2019-10-25 凸版印刷株式会社 Injection device
CN112121302A (en) * 2014-05-06 2020-12-25 穆医药有限公司 Non-invasive agent applicator
MX2017002661A (en) * 2014-08-29 2018-01-25 Srgi Holdings Llc Pixel array medical devices and methods.
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
EP3218043A4 (en) * 2014-11-12 2018-07-11 Mupharma Pty Ltd Non-invasive agent applicator
WO2016077759A1 (en) 2014-11-14 2016-05-19 Cytrellis Biosystems, Inc. Devices and methods for ablation of the skin
EP3253308A4 (en) 2015-02-05 2018-10-24 SRGI Holdings LLC Pixel array medical systems, devices and methods
US9730625B2 (en) 2015-03-02 2017-08-15 Verily Life Sciences Llc Automated blood sampling device
US10765361B2 (en) * 2015-03-02 2020-09-08 Verily Life Sciences Llc Automated sequential injection and blood draw
BR112017019272A2 (en) * 2015-03-10 2018-05-02 Allergan Pharmaceuticals Holdings Ireland Unlimited Company multiple needle injector
WO2016147476A1 (en) * 2015-03-18 2016-09-22 凸版印刷株式会社 Drug administration device, and manufacturing method for drug administration device
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11759231B2 (en) 2015-08-31 2023-09-19 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11490952B2 (en) 2015-08-31 2022-11-08 Srgi Holdings, Llc Pixel array medical devices and methods
US11564706B2 (en) 2019-10-28 2023-01-31 Srgi Holdings, Llc Pixel array medical systems, devices and methods
KR20180110103A (en) * 2016-02-11 2018-10-08 에스알쥐아이 홀딩스 엘엘씨 Pixel array medical system, apparatus and method
KR102561605B1 (en) 2016-03-29 2023-08-01 사이트렐리스 바이오시스템즈, 인크. Device and method for cosmetic skin resurfacing
KR102627434B1 (en) * 2016-08-08 2024-01-18 주식회사 엘지생활건강 Suction microneedle
US11464954B2 (en) 2016-09-21 2022-10-11 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
CN106725894B (en) * 2017-01-22 2020-06-05 袁晓辉 Intermittent negative pressure suction skin expansion device and use method thereof
US10765426B2 (en) * 2017-02-17 2020-09-08 Ethicon Llc Systems for coupling adjuncts to an end effector
CA3053641A1 (en) 2017-02-17 2018-08-23 Allergan, Inc. Microneedle array with active ingredient
WO2018217479A2 (en) 2017-05-11 2018-11-29 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
TWI778065B (en) * 2017-07-25 2022-09-21 瑞典商艾瑟莉恩公司 A suction applying device and an apparatus for sampling a bodily fluid
US11213667B2 (en) * 2018-07-11 2022-01-04 Santa Clara University 3D printed microneedles for microencapsulated mammalian cell extrusion
JP1632957S (en) 2018-10-30 2019-06-03
CN113329707A (en) 2018-12-19 2021-08-31 克利里特有限责任公司 System and method for tattoo removal using an applied electric field
CN109938777B (en) * 2019-04-02 2020-02-07 汕头大学医学院第一附属医院 Skin auxiliary inspection machine
JP2020179168A (en) * 2019-04-25 2020-11-05 コスメディ製薬株式会社 Applicator 2 for water soluble sheet-like preparation
EP4139678A1 (en) * 2020-04-22 2023-03-01 Paul Gilbert Fluid characteristic indicator
FR3110382B1 (en) * 2020-05-20 2022-05-13 Pkvitality Sensor for surface mounted body monitoring system
FR3113578B1 (en) * 2020-08-28 2023-02-10 Pkvitality METHOD FOR ALIGNING COMPONENT(S) OF A BODY MONITORING SYSTEM
CN115227957A (en) * 2022-07-26 2022-10-25 空芯微医疗科技(上海)有限责任公司 Method for preparing hollow microneedle and product thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3167073A (en) * 1962-01-16 1965-01-26 Rosenthal Sol Roy Transcutaneous injection device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US5250023A (en) * 1989-10-27 1993-10-05 Korean Research Institute on Chemical Technology Transdermal administration method of protein or peptide drug and its administration device thereof
US6050988A (en) * 1997-12-11 2000-04-18 Alza Corporation Device for enhancing transdermal agent flux
WO2001041864A1 (en) * 1999-12-10 2001-06-14 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466465A (en) * 1993-12-30 1995-11-14 Harrogate Holdings, Limited Transdermal drug delivery system
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
JP2713255B2 (en) * 1995-08-11 1998-02-16 日本電気株式会社 Leachate suction device
US6230051B1 (en) 1996-06-18 2001-05-08 Alza Corporation Device for enhancing transdermal agent delivery or sampling
DE69722414T2 (en) * 1996-07-03 2004-05-19 Altea Therapeutics Corp. MULTIPLE MECHANICAL MICROPERFORATION OF SKIN OR MUCOSA
US5983136A (en) * 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
JP2001525227A (en) * 1997-12-11 2001-12-11 アルザ・コーポレーション Device for increasing transdermal drug flow
US6126637A (en) * 1998-04-15 2000-10-03 Science Incorporated Fluid delivery device with collapsible needle cover
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3167073A (en) * 1962-01-16 1965-01-26 Rosenthal Sol Roy Transcutaneous injection device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US5250023A (en) * 1989-10-27 1993-10-05 Korean Research Institute on Chemical Technology Transdermal administration method of protein or peptide drug and its administration device thereof
US6050988A (en) * 1997-12-11 2000-04-18 Alza Corporation Device for enhancing transdermal agent flux
WO2001041864A1 (en) * 1999-12-10 2001-06-14 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery

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