WO2002005890A2 - Microdevice and method of manufacturing a microdevice - Google Patents
Microdevice and method of manufacturing a microdevice Download PDFInfo
- Publication number
- WO2002005890A2 WO2002005890A2 PCT/US2001/021791 US0121791W WO0205890A2 WO 2002005890 A2 WO2002005890 A2 WO 2002005890A2 US 0121791 W US0121791 W US 0121791W WO 0205890 A2 WO0205890 A2 WO 0205890A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- support
- skin
- recessed area
- skin penetrating
- bottom face
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15142—Devices intended for single use, i.e. disposable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
Definitions
- the present invention relates to a microdevice and to a method of manufacturing the microdevice.
- the invention is further directed to a method and device for withdrawing or delivering a substance transdermally to a patient.
- the invention is also directed to a method and apparatus for enhancing the penetration of a microneedle array.
- the skin is made up of several layers with the upper composite layer being the epithelial layer.
- the outermost layer of the skin is the stratum corneum that has well known barrier properties to prevent molecules and various substances from entering the body and analytes from exiting the body.
- the stratum corneum is a complex structure of compacted keratinized cell remnants having a thickness of about 10-30 microns.
- the stratum corneum forms a waterproof membrane to protect the body from invasion by various substances and the outward migration of various compounds.
- the natural impermeability of the stratum corneum prevents the administration of most pharmaceutical agents and other substances through the skin.
- Numerous methods and devices have been proposed to enhance the permeability of the skin and to increase the diffusion of various drugs through the skin to can be utilized by the body.
- the delivery of drugs through the skin is enhanced by either increasing the permeability of the skin or increasing the force or energy used to direct the drug through the skin.
- Another method of sampling and delivering various substances through the skin is by forming micropores or cuts through the stratum corneum.
- the devices for penetrating or piercing stratum corneum generally include a plurality of micron size needles or blades having a length to penetrate the stratum corneum without passing completely through the epidermis. Examples of these devices are disclosed in U.S. Patent No. 5,879,326 to Godshall et al.; U.S. Patent No.
- micron-sized needles or blades can be effective in delivering or sampling of substances in the body.
- these needles and blades having a length a few microns to a few hundred microns typically do not penetrate skin to a uniform depth.
- the natural elasticity and resilience of the skin will often result in the skin being deformed by the needles rather than pierced.
- a microneedle array when pressed against the skin often results in the outermost needles penetrating the skin while the innermost needles do not penetrate or only penetrate to depth less than the outermost needles.
- the prior methods and devices for the transdermal sampling and administration of substances have exhibited limited success. Accordingly, a continuing need exists in the industry for an improved device for the sampling and administration of various drugs and other substances to the body. Summary of the Invention
- the present invention is directed to a method and apparatus for the transdermal sampling or delivery of a substance though the skin of a patient.
- the invention is further directed to a method of manufacturing and assembling a device for delivering or withdrawing a substance through the skin of a patient.
- the invention is directed to a method and apparatus for delivering a pharmaceutical agent such as a drug or vaccine, to the stratum corneum of the skin to a sufficient depth where the pharmaceutical agent can be absorbed and utilized by the body.
- a primary object of the invention is to provide a device having a skin penetrating member and to a method of penetrating the skin for sampling or delivering a substance through the skin substantially without pain to the patient.
- Another object of the invention is to provide a device having a plurality of microtubes, needles, microneedles, blades or lancets for penetratmg or piercing the stratum corneum of the skin for withdrawing or delivering a substance though the skin of a patient.
- a further object of the invention is to provide a device having at least one skin penetrating member and a device for enhancing the penetration of the skin.
- Another object of the invention is to provide a device for sampling or delivering a substance to a patient where the device has a support and a microneedle device bonded to the support.
- a further object of the invention is to provide a device for withdrawing or delivering a substance where the device includes a skin penetrating device and a vacuum port for applying a vacuum to enhance penetration of the skin by the skin penetrating device.
- a still further object of the invention is to provide a method for enhancing skin penetration by a skin penetrating device in a target area by applying a vacuum to the surface of the target area and the skin penetrating device.
- Another object of the invention is to provide a method of assembling a device comprising fitting a microdevice into a recessed area in a support and applying a bonding agent to the recess to wick between the microdevice and the support.
- Still another object of the invention is to provide a method of bonding a microdevice to a support, where the support includes a recessed area and a channel having one end communicating with the channel, the method comprising fitting the microdevice in the recessed area and applying a bonding agent to the channel to flow into a gap between the support and the microdevice.
- the method comprises the steps of: providing a support having a bottom face with a recessed area having a dimension less than a dimension of said bottom face, positioning a skin penetrating device in said recessed area of said support.
- the skin penetrating device has a base and at least one skin penetrating member, the base has a dimension less than said dimension of said recessed area.
- a bonding agent is applied to at least one location between said support and said base in said recessed area, where the bonding agent has a viscosity to wick between the base and the support.
- a method of withdrawing a substance or delivering a substance through the skin of a patient comprising providing a support having a central passage, a bottom face, a one skin penetrating device on said bottom face, said central passage being in communication with said skin penetrating device, positioning said support on the skin of a patient with said bottom face of said support and said at least one skin penetrating device contacting said skin, reducing the pressure in an area between said support and said skin to draw said skin toward said skin penetrating member and to cause said skin penetrating device to penetrate said skin, and withdrawing or delivering a substance through the skin of said patient.
- Another object of the invention is to provide a device for delivering or withdrawing a substance from a patient, said device comprising: a support member having a bottom face and a recessed area having a dimension less than a dimension of said bottom face, a skin penetrating device having a base and at least one skin penetrating member, said base being positioned within said recessed area of said support, and a bonding material attaching said skin penetrating device to said support member and filling a space between said recessed area and said base of said skin penetrating device.
- Figure 1 is a perspective view of the sampling or delivery device in accordance with a first embodiment of the invention
- Figure 2 is an exploded cross-sectional view of the device of Figure 1;
- Figure 3 is a bottom view of the device of Figure 1 showing the support without the skin penetrating members;
- Figure 4 is a bottom view of the device of Figure 1 showing the skin penetrating member bonded to the support;
- Figure 5 is partial side elevational view in cross-section of the support and the skin penetrating member fitted in the recess of the support before bonding
- Figure 6 is a partial side elevational view in cross-section of the device showing the bonding agent for attaching the skin penetrating device to the support;
- Figure 7 is a side view showing the device in contact with the skin of a patient
- Figure 8 is a side view of the device in a second embodiment
- Figure 9 is a perspective view of the device of the embodiment of Figure 8 showing the bottom side and the recess for receiving the skin-penetrating device
- Figure 10 is a bottom view of the device of Figure 8 showing the skin penetrating members
- Figure 11 is a cross sectional side view of the device of Figure 8 in contact with the skin of a patient.
- Figure 12 is a cross sectional side view of Figure 8 showing the penetration of skin when a vacuum is applied to the imier area of the device.
- the present invention is directed to an intradermal device for sampling, monitoring or delivering a substance through the skin of a patient. More particularly, the invention is directed to a sampling, monitoring or delivery device and to a method for sampling or administering a substance into or below the stratum corneum of the skin of a patient. The invention is further directed to a method of manufacturing the sampling, monitoring or delivery device.
- penetrate refers to entering a layer of the skin without passing completely through.
- Piercing refers to passing completely through a layer of the skin.
- a pharmaceutical agent includes a substance having biological activity that can be delivered through the body membranes and surfaces, and particularly the skin. Examples include antibiotics, antiviral agents, analgesics, anesthetics, anorexics, antiarthritics, antidepressants, antihistamines, anti-inflammatory agents, antineoplastic agents, vaccines, including DNA vaccines, and the like.
- Other substances that can be delivered intradermally to a patient include proteins, peptides and fragments thereof. The proteins and peptides can be naturally occurring, synthesized or recombinantly produced.
- the device and method are also suitable for withdrawing a substance or monitoring the level of a substance in the body.
- substances that can be monitored or withdrawn include analytes, glucose, drugs and the like.
- the invention is directed to a device 10, having a support 12 and a microdevice 14.
- the device 10 can be a monitoring device for monitoring a substance level in the body, a sampling device for withdrawing a sample from the body, or a delivery device for delivering a substance to the body.
- support 12 in this embodiment has a base 16 with a generally circular configuration, hi further embodiments, base 16 can have a non-circular configuration depending on the intended use of the device.
- Base 16 includes a top face 18 and a bottom face 20 and a central passage 22. As shown in Figure 2, central passage 22 extends completely through support 12 to form a cavity within support 12.
- a collar 24 extends, from top face 18 and defines central passage 22. Collar 24 includes a top end 26, defining an inlet opening 28 to central passage 22. A flange 30 extends radially outward from top end 26of collar 24 to form a threaded coupling member. In the embodiment of Figure 1, the flange 30 and collar 24 form a female Luer-type fitting.
- Bottom face 20 of support 12 is substantially flat, as shown in Figure 2.
- a recessed area 32 is formed in bottom-face 20 and is in communication with central passage 22. Referring to Figures 2 and 3, recessed area 32 is shown as having a generally square configuration and includes a side face 34 and a bottom face 36. Side face 34 in the embodiment illustrated is substantially perpendicular to bottom face 20 of support 12. Bottom face 34 of recessed area 32 is generally perpendicular to side face 34. Generally, bottom face 36 of recessed area is coplanar with bottom face 20.
- an open channel 38 formed in bottom face 20 extends outward from recessed area 32 toward an outer edge 42 of support 12.
- two channels 38 extend from opposite corners of recessed area 32 to circular recesses 40.
- channels 38 can completely to outer ddge 42 of bottom face20.
- Microdevice 14 in the illustrated embodiments of the invention is a penetrating device suitable for use in monitoring, sampling or delivering a substance though the skin of a patient, hi preferred embodiments, microdevice 14 includes a plurality of skin penetratmg members 44 extending outwardly from a base 46.
- skin penetrating member refers to a member that is able to pierce or penetrate the skin to a desired depth.
- Skin penetrating members 44 are shown as microneedles having a substantially square cross- sectional shape and a beveled tip 48.
- An axial passage 50 extends through each skin penetrating member 44 and base 46 so that axial passage 50 extends from the top face 52 to beveled tip 48.
- skin penetrating members 44 are arranged in an array of substantially uniformly spaced apart rows and columns. The spacing between the rows and columns can be varied depending on the substance being delivered or withdrawn and the area of the skin contacted with the device. When, the skin penetrating devices are microneedles, the microneedles are spaced apart about 0.05 mm to about 5 mm.
- Base 46 of microdevice 14 is dimensioned to fit within recessed area 32 as shown in Figures 4 and 5.
- side face 34 of recessed area 32 has a height to define a depth of recessed area 32 that is less than a thickness of base 46 of microdevice 14.
- recessed area 32 has a depth approximately one-half the thickness of base 46. In an alternative embodiment, recessed area 32 can have a depth substantially equal to the thickness of base 46.
- base 46 has a thickness of about 250 microns.
- base 46 of microdevice 14 has a length and width slightly less than the length and width of recessed area 32 to define a gap 54 between a side edge 56 of base 46 and side face 34 of recessed area 32 as shown in Figure 5.
- base 46 has an outer dimension substantially equal to the dimension of recessed area 32.
- Device 10 is assembled by positioning microdevice 14 in recessed area 32 with a substantially uniform gap 54 formed around the perimeter of base 46.
- Top face 52 of base 46 preferably rests against bottom face 36 of recessed area 32 as shown in Figure 5.
- an adhesive is applied to recess 40 at the end of channel 38.
- the adhesive preferably has a sufficiently low viscosity to flow along channel 38 and wick into gap 54 by the surface tension of the adhesive.
- the adhesive fills gap 54 and surrounds base 46 to attach base 46 to support 12 and form a substantially fluid tight seal.
- the adhesive wicks between bottom face 36 of recessed area 32 and top face 52 of base 46 as shown in Figure 6 without the need to apply a force to the adhesive.
- the adhesive 58 flows along top face 52 of base 46 into central passage 22 of support 12.
- the surface tension of adhesive 58 fills an area between a vertical side wall 60 in central passage 22 and top face 52 of base 46.
- the adhesive flows along the surfaces of wall 60 and top surface 52 until adhesive 58 attains a radius of curvature 62 within central passage 22 substantially equal to a radius of curvature 64 of adhesive in gap 54.
- Adhesive 58 can be any suitable adhesive as know in the art capable of bonding the materials together.
- the adhesive is a UV curable accelerated adhesive such as the adhesive sold under the trade name Lock-Tite 3311.
- device 10 is placed against the skin 70 of a patient as shown in Figure 7 and pressed downwardly toward the skin 70 in the direction of arrow 72 to cause skin penetrating members 44 to pierce the surface of skin 70.
- Bottom face 20 of support 12 has a dimension to form a sealing flange against the surface of skin 70 completely surrounding microdevice 14.
- a syringe 74 having a Luer collar 76 and is coupled to flange 30 of collar 24 to form a fluid tight seal. Syringe 74 can then be actuated to dispense a substance into or through inlet 28 to central passage 22 and through axial passages 50 of skin penetrating members 44. Syringe 74 can be actuated to apply sufficient force to deliver the substance through the skin of the patient. Alternatively, syringe 74 can be used to extract or withdraw a substance from the patient through the skin.
- Bottom face 20 of support 12 can include a friction-enhancing member such as a rib or a tacky material applied to bottom face 20.
- support 12 is formed from a resilient material such that support 12 is able to conform to the shape of skin 70.
- Bottom face 20 of support 12 forms a sealing flange to contain fluid dispensed through skin penetrating member 44 to prevent leakage and to direct the fluid into the skin or to withdraw a substance through the skin of the patient.
- bottom face 20 frictionally grips the skin, thereby decreasing relative motion between the support 12, skin penetrating members 44 and the skin 70. This decreases lateral sheer forces on the skin penetrating members 44 to reduce the instance of 5 breakage and abrasion of the skin.
- Support 12 is preferably made from a plastic material that is non-reactive with the substance being delivered or withdrawn from the patient.
- plastic materials include, for example, polyethylene, polypropylene, polyesters, polyamines, polycarbonates, and copolymers thereof as known in the art.
- Microdevice 14 can also be made from suitable materials as known in the art.
- microdevice 14 includes a plurality of microneedles formed into an array formed from spaced-apart rows and columns. The microneedles can be formed from a silicon wafer that is machined or etched to form the microneedle array.
- the microneedle array can also be formed from stainless steel, tungsten steel, and alloys of nickel, molybdenum, chromium, cobalt and titanium.
- the microneedles can be formed from ceramic materials, glass polymers and other non-reactive metals, h further embodiments, microdevice 14 can be formed from needles that are mounted in a suitable base.
- the skin penetrating members have a length suitable to achieve the desired depth of penetration in the skin.
- the length and thickness of the skin penetrating members are selected based on the substance being administered or withdrawn and the thickness of the skin in the location where the device is to be applied.
- the skin penetrating members can be microneedles, microtubes, solid or hollow needles, lancets and the like.
- the skin penetrating members have a length of about 50 microns to about 2,000 microns and preferably, about 250 microns to 1,000 microns.
- the skin penetrating members are about 15-gauge to about 40-gauge needles, having a length of about 500 microns to about 1,000 microns.
- the skin penetrating members have a substantially square cross-sectional shape.
- the skin penetrating members can be triangular, cylindrical, pyramid-shaped or flat blades.
- Microdevice 14 can have a width and length as necessary to achieve the desired result. In one embodiment, microdevice 14 is about one cm 2 to about 10 cm 2 , i further embodiments, microdevice 14 can have a width and length of about one centimeter to about five centimeters.
- a pharmaceutical agent or drug solution is introduced into the central passage by a syringe or other fluid dispensing device
- a dried or lyopl ilized drug or pharmaceutical agent can be provided on the outer surfaces of the skin penetrating members or in the axial passages of the skin penetrating member.
- a diluent such as distilled water or saline solution can then be injected through the central passage and through the axial passage of the skin penetrating members to dissolve and reconstitute the drug or pharmaceutical agent and then deliver the drug to the patient.
- device 80 includes a support 82 and a microdevice 84 having a plurality of skin penetrating members 86.
- Support 82 has a substantially frustoconical top surface 88 and a bottom surface 90.
- Support 82 has a peripheral outer edge 92 and an annular flange 94 extending substantially perpendicular from bottom surface 90.
- a collar 96 extends from top surface 88 of support 82 in a generally axial direction.
- Collar 96 includes a flange 98 extending outwardly from a top end 100 of collar 96.
- An axial passage 102 extends through collar 96 to bottom surface 90 of support 82 to form a central opening 104 in bottom face 90.
- a collar 106 extends from top surface 88 of support 82 and is spaced from collar 96.
- Collar 106 includes a flange 108 extending radially outwardly at an outer end 105.
- An axial passage 110 extends through collar 106 to bottom surface 90 of support 82 to form an outlet port 112 in bottom surface 90.
- bottom surface 90 includes a recessed area 114 forming a ledge for receiving microdevice 84.
- Channels 116 and a recess forming an adhesive reservoir 118 are connected to recessed area 114 for directing an adhesive to recessed area 114 to bond microdevice 84 to support 82.
- device 80 is placed against the skin 120 as shown in Figure 11.
- Device 110 is positioned with flange 94 contacting skin 120 and encircling a target area 122.
- flange 94 has an axial length to lie in a plane that is coplanar with the tips 124 of skin penetrating members 86.
- Device 80 is pressed against the skin 120 and a suitable vacuum source is coupled to collar 106.
- vacuum source is a syringe having a Luer lock collar threaded onto flange 108 of collar 106.
- the plunger of the syringe can be extracted to create a reduced pressure in the target area 122 which pulls the skin upwardly into contact with skin penetrating members 86.
- Pulling the skin 70 upwardly by reducing the pressure in the space between bottom wall 90 and skin 120 enables skin penetrating members 86 to penetrate or pierce the skin substantially uniformly across the width of microdevice 84.
- the vacuum source is maintained during the sampling or delivery of a substance to maintain penetration of the skin by the skin penetrating members.
- maintaining the vacuum prevents movement of the device with respect to the skin to prevent breakage of the skin penetrating members and abrasion of the skin.
- a supply or sampling container such as a syringe 128, is coupled to collar 96 using a Luer type fitting.
- the syringe plunger is withdrawn to reduce the pressure in the central area of support 82 to withdraw a fluid through the axial passage in the skin penetrating members.
- a substance can be delivered to the patient by directing the substance to the central passage of support 82 and through the axial passage of skin penetrating member 86.
- a substance can be delivered to a patient under pressure as an active delivery system or without pressure as a passive delivery system. The device is left in contact with the skin for sufficient time to withdraw the desired substance or deliver the substance to the patient. The time required is dependent on the substance being delivered or withdrawn, the volume of the substance, and the target area on the skin.
- the device of the invention is generally designed to be a disposable, single-use device.
- the device can be used safely and effectively for intradermal delivery of a pharmaceutical agent or other substance.
- the device is particularly suitable for introducing a vaccine intradermally for efficiently delivering a small amount of a vaccine antigen for presentation to the Langerhans cells.
- the length, width and spacing of the microneedles can vary depending on the pharmaceutical agent being admimstered or required to penetrate the stratum corneum to the optimum depth for the specific pharmaceutical agent being administered.
- the microneedles are dimensioned to target the optimum intradermal delivery site to promote the desired immune response.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001273340A AU2001273340A1 (en) | 2000-07-14 | 2001-07-11 | Microdevice and method of manufacturing a microdevice |
DE60124917T DE60124917T2 (en) | 2000-07-14 | 2001-07-11 | MICRO-DEVICE AND METHOD OF MANUFACTURE |
EP01952607A EP1301237B1 (en) | 2000-07-14 | 2001-07-11 | Microdevice and method of manufacturing a microdevice |
JP2002511820A JP4892166B2 (en) | 2000-07-14 | 2001-07-11 | Micro device and method for manufacturing the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/616,771 US6440096B1 (en) | 2000-07-14 | 2000-07-14 | Microdevice and method of manufacturing a microdevice |
US09/616,771 | 2000-07-14 |
Publications (2)
Publication Number | Publication Date |
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WO2002005890A2 true WO2002005890A2 (en) | 2002-01-24 |
WO2002005890A3 WO2002005890A3 (en) | 2002-04-25 |
Family
ID=24470876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/021791 WO2002005890A2 (en) | 2000-07-14 | 2001-07-11 | Microdevice and method of manufacturing a microdevice |
Country Status (8)
Country | Link |
---|---|
US (2) | US6440096B1 (en) |
EP (1) | EP1301237B1 (en) |
JP (1) | JP4892166B2 (en) |
AT (1) | ATE346645T1 (en) |
AU (1) | AU2001273340A1 (en) |
DE (1) | DE60124917T2 (en) |
ES (1) | ES2276805T3 (en) |
WO (1) | WO2002005890A2 (en) |
Cited By (31)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2005521524A (en) * | 2002-04-02 | 2005-07-21 | ベクトン・ディキンソン・アンド・カンパニー | Intradermal delivery device with valve |
JP2006500973A (en) * | 2002-06-25 | 2006-01-12 | スン−ユン クウォン, | Rapidly dissolving microperforators and other applications for drug delivery |
JP2009501184A (en) * | 2005-07-13 | 2009-01-15 | エフ.ホフマン−ラ ロシュ アーゲー | Benzimidazole derivatives as 5-HT6 and 5-HT24 |
FR2923151A1 (en) * | 2007-11-02 | 2009-05-08 | Commissariat Energie Atomique | BLOOD SAMPLING DEVICE COMPRISING AT LEAST ONE FILTER. |
US8551391B2 (en) | 2004-02-17 | 2013-10-08 | Avery Dennison Corporation | Method of making microneedles |
US8561795B2 (en) | 2010-07-16 | 2013-10-22 | Seventh Sense Biosystems, Inc. | Low-pressure packaging for fluid devices |
US8808202B2 (en) | 2010-11-09 | 2014-08-19 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
US8821412B2 (en) | 2009-03-02 | 2014-09-02 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving fluids |
CN104056345A (en) * | 2013-03-22 | 2014-09-24 | 北京神州汉方医药科技有限公司 | Transdermal drug delivery device |
US9033898B2 (en) | 2010-06-23 | 2015-05-19 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
US9041541B2 (en) | 2010-01-28 | 2015-05-26 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
US9113836B2 (en) | 2009-03-02 | 2015-08-25 | Seventh Sense Biosystems, Inc. | Devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications |
US9119578B2 (en) | 2011-04-29 | 2015-09-01 | Seventh Sense Biosystems, Inc. | Plasma or serum production and removal of fluids under reduced pressure |
WO2015138207A1 (en) * | 2014-03-10 | 2015-09-17 | 3M Innovative Properties Company | Micro-needle device |
US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
US9333282B2 (en) | 2006-08-04 | 2016-05-10 | Kci Medical Resources | Wound-stimulating unit and method |
WO2016140750A1 (en) * | 2015-03-02 | 2016-09-09 | Verily Life Sciences Llc | Automated sequential injection and blood draw |
US10251792B2 (en) | 2013-02-20 | 2019-04-09 | Cytrellis Biosystems, Inc. | Methods and devices for skin tightening |
US10327689B2 (en) | 2015-03-02 | 2019-06-25 | Verily Life Sciences Llc | Automated blood sampling device |
CN109938777A (en) * | 2019-04-02 | 2019-06-28 | 汕头大学医学院第一附属医院 | A kind of skin auxiliary examination is mechanical |
US10543310B2 (en) | 2011-12-19 | 2020-01-28 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
US10555754B2 (en) | 2013-08-09 | 2020-02-11 | Cytrellis Biosystems, Inc. | Methods and apparatuses for skin treatment using non-thermal tissue ablation |
US10953143B2 (en) | 2013-12-19 | 2021-03-23 | Cytrellis Biosystems, Inc. | Methods and devices for manipulating subdermal fat |
US11166743B2 (en) | 2016-03-29 | 2021-11-09 | Cytrellis Biosystems, Inc. | Devices and methods for cosmetic skin resurfacing |
US11177029B2 (en) | 2010-08-13 | 2021-11-16 | Yourbio Health, Inc. | Systems and techniques for monitoring subjects |
US11202895B2 (en) | 2010-07-26 | 2021-12-21 | Yourbio Health, Inc. | Rapid delivery and/or receiving of fluids |
US11213667B2 (en) * | 2018-07-11 | 2022-01-04 | Santa Clara University | 3D printed microneedles for microencapsulated mammalian cell extrusion |
US11324534B2 (en) | 2014-11-14 | 2022-05-10 | Cytrellis Biosystems, Inc. | Devices and methods for ablation of the skin |
US11363977B2 (en) | 2017-07-25 | 2022-06-21 | Ascilion Ab | Suction applying device, an apparatus for sampling a bodily fluid and a method for detecting a component in a bodily fluid |
US11464954B2 (en) | 2016-09-21 | 2022-10-11 | Cytrellis Biosystems, Inc. | Devices and methods for cosmetic skin resurfacing |
EP3960228A4 (en) * | 2019-04-25 | 2023-05-31 | Cosmed Pharmaceutical Co., Ltd. | Applicator 2 of water-soluble sheet-like formulation |
Families Citing this family (233)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
US9717451B2 (en) * | 2000-06-08 | 2017-08-01 | Becton, Dickinson And Company | Device for withdrawing or administering a substance and method of manufacturing a device |
US6607513B1 (en) * | 2000-06-08 | 2003-08-19 | Becton, Dickinson And Company | Device for withdrawing or administering a substance and method of manufacturing a device |
US6603987B2 (en) * | 2000-07-11 | 2003-08-05 | Bayer Corporation | Hollow microneedle patch |
US6749575B2 (en) * | 2001-08-20 | 2004-06-15 | Alza Corporation | Method for transdermal nucleic acid sampling |
US6533949B1 (en) * | 2000-08-28 | 2003-03-18 | Nanopass Ltd. | Microneedle structure and production method therefor |
US7131987B2 (en) * | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
US7828827B2 (en) * | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
US6821281B2 (en) | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
AU2002237703A1 (en) * | 2000-11-09 | 2002-06-18 | Biovalve Technologies, Inc. | Microneedle adapter |
EP1345646A2 (en) * | 2000-12-14 | 2003-09-24 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
US6663820B2 (en) * | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
WO2002085447A2 (en) * | 2001-04-20 | 2002-10-31 | Alza Corporation | Microprojection array having a beneficial agent containing coating |
US6591124B2 (en) * | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
US7186235B2 (en) * | 2001-06-08 | 2007-03-06 | Becton, Dickinson And Company | Device for manipulating a needle or abrader array and method of use |
WO2003022330A2 (en) * | 2001-09-12 | 2003-03-20 | Becton, Dickinson And Company | Microneedle-based pen device for drug delivery and method for using same |
US20040087992A1 (en) * | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
US6830562B2 (en) | 2001-09-27 | 2004-12-14 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US7429258B2 (en) * | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
US20050033197A1 (en) * | 2001-12-06 | 2005-02-10 | Cottler Patrick S | Apparatus for fluid transport and related method thereof |
US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
EP1490147A2 (en) * | 2002-03-04 | 2004-12-29 | Nano Pass Technologies Ltd. | Devices and methods for transporting fluid across a biological barrier |
US7387742B2 (en) * | 2002-03-11 | 2008-06-17 | Becton, Dickinson And Company | Silicon blades for surgical and non-surgical use |
AU2003231967B2 (en) * | 2002-03-11 | 2006-10-12 | Beaver-Visitec International (Us), Inc. | System and method for the manufacture of surgical blades |
US7115108B2 (en) * | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
US6945952B2 (en) * | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
JP4460451B2 (en) * | 2002-08-29 | 2010-05-12 | ベクトン・ディキンソン・アンド・カンパニー | Substance delivery by rotating micro-peeling surface |
US20040051019A1 (en) | 2002-09-02 | 2004-03-18 | Mogensen Lasse Wesseltoft | Apparatus for and a method of adjusting the length of an infusion tube |
US8062573B2 (en) * | 2002-09-16 | 2011-11-22 | Theraject, Inc. | Solid micro-perforators and methods of use |
WO2004033021A1 (en) * | 2002-10-07 | 2004-04-22 | Biovalve Technologies, Inc. | Microneedle array patch |
DK200201823A (en) | 2002-11-26 | 2004-05-27 | Maersk Medical As | Connection piece for a hose connection |
US7578954B2 (en) * | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
US20090007436A1 (en) * | 2003-03-10 | 2009-01-08 | Daskal Vadim M | Silicon blades for surgical and non-surgical use |
US20050155955A1 (en) * | 2003-03-10 | 2005-07-21 | Daskal Vadim M. | Method for reducing glare and creating matte finish of controlled density on a silicon surface |
TW566423U (en) * | 2003-04-23 | 2003-12-11 | Ind Tech Res Inst | Structure for miniature gripping clip |
AU2004251699A1 (en) * | 2003-06-04 | 2005-01-06 | Georgia Tech Research Corporation | Drilling microneedle device |
IL156374A0 (en) * | 2003-06-10 | 2004-01-04 | Danenberg Holdings 2000 Ltd N | Method for removing a pigmented section of skin |
CA2530531A1 (en) * | 2003-06-30 | 2005-01-20 | Alza Corporation | Formulations for coated microprojections containing non-volatile counterions |
US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
IL157696A0 (en) * | 2003-09-01 | 2004-03-28 | Hawk Medical Technologies Ltd | Apparatus and method for removing a pigmented section of skin |
EP1662970A2 (en) * | 2003-09-17 | 2006-06-07 | Becton, Dickinson and Company | System and method for creating linear and non-linear trenches in silicon and other crystalline materials with a router |
US7956742B2 (en) | 2003-10-30 | 2011-06-07 | Motedata Inc. | Method and system for storing, retrieving, and managing data for tags |
US7388488B2 (en) * | 2003-10-30 | 2008-06-17 | Peter Lupoli | Method and system for storing, retrieving, and managing data for tags |
US7998119B2 (en) * | 2003-11-18 | 2011-08-16 | Nano Pass Technologies Ltd. | System and method for delivering fluid into flexible biological barrier |
EP1699524A4 (en) * | 2003-11-18 | 2009-07-15 | Nanopass Technologies Ltd | Enhanced penetration system and method for sliding microneedles |
US8017145B2 (en) * | 2003-12-22 | 2011-09-13 | Conopco, Inc. | Exfoliating personal care wipe article containing an array of projections |
EP1706171A1 (en) * | 2003-12-29 | 2006-10-04 | 3M Innovative Properties Company | Medical devices and kits including same |
WO2005087305A1 (en) * | 2004-03-12 | 2005-09-22 | Agency For Science, Technology And Research | Methods and moulds for use in fabricating side-ported microneedles |
WO2005094526A2 (en) | 2004-03-24 | 2005-10-13 | Corium International, Inc. | Transdermal delivery device |
EP1727577A1 (en) | 2004-03-26 | 2006-12-06 | Unomedical A/S | Injector device for infusion set |
US7331953B2 (en) * | 2004-04-01 | 2008-02-19 | The Gneral Hospital Corporation | Method and apparatus for dermatological treatment |
BRPI0509806A (en) * | 2004-04-12 | 2007-09-18 | Allergan Inc | multi-site injection system |
US7396484B2 (en) * | 2004-04-30 | 2008-07-08 | Becton, Dickinson And Company | Methods of fabricating complex blade geometries from silicon wafers and strengthening blade geometries |
BRPI0509788A (en) | 2004-05-13 | 2007-10-23 | Alza Corp | apparatus and method for transdermal delivery of parathyroid hormone agents |
ES2650188T3 (en) * | 2004-06-10 | 2018-01-17 | 3M Innovative Properties Company | Device and patch application kit |
US8062250B2 (en) | 2004-08-10 | 2011-11-22 | Unomedical A/S | Cannula device |
ATE490037T1 (en) * | 2004-08-16 | 2010-12-15 | Functional Microstructures Ltd | METHOD FOR PRODUCING A MICRONEEDLE OR A MICROIMPLANT |
US7316665B2 (en) * | 2004-08-25 | 2008-01-08 | Becton, Dickinson And Company | Method and device for the delivery of a substance including a covering |
WO2006055799A1 (en) * | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
JP4927752B2 (en) | 2004-11-18 | 2012-05-09 | スリーエム イノベイティブ プロパティズ カンパニー | Microneedle array applicator and holding device |
CA2587387C (en) | 2004-11-18 | 2013-06-25 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
KR20130026511A (en) | 2004-11-18 | 2013-03-13 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Low-profile microneedle array applicator |
EP1819379B1 (en) * | 2004-11-18 | 2016-08-31 | Nanopass Technologies Ltd. | System for delivering fluid into flexible biological barrier |
CN101072597B (en) | 2004-12-10 | 2010-06-16 | 优诺医疗有限公司 | Inserter |
WO2006064270A1 (en) * | 2004-12-17 | 2006-06-22 | Functional Microstructures Limited | Microneedle device for transdermal transport of fluid |
US7985199B2 (en) * | 2005-03-17 | 2011-07-26 | Unomedical A/S | Gateway system |
JP5301985B2 (en) | 2005-04-07 | 2013-09-25 | スリーエム イノベイティブ プロパティズ カンパニー | System and method for tool feedback sensing |
US20060253078A1 (en) * | 2005-04-25 | 2006-11-09 | Wu Jeffrey M | Method of treating skin disorders with stratum corneum piercing device |
US8137314B2 (en) * | 2006-08-23 | 2012-03-20 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with compressible or curved reservoir or conduit |
US8840586B2 (en) * | 2006-08-23 | 2014-09-23 | Medtronic Minimed, Inc. | Systems and methods allowing for reservoir filling and infusion medium delivery |
US8277415B2 (en) | 2006-08-23 | 2012-10-02 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
US8512288B2 (en) | 2006-08-23 | 2013-08-20 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
US9233203B2 (en) * | 2005-05-06 | 2016-01-12 | Medtronic Minimed, Inc. | Medical needles for damping motion |
US20080097291A1 (en) * | 2006-08-23 | 2008-04-24 | Hanson Ian B | Infusion pumps and methods and delivery devices and methods with same |
US7905868B2 (en) | 2006-08-23 | 2011-03-15 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
EP1904158B1 (en) | 2005-06-24 | 2013-07-24 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
JP5144510B2 (en) * | 2005-06-27 | 2013-02-13 | スリーエム イノベイティブ プロパティズ カンパニー | Microneedle array application device |
MX2008001803A (en) * | 2005-08-01 | 2008-04-16 | Hawk Medical Technologies Ltd | Eradication of pigmentation and scar tissue. |
EP1928537B1 (en) * | 2005-09-02 | 2015-01-21 | Intercell USA, Inc. | Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs |
ES2478623T3 (en) * | 2005-09-06 | 2014-07-22 | Theraject, Inc. | Solid solution perforator containing drug particles and / or drug adsorbent particles |
US9486274B2 (en) | 2005-09-07 | 2016-11-08 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US9011473B2 (en) | 2005-09-07 | 2015-04-21 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US10548659B2 (en) | 2006-01-17 | 2020-02-04 | Ulthera, Inc. | High pressure pre-burst for improved fluid delivery |
US9358033B2 (en) * | 2005-09-07 | 2016-06-07 | Ulthera, Inc. | Fluid-jet dissection system and method for reducing the appearance of cellulite |
US8518069B2 (en) | 2005-09-07 | 2013-08-27 | Cabochon Aesthetics, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
DE602005023458D1 (en) | 2005-09-12 | 2010-10-21 | Unomedical As | A delivery system for an infusion set having first and second spring units |
WO2007047539A2 (en) * | 2005-10-14 | 2007-04-26 | Medtronic, Inc. | Localized delivery to the lymphatic system |
US7885793B2 (en) | 2007-05-22 | 2011-02-08 | International Business Machines Corporation | Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution |
USD655807S1 (en) | 2005-12-09 | 2012-03-13 | Unomedical A/S | Medical device |
RU2419459C2 (en) | 2005-12-23 | 2011-05-27 | Уномедикал А/С | Drug introduction device |
EP1971278A4 (en) * | 2006-01-12 | 2009-12-23 | Nano Pass Technologies Ltd | Device for superficial abrasive treatment of the skin |
US9610459B2 (en) | 2009-07-24 | 2017-04-04 | Emkinetics, Inc. | Cooling systems and methods for conductive coils |
US9339641B2 (en) | 2006-01-17 | 2016-05-17 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
DE602007013723D1 (en) | 2006-02-09 | 2011-05-19 | Deka Products Lp | SYSTEMS FOR DISPENSING FLUIDS IN PATCH SIZE |
KR20080104342A (en) | 2006-02-28 | 2008-12-02 | 우노메디컬 에이/에스 | Inserter for infusion part and infusion part provided with needle protector |
WO2007124411A1 (en) * | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US8439838B2 (en) | 2006-06-07 | 2013-05-14 | Unomedical A/S | Inserter for transcutaneous sensor |
CA2653764A1 (en) | 2006-06-09 | 2007-12-13 | Unomedical A/S | Mounting pad |
NZ594136A (en) | 2006-06-15 | 2013-03-28 | Seagull Ip Pty Ltd | Delivery of bound material from body to surface using ultrasonic signal |
KR20090037492A (en) | 2006-08-02 | 2009-04-15 | 우노메디컬 에이/에스 | Cannula and delivery device |
US7828764B2 (en) * | 2006-08-23 | 2010-11-09 | Medtronic Minimed, Inc. | Systems and methods allowing for reservoir filling and infusion medium delivery |
US7811262B2 (en) * | 2006-08-23 | 2010-10-12 | Medtronic Minimed, Inc. | Systems and methods allowing for reservoir filling and infusion medium delivery |
US7682338B2 (en) * | 2006-08-23 | 2010-03-23 | Medtronic Minimed, Inc. | Infusion medium delivery system, device and method with needle inserter and needle inserter device and method |
US20080051765A1 (en) * | 2006-08-23 | 2008-02-28 | Medtronic Minimed, Inc. | Systems and methods allowing for reservoir filling and infusion medium delivery |
US7794434B2 (en) * | 2006-08-23 | 2010-09-14 | Medtronic Minimed, Inc. | Systems and methods allowing for reservoir filling and infusion medium delivery |
WO2008042902A2 (en) | 2006-10-02 | 2008-04-10 | Emkinetics, Inc. | Method and apparatus for magnetic induction therapy |
US9005102B2 (en) | 2006-10-02 | 2015-04-14 | Emkinetics, Inc. | Method and apparatus for electrical stimulation therapy |
US10786669B2 (en) | 2006-10-02 | 2020-09-29 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
US11224742B2 (en) | 2006-10-02 | 2022-01-18 | Emkinetics, Inc. | Methods and devices for performing electrical stimulation to treat various conditions |
EP1917990A1 (en) | 2006-10-31 | 2008-05-07 | Unomedical A/S | Infusion set |
WO2008091602A2 (en) | 2007-01-22 | 2008-07-31 | Corium International, Inc. | Applicators for microneedle arrays |
US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US8597243B2 (en) | 2007-04-30 | 2013-12-03 | Medtronic Minimed, Inc. | Systems and methods allowing for reservoir air bubble management |
US8323250B2 (en) | 2007-04-30 | 2012-12-04 | Medtronic Minimed, Inc. | Adhesive patch systems and methods |
US7959715B2 (en) | 2007-04-30 | 2011-06-14 | Medtronic Minimed, Inc. | Systems and methods allowing for reservoir air bubble management |
US7963954B2 (en) | 2007-04-30 | 2011-06-21 | Medtronic Minimed, Inc. | Automated filling systems and methods |
US8434528B2 (en) | 2007-04-30 | 2013-05-07 | Medtronic Minimed, Inc. | Systems and methods for reservoir filling |
US8613725B2 (en) | 2007-04-30 | 2013-12-24 | Medtronic Minimed, Inc. | Reservoir systems and methods |
EP2146760B1 (en) | 2007-04-30 | 2018-10-10 | Medtronic MiniMed, Inc. | Reservoir filling, bubble management, and infusion medium delivery systems and methods with same |
DK2155311T3 (en) | 2007-06-20 | 2013-02-04 | Unomedical As | METHOD AND APPARATUS FOR PREPARING A CATHETIC |
EP2185224A1 (en) | 2007-07-03 | 2010-05-19 | Unomedical A/S | Inserter having bistable equilibrium states |
DE602008005153D1 (en) | 2007-07-10 | 2011-04-07 | Unomedical As | INSERT WITH TWO SPRINGS |
US8246588B2 (en) | 2007-07-18 | 2012-08-21 | Unomedical A/S | Insertion device with pivoting action |
US8439940B2 (en) | 2010-12-22 | 2013-05-14 | Cabochon Aesthetics, Inc. | Dissection handpiece with aspiration means for reducing the appearance of cellulite |
WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
GB0802447D0 (en) * | 2008-02-09 | 2008-03-19 | Univ Manchester | Fluid extraction device, associated materials and methods |
CA2713485A1 (en) | 2008-02-13 | 2009-08-20 | Unomedical A/S | Sealing between a cannula part and a fluid path |
CA2715667A1 (en) | 2008-02-20 | 2009-08-27 | Unomedical A/S | Insertion device with horizontally moving part |
KR101383285B1 (en) * | 2008-05-21 | 2014-04-08 | 테라젝트, 인코포레이티드 | Method of manufacturing solid solution perforator patches and uses thereof |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
EP2334234A4 (en) | 2008-09-19 | 2013-03-20 | Tandem Diabetes Care Inc | Solute concentration measurement device and related methods |
MX2011005735A (en) | 2008-12-22 | 2011-06-21 | Unomedical As | Medical device comprising adhesive pad. |
WO2011014704A2 (en) | 2009-07-30 | 2011-02-03 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
EP2459252B1 (en) | 2009-07-30 | 2013-08-21 | Unomedical A/S | Inserter device with horizontal moving part |
US11096708B2 (en) | 2009-08-07 | 2021-08-24 | Ulthera, Inc. | Devices and methods for performing subcutaneous surgery |
BR112012002804A2 (en) | 2009-08-07 | 2016-05-31 | Unomedical As | sensor device and one or more cannulas |
US9358064B2 (en) | 2009-08-07 | 2016-06-07 | Ulthera, Inc. | Handpiece and methods for performing subcutaneous surgery |
JP2013508119A (en) | 2009-10-26 | 2013-03-07 | エムキネティクス, インコーポレイテッド | Method and apparatus for electromagnetic stimulation of nerves, muscles and body tissues |
RU2539991C2 (en) | 2009-12-16 | 2015-01-27 | Кронтек Фарма Аб | Injector and device |
WO2011075676A2 (en) | 2009-12-18 | 2011-06-23 | Knowlton Edward W | A skin treatment and drug delivery device |
CA2792138A1 (en) | 2010-03-30 | 2011-10-06 | Unomedical A/S | Medical device |
MX2012012567A (en) | 2010-04-28 | 2012-11-21 | Kimberly Clark Co | Method for increasing permeability of an epithelial barrier. |
EP2563450B1 (en) | 2010-04-28 | 2017-07-26 | Kimberly-Clark Worldwide, Inc. | Device for delivery of rheumatoid arthritis medication |
RU2585138C2 (en) | 2010-04-28 | 2016-05-27 | Кимберли-Кларк Ворлдвайд, Инк. | Medical devices for delivery of sirna |
JP5871907B2 (en) | 2010-04-28 | 2016-03-01 | キンバリー クラーク ワールドワイド インコーポレイテッド | Nanopatterned medical device with enhanced cell-cell interaction |
WO2011140274A2 (en) | 2010-05-04 | 2011-11-10 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
US8588884B2 (en) | 2010-05-28 | 2013-11-19 | Emkinetics, Inc. | Microneedle electrode |
CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
EP2433663A1 (en) | 2010-09-27 | 2012-03-28 | Unomedical A/S | Insertion system |
EP4108671A1 (en) | 2010-10-01 | 2022-12-28 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
EP2436412A1 (en) | 2010-10-04 | 2012-04-04 | Unomedical A/S | A sprinkler cannula |
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US11109887B2 (en) | 2013-12-06 | 2021-09-07 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
US11278309B2 (en) | 2010-12-17 | 2022-03-22 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
US10702684B2 (en) | 2010-12-17 | 2020-07-07 | Srgi Holdings, Llc | Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal |
US11612410B2 (en) | 2010-12-17 | 2023-03-28 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
US10736653B2 (en) | 2013-12-06 | 2020-08-11 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
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US10335190B2 (en) | 2013-12-06 | 2019-07-02 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
US10485575B2 (en) | 2010-12-17 | 2019-11-26 | Srgi Holdings Llc | Pixel array medical devices and methods |
US11103275B2 (en) | 2010-12-17 | 2021-08-31 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
PT2667801T (en) * | 2011-01-28 | 2019-03-04 | Massachusetts Gen Hospital | Method and apparatus for discontinuous dermabrasion |
US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
CN103717249B (en) | 2011-06-15 | 2017-03-22 | 克洛恩泰克制药股份公司 | Injection needle and device |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CN103974724B (en) | 2011-10-03 | 2019-08-30 | 现代泰克斯公司 | Nucleosides, nucleotide and nucleic acid of modification and application thereof |
US11197689B2 (en) | 2011-10-05 | 2021-12-14 | Unomedical A/S | Inserter for simultaneous insertion of multiple transcutaneous parts |
EP2583715A1 (en) | 2011-10-19 | 2013-04-24 | Unomedical A/S | Infusion tube system and method for manufacture |
JP6535464B2 (en) | 2011-10-27 | 2019-06-26 | ソレント・セラピューティクス・インコーポレイテッド | Implantable device for delivery of bioactive agents |
BR112014009713A2 (en) | 2011-10-27 | 2017-04-18 | Kimberly Clark Co | transdermal administration of high viscosity bioactive agents |
US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
US9440051B2 (en) | 2011-10-27 | 2016-09-13 | Unomedical A/S | Inserter for a multiplicity of subcutaneous parts |
CA2859387A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
AU2013243951A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of secreted proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
JP6145249B2 (en) * | 2012-05-25 | 2017-06-07 | 学校法人 関西大学 | Hollow fine needle and method for producing the same |
EP2865409B1 (en) * | 2012-06-22 | 2020-06-24 | Toppan Printing Co., Ltd. | Needle-shaped body and manufacturing method for needle-shaped body |
WO2014064534A2 (en) | 2012-10-05 | 2014-05-01 | Chrontech Pharma Ab | Injection needle, device, immunogenic compositions and method of use |
JP6144355B2 (en) | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | Chemically modified mRNA |
CA2894280C (en) | 2012-12-06 | 2018-07-31 | Srgi Holdings Llc | Pixel array medical devices and methods |
ES2743404T3 (en) | 2012-12-21 | 2020-02-19 | Corium Inc | Matrix for therapeutic agent supply and manufacturing method |
EP2968887B1 (en) | 2013-03-12 | 2022-05-04 | Corium, Inc. | Microprojection applicators |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
CA2903459C (en) | 2013-03-15 | 2024-02-20 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
EP2968118B1 (en) | 2013-03-15 | 2022-02-09 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
EP2968119B1 (en) | 2013-03-15 | 2019-09-18 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
JP2016518932A (en) * | 2013-05-06 | 2016-06-30 | ミューファーマ ピーティーワイ リミテッド | Non-invasive drug applicator |
ES2827049T3 (en) | 2013-10-02 | 2021-05-19 | Srgi Holdings Llc | Pixel Set Medical Devices |
AU2014329494B2 (en) | 2013-10-02 | 2019-06-20 | Edward Knowlton | Pixel array medical devices and methods |
EA201690675A1 (en) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | POLYNUCLEOTES ENCODING THE RECEPTOR OF LOW DENSITY LIPOPROTEINS |
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US20160279401A1 (en) * | 2015-03-27 | 2016-09-29 | Allergan, Inc. | Dissolvable microneedles for skin treatment |
EP3132822B1 (en) * | 2014-04-14 | 2018-10-31 | Toppan Printing Co., Ltd. | Injection device |
AU2015255634A1 (en) * | 2014-05-06 | 2016-11-17 | Mupharma Pty Ltd | Non-invasive agent applicator |
MX2017002661A (en) * | 2014-08-29 | 2018-01-25 | Srgi Holdings Llc | Pixel array medical devices and methods. |
EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
JP2017537690A (en) * | 2014-11-12 | 2017-12-21 | ミューファーマ ピーティーワイ リミテッド | Non-invasive drug applicator |
EP3253308A4 (en) | 2015-02-05 | 2018-10-24 | SRGI Holdings LLC | Pixel array medical systems, devices and methods |
CA2976544A1 (en) * | 2015-03-10 | 2016-09-15 | Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company | Multiple needle injector |
CN111643804B (en) * | 2015-03-18 | 2022-07-19 | 凸版印刷株式会社 | Medicament administration device |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
US11751904B2 (en) | 2015-08-31 | 2023-09-12 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
US11490952B2 (en) | 2015-08-31 | 2022-11-08 | Srgi Holdings, Llc | Pixel array medical devices and methods |
US11564706B2 (en) | 2019-10-28 | 2023-01-31 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
AU2017218014B2 (en) * | 2016-02-11 | 2020-12-17 | Edward Knowlton | Pixel array medical systems, devices and methods |
KR102627434B1 (en) * | 2016-08-08 | 2024-01-18 | 주식회사 엘지생활건강 | Suction microneedle |
CN106725894B (en) * | 2017-01-22 | 2020-06-05 | 袁晓辉 | Intermittent negative pressure suction skin expansion device and use method thereof |
US10765426B2 (en) * | 2017-02-17 | 2020-09-08 | Ethicon Llc | Systems for coupling adjuncts to an end effector |
AU2018222745B2 (en) | 2017-02-17 | 2021-02-18 | Allergan, Inc. | Microneedle array with active ingredient |
WO2018217479A2 (en) | 2017-05-11 | 2018-11-29 | Srgi Holdings, Llc | Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal |
JP1632957S (en) | 2018-10-30 | 2019-06-03 | ||
CN113329707A (en) | 2018-12-19 | 2021-08-31 | 克利里特有限责任公司 | System and method for tattoo removal using an applied electric field |
AU2021260929A1 (en) * | 2020-04-22 | 2022-11-24 | Paul Gilbert | Fluid characteristic indicator |
FR3110382B1 (en) * | 2020-05-20 | 2022-05-13 | Pkvitality | Sensor for surface mounted body monitoring system |
FR3113578B1 (en) * | 2020-08-28 | 2023-02-10 | Pkvitality | METHOD FOR ALIGNING COMPONENT(S) OF A BODY MONITORING SYSTEM |
CN115227957A (en) * | 2022-07-26 | 2022-10-25 | 空芯微医疗科技(上海)有限责任公司 | Method for preparing hollow microneedle and product thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250023A (en) | 1989-10-27 | 1993-10-05 | Korean Research Institute on Chemical Technology | Transdermal administration method of protein or peptide drug and its administration device thereof |
WO1997048440A1 (en) | 1996-06-18 | 1997-12-24 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
US5879326A (en) | 1995-05-22 | 1999-03-09 | Godshall; Ned Allen | Method and apparatus for disruption of the epidermis |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3167073A (en) * | 1962-01-16 | 1965-01-26 | Rosenthal Sol Roy | Transcutaneous injection device |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US5466465A (en) * | 1993-12-30 | 1995-11-14 | Harrogate Holdings, Limited | Transdermal drug delivery system |
JP2713255B2 (en) * | 1995-08-11 | 1998-02-16 | 日本電気株式会社 | Leachate suction device |
DE69722414T2 (en) * | 1996-07-03 | 2004-05-19 | Altea Therapeutics Corp. | MULTIPLE MECHANICAL MICROPERFORATION OF SKIN OR MUCOSA |
ATE231015T1 (en) * | 1996-09-17 | 2003-02-15 | Deka Products Lp | SYSTEM FOR DELIVERY OF MEDICATION THROUGH TRANSPORT |
US5993412A (en) * | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
WO1999029298A2 (en) * | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
WO1999029364A1 (en) * | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
US6126637A (en) * | 1998-04-15 | 2000-10-03 | Science Incorporated | Fluid delivery device with collapsible needle cover |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6331266B1 (en) * | 1999-09-29 | 2001-12-18 | Becton Dickinson And Company | Process of making a molded device |
DE60020159T2 (en) * | 1999-12-10 | 2005-10-06 | Alza Corp., Mountain View | SKIN TREATMENT DEVICE FOR EXTENDED TRANSDERMAL ADMINISTRATION OF MEDICAMENTS |
-
2000
- 2000-07-14 US US09/616,771 patent/US6440096B1/en not_active Expired - Lifetime
-
2001
- 2001-07-11 ES ES01952607T patent/ES2276805T3/en not_active Expired - Lifetime
- 2001-07-11 DE DE60124917T patent/DE60124917T2/en not_active Expired - Lifetime
- 2001-07-11 EP EP01952607A patent/EP1301237B1/en not_active Expired - Lifetime
- 2001-07-11 WO PCT/US2001/021791 patent/WO2002005890A2/en active IP Right Grant
- 2001-07-11 AU AU2001273340A patent/AU2001273340A1/en not_active Abandoned
- 2001-07-11 AT AT01952607T patent/ATE346645T1/en not_active IP Right Cessation
- 2001-07-11 JP JP2002511820A patent/JP4892166B2/en not_active Expired - Lifetime
-
2002
- 2002-07-10 US US10/192,474 patent/US20020183688A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250023A (en) | 1989-10-27 | 1993-10-05 | Korean Research Institute on Chemical Technology | Transdermal administration method of protein or peptide drug and its administration device thereof |
US5879326A (en) | 1995-05-22 | 1999-03-09 | Godshall; Ned Allen | Method and apparatus for disruption of the epidermis |
WO1997048440A1 (en) | 1996-06-18 | 1997-12-24 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
Cited By (46)
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JP2006500973A (en) * | 2002-06-25 | 2006-01-12 | スン−ユン クウォン, | Rapidly dissolving microperforators and other applications for drug delivery |
JP4829497B2 (en) * | 2002-06-25 | 2011-12-07 | セラジェクト, インコーポレイテッド | Rapidly dissolving microperforators and other applications for drug delivery |
US8551391B2 (en) | 2004-02-17 | 2013-10-08 | Avery Dennison Corporation | Method of making microneedles |
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US10939860B2 (en) | 2009-03-02 | 2021-03-09 | Seventh Sense Biosystems, Inc. | Techniques and devices associated with blood sampling |
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US9041541B2 (en) | 2010-01-28 | 2015-05-26 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
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US9119578B2 (en) | 2011-04-29 | 2015-09-01 | Seventh Sense Biosystems, Inc. | Plasma or serum production and removal of fluids under reduced pressure |
US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
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US10188335B2 (en) | 2011-04-29 | 2019-01-29 | Seventh Sense Biosystems, Inc. | Plasma or serum production and removal of fluids under reduced pressure |
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Also Published As
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EP1301237A2 (en) | 2003-04-16 |
ATE346645T1 (en) | 2006-12-15 |
ES2276805T3 (en) | 2007-07-01 |
JP4892166B2 (en) | 2012-03-07 |
EP1301237B1 (en) | 2006-11-29 |
US6440096B1 (en) | 2002-08-27 |
DE60124917D1 (en) | 2007-01-11 |
AU2001273340A1 (en) | 2002-01-30 |
WO2002005890A3 (en) | 2002-04-25 |
DE60124917T2 (en) | 2007-06-06 |
US20020183688A1 (en) | 2002-12-05 |
JP2004503342A (en) | 2004-02-05 |
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