WO2002002755A3 - Regulation of human thimet oligopeptidase-like enzyme - Google Patents

Regulation of human thimet oligopeptidase-like enzyme Download PDF

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Publication number
WO2002002755A3
WO2002002755A3 PCT/EP2001/007634 EP0107634W WO0202755A3 WO 2002002755 A3 WO2002002755 A3 WO 2002002755A3 EP 0107634 W EP0107634 W EP 0107634W WO 0202755 A3 WO0202755 A3 WO 0202755A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzyme
thimet oligopeptidase
regulation
human thimet
human
Prior art date
Application number
PCT/EP2001/007634
Other languages
French (fr)
Other versions
WO2002002755A2 (en
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to AU2001281950A priority Critical patent/AU2001281950A1/en
Publication of WO2002002755A2 publication Critical patent/WO2002002755A2/en
Publication of WO2002002755A3 publication Critical patent/WO2002002755A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Reagents which regulate human thimet oligopeptidase-like enzyme and reagents which bind to human thimet oligopeptidase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer and neurodegenerative diseases, such as Alzheimer's disease.
PCT/EP2001/007634 2000-07-05 2001-07-04 Regulation of human thimet oligopeptidase-like enzyme WO2002002755A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281950A AU2001281950A1 (en) 2000-07-05 2001-07-04 Regulation of human thimet oligopeptidase-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21635400P 2000-07-05 2000-07-05
US60/216,354 2000-07-05

Publications (2)

Publication Number Publication Date
WO2002002755A2 WO2002002755A2 (en) 2002-01-10
WO2002002755A3 true WO2002002755A3 (en) 2002-08-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007634 WO2002002755A2 (en) 2000-07-05 2001-07-04 Regulation of human thimet oligopeptidase-like enzyme

Country Status (2)

Country Link
AU (1) AU2001281950A1 (en)
WO (1) WO2002002755A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8968198B2 (en) 2006-02-22 2015-03-03 Dexcom, Inc. Analyte sensor
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US9357951B2 (en) 2009-09-30 2016-06-07 Dexcom, Inc. Transcutaneous analyte sensor

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8858434B2 (en) 2004-07-13 2014-10-14 Dexcom, Inc. Transcutaneous analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424205A (en) * 1990-10-05 1995-06-13 Athena Neurosciences, Inc. Amyloidin protease and uses thereof
US5883241A (en) * 1995-09-05 1999-03-16 Celltech Therapeutics Limited DNA sequences coding for a human metalloproteinase and variants thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424205A (en) * 1990-10-05 1995-06-13 Athena Neurosciences, Inc. Amyloidin protease and uses thereof
US5883241A (en) * 1995-09-05 1999-03-16 Celltech Therapeutics Limited DNA sequences coding for a human metalloproteinase and variants thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST [online] EMBL; 5 October 1998 (1998-10-05), NCI-CGAP: "qb79a03.x1 Soares_fetal_heart_NbHH19W Homo sapiens cDNA clone IMAGE:1706284 3' similar to SW:MEPD_HUMAN P52888 THIMET OLIGOPEPTIDASE ;, mRNA sequence.", XP002196340, Database accession no. AI160888 *
DATABASE MEPD_HUMAN [online] SWALL; "THIMET OLIGOPEPTIDASE (EC 3.4.24.15) (ENDOPEPTIDASE 24.15) (MP78).", Database accession no. P52888 *
KOIKE H ET AL: "THIMET OLIGOPEPTIDASE CLEAVES THE FULL-LENGTH ALZHEIMER AMYLOID PRECURSOR PROTEIN AT A BETA-SECRETASE CLEAVAGE SITE IN COS CELLS", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 126, no. 1, 1999, pages 235 - 242, XP000914809, ISSN: 0021-924X *
THOMPSON A ET AL: "CLONING AND FUNCTIONAL EXPRESSION OF A METALLOENDOPEPTIDASE FROM HUMAN BRAIN WITH THE ABILITY TO CLEASE A BETA-APP SUBSTRATE PEPTIDE", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 213, no. 1, 4 August 1995 (1995-08-04), pages 66 - 73, XP000651365, ISSN: 0006-291X *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8968198B2 (en) 2006-02-22 2015-03-03 Dexcom, Inc. Analyte sensor
US9357951B2 (en) 2009-09-30 2016-06-07 Dexcom, Inc. Transcutaneous analyte sensor

Also Published As

Publication number Publication date
WO2002002755A2 (en) 2002-01-10
AU2001281950A1 (en) 2002-01-14

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