WO2001096863A2 - Method and system for transporting and storing multiple reagent packs and reagent packs used therein - Google Patents

Method and system for transporting and storing multiple reagent packs and reagent packs used therein Download PDF

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Publication number
WO2001096863A2
WO2001096863A2 PCT/US2001/018636 US0118636W WO0196863A2 WO 2001096863 A2 WO2001096863 A2 WO 2001096863A2 US 0118636 W US0118636 W US 0118636W WO 0196863 A2 WO0196863 A2 WO 0196863A2
Authority
WO
WIPO (PCT)
Prior art keywords
reagent pack
reagent
gripper mechanism
pipetting
compartments
Prior art date
Application number
PCT/US2001/018636
Other languages
French (fr)
Other versions
WO2001096863A9 (en
WO2001096863A3 (en
Inventor
Robert J. Mattila
Mark J. Kittock
Original Assignee
Beckman Coulter, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter, Inc. filed Critical Beckman Coulter, Inc.
Priority to DE60122372T priority Critical patent/DE60122372T2/en
Priority to EP01948305A priority patent/EP1342091B1/en
Publication of WO2001096863A2 publication Critical patent/WO2001096863A2/en
Publication of WO2001096863A9 publication Critical patent/WO2001096863A9/en
Publication of WO2001096863A3 publication Critical patent/WO2001096863A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00435—Refrigerated reagent storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0429—Sample carriers adapted for special purposes
    • G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0489—Self-propelled units
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114165—Automated chemical analysis with conveyance of sample along a test line in a container or rack with step of insertion or removal from test line
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure

Definitions

  • the present invention relates generally to reagent handling methods and systems used in conjunction with immunodiagnostic instruments, and more specifically to methods and systems for transporting and sorting multiple reagent packs and reagent packs used in conjunction with the systems.
  • One of the disadvantages of many conventional reagent transporting and storage systems used in .conjunction with automated chemical analyzers is that they do not provide a refrigerated environment for receiving and storing multiple reagent packs in such a manner that each stored pack can be randomly accessed and brought from the storage position to the pipetting position.
  • Another disadvantage of many conventional reagent transporting and storage systems is that they have only limited capacities in that they often can service only one single pipetter. They are unable to leave a reagent pack in a pipetting position while moving another reagent pack to another pipetter.
  • the present invention is directed to a new method and system for transporting and sorting multiple reagent packs used in conjunction with an immunodiagnostic instrument, and is also directed to new reagent packs used in conjunction with the new system. It is one of the primary objects of the present invention to provide a new method and system for transporting and sorting multiple reagent packs used in conjunction with an immunodiagnostic instrument, with the capacity of providing a refrigerated environment for receiving and storing multiple reagent packs in such a manner that each stored pack can be randomly accessed and brought from the storage position to the pipetting position.
  • one aspect of the present invention provides a transporting and storing system to be used in conjunction with an immunodiagnostic instrument.
  • the transporting and storing system of the present invention includes a multiplicity of reagent packs; a gantry movably mounted on a rack structure for carrying a gripper mechanism, wherein the gripper mechanism has gripping jaws for engagement with the reagent pack; a power assembly for actuating the respective movement of the gantry, the gripper mechanism and the gripping jaws; a storage nest having a multiplicity of compartments, each adapted for storing a one of the respective reagent packs; and a pipetting nest having a multiplicity of compartment, each adapted for retaining a respective one of the reagent packs for simultaneous pipetting.
  • the transporting and storing system of the present invention also includes at least one transport route for allowing movement of the gripper mechanism carried by the gantry for transporting the reagent packs between the storage nest and the pipetting nest.
  • the transporting and storing system of the present invention further includes the means for positioning and positively retaining the reagent pack by the gripper mechanism, including complementary features on the reagent pack and the gripping jaws, for causing the reagent pack to be slightly lifted up or dropped down when engaged or disengaged by the gripping jaws and moved out or in of the storage compartment.
  • the transporting and storing system of the present invention includes the means for maintaining precise pipetting position of the reagent pack, including spring-loaded members located in the pipetting compartment, for limiting the movement of the reagent pack during pipetting.
  • the method of the present invention includes the steps of: providing a gripper mechanism having a pair of generally oppositely disposed and synchronically movable gripping jaws, each having an inner side for engagement with one of the reagent packs; mounting a gantry on a rack structure to move horizontally for carrying the gripper mechanism, such that it is vertically movable on the gantry and horizontally moveable with the gantry; aligning a multiplicity of storage compartments in vertical columns and horizontal rows for storing the reagent packs respectively; and aligning a multiplicity of pipetting compartment in at least one horizontal row for simultaneous pipetting, while leaving at least one vertical transport route between two adjacent and spaced apart columns of the compartments for allowing the vertical movement of the gripper mechanism, and at least one horizontal transport route between two adjacent and spaced apart rows of the compartments for allowing the horizontal movement of the gripper mechanism carried by the gantry, for transporting the reagent packs between the storage compartments and the pipetting compartments.
  • the transporting and storing method of the present invention also includes the steps of moving the gripper mechanism along the at least one vertical route and the at least one horizontal route to transport the reagent packs between the storage compartments and the pipetting compartments, and while leaving one of the reagent packs in a respective one of the pipetting compartment for pipetting, moving the gripper mechanism to transport another one of the reagent packs to another one of the pipetting compartments for simultaneous pipetting.
  • the transporting and storing method of the present invention further includes the steps of positioning and positively retaining the reagent pack with the gripper mechanism by utilizing holes with a tapered conical opening on the reagent pack and complementary conical pins on the gripping jaws, such that the reagent packs are slightly lifted up when being moved in and out of their respective the storage compartments to avoid direct contact therebetween, and maintaining precise pipetting position of the reagent pack by utilizing spring-loaded v-shaped members located in the pipetting compartments for limiting the movement of the reagent pack during pipetting.
  • a further aspect of the present invention provides a reagent pack used in conjunction with a transporting and storing system for an immunodiagnostic instrument, where the transporting and storing system has a gripper mechanism with inwardly protruding pins for positioning and positively retaining the reagent pack.
  • the reagent pack of the present invention has an elongated body having sufficient thickness for having at least one well, where the elongated body has a slim profile with a wide middle portion, a narrow front portion with a pointed front end, and a narrow ear portion with a rounded rear end having two generally opposite outer sides.
  • the reagent pack of the present invention also has the means for facilitating the position and the positive retention of the reagent pack by the gripper mechanism, including complementary holes on the outer sides of the elongated body for engagement with the inwardly protruding pins of the gripping mechanism of the transporting and storing system.
  • the new system of the present invention is well suited for receiving and storing multiple reagent packs in a refrigerated environment in such a manner that each stored reagent pack can be randomly accessed and brought from the storage to a pipetting position. This is accomplished in such a manner that requires minimal footwork and a degree of freedom.
  • FIGURE 1 is a perspective view of a reagent pack and the gripper mechanism of the transporting and storing system of the present invention, showing the alignment pins of the gripper mechanism disengaged from the reagent pack;
  • FIGURE 2 is a perspective view of a reagent pack and the gripper mechanism of the transporting and storing system of the present invention, showing the alignment pins of the gripper mechanism engaged with the reagent pack;
  • FIGURE 3 is a top view of the gripper mechanism of the transporting and storing system of the present invention, showing the conical shaped alignment pins;
  • FIGURE 4 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the gripper mechanism at its initial position;
  • FIGURE 5 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the first step of the transporting and storing method of the present invention where the gripper mechanism moves in a horizontal transport route of the storage nest to a desired column of reagent packs held in the storage nest;
  • FIGURE 6 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the second step of the transporting and storing method of the present invention where the gripper mechanism moves in a vertical transport route of the storage nest to a desired reagent pack held in a compartment of the storage nest;
  • FIGURE 7 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the third step of the transporting and storing method of the present invention where the gripper mechanism engages and lifts up the desired reagent pack from the bottom of the compartment of the storage nest;
  • FIGURE 8 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the fourth step of the transporting and storing method of the present invention where the gripper mechanism moves the reagent pack out of the compartment of the storage nest;
  • FIGURE 9 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the fifth step of the transporting and storing method of the present invention where the gripper mechanism moves the reagent pack to a nearby vertical transport route of the storage nest;
  • FIGURE 10 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the
  • FIGURE 13 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the ninth step of the transporting and storing method of the present invention where the gripper mechanism moves the reagent pack horizontally into the compartment of the pipetting nest to engage with the spring-loaded v-blocks thereof;
  • FIGURE 14 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the tenth step of the transporting and storing method of the present invention where the gripper mechanism is disengaged from the reagent pack which is retained by the spring- loaded v-blocks and settled onto the bottom of the compartment of the pipetting nest;
  • FIGURE 15 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the eleventh step of the transporting and storing method of the present invention where the disengaged gripper mechanism moves vertically to a horizontal transport route for returning to its initial position.
  • the present invention provides a new method and system for transporting and sorting multiple reagent packs used in conjunction with an immunodiagnostic instrument.
  • the transporting and storing system of the present invention includes a reagent pack 1.
  • the reagent pack 1 has an elongated body having a sufficient thickness and a slim profile with a wide middle portion, a narrow front portion with a pointed front end, and a narrow rear portion with a rounded rear end.
  • One or more wells are provided on the elongated body for containing reagents, samples and/or other fluids.
  • a gripper mechanism 4 is provided as part of a means for positioning of and positively retaining the reagent pack.
  • the facilitating means includes three conically tapered holes 2 and 3.
  • One conically tapered hole 2 is located at one outer side of the rear portion and the other two conically tapered holes 3 are located at the other (substantially opposite) outer side of the rear portion of the reagent pack 1.
  • the conically tapered holes are circular, or they can form elongated slots, or a combination of both.
  • the gripper mechanism 4 of the transporting and storing system of the present invention may be pneumatic or another kind, and is vertically movably supported on a gantry 5, which in turn is horizontally movably supported by a rack structure.
  • the gripper mechanism 4 includes a pair of opposite gripping jaws 15 with synchronized motion.
  • the motion may be accomplished by utilizing other types of arrangement and power sources which are not limited to pneumatic power.
  • the complementary part of the means for positioning of and positively retaining the reagent pack 1 is provided on the inner sides of the gripping jaws 15.
  • the complementary part includes three conically shaped pins 6.
  • One conically shaped pin 6 is located at the inner side of one of the gripper jaws 15 for engagement with the conically tapered hole 2 of the reagent pack 1, and the other two conically shaped pins 6 are located at the imier side of the opposite gripper jaw 15 for engagement with the conically tapered holes 3 of the reagent pack 1.
  • the holes 2 and 3 and the pins 6 of the complementary means for positioning and positively retaining the reagent packs by the gripper mechanism may be of other shapes, such as spherical, prismical, etc. What is important is that the entrance of the holes 2 and 3 on the reagent pack 1 are tapered (e.g., with a beveled larger opening), thereby increasing the tolerance of the gripper mechanism 4 with regard to the position of the reagent pack 1, and allowing for engagement between the pins 6 and the holes 2 and
  • each pin 6 has a straight cylindrical section at its end. This feature ensures positive retention of the reagent pack by the gripper mechanism 4 in the event that there is a loss in the power to the system, which may result in a loss of compression force of the gripping jaws 15 needed for engagement of the jaws 15 with the reagent pack 1. With the cylindrical section of the pins 6 being extended into the holes 2 and 3, the reagent pack 1 will be hanging on the pins 6 of the gripper mechanism, 4 even when it is not compressed by the gripping jaws 15.
  • the transporting and storing system of the present invention also includes a multi- unit storage nest 7 having a plurality of vertically and horizontally spaced compartments 8, each adapted to receive and hold a reagent pack 1. Additionally, the system includes a pipetting nest 9 also having multiple compartments 10 for positioning a reagent pack 1 for pipetting. Both nests 7 and 9 are designed to hold the reagent pack within the tolerance limits but without rigidly defining its position, as will be described in detail below.
  • the storage nest 7 has a multiplicity of compartments 8 arranged in multiple vertical columns, where the respective compartments in the multiple columns are also aligned in horizontal rows, thereby forming a two-dimensional matrix, such that when the reagent packs 1 are held in the storage nest 7, they are aligned in vertical columns and horizontal rows.
  • One or more empty or open vertical "transport routes" (with no compartment) are provided to allow the gripper mechanism 4 to transport the reagent packs 1 vertically within the storage nest 7 and between the storage nest 7 and the pipetting nest 9.
  • one or more empty or open horizontal "transport routes” are also provided to allow the gripper mechanism 4 to transport the reagent packs 1 horizontally.
  • Each compartment 8 of the storage nest 7 has a flat bottom 12 and two substantially opposite and vertical sidewalls 13.
  • the clearance between the retaining sidewalls 13 of the compartment 8 and the reagent pack 1 held therein provides limits to the horizontal motion of the reagent pack 1.
  • the pins 6 of the gripper mechanism 1 are synchronously disengaged from the holes 2 and 3 of the reagent pack 1, which allows the reagent pack 1 to drop down the distance of the small gap and rest on the flat bottom 12 of the compartment 8.
  • the gripping jaws 15 of the gripper mechanism 4 are moved in to be adjacent to the rear end of the reagent pack 1 and are ready to retrieve the reagent pack 1.
  • the pins 6 of the gripper mechanism 4 are intentionally positioned slightly higher than the center of the holes 2 and 3 of the reagent pack 1 but still within the range of tapered openings of the holes 2 and 3, such that when the gripping jaws 15 are compressed, the pins 6 are engaged with and guided by the tapered surfaces to finally align with and insert into the holes 2 and 3 and, during this process of engagement, causes the reagent pack 1 to be lifted up slightly, such that the same small gap is left between the bottom of the reagent pack 1 and the flat bottom 12 of the compartment 8.
  • This arrangement prevents any direct contact between the flat bottom 12 of the compartment 8 and the bottom of the reagent pack 1 and thereby eliminates any interference therebetween as the reagent pack 1 is retrieved from the compartment 8 of the storage nest 7.
  • the pipetting nest 9 has a multiplicity of compartments 10 aligned in a horizontal row. Each compartment 10 has a spring-loaded v-block 11 for engaging the pointed front end of the reagent pack 1 for its precise positioning. This is because, during pipetting, the reagent pack 1 has to be positioned with a relatively high precision and it has to be retained both horizontally and vertically.
  • the v-block 11 When the pins 6 of the gripper mechanism 4 are engaging the reagent pack 1, the v-block 11 translates to a position defined by the retained reagent pack 1. When the pins 6 are disengaged from the reagent pack 1, the v-block 11 springs back against rigid stops, which are placed at a distance that is slightly greater than the length of the pack 1. As a result, the reagent pack 1 moves into a position within the limits defined by the v-block 11. The v-block 11 limits the motion of the reagent pack 1 when a pipetter tip is withdrawn from the pack as the elastomeric seal of the reagent pack 1 creates a drag, which tends to cause the reagent pack 1 to be lifted up.
  • the transporting and storing method of the present invention includes the following steps:
  • the gripper mechanism 4 moves down vertically until it reaches the desired reagent pack 1. It stops when the pins 6 of the gripping jaws 15 are positioned at approximately "0.76 mm" (0.03 inch) above the center of the holes 2 and 3 of the reagent pack 1, as shown in Figure 6.
  • the gripper mechanism 4 is actuated and the gripping jaws 15 move synchronously towards each other until the pins 6 are fully engaged with the holes 2 and 3 of the reagent pack 1.
  • the reagent pack 1 is raised an amount necessary to compensate for position error caused by tolerance accumulation at a position defined by the pins 6 above the flat bottom 12 of the compartment 8 of the storage nest 7, as shown in Figure 7.
  • the gripper mechanism 4 moves vertically until the bottom of the reagent pack 1 is just above the sidewalls 13 of the compartment 8 of the storage nest 7, as shown in Figure 8. 5. The gripper mechanism 4 then moves the reagent pack 1 horizontally to a nearest vertical transport route 16a, as shown in Figure 9.
  • the gripper mechanism 4 moves the reagent pack 1 vertically up in the vertical transport route to the horizontal transport route 14a, as shown in Figure 10.
  • the gripper mechanism 4 moves the reagent pack 1 horizontally in the horizontal row to a vertical transport route next to one of the available compartments 10 of the pipetting nest 9, as shown in Figure 11.
  • the gripper mechanism 4 moves vertically in the transport route next to the available compartment 10 of the pipetting nest 9 until the bottom of the reagent pack 1 is above the bottom of the compartment 10, as shown in Figure 12. 9.
  • the gripper mechanism 4 moves the reagent pack 1 horizontally into the compartment 10 of the pipetting nest 9 and deflects the spring-loaded v-blocks 11 until the reagent pack 1 is centered in the compartment 10 of the pipetting nest 9, as shown in Figure 13.
  • the gripper mechanism 4 reverses and its pins 6 disengage from the reagent pack 1.
  • the v-blocks 11 return to their hard stops and align the reagent pack 1 to its precise pipetting position.
  • the reagent pack 1 lowers down a small distance under gravity to come to rest on the bottom of the compartment 10 of the pipetting nest, as shown in Figure 14.
  • the gripper mechanism 4 moves vertically down to the horizontal transport route 14a to return to its initial position, as shown in Figure 15. 12. While one reagent pack 1 is retained in one of the compartments 10 of the pipetting nest 9 for the pipetting procedure, the gripper mechanism 4 may repeat the above steps to transport another one of the reagent packs 1 from the storage nest 7 to another available compartment 10 of the pipetting nest 9 for simultaneous pipetting.
  • One of the novel features of the transporting and storing system and method of the present invention is the ability to transport a single desired pack from a storage to a pipetting position and to service multiple pipetting positions with a single transport system.
  • Another novel feature of the transporting and storing system and method of the present invention is the combination of the conically tapered holes on the reagent pack and the complementary matching pins on the gripper mechanism for positioning and positively retaining the reagent pack while transporting it from the storage position to the pipettmg position.

Abstract

A new method and system for transporting and sorting multiple reagent packs used in conjunction with an immunodiagnostic instrument is provided. The new system includes a multiplicity of reagent packs; a gantry movably mounted on a rack structure for carrying a gripper mechanism, wherein the gripper mechanism has gripping jaws for engagement with the reagent pack; a power assembly for actuating the respective movement of the gantry, the gripper mechanism and the gripping jaws; a storage nest having a multiplicity of compartments, each adapted for storing a one of the respective reagent packs; and a pipetting nest having a multiplicity of compartment, each adapted for retaining a respective one of the reagent packs for simultaneous pipetting. Methods of using the system and a novel reagent pack used in connection with the new system are also provided.

Description

METHOD AND SYSTEM FOR TRANSPORTING AND STORING MULTIPLE REAGENT PACKS AND REAGENT PACKS USED THEREIN
Background of the Invention Area of the Art
The present invention relates generally to reagent handling methods and systems used in conjunction with immunodiagnostic instruments, and more specifically to methods and systems for transporting and sorting multiple reagent packs and reagent packs used in conjunction with the systems.
Description of the Prior Art hiimunodiagnostic instruments are widely used in clinical chemistry sampling and analyzing applications, and often are involved in the processing of multiple reagent packs for performing various assays. Many times it is required that the system be capable of receiving and storing multiple reagent packs in a refrigerated environment in such a manner that each stored pack can be randomly accessed and brought from storage into a position for pipetting. It is desirable for this to be accomplished in such a manner that requires minimal footwork and a degree of freedom.
One of the disadvantages of many conventional reagent transporting and storage systems used in .conjunction with automated chemical analyzers is that they do not provide a refrigerated environment for receiving and storing multiple reagent packs in such a manner that each stored pack can be randomly accessed and brought from the storage position to the pipetting position. Another disadvantage of many conventional reagent transporting and storage systems is that they have only limited capacities in that they often can service only one single pipetter. They are unable to leave a reagent pack in a pipetting position while moving another reagent pack to another pipetter.
Therefore, it is desirable to provide a new method and system for transporting and sorting multiple reagent packs which can be used in conjunction with immunodiagnostic instruments and also overcome the disadvantages of conventional systems for handling reagent packs. Summary of the Invention
The present invention is directed to a new method and system for transporting and sorting multiple reagent packs used in conjunction with an immunodiagnostic instrument, and is also directed to new reagent packs used in conjunction with the new system. It is one of the primary objects of the present invention to provide a new method and system for transporting and sorting multiple reagent packs used in conjunction with an immunodiagnostic instrument, with the capacity of providing a refrigerated environment for receiving and storing multiple reagent packs in such a manner that each stored pack can be randomly accessed and brought from the storage position to the pipetting position.
It is also a primary object of the present invention to provide a new method and system for transporting and storing multiple reagent packs used in conjunction with an immunodiagnostic instrument, with the capacity of servicing multiple pipetting stations by leaving one reagent pack in one pipetting station while moving another reagent pack to another pipetting station.
It is another one of the primary objects of the present invention to provide a new reagent pack to be used in conjunction with the new transporting and sorting system.
Accordingly, one aspect of the present invention provides a transporting and storing system to be used in conjunction with an immunodiagnostic instrument. The transporting and storing system of the present invention includes a multiplicity of reagent packs; a gantry movably mounted on a rack structure for carrying a gripper mechanism, wherein the gripper mechanism has gripping jaws for engagement with the reagent pack; a power assembly for actuating the respective movement of the gantry, the gripper mechanism and the gripping jaws; a storage nest having a multiplicity of compartments, each adapted for storing a one of the respective reagent packs; and a pipetting nest having a multiplicity of compartment, each adapted for retaining a respective one of the reagent packs for simultaneous pipetting.
The transporting and storing system of the present invention also includes at least one transport route for allowing movement of the gripper mechanism carried by the gantry for transporting the reagent packs between the storage nest and the pipetting nest.
The transporting and storing system of the present invention further includes the means for positioning and positively retaining the reagent pack by the gripper mechanism, including complementary features on the reagent pack and the gripping jaws, for causing the reagent pack to be slightly lifted up or dropped down when engaged or disengaged by the gripping jaws and moved out or in of the storage compartment.
In addition, the transporting and storing system of the present invention includes the means for maintaining precise pipetting position of the reagent pack, including spring-loaded members located in the pipetting compartment, for limiting the movement of the reagent pack during pipetting.
Another aspect of the present invention provides a transporting and storing method. The method of the present invention includes the steps of: providing a gripper mechanism having a pair of generally oppositely disposed and synchronically movable gripping jaws, each having an inner side for engagement with one of the reagent packs; mounting a gantry on a rack structure to move horizontally for carrying the gripper mechanism, such that it is vertically movable on the gantry and horizontally moveable with the gantry; aligning a multiplicity of storage compartments in vertical columns and horizontal rows for storing the reagent packs respectively; and aligning a multiplicity of pipetting compartment in at least one horizontal row for simultaneous pipetting, while leaving at least one vertical transport route between two adjacent and spaced apart columns of the compartments for allowing the vertical movement of the gripper mechanism, and at least one horizontal transport route between two adjacent and spaced apart rows of the compartments for allowing the horizontal movement of the gripper mechanism carried by the gantry, for transporting the reagent packs between the storage compartments and the pipetting compartments.
The transporting and storing method of the present invention also includes the steps of moving the gripper mechanism along the at least one vertical route and the at least one horizontal route to transport the reagent packs between the storage compartments and the pipetting compartments, and while leaving one of the reagent packs in a respective one of the pipetting compartment for pipetting, moving the gripper mechanism to transport another one of the reagent packs to another one of the pipetting compartments for simultaneous pipetting. The transporting and storing method of the present invention further includes the steps of positioning and positively retaining the reagent pack with the gripper mechanism by utilizing holes with a tapered conical opening on the reagent pack and complementary conical pins on the gripping jaws, such that the reagent packs are slightly lifted up when being moved in and out of their respective the storage compartments to avoid direct contact therebetween, and maintaining precise pipetting position of the reagent pack by utilizing spring-loaded v-shaped members located in the pipetting compartments for limiting the movement of the reagent pack during pipetting.
A further aspect of the present invention provides a reagent pack used in conjunction with a transporting and storing system for an immunodiagnostic instrument, where the transporting and storing system has a gripper mechanism with inwardly protruding pins for positioning and positively retaining the reagent pack. The reagent pack of the present invention has an elongated body having sufficient thickness for having at least one well, where the elongated body has a slim profile with a wide middle portion, a narrow front portion with a pointed front end, and a narrow ear portion with a rounded rear end having two generally opposite outer sides.
The reagent pack of the present invention also has the means for facilitating the position and the positive retention of the reagent pack by the gripper mechanism, including complementary holes on the outer sides of the elongated body for engagement with the inwardly protruding pins of the gripping mechanism of the transporting and storing system.
As explained in greater detail below, the new system of the present invention is well suited for receiving and storing multiple reagent packs in a refrigerated environment in such a manner that each stored reagent pack can be randomly accessed and brought from the storage to a pipetting position. This is accomplished in such a manner that requires minimal footwork and a degree of freedom.
The invention is defined in its fullest scope in the appended claims and is described below in its preferred embodiments.
Description of the Figures
The above-mentioned and other features of this invention and the manner of obtaining them will become more apparent, and will be best understood by reference to the following description, taken in conjunction with the accompanying drawings. FIGURE 1 is a perspective view of a reagent pack and the gripper mechanism of the transporting and storing system of the present invention, showing the alignment pins of the gripper mechanism disengaged from the reagent pack;
FIGURE 2 is a perspective view of a reagent pack and the gripper mechanism of the transporting and storing system of the present invention, showing the alignment pins of the gripper mechanism engaged with the reagent pack;
FIGURE 3 is a top view of the gripper mechanism of the transporting and storing system of the present invention, showing the conical shaped alignment pins;
FIGURE 4 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the gripper mechanism at its initial position;
FIGURE 5 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the first step of the transporting and storing method of the present invention where the gripper mechanism moves in a horizontal transport route of the storage nest to a desired column of reagent packs held in the storage nest;
FIGURE 6 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the second step of the transporting and storing method of the present invention where the gripper mechanism moves in a vertical transport route of the storage nest to a desired reagent pack held in a compartment of the storage nest;
FIGURE 7 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the third step of the transporting and storing method of the present invention where the gripper mechanism engages and lifts up the desired reagent pack from the bottom of the compartment of the storage nest; FIGURE 8 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the fourth step of the transporting and storing method of the present invention where the gripper mechanism moves the reagent pack out of the compartment of the storage nest; FIGURE 9 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the fifth step of the transporting and storing method of the present invention where the gripper mechanism moves the reagent pack to a nearby vertical transport route of the storage nest; FIGURE 10 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the sixth step of the transporting and storing method of the present invention where the gripper mechanism moves the reagent pack in the vertical transport route of the storage nest up to the horizontal transport route; FIGURE 11 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the seventh step of the transporting and storing method of the present invention where the gripper mechanism moves the reagent pack in the horizontal transport route of the storage nest to a vertical transport route next to an available compartment of the pipetting nest; FIGURE 12 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the eighth step of the transporting and storing method of the present invention where the gripper mechanism moves the reagent pack in the vertical transport route next to the available compartment of the pipetting nest to a position close to the available compartment of the pipetting nest;
FIGURE 13 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the ninth step of the transporting and storing method of the present invention where the gripper mechanism moves the reagent pack horizontally into the compartment of the pipetting nest to engage with the spring-loaded v-blocks thereof;
FIGURE 14 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the tenth step of the transporting and storing method of the present invention where the gripper mechanism is disengaged from the reagent pack which is retained by the spring- loaded v-blocks and settled onto the bottom of the compartment of the pipetting nest;
FIGURE 15 is a perspective view of the gripper mechanism, the storage nest and the pipetting nest of the transporting and storing system of the present invention, showing the eleventh step of the transporting and storing method of the present invention where the disengaged gripper mechanism moves vertically to a horizontal transport route for returning to its initial position.
Detailed Description of the Invention The present invention provides a new method and system for transporting and sorting multiple reagent packs used in conjunction with an immunodiagnostic instrument.
Referring to Figures 1 through 4, the transporting and storing system of the present invention includes a reagent pack 1. The reagent pack 1 has an elongated body having a sufficient thickness and a slim profile with a wide middle portion, a narrow front portion with a pointed front end, and a narrow rear portion with a rounded rear end. One or more wells are provided on the elongated body for containing reagents, samples and/or other fluids.
On the outer sides of the rear portion, a gripper mechanism 4 is provided as part of a means for positioning of and positively retaining the reagent pack. In a preferred embodiment, the facilitating means includes three conically tapered holes 2 and 3. One conically tapered hole 2 is located at one outer side of the rear portion and the other two conically tapered holes 3 are located at the other (substantially opposite) outer side of the rear portion of the reagent pack 1. In a preferred embodiment, the conically tapered holes are circular, or they can form elongated slots, or a combination of both. The gripper mechanism 4 of the transporting and storing system of the present invention may be pneumatic or another kind, and is vertically movably supported on a gantry 5, which in turn is horizontally movably supported by a rack structure. The gripper mechanism 4 includes a pair of opposite gripping jaws 15 with synchronized motion. Of course, the motion may be accomplished by utilizing other types of arrangement and power sources which are not limited to pneumatic power.
The complementary part of the means for positioning of and positively retaining the reagent pack 1 is provided on the inner sides of the gripping jaws 15. In the preferred embodiment, the complementary part includes three conically shaped pins 6. One conically shaped pin 6 is located at the inner side of one of the gripper jaws 15 for engagement with the conically tapered hole 2 of the reagent pack 1, and the other two conically shaped pins 6 are located at the imier side of the opposite gripper jaw 15 for engagement with the conically tapered holes 3 of the reagent pack 1.
Of course, the holes 2 and 3 and the pins 6 of the complementary means for positioning and positively retaining the reagent packs by the gripper mechanism may be of other shapes, such as spherical, prismical, etc. What is important is that the entrance of the holes 2 and 3 on the reagent pack 1 are tapered (e.g., with a beveled larger opening), thereby increasing the tolerance of the gripper mechanism 4 with regard to the position of the reagent pack 1, and allowing for engagement between the pins 6 and the holes 2 and
3, respectively, even when the reagent pack 1 is not precisely positioned. A slightly misaligned reagent pack 1 can still be engaged by the pins 6 because the tapered recess of the holes 2 and 3 provides an increased engagement area for the pins 6. Once the pins 6 begin engagement with the tapered recess of the holes 2 and 3, the compression of the gripping jaws 15 will force the pins 6 to further extend into the holes 2 and 3, respectively, thereby causing the reagent pack 1 to be aligned with the gripper mechanism
4. Of course, the amount of misalignment tolerable by the gripper mechanism depends on the amount of taper in the conically tapered holes 2 and 3. In addition, in a preferred embodiment, each pin 6 has a straight cylindrical section at its end. This feature ensures positive retention of the reagent pack by the gripper mechanism 4 in the event that there is a loss in the power to the system, which may result in a loss of compression force of the gripping jaws 15 needed for engagement of the jaws 15 with the reagent pack 1. With the cylindrical section of the pins 6 being extended into the holes 2 and 3, the reagent pack 1 will be hanging on the pins 6 of the gripper mechanism, 4 even when it is not compressed by the gripping jaws 15.
Furthermore, when the gripper mechanism 4 is engaged with the reagent pack 1, the three pins 6 define a plane which precisely orients the reagent pack 1 during transportation by the gantry 5 from one position to another. In an alternative embodiment, the gripper mechanism 4 contains conically tapered holes which engage pins located on the reagent pack 1. In other respects, the operation of the gripper mechanism and reagent pack for this embodiment is the same. The transporting and storing system of the present invention also includes a multi- unit storage nest 7 having a plurality of vertically and horizontally spaced compartments 8, each adapted to receive and hold a reagent pack 1. Additionally, the system includes a pipetting nest 9 also having multiple compartments 10 for positioning a reagent pack 1 for pipetting. Both nests 7 and 9 are designed to hold the reagent pack within the tolerance limits but without rigidly defining its position, as will be described in detail below.
Referring to Figure 4, the storage nest 7 has a multiplicity of compartments 8 arranged in multiple vertical columns, where the respective compartments in the multiple columns are also aligned in horizontal rows, thereby forming a two-dimensional matrix, such that when the reagent packs 1 are held in the storage nest 7, they are aligned in vertical columns and horizontal rows. One or more empty or open vertical "transport routes" (with no compartment) are provided to allow the gripper mechanism 4 to transport the reagent packs 1 vertically within the storage nest 7 and between the storage nest 7 and the pipetting nest 9. Similarly, one or more empty or open horizontal "transport routes" are also provided to allow the gripper mechanism 4 to transport the reagent packs 1 horizontally.
Each compartment 8 of the storage nest 7 has a flat bottom 12 and two substantially opposite and vertical sidewalls 13. The clearance between the retaining sidewalls 13 of the compartment 8 and the reagent pack 1 held therein provides limits to the horizontal motion of the reagent pack 1.
When a reagent pack 1 is sent into a compartment 8 by the gripper mechanism 4, a small gap is intentionally maintained between the flat bottom 12 of the compartment 8 and the bottom of the reagent pack 1, as long as the pins 6 of the gripper mechanism 4 are still engaged with the holes 2 and 3 of the reagent pack 1. With this arrangement, any direct contact between the flat bottom 12 of the compartment 8 and the bottom of the reagent pack 1 is avoided, as the reagent pack 1 is sent into the compartment 8 of the storage nest 7, thereby eliminating interference therebetween that is a result of mechanical part tolerances. Once the reagent pack 1 is positioned within the compartment 8 between the two sidewalls 13 and above the flat bottom 12, the pins 6 of the gripper mechanism 1 are synchronously disengaged from the holes 2 and 3 of the reagent pack 1, which allows the reagent pack 1 to drop down the distance of the small gap and rest on the flat bottom 12 of the compartment 8.
When the reagent pack 1 needs to be removed from the compartment 8, the gripping jaws 15 of the gripper mechanism 4 are moved in to be adjacent to the rear end of the reagent pack 1 and are ready to retrieve the reagent pack 1. However, the pins 6 of the gripper mechanism 4 are intentionally positioned slightly higher than the center of the holes 2 and 3 of the reagent pack 1 but still within the range of tapered openings of the holes 2 and 3, such that when the gripping jaws 15 are compressed, the pins 6 are engaged with and guided by the tapered surfaces to finally align with and insert into the holes 2 and 3 and, during this process of engagement, causes the reagent pack 1 to be lifted up slightly, such that the same small gap is left between the bottom of the reagent pack 1 and the flat bottom 12 of the compartment 8. This arrangement prevents any direct contact between the flat bottom 12 of the compartment 8 and the bottom of the reagent pack 1 and thereby eliminates any interference therebetween as the reagent pack 1 is retrieved from the compartment 8 of the storage nest 7.
The pipetting nest 9 has a multiplicity of compartments 10 aligned in a horizontal row. Each compartment 10 has a spring-loaded v-block 11 for engaging the pointed front end of the reagent pack 1 for its precise positioning. This is because, during pipetting, the reagent pack 1 has to be positioned with a relatively high precision and it has to be retained both horizontally and vertically.
When the pins 6 of the gripper mechanism 4 are engaging the reagent pack 1, the v-block 11 translates to a position defined by the retained reagent pack 1. When the pins 6 are disengaged from the reagent pack 1, the v-block 11 springs back against rigid stops, which are placed at a distance that is slightly greater than the length of the pack 1. As a result, the reagent pack 1 moves into a position within the limits defined by the v-block 11. The v-block 11 limits the motion of the reagent pack 1 when a pipetter tip is withdrawn from the pack as the elastomeric seal of the reagent pack 1 creates a drag, which tends to cause the reagent pack 1 to be lifted up. After the pipetter tip is withdrawn, the reagent pack 1 is free to fall back down into its position in the compartment 10 of the pipetting nest 9, which prevents the pipetter tip from contacting the bottom of the wells of the reagent pack 1 during future assays. Referring to Figures 4 through 15, the transporting and storing method of the present invention includes the following steps:
1. Starting from its initial position, as shown in Figure 4, the gantry 5 with the gripper mechanism 4 moves horizontally through a horizontal transport route 14a, positions itself over the desired column of reagent packs 1, and opens its gripping jaws 15, as shown in Figure 5-
2. The gripper mechanism 4 moves down vertically until it reaches the desired reagent pack 1. It stops when the pins 6 of the gripping jaws 15 are positioned at approximately "0.76 mm" (0.03 inch) above the center of the holes 2 and 3 of the reagent pack 1, as shown in Figure 6.
3. The gripper mechanism 4 is actuated and the gripping jaws 15 move synchronously towards each other until the pins 6 are fully engaged with the holes 2 and 3 of the reagent pack 1. As a result, the reagent pack 1 is raised an amount necessary to compensate for position error caused by tolerance accumulation at a position defined by the pins 6 above the flat bottom 12 of the compartment 8 of the storage nest 7, as shown in Figure 7.
4. The gripper mechanism 4 moves vertically until the bottom of the reagent pack 1 is just above the sidewalls 13 of the compartment 8 of the storage nest 7, as shown in Figure 8. 5. The gripper mechanism 4 then moves the reagent pack 1 horizontally to a nearest vertical transport route 16a, as shown in Figure 9.
6. The gripper mechanism 4 moves the reagent pack 1 vertically up in the vertical transport route to the horizontal transport route 14a, as shown in Figure 10.
7. The gripper mechanism 4 moves the reagent pack 1 horizontally in the horizontal row to a vertical transport route next to one of the available compartments 10 of the pipetting nest 9, as shown in Figure 11.
8. The gripper mechanism 4 moves vertically in the transport route next to the available compartment 10 of the pipetting nest 9 until the bottom of the reagent pack 1 is above the bottom of the compartment 10, as shown in Figure 12. 9. The gripper mechanism 4 moves the reagent pack 1 horizontally into the compartment 10 of the pipetting nest 9 and deflects the spring-loaded v-blocks 11 until the reagent pack 1 is centered in the compartment 10 of the pipetting nest 9, as shown in Figure 13.
10. The gripper mechanism 4 reverses and its pins 6 disengage from the reagent pack 1. The v-blocks 11 return to their hard stops and align the reagent pack 1 to its precise pipetting position. The reagent pack 1 lowers down a small distance under gravity to come to rest on the bottom of the compartment 10 of the pipetting nest, as shown in Figure 14.
11. The gripper mechanism 4 moves vertically down to the horizontal transport route 14a to return to its initial position, as shown in Figure 15. 12. While one reagent pack 1 is retained in one of the compartments 10 of the pipetting nest 9 for the pipetting procedure, the gripper mechanism 4 may repeat the above steps to transport another one of the reagent packs 1 from the storage nest 7 to another available compartment 10 of the pipetting nest 9 for simultaneous pipetting.
One of the novel features of the transporting and storing system and method of the present invention is the ability to transport a single desired pack from a storage to a pipetting position and to service multiple pipetting positions with a single transport system.
Another novel feature of the transporting and storing system and method of the present invention is the combination of the conically tapered holes on the reagent pack and the complementary matching pins on the gripper mechanism for positioning and positively retaining the reagent pack while transporting it from the storage position to the pipettmg position.

Claims

What is claimed is:
1. A transporting and storing system preferably used in conjunction with an immunodiagnostic instrument, comprising: a. a multiplicity of reagent packs each having an elongated body with at least one well, the elongated body having sufficient thickness for said well and a slim profile with a wide middle portion, a narrow front portion with a pointed front end, and a narrow rear portion with a rounded rear end having two generally opposite outer sides; b. a gantry (5) mounted on a rack structure and movable horizontally for carrying a gripper mechanism (4) which is vertically movable on the gantry (5) and horizontally moveable with the gantry (4), the gripper mechanism (4) having a pair of generally oppositely disposed and synchronically movable gripping jaws (15) each having an inner side for engagement with said outer sides of said reagent pack; c. a power assembly for actuating the respective movement of said gantry (5), said gripper mechanism (4) and said gripping jaws (15); d. a storage nest (7) having a multiplicity of compartments (8) aligned in vertical columns and horizontal rows, each adapted for storing one of the respective reagent packs (1 ); e. a pipetting nest (9) having a multiplicity of compartments (10) aligned in at least one horizontal row, each adapted for retaining one of respective reagent packs (1 ) for simultaneous pipetting; f. at least one vertical transport route (16a) between two adjacent and spaced apart columns of said compartments for allowing the vertical movement of said gripper mechanism (4), and at least one horizontal transport route (14a) between two adjacent and spaced apart rows of said compartments for allowing the horizontal movement of said gripper mechanism carried by said gantry, for transporting said reagent packs (1) between said storage nest (7) and said pipetting nest (9); g. means (2, 3, 6) for positioning and positively retaining said reagent pack (1 ) by said gripper mechanism (4), for causing said reagent pack to be slightly lifted up when engaged by said gripping jaws (15) and moved in or out of said storage compartment (8, 10); and h. means for maintaining precise pipetting position of said reagent pack, including spring-loaded v-shaped members (11 ) located in said pipetting compartment (10), for limiting the movement of said reagent pack (1 ) during pipetting.
2. The system as defined in claim 1 , wherein said power assembly comprises a pneumatic power source.
3. The system as defined in any of the claims 1 or 2, wherein said at least one vertical transport route (16a) is located between two adjacent and spaced apart columns of said compartments (8) of said storage nest (7).
4. The system as defined in any of the claims 1 to 3, wherein said at least one horizontal transport route (14a) is located between said at least one row of said compartments of said pipetting nest and an adjacent and spaced apart row of said compartments of said storage nest (7).
5. The system as defined in any of the Claims 1 to 4, wherein said means for positioning and positively retaining said reagent pack by said gripper mechanism comprises at least two holes (3) with tapered conical opening on one of said two outer sides of said reagent pack (1) and at least one hole (2) with tapered conical opening on the other one of said two outer sides of said reagent pack (1 ), and further comprises at least two complementary conical pins (6) on said inner side of a corresponding one of said pair of gripping jaws (15) and at least one complementary conical pin (6) on said inner side of the other one of said pair of gripping jaws (15).
6. The system as defined in claims 1 to 4, wherein said means for positioning and positively retaining said reagent pack by said gripper mechanism (4) comprises at least two conical pins on one of said two outer sides of said reagent pack and at least one conical pin on the other one of said two outer sides of said reagent pack, and further comprises at least two complementary holes with tapered conical opening on said inner side of a corresponding one of said pair of gripping jaws (15) and at least one complementary hole with tapered conical opening on said inner side of the other one of said pair of gripping jaws (15).
7. A reagent pack (1 ) useable in conjunction with a transporting and storing system for an immunodiagnostic instrument, the transporting and storing system having a gripper mechanism (4) with outwardly protruding pins for positioning and positively retaining the reagent pack (1 ), the reagent pack
(1 ) comprising: a. an elongated body having sufficient thickness for having at least one well; b. said elongated body having a slim profile with a wide middle portion, a narrow front portion with a pointed front end, and a narrow ear portion with a rounded rear end having two generally opposite outer sides; c. means for facilitating position and positive retention of said reagent pack (1 ) by said gripper mechanism (4), including complementary holes (2, 3) on said outer sides of said elongated body for engagement with said inwardly protruding pins (6) of said gripping mechanism (4) of said transporting and storing system.
8. The reagent pack as defined in claim 7, wherein said complementary holes (2, 3) of said reagent pack (1 ) each has a tapered conical opening for causing said reagent pack (1 ) to be slightly lifted up when engaged by said gripping mechanism (4).
9. A transporting and storing system preferably used in conjunction with an immunodiagnostic instrument, comprising: a. a multiplicity of reagent packs (1 ); b. a gantry (5) movably mounted on a rack structure for carrying a gripper mechanism (4), the gripper mechanism having gripping jaws (15) for engagement with said reagent pack (1); c. a power assembly for actuating the respective movement of said gantry (5), said gripper mechanism (4) and said gripping jaws (15); d. a storage nest (7) having a multiplicity of compartments (8) each adapted for storing a respective one of said reagent packs (1 ); e. a pipetting nest (9) having a multiplicity of compartments (19) each adapted for retaining a respective one of said reagent packs (1) for simultaneous pipetting; f. at least one transport route (16a) for allowing movement of said gripper mechanism (4) carried by said gantry (5) for transporting said reagent packs (1 ) between said storage nest (7) and said pipetting nest (9); g. means for positioning and positively retaining said reagent pack (1 ) by said gripper mechanism (4), including complementary features on said reagent pack (1 ) and said gripping jaws (15), for causing said reagent pack (1) to be slightly lifted up when engaged by said gripping jaws (15) and moved in or out of said storage compartment (8, 10); and h. means for maintaining precise pipetting position of said reagent pack, including spring-loaded members (11) located in said pipetting compartment (10), for limiting the movement of said reagent pack (1) during pipetting.
10. The system as defined in claim 9, wherein said power assembly comprises a pneumatic power source.
11. The system as defined in claim 9, wherein said multiplicity of compartments (8) of said storage nest (7) are aligned in vertical columns and horizontal rows, and said multiplicity of compartments (10) of said pipetting nest (9) are aligned in at least one horizontal row.
12. The system as defined in claim 11 , wherein said at least one transport route comprises a vertical transport route (16a) located between two adjacent and spaced apart columns of said compartments (8) of said storage nest (7).
13. The system as defined in claim 12, wherein said at least one transport route (16a) further comprises a horizontal transport route (14a) located between said at least one row of said compartments (10) of said pipetting nest (9) and an adjacent and spaced apart row of said compartments (8) of said storage nest.
14. The system as defined in claim 9, wherein said means for positioning and positively retaining said reagent pack (1 ) by said gripper mechanism (4) comprises holes (2, 3) with tapered conical opening on said reagent pack
(I) and complementary conical pins (6) on said gripping jaws (15).
15. The system as defined in claim 9, wherein said spring-loaded members
(I I ) each has a v-shaped deflectible configuration.
16. A reagent pack usable in conjunction with a transporting and storing system for an immunodiagnostic instrument, the transporting and storing system having a gripper mechanism (4) with outwardly facing features (6) for positioning and positively retaining the reagent pack (1 ), the reagent pack (1 ) comprising inwardly facing complementary features (2, 3) for facilitating position and positive retention of said reagent pack (1 ) by said gripper mechanism (4).
17. The reagent pack as defined in claim 16, wherein said complementary features comprise conical pins (6) and complementary tapered conical holes (2, 3).
18. A method for transporting and storing multiple reagent packs used in conjunction with an immunodiagnostic instrument, comprising the steps of: a. providing a gripper mechanism having a pair of generally oppositely disposed and synchronically movable gripping jaws each having an inner side for engagement with one of said reagent packs, b. mounting a gantry on a rack structure to move horizontally for carrying said gripper mechanism such that it is vertically movable on the gantry and horizontally moveable with the gantry; c. supplying power to actuate the respective movement of said gantry, said gripper mechanism and said gripping jaws; d. aligning a multiplicity of storage compartments in vertical columns and horizontal rows for storing said reagent packs respectively, and aligning a multiplicity of pipetting compartment in at least one horizontal row for simultaneous pipetting; e. leaving at least one vertical transport route between two adjacent and spaced apart columns of said compartments for allowing the vertical movement of said gripper mechanism, and at least one horizontal transport route between two adjacent and spaced apart rows of said compartments for allowing the horizontal movement of said gripper mechanism carried by said gantry, for transporting said reagent packs between said storage compartments and said pipetting compartments; f. moving said gripper mechanism along said at least one vertical route and said at least one horizontal route to transport said reagent packs between said storage compartments and said pipetting compartments; g. while leaving one of said reagent packs in a respective one of said pipetting compartment for pipetting, moving said gripper mechanism to transport another one of said reagent packs to another one of said pipetting compartments for simultaneous pipetting; h. positioning and positively retaining said reagent pack with said gripper mechanism by utilizing holes with tapered conical opening on said reagent pack and complementary conical pins on said gripping jaws, such that said reagent packs are slightly lift up when being moved in and out of their respective said storage compartments to avoid direct contact therebetween; i. maintaining precise pipetting position of said reagent pack by utilizing spring-loaded v-shaped members located in said pipetting compartments for limiting the movement of said reagent pack during pipetting.
19. The method as defined in claim 18, further comprising the step of moving said gantry along a horizontal direction until said gripper mechanism is aligned with a column of said storage compartments containing a desired one of said reagent packs.
20. The method as defined in claim 18 or 19, further comprising the step of moving said gripper mechanism along a vertical direction until said gripping jaws are positioned adjacent to one of said storage compartments containing a desired one of said reagent packs.
21. The method as defined in any of the claims 18 to 20, further comprising the step of engaging said gripping jaws to a desired one of said reagent packs from a slightly higher elevation such that said reagent packs are slightly lift up when being engaged.
PCT/US2001/018636 2000-06-15 2001-06-08 Method and system for transporting and storing multiple reagent packs and reagent packs used therein WO2001096863A2 (en)

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US7491364B2 (en) 2009-02-17
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US20040219678A1 (en) 2004-11-04
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ATE336725T1 (en) 2006-09-15
EP1342091A2 (en) 2003-09-10

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