WO2001091723A3 - Fluorinated copolymer surfactants and use thereof in aerosol compositions - Google Patents

Fluorinated copolymer surfactants and use thereof in aerosol compositions Download PDF

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Publication number
WO2001091723A3
WO2001091723A3 PCT/US2001/017111 US0117111W WO0191723A3 WO 2001091723 A3 WO2001091723 A3 WO 2001091723A3 US 0117111 W US0117111 W US 0117111W WO 0191723 A3 WO0191723 A3 WO 0191723A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluorinated copolymer
aerosol compositions
copolymer surfactants
particles
surfactants
Prior art date
Application number
PCT/US2001/017111
Other languages
French (fr)
Other versions
WO2001091723A2 (en
Inventor
Joseph M Desimone
Terri Johnson Carson
John F Miller
Sharon Wells
Original Assignee
Glaxo Group Ltd
Univ North Carolina
Joseph M Desimone
Terri Johnson Carson
John F Miller
Sharon Wells
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Univ North Carolina, Joseph M Desimone, Terri Johnson Carson, John F Miller, Sharon Wells filed Critical Glaxo Group Ltd
Priority to AU2001265025A priority Critical patent/AU2001265025A1/en
Publication of WO2001091723A2 publication Critical patent/WO2001091723A2/en
Publication of WO2001091723A3 publication Critical patent/WO2001091723A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant

Abstract

Amphiphilic fluorinated block copolymers are disclosed which are useful for increasing the dispersability of particles, preferably drug particles, in a fluorine-containing propellant.
PCT/US2001/017111 2000-05-26 2001-05-25 Fluorinated copolymer surfactants and use thereof in aerosol compositions WO2001091723A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001265025A AU2001265025A1 (en) 2000-05-26 2001-05-25 Fluorinated copolymer surfactants and use thereof in aerosol compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/580,008 US6451287B1 (en) 2000-05-26 2000-05-26 Fluorinated copolymer surfactants and use thereof in aerosol compositions
US09/580,008 2000-05-26

Publications (2)

Publication Number Publication Date
WO2001091723A2 WO2001091723A2 (en) 2001-12-06
WO2001091723A3 true WO2001091723A3 (en) 2003-04-03

Family

ID=24319264

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/017111 WO2001091723A2 (en) 2000-05-26 2001-05-25 Fluorinated copolymer surfactants and use thereof in aerosol compositions

Country Status (3)

Country Link
US (1) US6451287B1 (en)
AU (1) AU2001265025A1 (en)
WO (1) WO2001091723A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257324A1 (en) * 2000-05-22 2006-11-16 Chiesi Farmaceutici S.P.A. Pharmaceutical solution formulations for pressurised metered dose inhalers
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
GB0125127D0 (en) * 2001-10-19 2001-12-12 Glaxo Group Ltd Compounds
GB0130703D0 (en) * 2001-12-21 2002-02-06 Glaxo Group Ltd Particles
JP2005517701A (en) * 2002-02-13 2005-06-16 グラクソ　グループ　リミテッド Carboxylic acid compounds for use as surfactants
GB0205327D0 (en) * 2002-03-06 2002-04-17 Glaxo Group Ltd compounds
US7632916B2 (en) 2002-08-02 2009-12-15 3M Innovative Properties Company Process to modify polymeric materials and resulting compositions
US6903173B2 (en) 2002-08-02 2005-06-07 3M Innovative Properties Co. Fluorinated polymers
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US20060211589A1 (en) * 2003-07-31 2006-09-21 Godfrey Anne P Pharmaceutical metered dose inhaler and methods relating thereto
MXPA06001642A (en) * 2003-08-11 2006-04-28 Glaxo Group Ltd Pharmaceutical metered dose inhaler and methods relating thereto.
CN100412101C (en) * 2006-01-27 2008-08-20 苏州大学 Amphipathic fluoride block copolymer and production thereof
CN100376614C (en) * 2006-02-21 2008-03-26 苏州大学 Fluorine-contg. block copolymers of pH-responsed and its prepn. method
CN104188907A (en) 2007-02-11 2014-12-10 Map药物公司 Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0636362A2 (en) * 1990-03-23 1995-02-01 Minnesota Mining And Manufacturing Company The use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations

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US4352789A (en) 1980-03-17 1982-10-05 Minnesota Mining And Manufacturing Company Aerosol compositions containing finely divided solid materials
US4608401A (en) 1982-09-02 1986-08-26 Union Carbide Corporation Method of encapsulating finely divided solid particles
US4771086A (en) 1982-09-02 1988-09-13 Union Carbide Corporation Encapsulating finely divided solid particles in stable suspensions
US4486572A (en) * 1983-07-06 1984-12-04 University Of Akron Synthesis of amphiphilic block copolymers and networks
US5320906A (en) 1986-12-15 1994-06-14 Vestar, Inc. Delivery vehicles with amphiphile-associated active ingredient
US4755563A (en) 1986-12-29 1988-07-05 E. I. Du Pont De Nemours And Company Block copolymer dispersants containing ionic moieties
GB8828477D0 (en) 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
IL97065A (en) 1990-02-02 1994-01-25 Fisons Plc Aerosol propellant compositions
US5118494A (en) 1990-03-23 1992-06-02 Minnesota Mining And Manufacturing Company Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
US5126123A (en) 1990-06-28 1992-06-30 Glaxo, Inc. Aerosol drug formulations
CA2085884C (en) 1990-06-29 2001-12-04 Asit Somani Pressurized hydrofluorocarbon aerosol compositions
US5518731A (en) 1990-09-27 1996-05-21 Allergan, Inc. Nonaqueous fluorinated drug delivery vehicle suspensions
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5496901A (en) 1992-03-27 1996-03-05 University Of North Carolina Method of making fluoropolymers
US5376359A (en) 1992-07-07 1994-12-27 Glaxo, Inc. Method of stabilizing aerosol formulations
US5492688A (en) 1993-04-28 1996-02-20 The Center For Innovative Technology Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent
US5312882A (en) 1993-07-30 1994-05-17 The University Of North Carolina At Chapel Hill Heterogeneous polymerization in carbon dioxide
US5612431A (en) 1994-09-21 1997-03-18 Minnesota Mining And Manufacturing Company Leaching of precious metal ore with fluoroaliphatic surfactant
GB9419536D0 (en) 1994-09-28 1994-11-16 Glaxo Inc Medicaments
US6013245A (en) 1995-01-26 2000-01-11 Glaxo Group Limited Aerosol formulation containing beclomethasone dipropionate and 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant
TWI230712B (en) * 1998-09-15 2005-04-11 Novartis Ag Polymers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0636362A2 (en) * 1990-03-23 1995-02-01 Minnesota Mining And Manufacturing Company The use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CANELAS DORIAN; YATES MATTHEW: "Poly(vinyl acetate) and Poly(vinyl acetate-co-ethylene) Latexes via Dispersion Polymerizations in Carbon Dioxide", MACROMOLECULES, vol. 31, no. 20, 1998, pages 6794 - 6805, XP002213042 *

Also Published As

Publication number Publication date
AU2001265025A1 (en) 2001-12-11
US6451287B1 (en) 2002-09-17
WO2001091723A2 (en) 2001-12-06

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