WO2001089455A3 - System and method for assessing the performance of a pharmaceutical agent delivery system - Google Patents

System and method for assessing the performance of a pharmaceutical agent delivery system Download PDF

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Publication number
WO2001089455A3
WO2001089455A3 PCT/US2001/016398 US0116398W WO0189455A3 WO 2001089455 A3 WO2001089455 A3 WO 2001089455A3 US 0116398 W US0116398 W US 0116398W WO 0189455 A3 WO0189455 A3 WO 0189455A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical agent
performance
assessing
agent delivery
electrodes
Prior art date
Application number
PCT/US2001/016398
Other languages
French (fr)
Other versions
WO2001089455A2 (en
Inventor
Adam J Simon
Original Assignee
Merck & Co Inc
Adam J Simon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Adam J Simon filed Critical Merck & Co Inc
Priority to CA002409603A priority Critical patent/CA2409603A1/en
Priority to AU2001264759A priority patent/AU2001264759B2/en
Priority to EP01939219A priority patent/EP1292359A4/en
Priority to JP2001585701A priority patent/JP2004532654A/en
Priority to AU6475901A priority patent/AU6475901A/en
Publication of WO2001089455A2 publication Critical patent/WO2001089455A2/en
Publication of WO2001089455A3 publication Critical patent/WO2001089455A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body

Abstract

A system and method for assessing the performance of a system for delivering a pharmaceutical agent to a portion of a body. A pair of electrodes are applied to the portion of the body. A pharmaceutical agent is infused into the portion of the body and the electrodes are energized by a signal generator, electrically stimulating the portion of the body. The voltage and current delivered to the portion of the body are measured using a data acquisition system thereby generating electrical parameter data. An immune response, gene expression level or other biological response to the pharmaceutical agent is measured and the electrical test data is correlated with the biological response to assess the performance of the system.
PCT/US2001/016398 2000-05-22 2001-05-22 System and method for assessing the performance of a pharmaceutical agent delivery system WO2001089455A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002409603A CA2409603A1 (en) 2000-05-22 2001-05-22 System and method for assessing the performance of a pharmaceutical agent delivery system
AU2001264759A AU2001264759B2 (en) 2000-05-22 2001-05-22 System and method for assessing the performance of a pharmaceutical agent delivery system
EP01939219A EP1292359A4 (en) 2000-05-22 2001-05-22 System and method for assessing the performance of a pharmaceutical agent delivery system
JP2001585701A JP2004532654A (en) 2000-05-22 2001-05-22 Drug administration system performance evaluation system and method
AU6475901A AU6475901A (en) 2000-05-22 2001-05-22 System and method for assessing the performance of a pharmaceutical agent delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20612100P 2000-05-22 2000-05-22
US60/206,121 2000-05-22

Publications (2)

Publication Number Publication Date
WO2001089455A2 WO2001089455A2 (en) 2001-11-29
WO2001089455A3 true WO2001089455A3 (en) 2002-08-29

Family

ID=22765067

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016398 WO2001089455A2 (en) 2000-05-22 2001-05-22 System and method for assessing the performance of a pharmaceutical agent delivery system

Country Status (6)

Country Link
US (1) US6928318B2 (en)
EP (1) EP1292359A4 (en)
JP (1) JP2004532654A (en)
AU (2) AU6475901A (en)
CA (1) CA2409603A1 (en)
WO (1) WO2001089455A2 (en)

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US7998745B2 (en) * 2006-09-05 2011-08-16 Tti Ellebeau, Inc. Impedance systems, devices, and methods for evaluating iontophoretic properties of compounds
KR101421760B1 (en) * 2006-10-17 2014-07-22 브이지엑스 파머시우티컬즈, 인크. Electroporation devices and methods of using same for electroporation of cells in mammals
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JP5383497B2 (en) 2006-12-01 2014-01-08 Ｔｔｉ・エルビュー株式会社 System and device for powering and / or controlling a device, for example a transdermal delivery device
WO2008087884A1 (en) * 2007-01-16 2008-07-24 Tti Ellebeau, Inc. Method for predicting medicament dose and program therefor
US7803582B2 (en) * 2007-03-17 2010-09-28 Hongzhan Xu Recombinant vector and use in gene therapy
EP2209490A4 (en) * 2007-11-14 2013-01-09 VGX Pharmaceuticals LLC Antibody production elicited by a dna vaccine delivered by electroporation
US8816205B2 (en) * 2009-04-03 2014-08-26 Ppc Broadband, Inc. Conductive elastomer and method of applying a conductive coating to a cable
US20130011909A1 (en) * 2011-06-30 2013-01-10 Texas Tech University System Methods and composition to enhance production of fully functional p-glycoprotein in pichia pastoris
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Also Published As

Publication number Publication date
US6928318B2 (en) 2005-08-09
WO2001089455A2 (en) 2001-11-29
US20020010415A1 (en) 2002-01-24
AU2001264759B2 (en) 2006-06-01
JP2004532654A (en) 2004-10-28
AU6475901A (en) 2001-12-03
EP1292359A4 (en) 2005-03-30
CA2409603A1 (en) 2001-11-29
EP1292359A2 (en) 2003-03-19

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