WO2001088534A3 - Methods for improving performance and reliability of biosensors - Google Patents

Methods for improving performance and reliability of biosensors Download PDF

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Publication number
WO2001088534A3
WO2001088534A3 PCT/US2001/015569 US0115569W WO0188534A3 WO 2001088534 A3 WO2001088534 A3 WO 2001088534A3 US 0115569 W US0115569 W US 0115569W WO 0188534 A3 WO0188534 A3 WO 0188534A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
biosensors
reliability
signal
improving performance
Prior art date
Application number
PCT/US2001/015569
Other languages
French (fr)
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WO2001088534A9 (en
WO2001088534A2 (en
Inventor
Norman A Parris
Russell O Potts
Michael Tierney
Christopher Uhegbu
Original Assignee
Cygnus Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnus Therapeutic Systems filed Critical Cygnus Therapeutic Systems
Publication of WO2001088534A2 publication Critical patent/WO2001088534A2/en
Publication of WO2001088534A3 publication Critical patent/WO2001088534A3/en
Publication of WO2001088534A9 publication Critical patent/WO2001088534A9/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase

Abstract

The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a predictive-kinetic method. Data from a transient region of a signal is used with suitable models and curve-fitting methods to predict the signal that would be measured for the system at the completion of the reaction. The values resulting from data processing of sensor response using the methods of the present invention are less sensitive to measurement variables.
PCT/US2001/015569 2000-05-16 2001-05-14 Methods for improving performance and reliability of biosensors WO2001088534A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20439700P 2000-05-16 2000-05-16
US60/204,397 2000-05-16
US24407800P 2000-10-27 2000-10-27
US60/244,078 2000-10-27

Publications (3)

Publication Number Publication Date
WO2001088534A2 WO2001088534A2 (en) 2001-11-22
WO2001088534A3 true WO2001088534A3 (en) 2002-03-07
WO2001088534A9 WO2001088534A9 (en) 2002-12-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015569 WO2001088534A2 (en) 2000-05-16 2001-05-14 Methods for improving performance and reliability of biosensors

Country Status (2)

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US (3) US6885883B2 (en)
WO (1) WO2001088534A2 (en)

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