WO2001087335A2 - Method for selectively inhibiting ghrelin action - Google Patents
Method for selectively inhibiting ghrelin action Download PDFInfo
- Publication number
- WO2001087335A2 WO2001087335A2 PCT/US2001/011752 US0111752W WO0187335A2 WO 2001087335 A2 WO2001087335 A2 WO 2001087335A2 US 0111752 W US0111752 W US 0111752W WO 0187335 A2 WO0187335 A2 WO 0187335A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ghrelin
- ghs
- compound
- gna
- mixture
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF] (Somatoliberin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/258,259 US20030211967A1 (en) | 2001-05-07 | 2001-05-07 | Method for selectively inhibiting ghrelin action |
AU2001259056A AU2001259056A1 (en) | 2000-05-17 | 2001-05-07 | Method for selectively inhibiting ghrelin action |
EP01932539A EP1286697A2 (en) | 2000-05-17 | 2001-05-07 | Method for selectively inhibiting ghrelin action |
US11/106,899 US20050201938A1 (en) | 2000-05-17 | 2005-04-15 | Method for selectively inhibiting ghrelin action |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20489700P | 2000-05-17 | 2000-05-17 | |
US60/204,897 | 2000-05-17 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/106,899 Continuation US20050201938A1 (en) | 2000-05-17 | 2005-04-15 | Method for selectively inhibiting ghrelin action |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001087335A2 true WO2001087335A2 (en) | 2001-11-22 |
WO2001087335A3 WO2001087335A3 (en) | 2002-05-16 |
Family
ID=22759933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/011752 WO2001087335A2 (en) | 2000-05-17 | 2001-05-07 | Method for selectively inhibiting ghrelin action |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1286697A2 (en) |
AU (1) | AU2001259056A1 (en) |
WO (1) | WO2001087335A2 (en) |
Cited By (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002060472A1 (en) * | 2001-01-31 | 2002-08-08 | Chugai Seiyaku Kabushiki Kaisha | Remedies for hyponutrition status |
WO2002090387A1 (en) * | 2001-05-10 | 2002-11-14 | Queensland University Of Technology | Reproductive cancer diagnosis and therapy |
WO2003051389A3 (en) * | 2001-12-18 | 2003-09-12 | Theratechnologies Inc | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
WO2004002986A2 (en) | 2002-06-28 | 2004-01-08 | Banyu Pharmaceutical Co., Ltd. | Novel benzimidazole derivatives |
WO2004004772A1 (en) * | 2002-07-05 | 2004-01-15 | Chugai Seiyaku Kabushiki Kaisha | Remedy for diabetes |
WO2004013274A2 (en) | 2002-08-01 | 2004-02-12 | Noxxon Pharma Ag | Ghrelin binding nucleic acids |
WO2004024183A1 (en) * | 2002-09-12 | 2004-03-25 | Pharmexa A/S | Immunization against autologous ghrelin |
US6716629B2 (en) | 2000-10-10 | 2004-04-06 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
WO2004056869A1 (en) * | 2002-12-20 | 2004-07-08 | 7Tm Pharma A/S | Ghrelin receptor inverse agonist for regulation of feeding behaviours |
WO2004084943A1 (en) * | 2003-03-19 | 2004-10-07 | Beth Israel Deaconess Medical Center, Inc | Use of antagonists of ghrelin or ghrelin receptor to treat intestinal inflammation |
WO2005000343A1 (en) * | 2003-06-11 | 2005-01-06 | Allergan, Inc. | Use of a clostridial toxin to reduce appetite |
WO2005026211A2 (en) * | 2003-09-05 | 2005-03-24 | Eli Lilly And Company | Anti-ghrelin antibodies |
EP1546389A2 (en) * | 2002-09-06 | 2005-06-29 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/igf-1 axis |
WO2005097830A2 (en) * | 2004-04-07 | 2005-10-20 | Aditech Pharma Ab | Uses of isolated binding members capable of reducing the biological activity of secretagogue compounds |
WO2005097831A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Uses of isolated binding members capable of binding specifically to secretagogues |
WO2005112903A2 (en) * | 2004-05-14 | 2005-12-01 | Novo Nordisk A/S | Use of ghrelin antagonists for improving cognition and memory |
WO2005113600A2 (en) * | 2004-05-18 | 2005-12-01 | Haptogen Ltd | Methods for the control, treatment and management of obesity |
WO2006019577A1 (en) * | 2004-07-14 | 2006-02-23 | Eli Lilly And Company | Anti-ghrelin antibodies |
EP1694355A1 (en) * | 2003-10-24 | 2006-08-30 | THE ACADEMIC HOSPITAL ROTTERDAM acting under the name Erasmus MC | Use of ghrelin and unacylated ghrelin compostions in insulin-related disease conditions |
WO2006091381A1 (en) * | 2005-02-23 | 2006-08-31 | Eli Lilly And Company | Humanized anti-ghrelin antibodies |
WO2007041052A2 (en) | 2005-09-29 | 2007-04-12 | Merck & Co., Inc. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
JP2007513608A (en) * | 2003-11-10 | 2007-05-31 | ノクソン・フアルマ・アクチエンゲゼルシヤフト | Nucleic acids that specifically bind to biologically active ghrelin |
US7252665B2 (en) | 2003-10-31 | 2007-08-07 | Medtronic, Inc | Ablation of stomach lining to reduce stomach acid secretion |
WO2007095347A2 (en) * | 2006-02-13 | 2007-08-23 | The Gov. Of The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Methods and compositions related to ghs-r antagonists |
US7282050B2 (en) | 2003-10-31 | 2007-10-16 | Medtronic, Inc. | Ablation of exterior of stomach to treat obesity |
WO2008060476A2 (en) | 2006-11-15 | 2008-05-22 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
EP2088154A1 (en) | 2004-03-09 | 2009-08-12 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
WO2009110510A1 (en) | 2008-03-06 | 2009-09-11 | 萬有製薬株式会社 | Alkylaminopyridine derivative |
EP2127676A2 (en) | 2004-11-01 | 2009-12-02 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
US7666833B2 (en) | 2001-12-18 | 2010-02-23 | Alizé Pharma SAS | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2010051236A1 (en) | 2008-10-30 | 2010-05-06 | Merck Sharp & Dohme Corp. | Isonicotinamide orexin receptor antagonists |
WO2010051206A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US7736392B2 (en) | 2005-04-28 | 2010-06-15 | Medtronic, Inc. | Bulking of upper esophageal sphincter for treatment of obesity |
WO2010075069A1 (en) | 2008-12-16 | 2010-07-01 | Schering Corporation | Bicyclic pyranone derivatives as nicotinic acid receptor agonists |
WO2010075068A1 (en) | 2008-12-16 | 2010-07-01 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
WO2011053821A1 (en) | 2009-10-30 | 2011-05-05 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same |
EP2330125A2 (en) | 2005-08-11 | 2011-06-08 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
EP2330124A2 (en) | 2005-08-11 | 2011-06-08 | Amylin Pharmaceuticals Inc. | Hybrid polypeptides with selectable properties |
WO2011069038A2 (en) | 2009-12-03 | 2011-06-09 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US8101576B2 (en) | 2006-12-13 | 2012-01-24 | Imperial Innovations Limited | Compounds and their effects on feeding behaviour |
US8101734B2 (en) | 2005-04-08 | 2012-01-24 | Noxxon Pharma Ag | Ghrelin binding nucleic acids |
US8217001B2 (en) | 2001-09-24 | 2012-07-10 | Imperial Innovations Limited | Modification of feeding behavior |
US8222217B2 (en) | 2007-05-31 | 2012-07-17 | Alize Pharma Sas | Unacylated ghrelin as therapeutic agent in the treatment of metabolic disorders |
WO2012116145A1 (en) | 2011-02-25 | 2012-08-30 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
US8318664B2 (en) | 2007-05-31 | 2012-11-27 | Alize Pharma Sas | Unacylated ghrelin fragments as therapeutic agent in the treatment of obesity |
WO2013059222A1 (en) | 2011-10-19 | 2013-04-25 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-4-nitrile orexin receptor antagonists |
US8440628B2 (en) * | 2002-05-21 | 2013-05-14 | Daiichi Sankyo Company, Limited | Medical compositions containing ghrelin |
US8476408B2 (en) | 2008-06-13 | 2013-07-02 | Alize Pharma Sas | Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease |
WO2013138352A1 (en) | 2012-03-15 | 2013-09-19 | Synergy Pharmaceuticals Inc. | Formulations of guanylate cyclase c agonists and methods of use |
WO2014022528A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
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WO2014130608A1 (en) | 2013-02-22 | 2014-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
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US8992928B2 (en) | 2006-02-11 | 2015-03-31 | Victor Raso | Isolated monoclonal antibody or antigen-binding fragment that cleaves octanoylated native ghrelin |
WO2015054500A2 (en) | 2013-10-09 | 2015-04-16 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for downregulation of pro-inflammatory cytokines |
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US10227644B2 (en) | 2000-02-18 | 2019-03-12 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of microvolume liquid reactions |
WO2020104456A1 (en) | 2018-11-20 | 2020-05-28 | Tes Pharma S.R.L | INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE |
WO2020167706A1 (en) | 2019-02-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
WO2021026047A1 (en) | 2019-08-08 | 2021-02-11 | Merck Sharp & Dohme Corp. | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
WO2022040070A1 (en) | 2020-08-18 | 2022-02-24 | Merck Sharp & Dohme Corp. | Bicycloheptane pyrrolidine orexin receptor agonists |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1608952B1 (en) | 2002-12-20 | 2016-08-10 | Life Technologies Corporation | Assay apparatus and method using microfluidic arrays |
Citations (3)
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WO1997021730A1 (en) * | 1995-12-13 | 1997-06-19 | Merck & Co., Inc. | Growth hormone secretagogue receptor family |
WO2000002919A1 (en) * | 1998-07-13 | 2000-01-20 | Merck & Co., Inc. | Growth hormone secretagogue related receptors and nucleic acids |
WO2000009538A2 (en) * | 1998-08-10 | 2000-02-24 | Merck & Co., Inc. | Canine growth hormone secretagogue receptor |
-
2001
- 2001-05-07 AU AU2001259056A patent/AU2001259056A1/en not_active Abandoned
- 2001-05-07 EP EP01932539A patent/EP1286697A2/en not_active Withdrawn
- 2001-05-07 WO PCT/US2001/011752 patent/WO2001087335A2/en active Application Filing
Patent Citations (3)
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WO1997021730A1 (en) * | 1995-12-13 | 1997-06-19 | Merck & Co., Inc. | Growth hormone secretagogue receptor family |
WO2000002919A1 (en) * | 1998-07-13 | 2000-01-20 | Merck & Co., Inc. | Growth hormone secretagogue related receptors and nucleic acids |
WO2000009538A2 (en) * | 1998-08-10 | 2000-02-24 | Merck & Co., Inc. | Canine growth hormone secretagogue receptor |
Non-Patent Citations (2)
Title |
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KOJIMA MASAYASU ET AL: "Ghrelin is a growth-hormone-releasing acylated peptide from stomach." NATURE (LONDON), vol. 402, no. 6762, 9 December 1999 (1999-12-09), pages 656-660, XP002187791 ISSN: 0028-0836 cited in the application * |
SMITH R G ET AL: "A nonpeptidyl growth hormone secretagogue." SCIENCE, (1993 JUN 11) 260 (5114) 1640-3. , XP002187790 cited in the application * |
Cited By (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10378049B2 (en) | 2000-02-18 | 2019-08-13 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of microvolume liquid reactions |
US10227644B2 (en) | 2000-02-18 | 2019-03-12 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of microvolume liquid reactions |
US9314764B2 (en) | 2000-10-10 | 2016-04-19 | Life Technologies Corporation | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
US6716629B2 (en) | 2000-10-10 | 2004-04-06 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
US9968903B2 (en) | 2000-10-10 | 2018-05-15 | Life Technologies Corporation | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
WO2002060472A1 (en) * | 2001-01-31 | 2002-08-08 | Chugai Seiyaku Kabushiki Kaisha | Remedies for hyponutrition status |
WO2002090387A1 (en) * | 2001-05-10 | 2002-11-14 | Queensland University Of Technology | Reproductive cancer diagnosis and therapy |
US8217001B2 (en) | 2001-09-24 | 2012-07-10 | Imperial Innovations Limited | Modification of feeding behavior |
US8071368B2 (en) | 2001-12-18 | 2011-12-06 | Alizé Pharma SAS | Methods for promoting growth and survival of insulin-secreting cells |
US7485620B2 (en) | 2001-12-18 | 2009-02-03 | Alizé Pharma SAS | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
WO2003051389A3 (en) * | 2001-12-18 | 2003-09-12 | Theratechnologies Inc | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
US7666833B2 (en) | 2001-12-18 | 2010-02-23 | Alizé Pharma SAS | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
US8518893B2 (en) | 2002-05-21 | 2013-08-27 | Asubio Pharma Co. Ltd. | Medical compositions containing ghrelin |
US8440628B2 (en) * | 2002-05-21 | 2013-05-14 | Daiichi Sankyo Company, Limited | Medical compositions containing ghrelin |
WO2004002986A2 (en) | 2002-06-28 | 2004-01-08 | Banyu Pharmaceutical Co., Ltd. | Novel benzimidazole derivatives |
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