WO2001085202A3 - Electroporation for introduction of molecules into cells - Google Patents
Electroporation for introduction of molecules into cells Download PDFInfo
- Publication number
- WO2001085202A3 WO2001085202A3 PCT/GB2001/001970 GB0101970W WO0185202A3 WO 2001085202 A3 WO2001085202 A3 WO 2001085202A3 GB 0101970 W GB0101970 W GB 0101970W WO 0185202 A3 WO0185202 A3 WO 0185202A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- skeletal muscle
- mammal
- antigen
- injection site
- electrodes
- Prior art date
Links
- 238000004520 electroporation Methods 0.000 title 1
- 210000002027 skeletal muscle Anatomy 0.000 abstract 5
- 241000124008 Mammalia Species 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 238000002347 injection Methods 0.000 abstract 3
- 239000007924 injection Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 230000004700 cellular uptake Effects 0.000 abstract 1
- 230000000899 immune system response Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01928065A EP1280550A2 (en) | 1997-04-03 | 2001-05-04 | Electroporation for introduction of molecules into cells |
AU54932/01A AU5493201A (en) | 1997-04-03 | 2001-05-04 | Method for introduction of molecules into cells |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4259497P | 1997-04-03 | 1997-04-03 | |
US09/055,084 US6110161A (en) | 1997-04-03 | 1998-04-03 | Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle |
US09/565,140 | 2000-05-05 | ||
US09/565,140 US6261281B1 (en) | 1997-04-03 | 2000-05-05 | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
US09/899,561 US20020038112A1 (en) | 1997-04-03 | 2001-07-05 | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
US10/141,561 US6610044B2 (en) | 1997-04-03 | 2002-05-07 | Method for genetic immunization |
US10/620,271 US6958060B2 (en) | 1997-04-03 | 2003-07-14 | Method for muscle delivery of drugs, nucleic acids and other compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001085202A2 WO2001085202A2 (en) | 2001-11-15 |
WO2001085202A3 true WO2001085202A3 (en) | 2002-03-28 |
Family
ID=35910568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2001/001970 WO2001085202A2 (en) | 1997-04-03 | 2001-05-04 | Electroporation for introduction of molecules into cells |
Country Status (4)
Country | Link |
---|---|
US (6) | US6261281B1 (en) |
EP (1) | EP1280550A2 (en) |
AU (1) | AU5493201A (en) |
WO (1) | WO2001085202A2 (en) |
Families Citing this family (208)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5993434A (en) * | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
US5702359A (en) * | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
US6261281B1 (en) * | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
US20040229363A1 (en) * | 1998-06-24 | 2004-11-18 | Ed Nolan | High efficiency transfection based on low electric field strength, long pulse length |
US20040052773A1 (en) * | 2002-01-18 | 2004-03-18 | Inovio As | Production of multi-chain protein from muscle |
EP1482974A4 (en) * | 2002-02-15 | 2006-08-02 | Zycos Inc | Electroporation methods for introducing bioactive agents into cells |
US7245963B2 (en) * | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
US8209006B2 (en) * | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
US9308043B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US7756583B2 (en) | 2002-04-08 | 2010-07-13 | Ardian, Inc. | Methods and apparatus for intravascularly-induced neuromodulation |
US8347891B2 (en) | 2002-04-08 | 2013-01-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
US20140018880A1 (en) | 2002-04-08 | 2014-01-16 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
US7620451B2 (en) | 2005-12-29 | 2009-11-17 | Ardian, Inc. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
US8774922B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods |
US7162303B2 (en) | 2002-04-08 | 2007-01-09 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
US8175711B2 (en) | 2002-04-08 | 2012-05-08 | Ardian, Inc. | Methods for treating a condition or disease associated with cardio-renal function |
US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US8145317B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods for renal neuromodulation |
US6978174B2 (en) | 2002-04-08 | 2005-12-20 | Ardian, Inc. | Methods and devices for renal nerve blocking |
US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
US8131371B2 (en) | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
US20070135875A1 (en) | 2002-04-08 | 2007-06-14 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US8145316B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US8774913B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
US9308044B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US7853333B2 (en) | 2002-04-08 | 2010-12-14 | Ardian, Inc. | Methods and apparatus for multi-vessel renal neuromodulation |
PL375961A1 (en) * | 2002-09-26 | 2005-12-12 | Pfizer Products Inc. | Use of excipients to increase dna uptake by swine muscle cells |
AU2003284239B2 (en) | 2002-10-21 | 2008-08-21 | Eisai Inc. | Compositions and methods for treating human papillomavirus-mediated disease |
US20050277127A1 (en) * | 2003-11-26 | 2005-12-15 | Epitomics, Inc. | High-throughput method of DNA immunogen preparation and immunization |
US20050287118A1 (en) * | 2003-11-26 | 2005-12-29 | Epitomics, Inc. | Bacterial plasmid with immunological adjuvant function and uses thereof |
US20050266554A1 (en) * | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
US7625753B2 (en) | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
CN109628371B (en) * | 2003-12-23 | 2021-02-19 | 维亚希特公司 | Definitive endoderm |
US7541185B2 (en) * | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
US8586357B2 (en) | 2003-12-23 | 2013-11-19 | Viacyte, Inc. | Markers of definitive endoderm |
US8647873B2 (en) | 2004-04-27 | 2014-02-11 | Viacyte, Inc. | PDX1 expressing endoderm |
MX2009009225A (en) | 2003-12-23 | 2009-09-28 | Cythera Inc | Definitive endoderm. |
US7985585B2 (en) | 2004-07-09 | 2011-07-26 | Viacyte, Inc. | Preprimitive streak and mesendoderm cells |
EP2377922B1 (en) | 2004-04-27 | 2020-04-08 | Viacyte, Inc. | PDX1 expressing endoderm |
FR2872055B1 (en) | 2004-06-24 | 2008-02-08 | Yves Leon Scherman | DEVICE FOR TRANSFERRING MOLECULES TO CELLS USING A FORCE OF PHYSICAL ORIGIN AND COMBINATION FOR IMPLEMENTING THE METHOD |
CA2966883A1 (en) | 2004-07-09 | 2006-02-16 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
US8187878B2 (en) * | 2004-08-13 | 2012-05-29 | University Of Georgia Research Foundation, Inc. | Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors |
US7937143B2 (en) | 2004-11-02 | 2011-05-03 | Ardian, Inc. | Methods and apparatus for inducing controlled renal neuromodulation |
US20070048289A1 (en) * | 2005-08-31 | 2007-03-01 | Grandjean Pierre A | Cellular intervention to treat damaged myocardium |
ES2743202T3 (en) | 2005-10-27 | 2020-02-18 | Viacyte Inc | Endoderm of the dorsal and ventral proximal intestine expressing PDX1 |
US20070253969A1 (en) * | 2005-11-14 | 2007-11-01 | Freda Stevenson | Materials and methods relating to DNA vaccination |
US11254916B2 (en) | 2006-03-02 | 2022-02-22 | Viacyte, Inc. | Methods of making and using PDX1-positive pancreatic endoderm cells |
US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
SG10201405380QA (en) | 2006-03-02 | 2014-10-30 | Cythera Inc | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
US8260411B1 (en) | 2006-09-06 | 2012-09-04 | Twin Star Medical, Inc. | Conductive injection and aspiration device and method |
US20100323442A1 (en) * | 2006-10-17 | 2010-12-23 | Emmanuel Edward Baetge | Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells |
EP2548438B1 (en) | 2006-11-08 | 2015-08-05 | Veritas Bio, LLC | In vivo delivery of double stranded RNA to a target cell |
WO2008063555A2 (en) | 2006-11-17 | 2008-05-29 | Genetronics, Inc. | Methods of enhancing immune response using electroporation-assisted vaccination and boosting |
US7695963B2 (en) | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
EP2612868B1 (en) | 2007-11-01 | 2018-08-15 | Astellas Pharma Inc. | Immunosuppressive polypeptides and nucleic acids |
JP5744719B2 (en) * | 2008-04-04 | 2015-07-08 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Chikungunya virus protein consensus sequence, nucleic acid molecule encoding the same, and compositions and methods using the same |
KR101652767B1 (en) | 2008-04-04 | 2016-08-31 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Vaccines and Immunotherapeutics using IL-28 and compositions and methods of using the same |
CN102282254B (en) | 2008-11-14 | 2015-12-16 | 维赛特公司 | Come from the encapsulating of the pancreatic cell of human pluripotent stem cells |
US8652129B2 (en) | 2008-12-31 | 2014-02-18 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
WO2010086743A2 (en) | 2009-02-02 | 2010-08-05 | Chrontech Pharma Ab | Compositions and methods that enhance an immune response |
US20100298697A1 (en) * | 2009-05-19 | 2010-11-25 | Medtronic, Inc. | Method and devices for improved efficiency of rna delivery to cells |
US8207138B2 (en) | 2009-05-19 | 2012-06-26 | Medtronic, Inc. | Methods and devices for improved efficiency of RNA delivery to cells |
KR20120093163A (en) | 2009-09-14 | 2012-08-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same |
US9109014B2 (en) | 2009-11-02 | 2015-08-18 | The Trustees Of The University Of Pennsylvania | Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom |
CA2784488A1 (en) | 2009-12-16 | 2011-06-23 | Chrontech Pharma Ab | Injection needle and device |
US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
WO2011097640A1 (en) | 2010-02-08 | 2011-08-11 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same |
WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
KR20180096814A (en) | 2010-09-27 | 2018-08-29 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Consensus antigen constructs and vaccines made there from, and methods of using same to treat malaria |
US20120237975A1 (en) | 2010-10-01 | 2012-09-20 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
JP6046041B2 (en) | 2010-10-25 | 2016-12-14 | メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ | Devices, systems, and methods for neuromodulation therapy evaluation and feedback |
EP3909973A3 (en) | 2010-11-12 | 2022-01-26 | The Trustees Of The University Of Pennsylvania | Consensus prostate antigens, nucleic acid molecules encoding the same and uses thereof |
WO2012106377A2 (en) | 2011-01-31 | 2012-08-09 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof |
US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
EP2672992B1 (en) | 2011-02-11 | 2020-04-08 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecule encoding hepatitis b virus core protein and vaccine comprising the same |
AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
US9457183B2 (en) | 2011-06-15 | 2016-10-04 | Tripep Ab | Injection needle and device |
CN103687625B (en) | 2011-07-11 | 2017-06-13 | 艾诺奥医药品有限公司 | Intersecting protective arenavirus vaccine and its application method |
KR101955365B1 (en) | 2011-07-12 | 2019-03-07 | 필라델피아 헬스 앤드 에듀케이션 코포레이션 디/비/에이 드렉셀 유니버시티 컬리지 오브 메디슨 | Novel Clostridium Difficile DNA Vaccine |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CN103946952A (en) | 2011-09-16 | 2014-07-23 | 宾夕法尼亚大学董事会 | RNA engineered t cells for the treatment of cancer |
US9708384B2 (en) | 2011-09-22 | 2017-07-18 | The Trustees Of The University Of Pennsylvania | Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens |
EP3682905B1 (en) | 2011-10-03 | 2021-12-01 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
US9272002B2 (en) | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
KR102101819B1 (en) | 2011-12-12 | 2020-04-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Compositions, comprising improved il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same |
US9750795B2 (en) | 2011-12-12 | 2017-09-05 | The Trustees Of The University Of Pennsylvania | Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections |
RS63244B1 (en) | 2011-12-16 | 2022-06-30 | Modernatx Inc | Modified mrna compositions |
ES2816450T3 (en) | 2012-02-22 | 2021-04-05 | Univ Pennsylvania | Use of ICOS-based CARs to improve antitumor activity and CAR persistence |
IN2014DN06522A (en) | 2012-02-22 | 2015-06-12 | Univ Pennsylvania | |
CA2865242A1 (en) | 2012-03-08 | 2013-09-12 | Medtronic Ardian Luxembourg S.A.R.L. | Biomarker sampling in the context of neuromodulation devices and associated systems and methods |
US9750568B2 (en) | 2012-03-08 | 2017-09-05 | Medtronic Ardian Luxembourg S.A.R.L. | Ovarian neuromodulation and associated systems and methods |
US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
EP2833892A4 (en) | 2012-04-02 | 2016-07-20 | Moderna Therapeutics Inc | Modified polynucleotides for the production of oncology-related proteins and peptides |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
AU2013245950B2 (en) | 2012-04-10 | 2016-04-21 | The Trustees Of The University Of Pennsylvania | Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
KR20240010758A (en) | 2012-04-12 | 2024-01-24 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
AU2013289971A1 (en) | 2012-07-13 | 2015-01-22 | The Trustees Of The University Of Pennsylvania | Enhancing activity of CAR T cells by co-introducing a bispecific antibody |
WO2014055442A2 (en) | 2012-10-01 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
US9598489B2 (en) | 2012-10-05 | 2017-03-21 | The Trustees Of The Univeristy Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
WO2014064534A2 (en) | 2012-10-05 | 2014-05-01 | Chrontech Pharma Ab | Injection needle, device, immunogenic compositions and method of use |
US20140110296A1 (en) | 2012-10-19 | 2014-04-24 | Medtronic Ardian Luxembourg S.A.R.L. | Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods |
ES2921623T3 (en) | 2012-11-26 | 2022-08-30 | Modernatx Inc | terminally modified RNA |
JP6523174B2 (en) | 2012-12-13 | 2019-05-29 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | WT1 vaccine |
CN114225019A (en) | 2013-03-15 | 2022-03-25 | 宾夕法尼亚大学理事会 | Cancer vaccines and methods of treatment using the same |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
MX2015011487A (en) | 2013-03-15 | 2016-02-03 | Univ Pennsylvania | Foot and mouth disease virus (fmdv) consensus proteins, coding sequences therefor and vaccines made therefrom. |
WO2014186409A1 (en) | 2013-05-15 | 2014-11-20 | Chrontech Pharma Ab | Immunogenic compositions for inhibiting hepatitis d virus |
KR20160037196A (en) | 2013-07-31 | 2016-04-05 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | Compositions for and methods of treating and preventing cancer targeting tumor associated carbohydrate antigens |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
AU2014329452B2 (en) | 2013-10-03 | 2019-06-20 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
SG11201604719WA (en) | 2013-12-13 | 2016-07-28 | Univ Pennsylvania | Dna antibody constructs and method of using same |
WO2015112626A1 (en) | 2014-01-21 | 2015-07-30 | June Carl H | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
US10194979B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US9980766B1 (en) | 2014-03-28 | 2018-05-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for renal neuromodulation |
US10194980B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
EP3217989B1 (en) | 2014-10-31 | 2022-01-05 | The Trustees of the University of Pennsylvania | Compositions and methods of stimulating and expanding t cells |
EP3215168B1 (en) | 2014-10-31 | 2023-08-02 | The Trustees of the University of Pennsylvania | Altering gene expression in modified t cells and uses thereof |
BR112017011556A2 (en) | 2014-12-01 | 2018-03-06 | Inovio Pharmaceuticals Inc | methods for generating a synthetic antibody, preventing or treating a disease, treating a subject of pathogen infection and a subject with cancer, product, nucleic acid molecule, and composition. |
EP4223873A3 (en) | 2015-01-31 | 2023-09-06 | The Trustees of the University of Pennsylvania | Compositions and methods for t cell delivery of therapeutic molecules |
KR102434330B1 (en) | 2015-05-01 | 2022-08-22 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | Glycan-dependent immunotherapeutic molecules |
US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
US11007260B2 (en) | 2015-07-21 | 2021-05-18 | Modernatx, Inc. | Infectious disease vaccines |
CN108348551A (en) | 2015-08-28 | 2018-07-31 | 宾夕法尼亚大学董事会 | Express the method and composition of the cell of signal transduction molecule in chimeric cell |
WO2017055522A1 (en) | 2015-09-29 | 2017-04-06 | Academisch Medisch Centrum | Stabilized env proteins of hiv |
CN108472309A (en) | 2015-10-22 | 2018-08-31 | 摩登纳特斯有限公司 | For varicellazoster virus(VZV)Nucleic acid vaccine |
WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
AU2016342376A1 (en) | 2015-10-22 | 2018-06-07 | Modernatx, Inc. | Sexually transmitted disease vaccines |
JP7123800B2 (en) | 2016-02-05 | 2022-08-23 | イノビオ ファーマシューティカルズ,インコーポレイティド | Cancer vaccine and method of treatment therewith |
WO2017165683A1 (en) | 2016-03-23 | 2017-09-28 | Novartis Ag | Cell secreted minibodies and uses thereof |
US10538786B2 (en) | 2016-04-13 | 2020-01-21 | Janssen Pharmaceuticals, Inc. | Recombinant arterivirus replicon systems and uses thereof |
US10233419B2 (en) | 2016-06-30 | 2019-03-19 | Zymergen Inc. | Apparatuses and methods for electroporation |
JP2018035137A (en) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag | Novel anti-fibroblast activated protein (FAP) binding agent and use thereof |
JP7382230B2 (en) | 2016-10-17 | 2023-11-16 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | Recombinant viral replicon system and its use |
MA46766A (en) | 2016-11-11 | 2019-09-18 | Modernatx Inc | INFLUENZA VACCINE |
KR102655641B1 (en) | 2016-12-05 | 2024-04-05 | 얀센 파마슈티칼즈, 인코포레이티드 | Compositions and methods for enhancing gene expression |
WO2018107088A2 (en) | 2016-12-08 | 2018-06-14 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
WO2018170256A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Herpes simplex virus vaccine |
MA52262A (en) | 2017-03-15 | 2020-02-19 | Modernatx Inc | BROAD SPECTRUM VACCINE AGAINST THE INFLUENZA VIRUS |
MA47787A (en) | 2017-03-15 | 2020-01-22 | Modernatx Inc | RESPIRATORY SYNCYTIAL VIRUS VACCINE |
US11344618B2 (en) | 2017-08-26 | 2022-05-31 | Academisch Medisch Centrum | HIV envelope glycoprotein immunogens |
MA50253A (en) | 2017-09-14 | 2020-07-22 | Modernatx Inc | ZIKA VIRUS RNA VACCINES |
US11235044B2 (en) | 2017-12-13 | 2022-02-01 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting MUC16 and uses thereof |
ES2938900T3 (en) | 2017-12-13 | 2023-04-17 | Inovio Pharmaceuticals Inc | PRAME-targeted cancer vaccines and their uses |
EP3723810A4 (en) | 2017-12-13 | 2022-02-23 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting mesothelin and uses thereof |
AU2018389786A1 (en) | 2017-12-19 | 2020-06-18 | Bavarian Nordic A/S | Methods and compositions for inducing an immune response against hepatitis B virus (HBV) |
EA202091513A1 (en) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | VACCINES AGAINST HEPATITIS B VIRUS (HBV) AND THEIR APPLICATION |
EP3727445B1 (en) | 2017-12-19 | 2023-08-16 | Janssen Sciences Ireland Unlimited Company | Hepatitis b virus (hbv) vaccines and uses thereof |
US11020476B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV) |
US11389531B2 (en) | 2017-12-19 | 2022-07-19 | Janssen Sciences Ireland Unlimited Company | Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines |
US20200332004A1 (en) | 2017-12-29 | 2020-10-22 | Cellectis | Method for improving production of car t cells |
JP2021511318A (en) | 2018-01-19 | 2021-05-06 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | Induction and enhancement of immune response using recombinant replicon system |
EP3746090A4 (en) | 2018-01-29 | 2021-11-17 | ModernaTX, Inc. | Rsv rna vaccines |
US20220170097A1 (en) | 2018-10-29 | 2022-06-02 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
WO2020191102A1 (en) | 2019-03-18 | 2020-09-24 | The Broad Institute, Inc. | Type vii crispr proteins and systems |
WO2020198413A1 (en) | 2019-03-27 | 2020-10-01 | The Trustees Of The University Of Pennsylvania | Tn-muc1 chimeric antigen receptor (car) t cell therapy |
TWI772823B (en) | 2019-06-18 | 2022-08-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators |
WO2020255019A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and a quinazoline derivative |
WO2020255010A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines |
WO2020255039A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives |
WO2020255035A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and pyrimidine derivatives |
WO2020254876A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Virus-like particle delivery of hepatitis b virus (hbv) vaccines |
WO2020255017A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
WO2020255015A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
US20220305114A1 (en) | 2019-06-18 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and small molecule pdl1 or pd1 inhibitor |
MA56533A (en) | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Co | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND ANTI-PD-1 ANTIBODIES |
EP3986454A1 (en) | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 or anti-pd-l1 antibody |
CN114340663A (en) | 2019-06-18 | 2022-04-12 | 爱尔兰詹森科学公司 | Combination of Hepatitis B Virus (HBV) vaccine and HBV-targeted RNAi |
CA3140708A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
WO2020255022A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and aminopyridine derivatives as hpk1 inhibitors |
WO2020255042A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and a pyrimidine derivative |
WO2020255013A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives |
CA3141003A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pd-l1 inhibitors |
US20220305117A1 (en) | 2019-06-18 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai |
WO2020255014A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Recombinant interleukin 12 construct and uses thereof |
WO2020255018A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Hepatitis b virus (hbv) vaccines and uses thereof |
WO2020255016A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
AU2020295807A1 (en) | 2019-06-20 | 2022-02-17 | Janssen Sciences Ireland Unlimited Company | Lipid nanoparticle or liposome delivery of hepatitis B virus (HBV) vaccines |
US20220305118A1 (en) | 2019-06-20 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | Carbohydrate nanocarrier delivery of hepatitis b virus (hbv) vaccines |
EP4065005A4 (en) * | 2019-11-27 | 2023-12-27 | North Carolina State University | Methods for controlling treatment volumes, thermal gradients, muscle stimulation, and immune responses in pulsed electric field treatments |
AU2021231890A1 (en) | 2020-03-06 | 2022-09-29 | Go Therapeutics, Inc. | Anti-glyco-CD44 antibodies and their uses |
CN115916963A (en) | 2020-03-27 | 2023-04-04 | 门德斯有限公司 | Ex vivo use of modified cells of leukemia origin for enhancing the efficacy of adoptive cell therapy |
EP4125943A1 (en) | 2020-03-27 | 2023-02-08 | Mendus B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
WO2021195286A1 (en) | 2020-03-27 | 2021-09-30 | Svenska Vaccinfabriken Produktion Ab | Compositions and methods for treating and preventing coronaviruses |
CA3181680A1 (en) | 2020-06-12 | 2021-12-16 | University Of Rochester | Encoding and expression of ace-trnas |
JP2023533528A (en) | 2020-07-08 | 2023-08-03 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | RNA replicon vaccine against HBV |
US20230372484A1 (en) | 2020-09-14 | 2023-11-23 | Vor Biopharma Inc. | Chimeric antigen receptors for treatment of cancer |
JP2023547520A (en) | 2020-11-05 | 2023-11-10 | メンドゥス・ベスローテン・フェンノートシャップ | Use of tumor-independent antigens in immunotherapy |
TW202245809A (en) | 2020-12-18 | 2022-12-01 | 美商詹森藥物公司 | Combination therapy for treating hepatitis b virus infection |
WO2022146654A1 (en) | 2020-12-28 | 2022-07-07 | Janssen Pharmaceuticals, Inc. | Transcription activator-like effector nucleases (talens) targeting hbv |
WO2022187591A1 (en) | 2021-03-05 | 2022-09-09 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
JP2024510989A (en) | 2021-03-12 | 2024-03-12 | メンドゥス・ベスローテン・フェンノートシャップ | Vaccination methods and use of CD47 blockers |
WO2023010118A1 (en) | 2021-07-29 | 2023-02-02 | Vor Biopharma Inc. | Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same |
WO2023010126A2 (en) | 2021-07-29 | 2023-02-02 | Vor Biopharma Inc. | Chimeric antigen receptors for treatment of cancer |
WO2023014863A1 (en) | 2021-08-05 | 2023-02-09 | Go Therapeutics, Inc. | Anti-glyco-muc4 antibodies and their uses |
AU2022339667A1 (en) | 2021-09-03 | 2024-04-11 | Go Therapeutics, Inc. | Anti-glyco-cmet antibodies and their uses |
WO2023034571A1 (en) | 2021-09-03 | 2023-03-09 | Go Therapeutics, Inc. | Anti-glyco-lamp1 antibodies and their uses |
US20230295244A1 (en) | 2021-09-29 | 2023-09-21 | Svenska Vaccinfabriken Produktion Ab | Compositions and methods for treating and preventing coronaviruses |
WO2023150753A1 (en) | 2022-02-07 | 2023-08-10 | University Of Rochester | Optimized sequences for enhanced trna expression or/and nonsense mutation suppression |
US20240002800A1 (en) | 2022-05-16 | 2024-01-04 | Mendus B.V. | Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy |
WO2023233290A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Sciences Ireland Unlimited Company | Rnai agents targeting pd-l1 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998043702A2 (en) * | 1997-04-03 | 1998-10-08 | Iacob Mathiesen | Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle |
WO1999001175A1 (en) * | 1997-06-30 | 1999-01-14 | Rhone-Poulenc Rorer S.A. | Device for optimized electrotransfer of nucleic acid vectors to tissues in vivo |
WO2000045823A1 (en) * | 1999-02-08 | 2000-08-10 | Chiron Corporation | Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0239267B2 (en) | 1984-06-12 | 1990-09-04 | Intaa Noba Kk | INIONCHUNYUSHIKICHIRYOSOCHI |
US4702732A (en) * | 1984-12-24 | 1987-10-27 | Trustees Of Boston University | Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands |
US4596556A (en) * | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
NZ219392A (en) | 1986-02-28 | 1989-05-29 | Smithkline Beckman Corp | Production of an immortalised primary cell line |
ATE131081T1 (en) | 1988-01-21 | 1995-12-15 | Massachusetts Inst Technology | MOLECULAR TRANSPORT THROUGH TISSUES USING ELECTROPORATION. |
US5389069A (en) | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
US4913699A (en) * | 1988-03-14 | 1990-04-03 | Parsons James S | Disposable needleless injection system |
US5501662A (en) | 1992-05-22 | 1996-03-26 | Genetronics, Inc. | Implantable electroporation method and apparatus for drug and gene delivery |
US5507724A (en) | 1992-07-01 | 1996-04-16 | Genetronics, Inc. | Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells |
US5304120A (en) | 1992-07-01 | 1994-04-19 | Btx Inc. | Electroporation method and apparatus for insertion of drugs and genes into endothelial cells |
US5273525A (en) | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
US5318514A (en) | 1992-08-17 | 1994-06-07 | Btx, Inc. | Applicator for the electroporation of drugs and genes into surface cells |
US5468223A (en) | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
JP3360865B2 (en) * | 1993-03-26 | 2003-01-07 | 東海旅客鉄道株式会社 | Train speed control method and device |
FR2703253B1 (en) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | APPLICATOR OF ELECTRIC PULSES FOR TREATING BIOLOGICAL TISSUES. |
US5439440A (en) | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
US5702359A (en) | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
IL108775A (en) | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
US5736524A (en) * | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
US5810762A (en) | 1995-04-10 | 1998-09-22 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
JPH10502858A (en) | 1995-05-02 | 1998-03-17 | フィリップス エレクトロニクス エヌ ベー | Method and apparatus for magnetic resonance imaging of a subject |
US5730723A (en) * | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
US6041252A (en) | 1995-06-07 | 2000-03-21 | Ichor Medical Systems Inc. | Drug delivery system and method |
WO1997007826A1 (en) | 1995-08-29 | 1997-03-06 | Cbr Laboratories, Inc. | In vivo electroporation of cells |
US5944710A (en) | 1996-06-24 | 1999-08-31 | Genetronics, Inc. | Electroporation-mediated intravascular delivery |
WO1998027966A2 (en) | 1996-12-23 | 1998-07-02 | Bavarian Nordic Research Institute A/S | Encapsulated cells producing antibodies |
FR2758569B1 (en) | 1997-01-20 | 1999-04-02 | Centre Nat Rech Scient | BIOLOGICAL MATERIAL FOR THE TREATMENT OF A MAMMAL BY TRANSFERRING ANTIBODY GENE AND PHARMACEUTICAL COMPOSITION CONCERNING THE SAME |
US20020168339A1 (en) * | 1997-01-20 | 2002-11-14 | Marc Piechaczyk | Biological material for treating a mammal by antibody gene transfer and pharmaceutical composition containing same |
US6261281B1 (en) * | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
BR9810372A (en) | 1997-06-30 | 2000-09-05 | Rhone Poulenc Rorer Sa | Nucleic acid transfer process into cells of multicellular eukaryotic organisms in vivo, composition, nucleic acid and electric field, and, combination product |
US5965925A (en) | 1997-10-22 | 1999-10-12 | Artisan Components, Inc. | Integrated circuit layout methods and layout structures |
US6009347A (en) | 1998-01-27 | 1999-12-28 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
US6440944B2 (en) * | 1998-10-16 | 2002-08-27 | Genvec, Inc. | Methods of administering adenoviral vectors |
US20030018006A1 (en) | 2001-06-29 | 2003-01-23 | Academia Sinica | In vivo electroporation-mediated cytokine/immunocytokine-based antitumoral gene |
-
2000
- 2000-05-05 US US09/565,140 patent/US6261281B1/en not_active Expired - Lifetime
-
2001
- 2001-05-04 WO PCT/GB2001/001970 patent/WO2001085202A2/en not_active Application Discontinuation
- 2001-05-04 EP EP01928065A patent/EP1280550A2/en not_active Withdrawn
- 2001-05-04 AU AU54932/01A patent/AU5493201A/en not_active Abandoned
- 2001-07-05 US US09/899,561 patent/US20020038112A1/en not_active Abandoned
-
2002
- 2002-05-07 US US10/141,561 patent/US6610044B2/en not_active Expired - Lifetime
-
2003
- 2003-07-14 US US10/620,271 patent/US6958060B2/en not_active Expired - Lifetime
-
2005
- 2005-10-20 US US11/254,567 patent/US20060041219A1/en not_active Abandoned
-
2008
- 2008-02-15 US US12/070,233 patent/US7931640B2/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998043702A2 (en) * | 1997-04-03 | 1998-10-08 | Iacob Mathiesen | Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle |
WO1999001175A1 (en) * | 1997-06-30 | 1999-01-14 | Rhone-Poulenc Rorer S.A. | Device for optimized electrotransfer of nucleic acid vectors to tissues in vivo |
WO2000045823A1 (en) * | 1999-02-08 | 2000-08-10 | Chiron Corporation | Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo |
Non-Patent Citations (17)
Title |
---|
BACHY MONIQUE ET AL: "Electric pulses increase the immunogenicity of an influenza DNA vaccine injected intramuscularly in the mouse.", VACCINE, vol. 19, no. 13-14, 8 February 2001 (2001-02-08), pages 1688 - 1693, XP002183367, ISSN: 0264-410X * |
BIOELECTROCHEMISTRY AND BIOENERGETICS, vol. 49, no. 1, October 1999 (1999-10-01), pages 11 - 20, ISSN: 0302-4598 * |
CURR OPIN MOL THER, (2000 APR) 2 (2) 150-4. REF: 39 * |
DANKO I ET AL: "PHARMACOLOGICAL ENHANCEMENT OF IN VIVO FOREIGN GENE EXPRESSION IN MUSCLE", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 1, no. 2, March 1994 (1994-03-01), pages 114 - 121, XP001030901, ISSN: 0969-7128 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 20 January 1998 (1998-01-20), LE BORGNE SYLVIE ET AL: "In vivo induction of specific cytotoxic T lymphocytes in mice and rhesus macaques immunized with DNA vector encoding an HIV epitope fused with hepatitis B surface antigen.", XP002183372, Database accession no. PREV199800126231 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2000, SELBY MARK ET AL: "Enhancement of DNA vaccine potency by electroporation in vivo.", XP002183376, Database accession no. PREV200000467774 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; April 1999 (1999-04-01), MATHIESEN I: "Electropermeabilization of skeletal muscle enhances gene transfer in vivo.", XP002183374, Database accession no. PREV199900227202 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; October 1999 (1999-10-01), SIN JEONG-IM ET AL: "DNA priming-protein boosting enhances both antigen-specific antibody and Th1-type cellular immune responses in a murine herpes simplex virus-2 gD vaccine model.", XP002183371, Database accession no. PREV200000068151 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; October 1999 (1999-10-01), ZEWERT THOMAS E ET AL: "Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway enlarging molecule.", XP002183373, Database accession no. PREV200000412516 * |
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; SMITH L C ET AL: "Advances in plasmid gene delivery and expression in skeletal muscle.", XP002183375, retrieved from STN Database accession no. 2001206600 * |
DNA AND CELL BIOLOGY, vol. 18, no. 10, October 1999 (1999-10-01), pages 771 - 779, ISSN: 1044-5498 * |
GENE THERAPY, vol. 6, no. 4, April 1999 (1999-04-01), pages 508 - 514, ISSN: 0969-7128 * |
JOURNAL OF BIOTECHNOLOGY, vol. 83, no. 1-2, 2000, pages 147 - 152, ISSN: 0168-1656 * |
KADOWAKI SHIN-ETSU ET AL: "Protection against influenza virus infection in mice immunized by administration of hemagglutinin-expressing DNAs with electroporation.", VACCINE, vol. 18, no. 25, 2000, pages 2779 - 2788, XP002183369, ISSN: 0264-410X * |
MENDIRATTA SANJEEV KUMAR ET AL: "Therapeutic tumor immunity induced by polyimmunization with melanoma antigens gp100 and TRP-2.", CANCER RESEARCH, vol. 61, no. 3, 1 February 2001 (2001-02-01), pages 859 - 863, XP002183368, ISSN: 0008-5472 * |
VIROLOGY, vol. 240, no. 2, 20 January 1998 (1998-01-20), pages 304 - 315, ISSN: 0042-6822 * |
ZUCCHELLI S ET AL: "Enhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer.", JOURNAL OF VIROLOGY, (2000 DEC) 74 (24) 11598-607., XP002183370 * |
Also Published As
Publication number | Publication date |
---|---|
US6610044B2 (en) | 2003-08-26 |
US20020038112A1 (en) | 2002-03-28 |
US7931640B2 (en) | 2011-04-26 |
US20030065362A1 (en) | 2003-04-03 |
US6958060B2 (en) | 2005-10-25 |
EP1280550A2 (en) | 2003-02-05 |
US20080147131A1 (en) | 2008-06-19 |
AU5493201A (en) | 2001-11-20 |
US20060041219A1 (en) | 2006-02-23 |
US20040092907A1 (en) | 2004-05-13 |
US6261281B1 (en) | 2001-07-17 |
WO2001085202A2 (en) | 2001-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2001085202A3 (en) | Electroporation for introduction of molecules into cells | |
PL337583A1 (en) | Improved method of transferring nucleic acid to a striated muscle and connection enabling accomplishment of this method | |
DE69830178D1 (en) | COMPOSITION OF MIXTURES IN VAGAL-INDUCED ASYSTOLIA | |
DE69728057D1 (en) | IONTOPHORETIC TRIGGERABLE DELIVERY DEVICE TO REDUCE ELECTRICAL SENSITIVES | |
AU2001234857A1 (en) | Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo | |
AU5776594A (en) | Defibrillation method and apparatus | |
ATE246103T1 (en) | GROUND POWER SUPPLY FOR AN ELECTRIC VEHICLE WITH GROUND CONNECTION DEVICE | |
EP1034188A4 (en) | Method of designing agonists and antagonists to igf receptor | |
WO2002068040A3 (en) | Apparatus for stimulating a muscle of a subject | |
AU2001245852A1 (en) | Stimulatory device and methods to electrically stimulate the phrenic nerve | |
SG43399A1 (en) | Electrical connector with improved terminal- receiving passage means | |
WO1998021343A8 (en) | Genes encoding telomerase proteins | |
DE69414686T2 (en) | ELECTRICAL CONNECTING STRUCTURE AND METHOD FOR ELECTRICALLY CONNECTING CONNECTIONS TO EACH OTHER | |
IT8819023A0 (en) | CARRY OUT METHOD AND EQUIPMENT FOR SERIES AND PHASE BOLT CONNECTIONS IN AN ELECTRIC GENERATOR. | |
IL149744A0 (en) | A body formed of set, initially pasty material and including an electrically conducting path and a method of making such a body | |
AU3162097A (en) | Retinoid metabolizing protein | |
MX9602820A (en) | Method and apparatus to sense changes in the state of a resin bed. | |
HK1025125A1 (en) | The neurotrophic factor nnt-1. | |
DE68918933T2 (en) | Electrical connector with preloaded contacts and process for its manufacture. | |
ATA138388A (en) | CONCRETE FOUNDATION FOR STEEL POLES OF ELECTRICAL HIGH VOLTAGE PIPES, SKI LIFTS AND THE LIKE | |
WO2002018575A3 (en) | Genes expressed in the cell cycle | |
WO1998052613A3 (en) | Method of administration for a therapeutic agent utilizing suitable forms of hyaluronic acid and combinations with electroporation | |
IL122626A0 (en) | Nucleic acids encoding hev structural proteins hev structural proteins encoded thereby and uses thereof | |
PT93934A (en) | Device and method for the iontophoretic release of drugs | |
DE29619483U1 (en) | Electrical connector, in particular connector for connection to solenoid valves |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ CZ DE DE DK DK DM DZ EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ CZ DE DE DK DK DM DZ EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001928065 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2001928065 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2001928065 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: JP |