WO2001085027A3 - Drug deliver catheter device with active electrode - Google Patents

Drug deliver catheter device with active electrode Download PDF

Info

Publication number
WO2001085027A3
WO2001085027A3 PCT/US2001/014524 US0114524W WO0185027A3 WO 2001085027 A3 WO2001085027 A3 WO 2001085027A3 US 0114524 W US0114524 W US 0114524W WO 0185027 A3 WO0185027 A3 WO 0185027A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
drug
imaging
delivery
active electrode
Prior art date
Application number
PCT/US2001/014524
Other languages
French (fr)
Other versions
WO2001085027A2 (en
Inventor
John Kucharczyk
Michael E Moseley
Original Assignee
Image Guided Neurologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/566,798 external-priority patent/US7505807B1/en
Application filed by Image Guided Neurologics Inc filed Critical Image Guided Neurologics Inc
Priority to EP01931071A priority Critical patent/EP1280456A2/en
Publication of WO2001085027A2 publication Critical patent/WO2001085027A2/en
Publication of WO2001085027A3 publication Critical patent/WO2001085027A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/285—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M2025/0166—Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum

Abstract

The invention is an apparatus and method for treatments and targeted drug delivery into a living patient, particularly but not exclusively using magnetic resonance (MR) imaging. The apparatus is useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device (38) positioned at a target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
PCT/US2001/014524 2000-05-08 2001-05-04 Drug deliver catheter device with active electrode WO2001085027A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP01931071A EP1280456A2 (en) 2000-05-08 2001-05-04 Drug deliver catheter device with active electrode

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/566,798 2000-05-08
US09/566,798 US7505807B1 (en) 1997-05-15 2000-05-08 Magnetic resonance apparatus for use with active electrode and drug deliver catheter

Publications (2)

Publication Number Publication Date
WO2001085027A2 WO2001085027A2 (en) 2001-11-15
WO2001085027A3 true WO2001085027A3 (en) 2002-04-25

Family

ID=24264414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/014524 WO2001085027A2 (en) 2000-05-08 2001-05-04 Drug deliver catheter device with active electrode

Country Status (2)

Country Link
EP (1) EP1280456A2 (en)
WO (1) WO2001085027A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9008761B2 (en) 2010-02-01 2015-04-14 Proteus Digital Health, Inc. Two-wrist data gathering system
US9014779B2 (en) 2010-02-01 2015-04-21 Proteus Digital Health, Inc. Data gathering system
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1788498A1 (en) * 2005-11-21 2007-05-23 BrainLAB AG Apparatus for infusing substances
JP5241714B2 (en) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス， インコーポレイテッド Smart parenteral delivery system
EP2198317A2 (en) * 2007-09-24 2010-06-23 Boston Scientific Limited Mri phase visualization of interventional devices
US9731122B2 (en) 2013-04-29 2017-08-15 Rainbow Medical Ltd. Electroosmotic tissue treatment
US9616221B2 (en) 2015-07-08 2017-04-11 Rainbow Medical Ltd. Electrical treatment of Alzheimer's disease
US9724515B2 (en) 2015-10-29 2017-08-08 Rainbow Medical Ltd. Electrical substance clearance from the brain for treatment of Alzheimer's disease
US10898716B2 (en) 2015-10-29 2021-01-26 Rainbow Medical Ltd. Electrical substance clearance from the brain
US10518085B2 (en) 2015-12-29 2019-12-31 Rainbow Medical Ltd. Disc therapy
US9770591B2 (en) 2015-12-29 2017-09-26 Rainbow Medical Ltd. Disc therapy
US9950156B2 (en) 2016-09-13 2018-04-24 Rainbow Medical Ltd. Disc therapy
US11484706B2 (en) 2015-12-29 2022-11-01 Discure Technologies Ltd Disc therapy
US10569086B2 (en) 2017-01-11 2020-02-25 Rainbow Medical Ltd. Electrical microglial cell activation
US10758722B2 (en) 2017-05-03 2020-09-01 Rainbow Medical Ltd. Electrical treatment of Parkinson's disease
EP3765141A1 (en) 2018-03-14 2021-01-20 Rainbow Medical Ltd. Electrical substance clearance from the brain
US11123197B2 (en) 2019-09-03 2021-09-21 Rainbow Medical Ltd. Hydropneumatic artificial intervertebral disc
US10881858B1 (en) 2019-09-18 2021-01-05 Rainbow Medical Ltd. Electrical substance clearance from the brain
US11298530B1 (en) 2021-05-03 2022-04-12 Discure Technologies Ltd. Synergistic therapies for intervertebral disc degeneration
US11344721B1 (en) 2021-08-16 2022-05-31 Rainbow Medical Ltd. Cartilage treatment
US11413455B1 (en) 2022-02-08 2022-08-16 Rainbow Medical Ltd. Electrical treatment of Alzheimer's disease

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468636A1 (en) * 1990-06-18 1992-01-29 Boaz Avitall Implantable iontophoretic delivery system
US5647361A (en) * 1992-09-28 1997-07-15 Fonar Corporation Magnetic resonance imaging method and apparatus for guiding invasive therapy
US5893881A (en) * 1995-09-08 1999-04-13 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain by delivering a bolus of analgesic
US5925066A (en) * 1995-10-26 1999-07-20 Galvani, Ltd. Atrial arrythmia sensor with drug and electrical therapy control apparatus
US5964705A (en) * 1997-08-22 1999-10-12 Image-Guided Drug Delivery System, Inc. MR-compatible medical devices

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403138D0 (en) 1984-02-07 1984-03-14 Graham N B Sustained release of active ingredient
US4824436A (en) 1985-04-09 1989-04-25 Harvey Wolinsky Method for the prevention of restenosis
US5017566A (en) 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5171217A (en) 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5226902A (en) 1991-07-30 1993-07-13 University Of Utah Pulsatile drug delivery device using stimuli sensitive hydrogel
US5344402A (en) 1993-06-30 1994-09-06 Cardiovascular Dynamics, Inc. Low profile perfusion catheter
US5514092A (en) 1994-08-08 1996-05-07 Schneider (Usa) Inc. Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468636A1 (en) * 1990-06-18 1992-01-29 Boaz Avitall Implantable iontophoretic delivery system
US5647361A (en) * 1992-09-28 1997-07-15 Fonar Corporation Magnetic resonance imaging method and apparatus for guiding invasive therapy
US5893881A (en) * 1995-09-08 1999-04-13 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain by delivering a bolus of analgesic
US5925066A (en) * 1995-10-26 1999-07-20 Galvani, Ltd. Atrial arrythmia sensor with drug and electrical therapy control apparatus
US5964705A (en) * 1997-08-22 1999-10-12 Image-Guided Drug Delivery System, Inc. MR-compatible medical devices

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
US9008761B2 (en) 2010-02-01 2015-04-14 Proteus Digital Health, Inc. Two-wrist data gathering system
US9014779B2 (en) 2010-02-01 2015-04-21 Proteus Digital Health, Inc. Data gathering system

Also Published As

Publication number Publication date
WO2001085027A2 (en) 2001-11-15
EP1280456A2 (en) 2003-02-05

Similar Documents

Publication Publication Date Title
WO2001085027A3 (en) Drug deliver catheter device with active electrode
Aryal et al. Multiple treatments with liposomal doxorubicin and ultrasound-induced disruption of blood–tumor and blood–brain barriers improve outcomes in a rat glioma model
US6514221B2 (en) Blood-brain barrier opening
US9669198B2 (en) System and method for intracranial implantation of therapeutic or diagnostic agents
JP3981415B2 (en) Inflatable device for tumor therapy
CA2413798A1 (en) Needle for intradermal delivery of substances having penetration limiting means
US8715240B2 (en) Apparatus and method for convection enhanced therapeutic delivery
EP1835956A2 (en) Introduction of agent with medical device
CN105377354A (en) Apparatus, systems and methods for delivery of medication to the brain to treat neurological condidtions
EP1180380A3 (en) Catheter apparatus for medical treatment
Thomale et al. Local chemotherapy in the rat brainstem with multiple catheters: a feasibility study
Treat et al. MRI-guided focused ultrasound-enhanced chemotherapy of 9L rat gliosarcoma: Survival study
Naidoo et al. Convection-Enhanced Drug Delivery in the Central Nervous System
Hayashi et al. Gamma Knife pituitary radiosurgery for thalamic pain syndrome: new treatment trial in our institutional experience
Liu et al. Focused ultrasound induced blood‐brain barrier disruption to enhance chemotherapeutic drugs (BCNU) delivery for glioblastoma treatment
WO2020206244A1 (en) Systems and methods for advancing a catheter to a target site
Edwards et al. Hyperthermia treatment for malignant brain tumors: nursing management during therapy
Mortele et al. Magnetic Resonance Imaging Guidance for Tumor Ablation
LAZORTHES et al. Advances in Drug Delivery Systems and Applications

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2001931071

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001931071

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP