WO2001083527A3 - Glucagon antagonists - Google Patents

Glucagon antagonists Download PDF

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Publication number
WO2001083527A3
WO2001083527A3 PCT/US2001/014321 US0114321W WO0183527A3 WO 2001083527 A3 WO2001083527 A3 WO 2001083527A3 US 0114321 W US0114321 W US 0114321W WO 0183527 A3 WO0183527 A3 WO 0183527A3
Authority
WO
WIPO (PCT)
Prior art keywords
domain
vehicle
glucagon antagonist
preferred
glucagon
Prior art date
Application number
PCT/US2001/014321
Other languages
French (fr)
Other versions
WO2001083527A2 (en
Inventor
William S Marshall
Kevin Lee Stark
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Priority to JP2001580951A priority Critical patent/JP2003531632A/en
Priority to AU2001255798A priority patent/AU2001255798A1/en
Priority to EP01929003A priority patent/EP1278772A2/en
Publication of WO2001083527A2 publication Critical patent/WO2001083527A2/en
Publication of WO2001083527A3 publication Critical patent/WO2001083527A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

The present invention concerns therapeutic agents that antagonize the activity of glucagon. In accordance with the present invention, the compounds of the invention comprise: a. a glucagon antagonist domain, preferably the amino acid sequence of SEQ ID NO: 7, or sequences derived therefrom by phage display, RNA-peptide screening, or the other techniques; and b. a vehicle, such as a polymer (e.g., PEG or dextran) or an Fc domain, which is preferred; wherein the vehicle is covalently attached to the glucagon antagonist domain. The vehicle and the glucagon antagonist domain may be linked through the N- or C-terminus of the glucagon antagonist domain. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.
PCT/US2001/014321 2000-05-03 2001-05-03 Glucagon antagonists WO2001083527A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001580951A JP2003531632A (en) 2000-05-03 2001-05-03 Glucagon antagonist
AU2001255798A AU2001255798A1 (en) 2000-05-03 2001-05-03 Glucagon antagonists
EP01929003A EP1278772A2 (en) 2000-05-03 2001-05-03 Glucagon antagonists

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20143600P 2000-05-03 2000-05-03
US60/201,436 2000-05-03
US09/847,249 2001-05-02
US09/847,249 US6677136B2 (en) 2000-05-03 2001-05-02 Glucagon antagonists

Publications (2)

Publication Number Publication Date
WO2001083527A2 WO2001083527A2 (en) 2001-11-08
WO2001083527A3 true WO2001083527A3 (en) 2002-08-01

Family

ID=26896746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/014321 WO2001083527A2 (en) 2000-05-03 2001-05-03 Glucagon antagonists

Country Status (5)

Country Link
US (1) US6677136B2 (en)
EP (1) EP1278772A2 (en)
JP (1) JP2003531632A (en)
AU (1) AU2001255798A1 (en)
WO (1) WO2001083527A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
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US9156902B2 (en) 2011-06-22 2015-10-13 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists

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US20190330295A1 (en) * 2005-05-04 2019-10-31 Zealand Pharma A/S Glucagon-like-peptide-2 (glp-2) analogues
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WO2007100535A2 (en) * 2006-02-22 2007-09-07 Merck & Co., Inc. Oxyntomodulin derivatives
US8669228B2 (en) * 2007-01-05 2014-03-11 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility in physiological pH buffers
AU2008216265B2 (en) * 2007-02-15 2014-04-03 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
CA2707861A1 (en) * 2007-10-30 2009-05-07 Indiana University Research And Technology Corporation Glucagon antagonists
JP5771005B2 (en) * 2007-10-30 2015-08-26 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ Glucagon antagonist and compound showing GLP-1 agonist activity
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US8703701B2 (en) 2009-12-18 2014-04-22 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
CA2788304A1 (en) 2010-01-27 2011-08-04 Indiana University Research And Technology Corporation Glucagon antagonist - gip agonist conjugates and compositions for the treatment of metabolic disorders and obesity
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KR20130062931A (en) 2010-05-13 2013-06-13 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
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EA201390941A1 (en) 2010-12-22 2013-12-30 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн GLUCAGON ANALOGUES, EXPERIENCING ACTIVITY ON GIP RECEPTOR
EP3434687B1 (en) 2011-06-10 2021-03-10 Hanmi Science Co., Ltd. Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
RU2733544C2 (en) * 2011-06-17 2020-10-05 Ханми Сайенс Ко., Лтд. Conjugate containing oxintomodulin and immunoglobulin fragment, and its application
US9309301B2 (en) 2011-06-22 2016-04-12 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
JP6396211B2 (en) * 2011-07-04 2018-09-26 インペリアル・イノベイションズ・リミテッド New compounds and their effects on feeding behavior
CN103958682A (en) * 2011-10-21 2014-07-30 诺松制药股份公司 Glucagon binding nucleic acids
CA2847246A1 (en) 2011-11-17 2013-05-23 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
ES2602486T3 (en) 2012-06-21 2017-02-21 Indiana University Research And Technology Corporation Glucagon analogs showing GIP receptor activity
KR101968344B1 (en) 2012-07-25 2019-04-12 한미약품 주식회사 A composition for treating hyperlipidemia comprising oxyntomodulin analog
ES2748158T3 (en) 2012-11-06 2020-03-13 Hanmi Pharm Ind Co Ltd Liquid formulation of protein conjugate comprising oxyntomodulin and an immunoglobulin fragment
KR101993393B1 (en) 2012-11-06 2019-10-01 한미약품 주식회사 A composition for treating diabetes or diabesity comprising oxyntomodulin analog
US20160024169A1 (en) 2013-03-14 2016-01-28 Indiana University Research And Technology Corporation Insulin-incretin conjugates
TWI802396B (en) 2014-09-16 2023-05-11 南韓商韓美藥品股份有限公司 Use of a long acting glp-1/glucagon receptor dual agonist for the treatment of non-alcoholic fatty liver disease
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US11135271B2 (en) 2014-12-30 2021-10-05 Hanmi Pharm. Co., Ltd. Glucagon derivatives with improved stability
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9156902B2 (en) 2011-06-22 2015-10-13 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists

Also Published As

Publication number Publication date
US20030032588A1 (en) 2003-02-13
JP2003531632A (en) 2003-10-28
AU2001255798A1 (en) 2001-11-12
WO2001083527A2 (en) 2001-11-08
EP1278772A2 (en) 2003-01-29
US6677136B2 (en) 2004-01-13

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