WO2001081896A1 - An ultra-fast nucleic acid sequencing device and a method for making and using the same - Google Patents
An ultra-fast nucleic acid sequencing device and a method for making and using the same Download PDFInfo
- Publication number
- WO2001081896A1 WO2001081896A1 PCT/US2001/013101 US0113101W WO0181896A1 WO 2001081896 A1 WO2001081896 A1 WO 2001081896A1 US 0113101 W US0113101 W US 0113101W WO 0181896 A1 WO0181896 A1 WO 0181896A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- detecting
- opening
- region
- detecting region
- component
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 79
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 73
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 73
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 73
- 238000012163 sequencing technique Methods 0.000 title abstract description 68
- 239000004065 semiconductor Substances 0.000 claims abstract description 75
- 229920000642 polymer Polymers 0.000 claims abstract description 53
- 229910052751 metal Inorganic materials 0.000 claims abstract description 17
- 239000002184 metal Substances 0.000 claims abstract description 17
- 230000004044 response Effects 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 10
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 65
- 229910052710 silicon Inorganic materials 0.000 claims description 65
- 239000010703 silicon Substances 0.000 claims description 65
- 230000033001 locomotion Effects 0.000 claims description 13
- 230000007423 decrease Effects 0.000 claims description 8
- 239000002159 nanocrystal Substances 0.000 claims description 8
- 230000005284 excitation Effects 0.000 claims 2
- 102000053602 DNA Human genes 0.000 abstract description 93
- 108020004414 DNA Proteins 0.000 abstract description 93
- 229920002477 rna polymer Polymers 0.000 abstract description 30
- 239000002773 nucleotide Substances 0.000 abstract description 13
- 125000003729 nucleotide group Chemical group 0.000 abstract description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 62
- 239000000377 silicon dioxide Substances 0.000 description 31
- 239000000758 substrate Substances 0.000 description 26
- 235000012239 silicon dioxide Nutrition 0.000 description 25
- 239000007788 liquid Substances 0.000 description 22
- 230000003647 oxidation Effects 0.000 description 22
- 238000007254 oxidation reaction Methods 0.000 description 22
- 238000005530 etching Methods 0.000 description 16
- 150000002500 ions Chemical class 0.000 description 15
- 238000005259 measurement Methods 0.000 description 14
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
- 238000001712 DNA sequencing Methods 0.000 description 10
- 230000008901 benefit Effects 0.000 description 9
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 8
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 8
- 239000012212 insulator Substances 0.000 description 7
- 230000005641 tunneling Effects 0.000 description 7
- 108020004682 Single-Stranded DNA Proteins 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 6
- 238000000609 electron-beam lithography Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 6
- 239000010931 gold Substances 0.000 description 6
- 229910052737 gold Inorganic materials 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000003321 amplification Effects 0.000 description 5
- 230000005684 electric field Effects 0.000 description 5
- 238000001962 electrophoresis Methods 0.000 description 5
- 230000002068 genetic effect Effects 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 238000003199 nucleic acid amplification method Methods 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 229930024421 Adenine Natural products 0.000 description 4
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 4
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 4
- 229960000643 adenine Drugs 0.000 description 4
- 229940104302 cytosine Drugs 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000002105 nanoparticle Substances 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 229940113082 thymine Drugs 0.000 description 4
- 238000003559 RNA-seq method Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 238000001502 gel electrophoresis Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 229910052581 Si3N4 Inorganic materials 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000005669 field effect Effects 0.000 description 2
- 238000005468 ion implantation Methods 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N isopropyl alcohol Natural products CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 238000001459 lithography Methods 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000001272 nitrous oxide Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 238000001020 plasma etching Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000005549 size reduction Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 101710092462 Alpha-hemolysin Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000000370 acceptor Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000002019 doping agent Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005421 electrostatic potential Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229940043265 methyl isobutyl ketone Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 238000005036 potential barrier Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- 238000012882 sequential analysis Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Nanotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001578932A JP4719906B2 (en) | 2000-04-24 | 2001-04-24 | Field effect transistor device for ultrafast nucleic acid sequencing |
AU2001259128A AU2001259128A1 (en) | 2000-04-24 | 2001-04-24 | An ultra-fast nucleic acid sequencing device and a method for making and using the same |
US10/258,439 US7001792B2 (en) | 2000-04-24 | 2001-04-24 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
EP01932615A EP1285252A1 (en) | 2000-04-24 | 2001-04-24 | An ultra-fast nucleic acid sequencing device and a method for making and using the same |
US11/301,259 US8232582B2 (en) | 2000-04-24 | 2005-12-13 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
US11/929,794 US9063081B2 (en) | 2000-04-24 | 2007-10-30 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
US13/409,800 US8426232B2 (en) | 2000-04-24 | 2012-03-01 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
US13/617,626 US8546168B2 (en) | 2000-04-24 | 2012-09-14 | Method and apparatus for detecting nucleotides |
US14/039,142 US9228976B2 (en) | 2000-04-24 | 2013-09-27 | Method and apparatus for detecting nucleotides |
US14/745,753 US9410923B2 (en) | 2000-04-24 | 2015-06-22 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
US15/231,480 US9758824B2 (en) | 2000-04-24 | 2016-08-08 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19913000P | 2000-04-24 | 2000-04-24 | |
US60/199,130 | 2000-04-24 | ||
US21768100P | 2000-07-12 | 2000-07-12 | |
US60/217,681 | 2000-07-12 | ||
US09/653,543 | 2000-08-31 | ||
US09/653,543 US6413792B1 (en) | 2000-04-24 | 2000-08-31 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
US25958401P | 2001-01-04 | 2001-01-04 | |
US60/259,584 | 2001-01-04 |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/653,543 Continuation-In-Part US6413792B1 (en) | 2000-04-24 | 2000-08-31 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
US14/745,753 Continuation-In-Part US9410923B2 (en) | 2000-04-24 | 2015-06-22 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/258,439 A-371-Of-International US7001792B2 (en) | 2000-04-24 | 2001-04-24 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
US10258439 A-371-Of-International | 2001-04-24 | ||
US11/301,259 Division US8232582B2 (en) | 2000-04-24 | 2005-12-13 | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001081896A1 true WO2001081896A1 (en) | 2001-11-01 |
WO2001081896B1 WO2001081896B1 (en) | 2002-02-14 |
Family
ID=27498237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/013101 WO2001081896A1 (en) | 2000-04-24 | 2001-04-24 | An ultra-fast nucleic acid sequencing device and a method for making and using the same |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1285252A1 (en) |
JP (1) | JP4719906B2 (en) |
AU (1) | AU2001259128A1 (en) |
WO (1) | WO2001081896A1 (en) |
Cited By (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6846702B1 (en) | 2003-10-24 | 2005-01-25 | Agilent Technologies, Inc. | Nanopore chip with N-type semiconductor |
EP1574837A1 (en) * | 2004-03-10 | 2005-09-14 | Agilent Technologies Inc. a Delaware Corporation | Method and apparatus for sequencing polymers through tunneling conductance variation detection |
US7138672B2 (en) | 2003-09-25 | 2006-11-21 | Agilent Technologies, Inc. | Apparatus and method for making a tensile diaphragm with an insert |
US7250115B2 (en) | 2003-06-12 | 2007-07-31 | Agilent Technologies, Inc | Nanopore with resonant tunneling electrodes |
WO2007117832A2 (en) * | 2006-03-12 | 2007-10-18 | Applera Corporation | Methods of detecting target nucleic acids |
US7347921B2 (en) | 2003-07-17 | 2008-03-25 | Agilent Technologies, Inc. | Apparatus and method for threading a biopolymer through a nanopore |
WO2008092760A1 (en) | 2007-02-02 | 2008-08-07 | International Business Machines Corporation | Systems and methods for polymer characterization |
WO2008132643A1 (en) * | 2007-04-25 | 2008-11-06 | Nxp B.V. | Apparatus and method for molecule detection using nanopores |
US7888013B2 (en) | 2004-08-27 | 2011-02-15 | National Institute For Materials Science | Method of analyzing DNA sequence using field-effect device, and base sequence analyzer |
US7972858B2 (en) | 2004-08-13 | 2011-07-05 | President And Fellows Of Harvard College | Ultra high-throughput opti-nanopore DNA readout platform |
US8192600B2 (en) * | 2007-09-27 | 2012-06-05 | The Board Of Trustees Of The University Of Illinois | Solid state device |
US8354336B2 (en) | 2010-06-22 | 2013-01-15 | International Business Machines Corporation | Forming an electrode having reduced corrosion and water decomposition on surface using an organic protective layer |
WO2013017671A1 (en) * | 2011-08-02 | 2013-02-07 | Izon Science Limited | Characterisation of particles |
CN103193189A (en) * | 2013-02-21 | 2013-07-10 | 东南大学 | Multielectrode nanopore device for DNA detection and production method thereof |
US8563237B2 (en) * | 2004-09-30 | 2013-10-22 | Agilent Technologies, Inc. | Biopolymer resonant tunneling with a gate voltage source |
CN103376275A (en) * | 2012-04-17 | 2013-10-30 | 国际商业机器公司 | Graphene transistor gated by charges through a nanopore for bio-molecular sensing and dna sequencing |
US8598018B2 (en) | 2010-06-22 | 2013-12-03 | International Business Machines Corporation | Forming an electrode having reduced corrosion and water decomposition on surface using a custom oxide layer |
CN103424457A (en) * | 2012-05-18 | 2013-12-04 | 中国科学院微电子研究所 | Biosensor and DNA sequencing method thereof |
US8841217B1 (en) | 2013-03-13 | 2014-09-23 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
US8890216B2 (en) | 2006-12-14 | 2014-11-18 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US8912005B1 (en) | 2010-09-24 | 2014-12-16 | Life Technologies Corporation | Method and system for delta double sampling |
US8912580B2 (en) | 2009-05-29 | 2014-12-16 | Life Technologies Corporation | Active chemically-sensitive sensors with in-sensor current sources |
US8936763B2 (en) | 2008-10-22 | 2015-01-20 | Life Technologies Corporation | Integrated sensor arrays for biological and chemical analysis |
US8940148B2 (en) | 2010-06-22 | 2015-01-27 | International Business Machines Corporation | Nano-fluidic field effective device to control DNA transport through the same |
US9080968B2 (en) | 2013-01-04 | 2015-07-14 | Life Technologies Corporation | Methods and systems for point of use removal of sacrificial material |
CN105531360A (en) * | 2013-11-08 | 2016-04-27 | 株式会社日立高新技术 | DNA transport control device and method for producing same, as well as dna sequencing device |
US9377431B2 (en) | 2013-07-24 | 2016-06-28 | Globalfoundries Inc. | Heterojunction nanopore for sequencing |
US9535033B2 (en) | 2012-08-17 | 2017-01-03 | Quantum Biosystems Inc. | Sample analysis method |
US9618475B2 (en) | 2010-09-15 | 2017-04-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US9644236B2 (en) | 2013-09-18 | 2017-05-09 | Quantum Biosystems Inc. | Biomolecule sequencing devices, systems and methods |
US9671363B2 (en) | 2013-03-15 | 2017-06-06 | Life Technologies Corporation | Chemical sensor with consistent sensor surface areas |
US9759681B2 (en) | 2012-08-08 | 2017-09-12 | Hitachi High-Technologies Corporation | Biomolecule detection method, biomolecule detection device and analysis device |
US9823217B2 (en) | 2013-03-15 | 2017-11-21 | Life Technologies Corporation | Chemical device with thin conductive element |
US9835585B2 (en) | 2013-03-15 | 2017-12-05 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
US9841398B2 (en) | 2013-01-08 | 2017-12-12 | Life Technologies Corporation | Methods for manufacturing well structures for low-noise chemical sensors |
US9927393B2 (en) | 2009-05-29 | 2018-03-27 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US9960253B2 (en) | 2010-07-03 | 2018-05-01 | Life Technologies Corporation | Chemically sensitive sensor with lightly doped drains |
US9970984B2 (en) | 2011-12-01 | 2018-05-15 | Life Technologies Corporation | Method and apparatus for identifying defects in a chemical sensor array |
US9985624B2 (en) | 2012-05-29 | 2018-05-29 | Life Technologies Corporation | System for reducing noise in a chemical sensor array |
US9989489B2 (en) | 2006-12-14 | 2018-06-05 | Life Technnologies Corporation | Methods for calibrating an array of chemically-sensitive sensors |
US9995708B2 (en) | 2013-03-13 | 2018-06-12 | Life Technologies Corporation | Chemical sensor with sidewall spacer sensor surface |
US10077472B2 (en) | 2014-12-18 | 2018-09-18 | Life Technologies Corporation | High data rate integrated circuit with power management |
US10100357B2 (en) | 2013-05-09 | 2018-10-16 | Life Technologies Corporation | Windowed sequencing |
WO2018213254A1 (en) * | 2017-05-16 | 2018-11-22 | Sensor Kinesis Corporation | Method and apparatus using surface acoustic waves |
CN109313177A (en) * | 2016-06-23 | 2019-02-05 | 豪夫迈·罗氏有限公司 | The period of AC signal from nano-pore sequencing is to cycle analysis |
US10202644B2 (en) | 2010-03-03 | 2019-02-12 | Quantum Biosystems Inc. | Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide |
US10261066B2 (en) | 2013-10-16 | 2019-04-16 | Quantum Biosystems Inc. | Nano-gap electrode pair and method of manufacturing same |
US10379079B2 (en) | 2014-12-18 | 2019-08-13 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US10415079B2 (en) | 2006-12-14 | 2019-09-17 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
US10438811B1 (en) | 2014-04-15 | 2019-10-08 | Quantum Biosystems Inc. | Methods for forming nano-gap electrodes for use in nanosensors |
US10451585B2 (en) | 2009-05-29 | 2019-10-22 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US10458942B2 (en) | 2013-06-10 | 2019-10-29 | Life Technologies Corporation | Chemical sensor array having multiple sensors per well |
US10481123B2 (en) | 2010-06-30 | 2019-11-19 | Life Technologies Corporation | Ion-sensing charge-accumulation circuits and methods |
US10563252B2 (en) | 2004-06-25 | 2020-02-18 | University Of Hawaii | Ultrasensitive biosensors |
US10605767B2 (en) | 2014-12-18 | 2020-03-31 | Life Technologies Corporation | High data rate integrated circuit with transmitter configuration |
CN111094976A (en) * | 2018-02-16 | 2020-05-01 | 伊鲁米纳公司 | Apparatus for sequencing |
US10641729B2 (en) | 2010-06-30 | 2020-05-05 | Life Technologies Corporation | Column ADC |
WO2020210981A1 (en) * | 2019-04-16 | 2020-10-22 | Boe Technology Group Co., Ltd. | Micro-channel device and manufacturing method thereof and micro-fluidic system |
US10822641B2 (en) | 2004-11-12 | 2020-11-03 | The Board Of Trustees Of The Leland Stanford Junior University | Charge perturbation detection system for DNA and other molecules |
US11307166B2 (en) | 2010-07-01 | 2022-04-19 | Life Technologies Corporation | Column ADC |
US11339430B2 (en) | 2007-07-10 | 2022-05-24 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6413792B1 (en) * | 2000-04-24 | 2002-07-02 | Eagle Research Development, Llc | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
ATE529734T1 (en) * | 2005-04-06 | 2011-11-15 | Harvard College | MOLECULAR CHARACTERIZATION WITH CARBON NANOTUBE CONTROL |
GB0625070D0 (en) * | 2006-12-15 | 2007-01-24 | Imp Innovations Ltd | Characterization of molecules |
US8470164B2 (en) | 2008-06-25 | 2013-06-25 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
JP5586001B2 (en) * | 2009-08-26 | 2014-09-10 | 独立行政法人物質・材料研究機構 | Nanoribbon and manufacturing method thereof, FET using nanoribbon and manufacturing method thereof, base sequence determination method using nanoribbon and apparatus thereof |
EP2574923A1 (en) | 2011-09-28 | 2013-04-03 | Koninklijke Philips Electronics N.V. | Apparatus for the processing of single molecules |
JP6282036B2 (en) | 2012-12-27 | 2018-02-21 | クオンタムバイオシステムズ株式会社 | Method and control apparatus for controlling movement speed of substance |
US8962366B2 (en) | 2013-01-28 | 2015-02-24 | Life Technologies Corporation | Self-aligned well structures for low-noise chemical sensors |
US9116117B2 (en) | 2013-03-15 | 2015-08-25 | Life Technologies Corporation | Chemical sensor with sidewall sensor surface |
WO2014149778A1 (en) | 2013-03-15 | 2014-09-25 | Life Technologies Corporation | Chemical sensors with consistent sensor surface areas |
JP2015154750A (en) * | 2014-02-20 | 2015-08-27 | 国立大学法人大阪大学 | Electrode for biomolecule sequencing apparatus, and biomolecule sequencing apparatus, method, and program |
WO2015170782A1 (en) | 2014-05-08 | 2015-11-12 | Osaka University | Devices, systems and methods for linearization of polymers |
JP6434744B2 (en) * | 2014-08-07 | 2018-12-05 | ローラス株式会社 | Semiconductor biosensor |
WO2016038719A1 (en) * | 2014-09-11 | 2016-03-17 | 株式会社日立製作所 | Device and method for forming same |
US10969377B2 (en) * | 2014-11-12 | 2021-04-06 | Hitachi, Ltd. | Biopolymer analysis device and biopolymer analysis method |
KR101737946B1 (en) | 2016-08-16 | 2017-05-19 | 서울대학교산학협력단 | Method of manufacturing sample for film property measurement and analysis, and sample manuvactured by the method |
CN110177618B (en) | 2016-10-03 | 2021-12-14 | 纳生科技有限公司 | Method and apparatus for analyzing and identifying molecules |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5653939A (en) * | 1991-11-19 | 1997-08-05 | Massachusetts Institute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5871918A (en) * | 1996-06-20 | 1999-02-16 | The University Of North Carolina At Chapel Hill | Electrochemical detection of nucleic acid hybridization |
WO1999036573A1 (en) * | 1998-01-20 | 1999-07-22 | Schichman Steven A | Detection of genetic information |
US6002131A (en) * | 1998-03-25 | 1999-12-14 | The Board Of Trustees Of The Leland Stanford Junior University | Scanning probe potentiometer |
US6060327A (en) * | 1997-05-14 | 2000-05-09 | Keensense, Inc. | Molecular wire injection sensors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8522785D0 (en) * | 1985-09-14 | 1985-10-16 | Emi Plc Thorn | Chemical-sensitive semiconductor device |
JPH08278281A (en) * | 1995-04-07 | 1996-10-22 | Hitachi Ltd | Field effect type chemical substance detection device and dna sequanator using it |
DE69632921T2 (en) * | 1995-12-01 | 2005-07-14 | Innogenetics N.V. | SYSTEM AND METHOD FOR DETERMINING THE IMPEDANCE AND MANUFACTURING METHOD |
JP3245124B2 (en) * | 1998-02-19 | 2002-01-07 | インターナショナル・ビジネス・マシーンズ・コーポレーション | Field effect transistor having vertical gate sidewalls and method of manufacturing the same |
JP3233207B2 (en) * | 1998-03-20 | 2001-11-26 | 日本電気株式会社 | Method for manufacturing field effect transistor |
EP1192453B1 (en) * | 1999-06-22 | 2012-02-15 | President and Fellows of Harvard College | Molecular and atomic scale evaluation of biopolymers |
-
2001
- 2001-04-24 WO PCT/US2001/013101 patent/WO2001081896A1/en not_active Application Discontinuation
- 2001-04-24 AU AU2001259128A patent/AU2001259128A1/en not_active Abandoned
- 2001-04-24 JP JP2001578932A patent/JP4719906B2/en not_active Expired - Lifetime
- 2001-04-24 EP EP01932615A patent/EP1285252A1/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5653939A (en) * | 1991-11-19 | 1997-08-05 | Massachusetts Institute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5871918A (en) * | 1996-06-20 | 1999-02-16 | The University Of North Carolina At Chapel Hill | Electrochemical detection of nucleic acid hybridization |
US6060327A (en) * | 1997-05-14 | 2000-05-09 | Keensense, Inc. | Molecular wire injection sensors |
WO1999036573A1 (en) * | 1998-01-20 | 1999-07-22 | Schichman Steven A | Detection of genetic information |
US6002131A (en) * | 1998-03-25 | 1999-12-14 | The Board Of Trustees Of The Leland Stanford Junior University | Scanning probe potentiometer |
Cited By (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7250115B2 (en) | 2003-06-12 | 2007-07-31 | Agilent Technologies, Inc | Nanopore with resonant tunneling electrodes |
US7347921B2 (en) | 2003-07-17 | 2008-03-25 | Agilent Technologies, Inc. | Apparatus and method for threading a biopolymer through a nanopore |
US7138672B2 (en) | 2003-09-25 | 2006-11-21 | Agilent Technologies, Inc. | Apparatus and method for making a tensile diaphragm with an insert |
US6846702B1 (en) | 2003-10-24 | 2005-01-25 | Agilent Technologies, Inc. | Nanopore chip with N-type semiconductor |
CN100368796C (en) * | 2004-03-10 | 2008-02-13 | 安捷伦科技有限公司 | Method and apparatus for sequencing polymers through tunneling conductance variation detection |
US7279337B2 (en) | 2004-03-10 | 2007-10-09 | Agilent Technologies, Inc. | Method and apparatus for sequencing polymers through tunneling conductance variation detection |
EP1574837A1 (en) * | 2004-03-10 | 2005-09-14 | Agilent Technologies Inc. a Delaware Corporation | Method and apparatus for sequencing polymers through tunneling conductance variation detection |
US10563252B2 (en) | 2004-06-25 | 2020-02-18 | University Of Hawaii | Ultrasensitive biosensors |
US7972858B2 (en) | 2004-08-13 | 2011-07-05 | President And Fellows Of Harvard College | Ultra high-throughput opti-nanopore DNA readout platform |
US8802838B2 (en) | 2004-08-13 | 2014-08-12 | President And Fellows Of Harvard College | Ultra high-throughput opti-nanopore DNA readout platform |
US7888013B2 (en) | 2004-08-27 | 2011-02-15 | National Institute For Materials Science | Method of analyzing DNA sequence using field-effect device, and base sequence analyzer |
US8563237B2 (en) * | 2004-09-30 | 2013-10-22 | Agilent Technologies, Inc. | Biopolymer resonant tunneling with a gate voltage source |
US10822641B2 (en) | 2004-11-12 | 2020-11-03 | The Board Of Trustees Of The Leland Stanford Junior University | Charge perturbation detection system for DNA and other molecules |
WO2007117832A2 (en) * | 2006-03-12 | 2007-10-18 | Applera Corporation | Methods of detecting target nucleic acids |
US9677126B2 (en) | 2006-03-12 | 2017-06-13 | Applied Biosystems, Llc | Methods of detecting target nucleic acids |
WO2007117832A3 (en) * | 2006-03-12 | 2008-12-18 | Applera Corp | Methods of detecting target nucleic acids |
US9434982B2 (en) | 2006-03-12 | 2016-09-06 | Applied Biosystems Llc | Methods of detecting target nucleic acids |
US8637247B2 (en) | 2006-03-12 | 2014-01-28 | Applied Biosystems, Llc | Methods of detecting target nucleic acids |
US10196680B2 (en) | 2006-03-12 | 2019-02-05 | Applied Biosystems, Llc | Methods of detecting target nucleic acids |
US9074252B2 (en) | 2006-03-12 | 2015-07-07 | Applied Biosystems, Llc | Methods of detecting target nucleic acids |
US8890216B2 (en) | 2006-12-14 | 2014-11-18 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US9989489B2 (en) | 2006-12-14 | 2018-06-05 | Life Technnologies Corporation | Methods for calibrating an array of chemically-sensitive sensors |
US10203300B2 (en) | 2006-12-14 | 2019-02-12 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US10415079B2 (en) | 2006-12-14 | 2019-09-17 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
US9951382B2 (en) | 2006-12-14 | 2018-04-24 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US10502708B2 (en) | 2006-12-14 | 2019-12-10 | Life Technologies Corporation | Chemically-sensitive sensor array calibration circuitry |
US10633699B2 (en) | 2006-12-14 | 2020-04-28 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
WO2008092760A1 (en) | 2007-02-02 | 2008-08-07 | International Business Machines Corporation | Systems and methods for polymer characterization |
US8003319B2 (en) | 2007-02-02 | 2011-08-23 | International Business Machines Corporation | Systems and methods for controlling position of charged polymer inside nanopore |
WO2008132643A1 (en) * | 2007-04-25 | 2008-11-06 | Nxp B.V. | Apparatus and method for molecule detection using nanopores |
CN101668866B (en) * | 2007-04-25 | 2014-11-19 | Nxp股份有限公司 | Apparatus and method for molecule detection using nanopores |
US9034637B2 (en) | 2007-04-25 | 2015-05-19 | Nxp, B.V. | Apparatus and method for molecule detection using nanopores |
CN101668866A (en) * | 2007-04-25 | 2010-03-10 | Nxp股份有限公司 | Apparatus and method for molecule detection using nanopores |
US11339430B2 (en) | 2007-07-10 | 2022-05-24 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US8192600B2 (en) * | 2007-09-27 | 2012-06-05 | The Board Of Trustees Of The University Of Illinois | Solid state device |
US8702929B2 (en) | 2007-09-27 | 2014-04-22 | The Board Of Trustees Of The University Of Illinois | Solid state device |
US11448613B2 (en) | 2008-10-22 | 2022-09-20 | Life Technologies Corporation | ChemFET sensor array including overlying array of wells |
US9944981B2 (en) | 2008-10-22 | 2018-04-17 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US9964515B2 (en) | 2008-10-22 | 2018-05-08 | Life Technologies Corporation | Integrated sensor arrays for biological and chemical analysis |
US11874250B2 (en) | 2008-10-22 | 2024-01-16 | Life Technologies Corporation | Integrated sensor arrays for biological and chemical analysis |
US8936763B2 (en) | 2008-10-22 | 2015-01-20 | Life Technologies Corporation | Integrated sensor arrays for biological and chemical analysis |
US10809226B2 (en) | 2009-05-29 | 2020-10-20 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US9927393B2 (en) | 2009-05-29 | 2018-03-27 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US8912580B2 (en) | 2009-05-29 | 2014-12-16 | Life Technologies Corporation | Active chemically-sensitive sensors with in-sensor current sources |
US8994076B2 (en) | 2009-05-29 | 2015-03-31 | Life Technologies Corporation | Chemically-sensitive field effect transistor based pixel array with protection diodes |
US10451585B2 (en) | 2009-05-29 | 2019-10-22 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US11768171B2 (en) | 2009-05-29 | 2023-09-26 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US10202644B2 (en) | 2010-03-03 | 2019-02-12 | Quantum Biosystems Inc. | Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide |
US10876159B2 (en) | 2010-03-03 | 2020-12-29 | Quantum Biosystems Inc. | Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide |
US8354336B2 (en) | 2010-06-22 | 2013-01-15 | International Business Machines Corporation | Forming an electrode having reduced corrosion and water decomposition on surface using an organic protective layer |
US8940148B2 (en) | 2010-06-22 | 2015-01-27 | International Business Machines Corporation | Nano-fluidic field effective device to control DNA transport through the same |
US9651518B2 (en) | 2010-06-22 | 2017-05-16 | International Business Machines Corporation | Nano-fluidic field effective device to control DNA transport through the same |
US8598018B2 (en) | 2010-06-22 | 2013-12-03 | International Business Machines Corporation | Forming an electrode having reduced corrosion and water decomposition on surface using a custom oxide layer |
US10641729B2 (en) | 2010-06-30 | 2020-05-05 | Life Technologies Corporation | Column ADC |
US10481123B2 (en) | 2010-06-30 | 2019-11-19 | Life Technologies Corporation | Ion-sensing charge-accumulation circuits and methods |
US11307166B2 (en) | 2010-07-01 | 2022-04-19 | Life Technologies Corporation | Column ADC |
US9960253B2 (en) | 2010-07-03 | 2018-05-01 | Life Technologies Corporation | Chemically sensitive sensor with lightly doped drains |
US9958415B2 (en) | 2010-09-15 | 2018-05-01 | Life Technologies Corporation | ChemFET sensor including floating gate |
US9618475B2 (en) | 2010-09-15 | 2017-04-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US9958414B2 (en) | 2010-09-15 | 2018-05-01 | Life Technologies Corporation | Apparatus for measuring analytes including chemical sensor array |
US8912005B1 (en) | 2010-09-24 | 2014-12-16 | Life Technologies Corporation | Method and system for delta double sampling |
WO2013017671A1 (en) * | 2011-08-02 | 2013-02-07 | Izon Science Limited | Characterisation of particles |
US9664643B2 (en) | 2011-08-02 | 2017-05-30 | Izon Science Limited | Characterization of particles |
US10365321B2 (en) | 2011-12-01 | 2019-07-30 | Life Technologies Corporation | Method and apparatus for identifying defects in a chemical sensor array |
US10598723B2 (en) | 2011-12-01 | 2020-03-24 | Life Technologies Corporation | Method and apparatus for identifying defects in a chemical sensor array |
US9970984B2 (en) | 2011-12-01 | 2018-05-15 | Life Technologies Corporation | Method and apparatus for identifying defects in a chemical sensor array |
US9758822B2 (en) | 2012-04-17 | 2017-09-12 | International Business Machines Corporation | Graphene transistor gated by charges through a nanopore for bio-molecular sensing and DNA sequencing |
US10385390B2 (en) | 2012-04-17 | 2019-08-20 | International Business Machines Corporation | Graphene transistor gated by charges through a nanopore for bio-molecular sensing and DNA sequencing |
US9758821B2 (en) | 2012-04-17 | 2017-09-12 | International Business Machines Corporation | Graphene transistor gated by charges through a nanopore for bio-molecular sensing and DNA sequencing |
CN103376275B (en) * | 2012-04-17 | 2016-08-17 | 国际商业机器公司 | Base or the method identifying biomolecule and nano-device is distinguished for electricity |
CN103376275A (en) * | 2012-04-17 | 2013-10-30 | 国际商业机器公司 | Graphene transistor gated by charges through a nanopore for bio-molecular sensing and dna sequencing |
US9765392B2 (en) | 2012-04-17 | 2017-09-19 | International Business Machines Corporation | Graphene transistor gated by charges through a nanopore for bio-molecular sensing and DNA sequencing |
CN103424457A (en) * | 2012-05-18 | 2013-12-04 | 中国科学院微电子研究所 | Biosensor and DNA sequencing method thereof |
US9985624B2 (en) | 2012-05-29 | 2018-05-29 | Life Technologies Corporation | System for reducing noise in a chemical sensor array |
US10404249B2 (en) | 2012-05-29 | 2019-09-03 | Life Technologies Corporation | System for reducing noise in a chemical sensor array |
US9759681B2 (en) | 2012-08-08 | 2017-09-12 | Hitachi High-Technologies Corporation | Biomolecule detection method, biomolecule detection device and analysis device |
US9535033B2 (en) | 2012-08-17 | 2017-01-03 | Quantum Biosystems Inc. | Sample analysis method |
US9852919B2 (en) | 2013-01-04 | 2017-12-26 | Life Technologies Corporation | Methods and systems for point of use removal of sacrificial material |
US9080968B2 (en) | 2013-01-04 | 2015-07-14 | Life Technologies Corporation | Methods and systems for point of use removal of sacrificial material |
US9841398B2 (en) | 2013-01-08 | 2017-12-12 | Life Technologies Corporation | Methods for manufacturing well structures for low-noise chemical sensors |
US10436742B2 (en) | 2013-01-08 | 2019-10-08 | Life Technologies Corporation | Methods for manufacturing well structures for low-noise chemical sensors |
CN103193189A (en) * | 2013-02-21 | 2013-07-10 | 东南大学 | Multielectrode nanopore device for DNA detection and production method thereof |
US9995708B2 (en) | 2013-03-13 | 2018-06-12 | Life Technologies Corporation | Chemical sensor with sidewall spacer sensor surface |
US8841217B1 (en) | 2013-03-13 | 2014-09-23 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
US10422767B2 (en) | 2013-03-15 | 2019-09-24 | Life Technologies Corporation | Chemical sensor with consistent sensor surface areas |
US9671363B2 (en) | 2013-03-15 | 2017-06-06 | Life Technologies Corporation | Chemical sensor with consistent sensor surface areas |
US9823217B2 (en) | 2013-03-15 | 2017-11-21 | Life Technologies Corporation | Chemical device with thin conductive element |
US9835585B2 (en) | 2013-03-15 | 2017-12-05 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
US11028438B2 (en) | 2013-05-09 | 2021-06-08 | Life Technologies Corporation | Windowed sequencing |
US10655175B2 (en) | 2013-05-09 | 2020-05-19 | Life Technologies Corporation | Windowed sequencing |
US10100357B2 (en) | 2013-05-09 | 2018-10-16 | Life Technologies Corporation | Windowed sequencing |
US10458942B2 (en) | 2013-06-10 | 2019-10-29 | Life Technologies Corporation | Chemical sensor array having multiple sensors per well |
US9377431B2 (en) | 2013-07-24 | 2016-06-28 | Globalfoundries Inc. | Heterojunction nanopore for sequencing |
US9377432B2 (en) | 2013-07-24 | 2016-06-28 | Globalfoundries Inc. | Heterojunction nanopore for sequencing |
US9644236B2 (en) | 2013-09-18 | 2017-05-09 | Quantum Biosystems Inc. | Biomolecule sequencing devices, systems and methods |
US10557167B2 (en) | 2013-09-18 | 2020-02-11 | Quantum Biosystems Inc. | Biomolecule sequencing devices, systems and methods |
US10466228B2 (en) | 2013-10-16 | 2019-11-05 | Quantum Biosystems Inc. | Nano-gap electrode pair and method of manufacturing same |
US10261066B2 (en) | 2013-10-16 | 2019-04-16 | Quantum Biosystems Inc. | Nano-gap electrode pair and method of manufacturing same |
CN105531360B (en) * | 2013-11-08 | 2017-07-11 | 株式会社日立高新技术 | DNA conveys control device and its manufacture method and DNA sequencing device |
CN105531360A (en) * | 2013-11-08 | 2016-04-27 | 株式会社日立高新技术 | DNA transport control device and method for producing same, as well as dna sequencing device |
US10438811B1 (en) | 2014-04-15 | 2019-10-08 | Quantum Biosystems Inc. | Methods for forming nano-gap electrodes for use in nanosensors |
US10077472B2 (en) | 2014-12-18 | 2018-09-18 | Life Technologies Corporation | High data rate integrated circuit with power management |
US10379079B2 (en) | 2014-12-18 | 2019-08-13 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US11536688B2 (en) | 2014-12-18 | 2022-12-27 | Life Technologies Corporation | High data rate integrated circuit with transmitter configuration |
US10605767B2 (en) | 2014-12-18 | 2020-03-31 | Life Technologies Corporation | High data rate integrated circuit with transmitter configuration |
CN109313177A (en) * | 2016-06-23 | 2019-02-05 | 豪夫迈·罗氏有限公司 | The period of AC signal from nano-pore sequencing is to cycle analysis |
WO2018213254A1 (en) * | 2017-05-16 | 2018-11-22 | Sensor Kinesis Corporation | Method and apparatus using surface acoustic waves |
US11391693B2 (en) | 2018-02-16 | 2022-07-19 | Illumina, Inc. | Device for sequencing |
CN111094976B (en) * | 2018-02-16 | 2022-05-13 | 伊鲁米纳公司 | Apparatus for sequencing |
US11774400B2 (en) | 2018-02-16 | 2023-10-03 | Illumina, Inc. | Device for sequencing |
CN111094976A (en) * | 2018-02-16 | 2020-05-01 | 伊鲁米纳公司 | Apparatus for sequencing |
US11534755B2 (en) | 2019-04-16 | 2022-12-27 | Boe Technology Group Co., Ltd. | Micro-channel device and manufacturing method thereof and micro-fluidic system |
WO2020210981A1 (en) * | 2019-04-16 | 2020-10-22 | Boe Technology Group Co., Ltd. | Micro-channel device and manufacturing method thereof and micro-fluidic system |
Also Published As
Publication number | Publication date |
---|---|
JP4719906B2 (en) | 2011-07-06 |
JP2003533676A (en) | 2003-11-11 |
EP1285252A1 (en) | 2003-02-26 |
AU2001259128A1 (en) | 2001-11-07 |
WO2001081896B1 (en) | 2002-02-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9758824B2 (en) | Ultra-fast nucleic acid sequencing device and a method for making and using the same | |
US7001792B2 (en) | Ultra-fast nucleic acid sequencing device and a method for making and using the same | |
JP4719906B2 (en) | Field effect transistor device for ultrafast nucleic acid sequencing | |
US6413792B1 (en) | Ultra-fast nucleic acid sequencing device and a method for making and using the same | |
US9989516B2 (en) | Electro-diffusion enhanced bio-molecule charge detection using electrostatic interaction | |
US20100273166A1 (en) | biosensor device and method of sequencing biological particles | |
US20020127855A1 (en) | Method for fabricating a pattern in a mask on a surface of an object and product manufactured thereby | |
US11747320B2 (en) | Nanopore device and methods of electrical array addressing and sensing | |
CN114910538A (en) | Biosensor system and method for analyzing test sample using the same | |
KR20140014454A (en) | Fabrication method of metal gates-embedded nanochannel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ CZ DE DE DK DK DM DZ EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: B1 Designated state(s): AE AG AL AM AT AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ CZ DE DE DK DK DM DZ EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: B1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
B | Later publication of amended claims | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001932615 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 2001 578932 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10258439 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 2001932615 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2001932615 Country of ref document: EP |