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Publication numberWO2001081622 A3
Publication typeApplication
Application numberPCT/EP2001/003972
Publication date4 Sep 2003
Filing date6 Apr 2001
Priority date6 Apr 2000
Also published asDE60126593D1, DE60126593T2, EP1268857A2, EP1268861A2, EP1272670A2, EP1274865A2, EP1274865B1, EP1274866A2, EP1278893A2, EP1360319A2, EP1370685A2, EP2014776A2, EP2014776A3, US7195870, US20030082609, US20030148326, US20030148327, US20030162194, US20040067491, US20040076956, US20050282157, WO2001076451A2, WO2001076451A3, WO2001076451A9, WO2001077164A2, WO2001077164A3, WO2001077164A8, WO2001077375A2, WO2001077375A3, WO2001077375A8, WO2001077376A2, WO2001077376A3, WO2001077376A8, WO2001077377A2, WO2001077377A3, WO2001077377A8, WO2001077378A2, WO2001077378A3, WO2001081622A2, WO2001081622A8, WO2001092565A2, WO2001092565A3, WO2001092565A8
Publication numberPCT/2001/3972, PCT/EP/1/003972, PCT/EP/1/03972, PCT/EP/2001/003972, PCT/EP/2001/03972, PCT/EP1/003972, PCT/EP1/03972, PCT/EP1003972, PCT/EP103972, PCT/EP2001/003972, PCT/EP2001/03972, PCT/EP2001003972, PCT/EP200103972, WO 0181622 A3, WO 0181622A3, WO 2001/081622 A3, WO 2001081622 A3, WO 2001081622A3, WO-A3-0181622, WO-A3-2001081622, WO0181622 A3, WO0181622A3, WO2001/081622A3, WO2001081622 A3, WO2001081622A3
InventorsAlexander Olek, Christian Piepenbrock, Kurt Berlin
ApplicantEpigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Diagnosis of diseases associated with dna repair
WO 2001081622 A3
Abstract
The present invention relates to the chemically modified genomic sequences of genes associated with DNA repair, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with DNA repair which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with DNA repair.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
WO1998056952A1 *9 Jun 199817 Dec 1998University Of Southern CaliforniaA cancer diagnostic method based upon dna methylation differences
WO1999028498A2 *27 Nov 199810 Jun 1999Epigenomics GmbhMethod for producing complex dna methylation fingerprints
WO2001068911A2 *15 Mar 200120 Sep 2001Epigenomics AgDiagnosis of diseases associated with the cell cycle
US5744305 *6 Jun 199528 Apr 1998Affymetrix, Inc.Arrays of materials attached to a substrate
Non-Patent Citations
Reference
1 *"CHARACTERIZATION OF A PUTATIVE PROMOTER REGION OF THE HUMAN POLY(ADP-RIBOSE) POLYMERASE GENE: STRUCTURAL SIMILARITY TO THAT OF THE DNA POLYMERASE BETA GENE", BIOCHEM. BIOPHYS. RES. COMM., vol. 167, 1990, US, pages 701 - 710
2 *AUER B. ET AL.: "HUMAN NUCLEAR NAD ADP-RIBOSYLTRANSFERASE( POLYMERIZING): ORGANIZATION OF THE GENE", DNA, vol. 8, no. 8, 1 October 1989 (1989-10-01), US, pages 575 - 580, XP000569183
3 *DATABASE EBI [online] 1 February 1990 (1990-02-01), AUER ET AL.: "Human nuclear NAD+ ADP-rybosyltransferase (polymerizing): organization of the gene", XP002219548, Database accession no. m29544
4 *DATABASE EBI [online] 1 July 1994 (1994-07-01), OGURA T. ET AL., XP002219551, Database accession no. X16674
5 *DATABASE EBI [online] 23 July 1991 (1991-07-23), HERZOG H. ET AL.: "Human pADPRT is involved in the regulation of its own gene", XP002219550, Database accession no. M60436
6 *DATABASE EBI [online] 23 October 1995 (1995-10-23), MACDONALD M., XP002219552, Database accession no. Z66254
7 *DATABASE EBI [online] 24 March 1999 (1999-03-24), "National Cancer Institute, Cancer Genome Anatomy project (CGAP)", XP002219546, Database accession no. AI538438
8 *DATABASE EBI [online] 30 January 2000 (2000-01-30), RAMSAY H., XP002219549, Database accession no. AL137852
9 *DATABASE EBI [online] 5 October 2001 (2001-10-05), OLEK A. ET AL.: "Diagnosis of diseases associated with cell cycle", XP002219671, Database accession no. AX251771
10 *DATABASE EBI [online] HILLIER L. ET AL.: "Generation and analysis of 280000 human expressed sequence tags", XP002219547, Database accession no. AA086258
11 *DATABASE EBI 5 October 2001 (2001-10-05), OLEK A.: "Diagnosis of diseases associated with cell cycle", XP002219672
12 *ESTELLER MANEL ET AL: "Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.", CANCER RESEARCH, vol. 59, no. 4, 15 February 1999 (1999-02-15), pages 793 - 797, XP002182504, ISSN: 0008-5472
13 *HAUG T. ET AL.: "Human uracyl-DNA glycosylase gene: sequence organization,methylation pttern, and mapping to chromosome 12q23-q24.1", GENOMICS, vol. 36, 1996, US, pages 408 - 416, XP002219668
14 *HERMAN JAMES G ET AL: "Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 12, 9 June 1998 (1998-06-09), June 9, 1998, pages 6870 - 6875, XP002219669, ISSN: 0027-8424
15 *MACDONALD M. ET AL.: "Purification of CPG islands using a methylated DNA binding column", NATURE GENETICS, vol. 6, 1994, pages 236 - 244
16 *REIN ET AL: "Identifying 5-methylcytosine and related modifications in DNA genomes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 26, no. 10, 1998, pages 2255 - 2264, XP002143106, ISSN: 0305-1048
17 *WHEELER J M D ET AL: "Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: The predominant role of hMLH1.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 18, 31 August 1999 (1999-08-31), Aug. 31, 1999, pages 10296 - 10301, XP002219670, ISSN: 0027-8424
Classifications
International ClassificationA61P13/12, C07K14/46, A61P7/04, A61P9/10, C12M1/00, C12Q1/68, C07K14/47, G01N37/00, A61P35/00, C07K14/82, A61K48/00, G01N33/53, G01N27/62, C12N15/09, A61P29/00, A61K31/711, G01N33/483, G01N33/566, C12Q1/48, B01J19/00, A61P11/06
Cooperative ClassificationC12Q2600/156, C12Q2600/154, C12Q1/6886, C07K14/82, C07K14/4703, C12Q1/6883
European ClassificationC07K14/82, C12Q1/68M6, C07K14/47A1A, C12Q1/68M6B
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