WO2001078106A3 - Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis - Google Patents

Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis Download PDF

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Publication number
WO2001078106A3
WO2001078106A3 PCT/US2001/010386 US0110386W WO0178106A3 WO 2001078106 A3 WO2001078106 A3 WO 2001078106A3 US 0110386 W US0110386 W US 0110386W WO 0178106 A3 WO0178106 A3 WO 0178106A3
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WO
WIPO (PCT)
Prior art keywords
time
trap
flight
tandem
ions
Prior art date
Application number
PCT/US2001/010386
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French (fr)
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WO2001078106A2 (en
Inventor
Anatoli Verentchikov
Jennifer Campbell
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Perseptive Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perseptive Biosystems Inc filed Critical Perseptive Biosystems Inc
Priority to EP01922943A priority Critical patent/EP1303867A2/en
Priority to JP2001575462A priority patent/JP2003530675A/en
Publication of WO2001078106A2 publication Critical patent/WO2001078106A2/en
Publication of WO2001078106A3 publication Critical patent/WO2001078106A3/en

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Abstract

The use of a segmented-ion trap with collisional damping is disclosed to improve performance (resolution and mass accuracy) of single stage and tandem time-of-flight mass spectrometers. In the case of single stage spectrometers ions are directly injected from a pulsed ion source into the trap supplied with RF field and filled with gas at millitorr pressure. Subsequently, the ions are dynamically trapped by an RF-field, cooled in gas collisions and ejected out of the trap by a homogeneous electric field into a time-of-flight mass spectrometer. In the case of tandem mass spectrometric analysis the pulsed ion beam is injected into a time-of-flight analyzer to select ions-of-interest prior to injection into the trap at medium energy to achieve fragmentation in the trap.
PCT/US2001/010386 2000-04-10 2001-03-28 Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis WO2001078106A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01922943A EP1303867A2 (en) 2000-04-10 2001-03-28 Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
JP2001575462A JP2003530675A (en) 2000-04-10 2001-03-28 Preparation of ion pulses for time-of-flight and tandem time-of-flight mass spectrometers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/546,465 US6545268B1 (en) 2000-04-10 2000-04-10 Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
US09/546,465 2000-04-10

Publications (2)

Publication Number Publication Date
WO2001078106A2 WO2001078106A2 (en) 2001-10-18
WO2001078106A3 true WO2001078106A3 (en) 2003-02-06

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010386 WO2001078106A2 (en) 2000-04-10 2001-03-28 Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis

Country Status (4)

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US (2) US6545268B1 (en)
EP (1) EP1303867A2 (en)
JP (1) JP2003530675A (en)
WO (1) WO2001078106A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US6670606B2 (en) 2003-12-30
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