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Publication numberWO2001077378 A3
Publication typeApplication
Application numberPCT/EP2001/004015
Publication date17 Oct 2002
Filing date6 Apr 2001
Priority date6 Apr 2000
Also published asDE60126593D1, DE60126593T2, EP1268857A2, EP1268861A2, EP1272670A2, EP1274865A2, EP1274865B1, EP1274866A2, EP1278893A2, EP1360319A2, EP1370685A2, EP2014776A2, EP2014776A3, US7195870, US20030082609, US20030148326, US20030148327, US20030162194, US20040067491, US20040076956, US20050282157, WO2001076451A2, WO2001076451A3, WO2001076451A9, WO2001077164A2, WO2001077164A3, WO2001077164A8, WO2001077375A2, WO2001077375A3, WO2001077375A8, WO2001077376A2, WO2001077376A3, WO2001077376A8, WO2001077377A2, WO2001077377A3, WO2001077377A8, WO2001077378A2, WO2001081622A2, WO2001081622A3, WO2001081622A8, WO2001092565A2, WO2001092565A3, WO2001092565A8
Publication numberPCT/2001/4015, PCT/EP/1/004015, PCT/EP/1/04015, PCT/EP/2001/004015, PCT/EP/2001/04015, PCT/EP1/004015, PCT/EP1/04015, PCT/EP1004015, PCT/EP104015, PCT/EP2001/004015, PCT/EP2001/04015, PCT/EP2001004015, PCT/EP200104015, WO 0177378 A3, WO 0177378A3, WO 2001/077378 A3, WO 2001077378 A3, WO 2001077378A3, WO-A3-0177378, WO-A3-2001077378, WO0177378 A3, WO0177378A3, WO2001/077378A3, WO2001077378 A3, WO2001077378A3
InventorsAlexander Olek, Christian Piepenbrock, Kurt Berlin
ApplicantEpigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Diagnosis of diseases associated with dna adducts
WO 2001077378 A3
Abstract
The present invention relates to the chemically modified genomic sequences of genes associated with DNA adducts, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with DNA adducts which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with DNA adducts.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
WO1995011995A1 *26 Oct 19944 May 1995Affymax Technologies N.V.Arrays of nucleic acid probes on biological chips
WO1999028498A2 *27 Nov 199810 Jun 1999Epigenomics GmbhMethod for producing complex dna methylation fingerprints
Non-Patent Citations
Reference
1 *DATABASE EMBL XP002182505
2 *DATABASE EMBL XP002182506
3 *ESTELLER MANEL ET AL: "Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.", CANCER RESEARCH, vol. 59, no. 4, 15 February 1999 (1999-02-15), pages 793 - 797, XP002182504, ISSN: 0008-5472
4 *NIEMEYER C M ET AL: "DNA MICROARRAYS**", ANGEWANDTE CHEMIE, VCH VERLAGSGESELLSCHAFT, WEINHEIM, DE, vol. 38, no. 19, 1999, pages 3039 - 3043, XP000961724, ISSN: 0044-8249
5 *REIN ET AL: "Identifying 5-methylcytosine and related modifications in DNA genomes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 26, no. 10, 1998, pages 2255 - 2264, XP002143106, ISSN: 0305-1048
6 *WATTS G S ET AL: "METHYLATION OF DISCRETE REGIONS OF THE O6-METHYLGUANINE DNA METHYLTRANSFERASE (MGMT) CPG ISLAND IS ASSOCIATED WITH HETEROCHROMATINIZATION OF THE MGMT TRANSCRIPTION START SITE AND SILENCING OF THE GENE", MOLECULAR CELL BIOLOGY, XX, XX, vol. 17, no. 9, September 1997 (1997-09-01), pages 5612 - 5619, XP000870077
Classifications
International ClassificationG01N27/62, A61P35/00, G01N33/566, A61P9/10, A61K31/711, G01N33/53, C07K14/82, B01J19/00, A61P11/06, C07K14/46, A61P7/04, C12Q1/68, G01N37/00, G01N33/483, A61P13/12, C07K14/47, C12Q1/48, A61K48/00, C12N15/09, C12M1/00, A61P29/00
Cooperative ClassificationC12Q2600/154, C12Q2600/156, C12Q1/6883, C12Q1/6886, C07K14/4703, C07K14/82
European ClassificationC12Q1/68M6, C07K14/82, C07K14/47A1A, C12Q1/68M6B
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