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Publication numberWO2001077375 A3
Publication typeApplication
Application numberPCT/EP2001/003968
Publication date27 Jun 2002
Filing date6 Apr 2001
Priority date6 Apr 2000
Also published asDE60126593D1, DE60126593T2, EP1268857A2, EP1268861A2, EP1272670A2, EP1274865A2, EP1274865B1, EP1274866A2, EP1278893A2, EP1360319A2, EP1370685A2, EP2014776A2, EP2014776A3, US7195870, US20030082609, US20030148326, US20030148327, US20030162194, US20040067491, US20040076956, US20050282157, WO2001076451A2, WO2001076451A3, WO2001076451A9, WO2001077164A2, WO2001077164A3, WO2001077164A8, WO2001077375A2, WO2001077375A8, WO2001077376A2, WO2001077376A3, WO2001077376A8, WO2001077377A2, WO2001077377A3, WO2001077377A8, WO2001077378A2, WO2001077378A3, WO2001081622A2, WO2001081622A3, WO2001081622A8, WO2001092565A2, WO2001092565A3, WO2001092565A8
Publication numberPCT/2001/3968, PCT/EP/1/003968, PCT/EP/1/03968, PCT/EP/2001/003968, PCT/EP/2001/03968, PCT/EP1/003968, PCT/EP1/03968, PCT/EP1003968, PCT/EP103968, PCT/EP2001/003968, PCT/EP2001/03968, PCT/EP2001003968, PCT/EP200103968, WO 0177375 A3, WO 0177375A3, WO 2001/077375 A3, WO 2001077375 A3, WO 2001077375A3, WO-A3-0177375, WO-A3-2001077375, WO0177375 A3, WO0177375A3, WO2001/077375A3, WO2001077375 A3, WO2001077375A3
InventorsAlexander Olek, Christian Piepenbrock, Kurt Berlin
ApplicantEpigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Diagnosis of diseases associated with gene regulation
WO 2001077375 A3
Abstract
The present invention relates to the chemically modified genomic sequences of genes associated with gene regulation, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with gene regulation which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with gene regulation.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
WO1995011995A1 *26 Oct 19944 May 1995Affymax Technologies N.V.Arrays of nucleic acid probes on biological chips
WO1999028498A2 *27 Nov 199810 Jun 1999Epigenomics GmbhMethod for producing complex dna methylation fingerprints
Non-Patent Citations
Reference
1 *DATABASE EMBL XP002181265
2 *HERMAN J G ET AL: "METHYLATION-SPECIFIC PCR: A NOVEL PCR ASSAY FOR METHYLATION STATUS OF CPG ISLANDS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 1 September 1996 (1996-09-01), pages 9821 - 9826, XP002910406, ISSN: 0027-8424
3 *MASS MARC J ET AL: "Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene P53 in human lung cells: A model for a mechanism of carcinogenesis.", MUTATION RESEARCH, vol. 386, no. 3, 1997, pages 263 - 277, XP001022349, ISSN: 0027-5107
4 *NIEMEYER C M ET AL: "DNA MICROARRAYS**", ANGEWANDTE CHEMIE, VCH VERLAGSGESELLSCHAFT, WEINHEIM, DE, vol. 38, no. 19, 1999, pages 3039 - 3043, XP000961724, ISSN: 0044-8249
5 *REIN ET AL: "Identifying 5-methylcytosine and related modifications in DNA genomes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 26, no. 10, 1998, pages 2255 - 2264, XP002143106, ISSN: 0305-1048
Classifications
International ClassificationC12Q1/48, G01N33/566, A61P7/04, C07K14/82, A61P13/12, C12M1/00, C12N15/09, A61P11/06, A61P29/00, A61K48/00, C12Q1/68, A61P35/00, G01N37/00, G01N33/483, C07K14/46, C07K14/47, B01J19/00, G01N33/53, A61K31/711, A61P9/10, G01N27/62
Cooperative ClassificationC12Q2600/156, C12Q2600/154, C12Q1/6883, C07K14/82, C12Q1/6886, C07K14/4703
European ClassificationC12Q1/68M6, C12Q1/68M6B, C07K14/47A1A, C07K14/82
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