WO2001077353A3 - Expression of pollen allergens in plastids - Google Patents

Expression of pollen allergens in plastids Download PDF

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Publication number
WO2001077353A3
WO2001077353A3 PCT/EP2001/003788 EP0103788W WO0177353A3 WO 2001077353 A3 WO2001077353 A3 WO 2001077353A3 EP 0103788 W EP0103788 W EP 0103788W WO 0177353 A3 WO0177353 A3 WO 0177353A3
Authority
WO
WIPO (PCT)
Prior art keywords
plastids
expression
plants
pollen allergens
host
Prior art date
Application number
PCT/EP2001/003788
Other languages
French (fr)
Other versions
WO2001077353A2 (en
Inventor
Peter Bernard Heifetz
Stephen Arthur Goff
Annmarie Bloom Tuttle
Monika Else Griot-Wenk
Original Assignee
Syngenta Participations Ag
Peter Bernard Heifetz
Stephen Arthur Goff
Annmarie Bloom Tuttle
Griot Wenk Monika Else
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag, Peter Bernard Heifetz, Stephen Arthur Goff, Annmarie Bloom Tuttle, Griot Wenk Monika Else filed Critical Syngenta Participations Ag
Priority to AU2001252246A priority Critical patent/AU2001252246A1/en
Publication of WO2001077353A2 publication Critical patent/WO2001077353A2/en
Publication of WO2001077353A3 publication Critical patent/WO2001077353A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8214—Plastid transformation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

Abstract

The present invention discloses transgenic plants expressing therapeutically active proteins, preferably from their plastid genome or targeted to the vacuole. The present invention also describes the administration of such transgenic plants to a host in need thereof for the prevention or treatment of diseases. In a preferred embodiment, such plants or matter derived from such plants is administered orally to a host.
PCT/EP2001/003788 2000-04-05 2001-04-03 Expression of pollen allergens in plastids WO2001077353A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001252246A AU2001252246A1 (en) 2000-04-05 2001-04-03 Therapeutically active proteins in plants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54361900A 2000-04-05 2000-04-05
US09/543,619 2000-04-05

Publications (2)

Publication Number Publication Date
WO2001077353A2 WO2001077353A2 (en) 2001-10-18
WO2001077353A3 true WO2001077353A3 (en) 2002-04-11

Family

ID=24168804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003788 WO2001077353A2 (en) 2000-04-05 2001-04-03 Expression of pollen allergens in plastids

Country Status (2)

Country Link
AU (1) AU2001252246A1 (en)
WO (1) WO2001077353A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186560B2 (en) * 1999-09-21 2007-03-06 Rutgers, The State University Of New Jersey High level expression of immunogenic proteins in the plastids of higher plants
ES2296642T3 (en) 1999-09-21 2008-05-01 Rutgers, The State University Of New Jersey SPECIFIC RECOMBINATION SYSTEM OF THE SITE TO MANIPULATE THE PLASTIDE GENOME OF UPPER PLANTS.
US7534936B2 (en) 2001-03-29 2009-05-19 Rutgers, The State University Of New Jersey Transgenic plants having transformed plastid genomes and progeny thereof
US8841511B2 (en) 2003-03-03 2014-09-23 Rutgers, The State University Of New Jersey Removal of plastid sequences by transiently expressed site-specific recombinases
WO2007121467A2 (en) 2006-04-18 2007-10-25 Rutgers, The State University Of New Jersey Compositions and methods for increasing transgene expression in the plastids of higher plants

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001486A1 (en) * 1987-08-11 1989-02-23 New York University Biologically active bactericidal/permeability-increasing protein fragments
WO1994005790A1 (en) * 1992-09-10 1994-03-17 Immulogic Pharmaceutical Corporation Cloning and sequencing of allergens of dermatophagoides (house dust mite)
WO1994010314A1 (en) * 1992-10-30 1994-05-11 The University Of Melbourne Allergenic proteins and peptides from johnson grass pollen
EP0770681A2 (en) * 1992-04-09 1997-05-02 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from ambrosia artemisiifolia
WO1998004274A1 (en) * 1996-07-31 1998-02-05 University Of Manitoba Recombinant mosquito salivary allergens
WO1998006861A2 (en) * 1996-08-15 1998-02-19 Agrivax Incorporated Delivery of tolerogenic antigens via edible plants or plant-derived products
WO2000020612A2 (en) * 1998-10-07 2000-04-13 Syngenta Participations Ag Therapeutically active proteins in plants

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001486A1 (en) * 1987-08-11 1989-02-23 New York University Biologically active bactericidal/permeability-increasing protein fragments
EP0770681A2 (en) * 1992-04-09 1997-05-02 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from ambrosia artemisiifolia
WO1994005790A1 (en) * 1992-09-10 1994-03-17 Immulogic Pharmaceutical Corporation Cloning and sequencing of allergens of dermatophagoides (house dust mite)
WO1994010314A1 (en) * 1992-10-30 1994-05-11 The University Of Melbourne Allergenic proteins and peptides from johnson grass pollen
WO1998004274A1 (en) * 1996-07-31 1998-02-05 University Of Manitoba Recombinant mosquito salivary allergens
WO1998006861A2 (en) * 1996-08-15 1998-02-19 Agrivax Incorporated Delivery of tolerogenic antigens via edible plants or plant-derived products
WO2000020612A2 (en) * 1998-10-07 2000-04-13 Syngenta Participations Ag Therapeutically active proteins in plants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BREITENEDER H ET AL: "THE GENE CODING FOR THE MAJOR BIRCH POLLEN ALLERGEN BETVL, IS HIGHLY HOMOLOGOUS TO A PEA DISEASE RESISTANCE RESPONSE GENE", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 8, no. 7, 1 July 1989 (1989-07-01), pages 1935 - 1938, XP000050673, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
AU2001252246A1 (en) 2001-10-23
WO2001077353A2 (en) 2001-10-18

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