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Publication numberWO2001077164 A3
Publication typeApplication
Application numberPCT/EP2001/003969
Publication date20 Jun 2002
Filing date6 Apr 2001
Priority date6 Apr 2000
Also published asDE60126593D1, DE60126593T2, EP1268857A2, EP1268861A2, EP1272670A2, EP1274865A2, EP1274865B1, EP1274866A2, EP1278893A2, EP1360319A2, EP1370685A2, EP2014776A2, EP2014776A3, US7195870, US20030082609, US20030148326, US20030148327, US20030162194, US20040067491, US20040076956, US20050282157, WO2001076451A2, WO2001076451A3, WO2001076451A9, WO2001077164A2, WO2001077164A8, WO2001077375A2, WO2001077375A3, WO2001077375A8, WO2001077376A2, WO2001077376A3, WO2001077376A8, WO2001077377A2, WO2001077377A3, WO2001077377A8, WO2001077378A2, WO2001077378A3, WO2001081622A2, WO2001081622A3, WO2001081622A8, WO2001092565A2, WO2001092565A3, WO2001092565A8
Publication numberPCT/2001/3969, PCT/EP/1/003969, PCT/EP/1/03969, PCT/EP/2001/003969, PCT/EP/2001/03969, PCT/EP1/003969, PCT/EP1/03969, PCT/EP1003969, PCT/EP103969, PCT/EP2001/003969, PCT/EP2001/03969, PCT/EP2001003969, PCT/EP200103969, WO 0177164 A3, WO 0177164A3, WO 2001/077164 A3, WO 2001077164 A3, WO 2001077164A3, WO-A3-0177164, WO-A3-2001077164, WO0177164 A3, WO0177164A3, WO2001/077164A3, WO2001077164 A3, WO2001077164A3
InventorsAlexander Olek, Christian Piepenbrock, Kurt Berlin
ApplicantEpigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Diagnosis of diseases associated with apoptosis by means of assessing the methylation status of genes associated with apoptosis
WO 2001077164 A3
Abstract
The present invention relates to the chemically modified genomic sequences of genes associated with apoptosis, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with apoptosis which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with apoptosis.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
WO1999028498A2 *27 Nov 199810 Jun 1999Epigenomics GmbhMethod for producing complex dna methylation fingerprints
WO1999029898A2 *4 Dec 199817 Jun 1999MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.Method for identifying nucleic acids by means of matrix-assisted laser desorption/ionisation mass spectrometry
WO2001068911A2 *15 Mar 200120 Sep 2001Epigenomics AgDiagnosis of diseases associated with the cell cycle
WO2001068912A2 *15 Mar 200120 Sep 2001Epigenomics AgDiagnosis of diseases associated with tumor suppressor genes and oncogenes
WO2001077376A2 *6 Apr 200118 Oct 2001Epigenomics AgDiagnosis of diseases associated with metastasis
US5744305 *6 Jun 199528 Apr 1998Affymetrix, Inc.Arrays of materials attached to a substrate
Non-Patent Citations
Reference
1 *ALLAN LA ET AL.: "The p21WAFi1/CIP1 promoter is methylated in Rat- cells: stable restoration of p53-dependent p21WAF1/CIP1 expression after transfection of a genomic clone containing the p21WAF1/CIP1 gene.", MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 4, February 2000 (2000-02-01), pages 1291 - 1298, XP001026537
2 *DATABASE EMBL [online] EBI; 11 December 1993 (1993-12-11), DEISS LP ET AL.: "DAP-kinase", XP002187216, retrieved from HTTP://WWW.EBI.AC.UK/CGI-BIN/EMBLFETCH Database accession no. X76104
3 *DATABASE GENBANK [online] NCBI; 6 March 1995 (1995-03-06), ITHO N ET AL: "Human Fas antigen (fas) mRNA, complete cds", XP002187215, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ Database accession no. M67454
4 *DEISS LP ET AL: "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.", GENES & DEVELOPMENT, vol. 9, 1995, pages 15 - 30, XP002102392
5 *ITHO N ET AL.: "The polypetide encoded by the cDNA for human cell surface antigen FAS can mediate apoptosis.", CELL, vol. 66, no. 2, 1991, pages 233 - 243
6 *KATZENELLENBOGEN RA ET AL.: "Hypermethylation of the DAP-Kinase CpG island is a common alteration in B-cell malignancies.", NEOPLASIA, vol. 93, no. 12, June 1999 (1999-06-01), pages 4347 - 4353, XP002187214
7 *SALVATORE P ET AL.: "High resolution analysis of the galectin-1 gene promoter region in expressing and nonexpressing tissues.", FEBS LETTERS, vol. 421, no. 2, 1998, pages 152 - 158, XP004261737
8 *UEKI T ET AL.: "Hypermethylation of multiple genes in pancreatic adenocarcinoma.", CANCER RESAERCH, vol. 60, no. 7, 1 April 2000 (2000-04-01), pages 1835 - 1839, XP001026187
Classifications
International ClassificationA61P7/04, G01N33/566, B01J19/00, C12M1/00, G01N33/53, A61P29/00, C07K14/82, A61P13/12, C12Q1/48, A61P9/10, G01N37/00, A61K48/00, C07K14/46, C12Q1/68, C12N15/09, A61K31/711, A61P11/06, A61P35/00, C07K14/47, G01N33/483, G01N27/62
Cooperative ClassificationC12Q2600/154, C12Q2600/156, C12Q1/6886, C07K14/4703, C07K14/82, C12Q1/6883
European ClassificationC07K14/82, C07K14/47A1A, C12Q1/68M6, C12Q1/68M6B
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