Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberWO2001076451 A3
Publication typeApplication
Application numberPCT/EP2001/004016
Publication date4 Sep 2003
Filing date6 Apr 2001
Priority date6 Apr 2000
Also published asDE60126593D1, DE60126593T2, EP1268857A2, EP1268861A2, EP1272670A2, EP1274865A2, EP1274865B1, EP1274866A2, EP1278893A2, EP1360319A2, EP1370685A2, EP2014776A2, EP2014776A3, US7195870, US20030082609, US20030148326, US20030148327, US20030162194, US20040067491, US20040076956, US20050282157, WO2001076451A2, WO2001076451A9, WO2001077164A2, WO2001077164A3, WO2001077164A8, WO2001077375A2, WO2001077375A3, WO2001077375A8, WO2001077376A2, WO2001077376A3, WO2001077376A8, WO2001077377A2, WO2001077377A3, WO2001077377A8, WO2001077378A2, WO2001077378A3, WO2001081622A2, WO2001081622A3, WO2001081622A8, WO2001092565A2, WO2001092565A3, WO2001092565A8
Publication numberPCT/2001/4016, PCT/EP/1/004016, PCT/EP/1/04016, PCT/EP/2001/004016, PCT/EP/2001/04016, PCT/EP1/004016, PCT/EP1/04016, PCT/EP1004016, PCT/EP104016, PCT/EP2001/004016, PCT/EP2001/04016, PCT/EP2001004016, PCT/EP200104016, WO 0176451 A3, WO 0176451A3, WO 2001/076451 A3, WO 2001076451 A3, WO 2001076451A3, WO-A3-0176451, WO-A3-2001076451, WO0176451 A3, WO0176451A3, WO2001/076451A3, WO2001076451 A3, WO2001076451A3
InventorsAlexander Olek, Christian Piepenbrock, Kurt Berlin
ApplicantEpigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Diagnosis of diseases associated with metabolism
WO 2001076451 A3
Abstract
The present invention relates to the chemically modified genomic sequences of genes associated with metabolism, to oligonuecleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with metabolism which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with metabolism.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
WO1997046705A1 *3 Jun 199711 Dec 1997The Johns Hopkins University School Of MedicineMethylation specific detection
WO1998056952A1 *9 Jun 199817 Dec 1998University Of Southern CaliforniaA cancer diagnostic method based upon dna methylation differences
WO1999028498A2 *27 Nov 199810 Jun 1999Epigenomics GmbhMethod for producing complex dna methylation fingerprints
US5744305 *6 Jun 199528 Apr 1998Affymetrix, Inc.Arrays of materials attached to a substrate
Non-Patent Citations
Reference
1 *CROSS S.H. ET AL.: "Purification of CpG islands using a methylated DNA binding column", NATURE GENETICS, vol. 6, 1994, pages 236 - 244, XP002911234, DOI: doi:10.1038/ng0394-236
2 *DATABASE EBI [online] 18 October 1995 (1995-10-18), MACDONALD M. ET AL., XP002227176, Database accession no. Z56355
3 *DATABASE EBI [online] 20 July 1992 (1992-07-20), KANO M., XP002227074, Database accession no. D10500
4 *DATABASE EBI [online] BIRREN B. ET AL.: "Homo sapiens chromosome 11, clone RP11-56J3", XP002227073, Database accession no. AC015692
5 *DATABASE EBI [online] NAKAMURA Y., XP002227075, Database accession no. D83989
6 *DOTTORI M ET AL: "CLONING AND CHARACTERIZATION OF EPHA3 (HEK) GENE PROMOTER: DNA METHYLATION REGULATES EXPRESSION IN HEMATOPOIETIC TUMOR CELLS", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 94, no. 7, 1999, pages 2477 - 2486, XP000907581, ISSN: 0006-4971
7 *ESTELLER MANEL ET AL: "Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 4, 15 February 1999 (1999-02-15), pages 793 - 797, XP002182504, ISSN: 0008-5472
8 *HERMAN J G ET AL: "Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.", CANCER RESEARCH. UNITED STATES 15 FEB 1996, vol. 56, no. 4, 15 February 1996 (1996-02-15), pages 722 - 727, XP001120841, ISSN: 0008-5472
9 *HERMAN J G ET AL: "METHYLATION-SPECIFIC PCR: A NOVEL PCR ASSAY FOR METHYLATION STATUS OF CPG ISLANDS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 1 September 1996 (1996-09-01), pages 9821 - 9826, XP002910406, ISSN: 0027-8424
10 *HUANG Y ET AL: "DECREASED EXPRESSION OF MANGANESE SUPEROXIDE DISMUTASE IN TRANSFORMED CELLS IS ASSOCIATED WITH INCREASED CYTOSINE METHYLATIONOF THE SOD2 GENE", DNA AND CELL BIOLOGY, NEW YORK, NY, US, vol. 18, no. 8, August 1999 (1999-08-01), pages 643 - 652-1592, XP000892711, ISSN: 1044-5498
11 *KANO M. ET AL.: "Structure and expression of the human mitochondrial acetoacetyl-CoA thiolase-encoding gene.", GENE, vol. 109, 1991, NL, pages 285 - 290, XP001121791
12 *MIKI Y. ET AL.: "Mutation analysis in the BRCA2 gene in primary breast cancers", NATURE GENETICS, vol. 13, 1996, pages 245 - 247
13 *MYÖHÄNEN S ET AL: "Automated fluorescent genomic sequencing as applied to the methylation analysis of the human ornithine decarboxylase gene.", DNA SEQUENCE: THE JOURNAL OF DNA SEQUENCING AND MAPPING. SWITZERLAND 1994, vol. 5, no. 1, 1994, pages 1 - 8, XP002227072, ISSN: 1042-5179
14 *STEINMETZ K L ET AL: "HYPOMETHYLATION OF THE RAT GLUTATHIONE S-TRANSFERASE PI (GSTP) PROMOTER REGION ISOLATED FROM METHYL-DEFICIENT LIVERS AND GSTP-POSITIVE LIVER NEOPLASMS", CARCINOGENESIS, XX, XX, vol. 19, no. 8, 1998, pages 1487 - 1494, XP002938224
15 *WISE THOMAS L ET AL: "The undermethylated state of a CpG island region in Igf2 transgenes is dependent on the H19 enhancers.", GENOMICS, vol. 60, no. 3, pages 258 - 271, XP002227071, ISSN: 0888-7543
Classifications
International ClassificationC12Q1/48, C12M1/00, A61P7/04, A61P13/12, A61P11/06, C07K14/47, G01N33/53, B01J19/00, A61P29/00, A61K31/711, A61K48/00, G01N37/00, C12Q1/68, C12N15/09, C07K14/46, G01N33/483, G01N33/566, A61P35/00, G01N27/62, C07K14/82, A61P9/10
Cooperative ClassificationC12Q2600/154, C12Q2600/156, C07K14/4703, C12Q1/6883, C07K14/82, C12Q1/6886
European ClassificationC07K14/47A1A, C07K14/82, C12Q1/68M6, C12Q1/68M6B
Legal Events
DateCodeEventDescription
18 Oct 2001ALDesignated countries for regional patents
Kind code of ref document: A2
Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG
18 Oct 2001AKDesignated states
Kind code of ref document: A2
Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW
12 Dec 2001121Ep: the epo has been informed by wipo that ep was designated in this application
13 Dec 2001DFPERequest for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
8 Aug 2002AKDesignated states
Kind code of ref document: C2
Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW
8 Aug 2002COPCorrected version of pamphlet
Free format text: PAGES 1-17, DESCRIPTION, REPLACED BY NEW PAGES 1-19; PAGES 18-22, CLAIMS, REPLACED BY NEW PAGES 20-25; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE
8 Aug 2002ALDesignated countries for regional patents
Kind code of ref document: C2
Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG
25 Sep 2002WWEWipo information: entry into national phase
Ref document number: 2001955278
Country of ref document: EP
24 Oct 2002WWEWipo information: entry into national phase
Ref document number: 2001277487
Country of ref document: AU
11 Mar 2003WWEWipo information: entry into national phase
Ref document number: 10240454
Country of ref document: US
12 Nov 2003WWPWipo information: published in national office
Ref document number: 2001955278
Country of ref document: EP
12 Jan 2005NENPNon-entry into the national phase in:
Ref country code: JP
1 Nov 2007WWWWipo information: withdrawn in national office
Ref document number: 2001955278
Country of ref document: EP