WO2001071345A8 - Optically and fluidically enhanced in vitro diagnostic test chamber - Google Patents

Optically and fluidically enhanced in vitro diagnostic test chamber

Info

Publication number
WO2001071345A8
WO2001071345A8 PCT/US2001/009100 US0109100W WO0171345A8 WO 2001071345 A8 WO2001071345 A8 WO 2001071345A8 US 0109100 W US0109100 W US 0109100W WO 0171345 A8 WO0171345 A8 WO 0171345A8
Authority
WO
WIPO (PCT)
Prior art keywords
inlet
outlet
wells
defines
well
Prior art date
Application number
PCT/US2001/009100
Other languages
French (fr)
Other versions
WO2001071345A1 (en
WO2001071345A9 (en
Inventor
Dianna Innerst
Adonis Kassinos
C Benjamin Wooley
Brett Wilmarth
William J Sell
Emi Zychlinsky
Donald Marino
Sandy Yamada
Renee Ryan
Karen Ding
Michael Zatzke
Original Assignee
Hitachi Chemical Diagnostics I
Dianna Innerst
Adonis Kassinos
C Benjamin Wooley
Brett Wilmarth
William J Sell
Emi Zychlinsky
Donald Marino
Sandy Yamada
Renee Ryan
Karen Ding
Michael Zatzke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Chemical Diagnostics I, Dianna Innerst, Adonis Kassinos, C Benjamin Wooley, Brett Wilmarth, William J Sell, Emi Zychlinsky, Donald Marino, Sandy Yamada, Renee Ryan, Karen Ding, Michael Zatzke filed Critical Hitachi Chemical Diagnostics I
Priority to EP01920628A priority Critical patent/EP1266215B1/en
Priority to AU2001247661A priority patent/AU2001247661A1/en
Priority to DE60120654T priority patent/DE60120654T2/en
Priority to JP2001569481A priority patent/JP4829460B2/en
Priority to US10/221,527 priority patent/US7189354B2/en
Publication of WO2001071345A1 publication Critical patent/WO2001071345A1/en
Publication of WO2001071345A8 publication Critical patent/WO2001071345A8/en
Publication of WO2001071345A9 publication Critical patent/WO2001071345A9/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis

Abstract

An enclosed chamber is used in a system for screening of a liquid specimen through binding assays. The enclosed chamber includes an inlet, an outlet, and a plurality of discrete reactant containing wells communicated by a common reagent flow path between the inlet and the outlet. A transparent member or coverslip defines on an inside thereof the plurality of wells. Each well has a bottom for receiving an allergen/antigen/reactant, which emits light upon reacting. The coverslip can optionally define at least one lens at each well. A bottom encloses the plurality of wells and defines between the inlet and the outlet a common reagent flow path between the inlet and the outlet. This bottom defines for each of the plurality of wells a flow-diverting member. An opaque partition is disclosed for surrounding the individual lenses and generally isolating the light path from each well.
PCT/US2001/009100 2000-03-21 2001-03-20 Optically and fluidically enhanced in vitro diagnostic test chamber WO2001071345A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01920628A EP1266215B1 (en) 2000-03-21 2001-03-20 Optically and fluidically enhanced in vitro diagnostic test chamber
AU2001247661A AU2001247661A1 (en) 2000-03-21 2001-03-20 Optically and fluidically enhanced in vitro diagnostic test chamber
DE60120654T DE60120654T2 (en) 2000-03-21 2001-03-20 OPTICAL AND FLUIDICALLY IMPROVED IN-VITRO DIAGNOSTIC TEST CHAMBER
JP2001569481A JP4829460B2 (en) 2000-03-21 2001-03-20 Sealed container and screening method
US10/221,527 US7189354B2 (en) 2000-03-21 2001-03-20 Optically and fluidically enhanced in vitro diagnostic test chamber

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19132400P 2000-03-21 2000-03-21
US60/191,324 2000-03-21

Publications (3)

Publication Number Publication Date
WO2001071345A1 WO2001071345A1 (en) 2001-09-27
WO2001071345A8 true WO2001071345A8 (en) 2001-12-06
WO2001071345A9 WO2001071345A9 (en) 2002-12-19

Family

ID=22705029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/009100 WO2001071345A1 (en) 2000-03-21 2001-03-20 Optically and fluidically enhanced in vitro diagnostic test chamber

Country Status (8)

Country Link
US (1) US7189354B2 (en)
EP (1) EP1266215B1 (en)
JP (1) JP4829460B2 (en)
AT (2) ATE350161T1 (en)
AU (1) AU2001247661A1 (en)
DE (2) DE60125844T2 (en)
ES (2) ES2270990T3 (en)
WO (1) WO2001071345A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4199609B2 (en) * 2002-07-12 2008-12-17 三菱化学株式会社 ANALYSIS CHIP, ANALYSIS CHIP UNIT, ANALYSIS DEVICE, AND METHOD FOR PRODUCING ANALYSIS CHIP
EP1564556A1 (en) * 2004-02-17 2005-08-17 DST Diagnostic Science & Technology GmbH Method and apparatus for assaying several analytes simultaneously with an internal control
GB2414298B (en) * 2004-05-18 2008-09-10 Michael Strachan Walker Diagnostic method and apparatus
JP2006189292A (en) * 2005-01-05 2006-07-20 Ulvac Japan Ltd Micro-flow passage device and its manufacturing method
CN101278186A (en) * 2005-10-03 2008-10-01 皇家飞利浦电子股份有限公司 Biosensors with improved sensitivity
WO2009087857A1 (en) * 2008-01-07 2009-07-16 Shimadzu Corporation Reaction container
JP2009175108A (en) * 2008-01-28 2009-08-06 Sharp Corp Assay-use micro-channel device
JP2013221918A (en) * 2012-04-19 2013-10-28 Rohm Co Ltd Microchip
TW202246775A (en) 2021-01-21 2022-12-01 日商東麗股份有限公司 Allergen-immobilized carrier and method for detecting allergen-specific antibody

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284725A (en) 1976-08-13 1981-08-18 Dynasciences Corporation Virus titration and identification system
US4459360A (en) 1981-10-05 1984-07-10 Mast Medical Industries, Ltd. Multiple-component binding assay system and method of making and using it
US4567149A (en) * 1983-03-17 1986-01-28 Mast Immunosystems, Ltd. Binding assay system and method of making and using same
EP0177718B1 (en) * 1984-09-11 1989-12-06 Partec AG Method and device for sorting microscopic particles
WO1986006488A1 (en) 1985-04-29 1986-11-06 Hichem Diagnostics, Inc., Dba Bural Technologies Diagnostic test kit
US4956150A (en) * 1985-11-27 1990-09-11 Alerchek Disposable microtiter stick
JPS62178922A (en) * 1986-02-03 1987-08-06 Sony Corp Optical device
US5447837A (en) * 1987-08-05 1995-09-05 Calypte, Inc. Multi-immunoassay diagnostic system for antigens or antibodies or both
JPH01242965A (en) * 1988-03-23 1989-09-27 Shimadzu Corp Film for fixing dna and dna fixing method
US5244630A (en) 1988-04-22 1993-09-14 Abbott Laboratories Device for performing solid-phase diagnostic assay
US5281540A (en) * 1988-08-02 1994-01-25 Abbott Laboratories Test array for performing assays
US5550063A (en) * 1991-02-11 1996-08-27 Biostar, Inc. Methods for production of an optical assay device
JPH06153996A (en) * 1992-11-18 1994-06-03 Hitachi Ltd Method for detecting polynucleotide
JPH06300762A (en) * 1993-04-14 1994-10-28 Nippon Telegr & Teleph Corp <Ntt> Non-separate type apparatus for fluorescent immunoassay
DE19647644C2 (en) 1996-11-18 1999-04-15 Fraunhofer Ges Forschung Micromechanical transmission measuring cell
WO1999052633A1 (en) 1998-04-14 1999-10-21 Ivd Systems Test cartridge with a single inlet port
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array

Also Published As

Publication number Publication date
EP1266215A4 (en) 2003-04-02
JP4829460B2 (en) 2011-12-07
DE60125844D1 (en) 2007-02-15
EP1266215B1 (en) 2006-06-14
ATE330220T1 (en) 2006-07-15
WO2001071345A1 (en) 2001-09-27
DE60120654T2 (en) 2007-05-31
DE60120654D1 (en) 2006-07-27
AU2001247661A1 (en) 2001-10-03
ES2282753T3 (en) 2007-10-16
US7189354B2 (en) 2007-03-13
WO2001071345A9 (en) 2002-12-19
JP2003530547A (en) 2003-10-14
ES2270990T3 (en) 2007-04-16
US20040071596A1 (en) 2004-04-15
EP1266215A1 (en) 2002-12-18
ATE350161T1 (en) 2007-01-15
DE60125844T2 (en) 2007-05-16

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