WO2001069230A2 - Methods and apparatus for the location and concentration of polar analytes using an alternating electric field - Google Patents
Methods and apparatus for the location and concentration of polar analytes using an alternating electric field Download PDFInfo
- Publication number
- WO2001069230A2 WO2001069230A2 PCT/US2001/007576 US0107576W WO0169230A2 WO 2001069230 A2 WO2001069230 A2 WO 2001069230A2 US 0107576 W US0107576 W US 0107576W WO 0169230 A2 WO0169230 A2 WO 0169230A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electric field
- polar analyte
- analyte
- alternating electric
- translation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/24—Extraction; Separation; Purification by electrochemical means
- C07K1/26—Electrophoresis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Pathology (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Fluid Mechanics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Electrostatic Separation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT01918488T ATE289065T1 (en) | 2000-03-10 | 2001-03-08 | METHOD AND DEVICE FOR LOCATION AND CONCENTRATION OF POLAR ANALYTES USING AN ALTERNATING ELECTRICAL FIELD |
EP01918488A EP1261863B1 (en) | 2000-03-10 | 2001-03-08 | Method and apparatus for the location and concentration of polar analytes using an alternating electric field |
AU2001245558A AU2001245558A1 (en) | 2000-03-10 | 2001-03-08 | Methods and apparatus for the location and concentration of polar analytes usingan alternating electric field |
DE60108848T DE60108848T2 (en) | 2000-03-10 | 2001-03-08 | METHOD AND DEVICE FOR THE LOCATION AND CONCENTRATION OF POLAR ANALYTES BY MEANS OF AN ELECTRIC CHANGE AREA |
CA002402189A CA2402189A1 (en) | 2000-03-10 | 2001-03-08 | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
JP2001568062A JP2003527601A (en) | 2000-03-10 | 2001-03-08 | Method and apparatus for locating and concentrating polar analytes using an alternating electric field |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/522,638 US6537433B1 (en) | 2000-03-10 | 2000-03-10 | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
US09/522,638 | 2000-03-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001069230A2 true WO2001069230A2 (en) | 2001-09-20 |
WO2001069230A3 WO2001069230A3 (en) | 2002-06-20 |
Family
ID=24081685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/007576 WO2001069230A2 (en) | 2000-03-10 | 2001-03-08 | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
Country Status (8)
Country | Link |
---|---|
US (4) | US6537433B1 (en) |
EP (1) | EP1261863B1 (en) |
JP (1) | JP2003527601A (en) |
AT (1) | ATE289065T1 (en) |
AU (1) | AU2001245558A1 (en) |
CA (1) | CA2402189A1 (en) |
DE (1) | DE60108848T2 (en) |
WO (1) | WO2001069230A2 (en) |
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WO2004083823A1 (en) * | 2003-03-19 | 2004-09-30 | Nec Corporation | Microchip, sampling method, sample separating method, sample analyzing method, and sample recovering method |
US7147764B2 (en) | 2003-03-28 | 2006-12-12 | Applera Corporation | Dual electrode injection of analyte into a capillary electrophoretic device |
WO2007041692A2 (en) | 2005-10-04 | 2007-04-12 | Magic Technologies, Inc. | Microfluidic detection of analytes |
US7384780B2 (en) | 2002-12-11 | 2008-06-10 | Yokogawa Electric Corporation | Hybridization method and hybridization equipment |
JP2010188342A (en) * | 2002-07-08 | 2010-09-02 | Deltadot Ltd | Material separation device |
US8460887B2 (en) | 2003-07-12 | 2013-06-11 | Accelerate Diagnostics, Inc. | Sensitive and rapid determination of antimicrobial susceptibility |
US9657327B2 (en) | 2003-07-12 | 2017-05-23 | Accelerate Diagnostics, Inc. | Rapid microbial detection and antimicrobial susceptibility testing |
US9677109B2 (en) | 2013-03-15 | 2017-06-13 | Accelerate Diagnostics, Inc. | Rapid determination of microbial growth and antimicrobial susceptibility |
US9714420B2 (en) | 2011-03-07 | 2017-07-25 | Accelerate Diagnostics, Inc. | Rapid cell purification systems |
US10023895B2 (en) | 2015-03-30 | 2018-07-17 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing |
US10253355B2 (en) | 2015-03-30 | 2019-04-09 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
US10254204B2 (en) | 2011-03-07 | 2019-04-09 | Accelerate Diagnostics, Inc. | Membrane-assisted purification |
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US6537433B1 (en) * | 2000-03-10 | 2003-03-25 | Applera Corporation | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
WO2002014462A1 (en) * | 2000-08-14 | 2002-02-21 | The Regents Of The University Of California | Biosensors and methods for their use |
US7147441B2 (en) * | 2000-12-20 | 2006-12-12 | Board Of Trustees Of The University Of Arkansas, N.A. | Microfluidics and small volume mixing based on redox magnetohydrodynamics methods |
US20020187503A1 (en) * | 2001-05-02 | 2002-12-12 | Michael Harrold | Concentration and purification of analytes using electric fields |
US7014744B2 (en) * | 2001-08-24 | 2006-03-21 | Applera Corporation | Method of purification and concentration using AC fields with a transfer tip |
US6814859B2 (en) * | 2002-02-13 | 2004-11-09 | Nanostream, Inc. | Frit material and bonding method for microfluidic separation devices |
JP4128084B2 (en) * | 2003-01-07 | 2008-07-30 | クラスターテクノロジー株式会社 | Sample characterization method and apparatus |
AU2004230592B2 (en) * | 2003-04-14 | 2007-10-04 | Caliper Life Sciences, Inc. | Reduction of migration shift assay interference |
JP4453334B2 (en) * | 2003-10-21 | 2010-04-21 | ソニー株式会社 | Hybridization apparatus and method |
US7384791B2 (en) * | 2004-01-21 | 2008-06-10 | Hewlett-Packard Development Company, L.P. | Method of analyzing blood |
US7390387B2 (en) * | 2004-03-25 | 2008-06-24 | Hewlett-Packard Development Company, L.P. | Method of sorting cells in series |
US7160425B2 (en) * | 2004-03-25 | 2007-01-09 | Hewlett-Packard Development Company, L.P. | Cell transporter for a biodevice |
US7390388B2 (en) * | 2004-03-25 | 2008-06-24 | Hewlett-Packard Development Company, L.P. | Method of sorting cells on a biodevice |
US8057655B1 (en) * | 2004-08-20 | 2011-11-15 | The Board Of Trustees Of The Leland Stanford Junior University | Sub-micron object control arrangement and approach therefor |
JP4619728B2 (en) * | 2004-09-02 | 2011-01-26 | 株式会社エンプラス | Sample analyzer |
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US9995668B2 (en) * | 2006-02-01 | 2018-06-12 | Ecole polytechnique fédérale de Lausanne (EPFL) | Apparatus for manipulating, modifying and characterizing particles in a micro channel |
US8029657B1 (en) * | 2006-03-14 | 2011-10-04 | University Of Tennessee Research Foundation | Parallel plate electrodes for particle concentration or removal |
US7731826B2 (en) * | 2006-08-17 | 2010-06-08 | Electronic Bio Sciences, Llc | Controlled translocation of a polymer in an electrolytic sensing system |
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US20090095635A1 (en) * | 2007-07-20 | 2009-04-16 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis of a radiolabeled compound using electrochemical trapping and release |
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5059294A (en) * | 1985-12-26 | 1991-10-22 | The University Of Puerto Rico | Method for separating nucleic acids and nucleic acid probes |
WO1993005390A1 (en) * | 1991-08-28 | 1993-03-18 | Guzman Norberto A | Automated capillary electrophoresis apparatus |
GB2266153A (en) * | 1992-04-16 | 1993-10-20 | British Tech Group | Dielectrophoretic separating of a mixture of particles |
US5344535A (en) * | 1989-11-27 | 1994-09-06 | British Technology Group Limited | Dielectrophoretic characterization of micro-organisms and other particles |
DE19500683A1 (en) * | 1994-12-10 | 1996-06-13 | Guenter Prof Dr Fuhr | Trapping or movement of micro-particles in micro-structures generating electromagnetic cage field |
WO1996042013A1 (en) * | 1995-06-08 | 1996-12-27 | Visible Genetics Inc. | Microelectrophoresis chip for moving and separating nucleic acids and other charged molecules |
WO1999063332A1 (en) * | 1998-06-05 | 1999-12-09 | Sarnoff Corporation | Apparatus for separating molecules |
US6007690A (en) * | 1996-07-30 | 1999-12-28 | Aclara Biosciences, Inc. | Integrated microfluidic devices |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2417850A (en) | 1942-04-14 | 1947-03-25 | Willis M Winslow | Method and means for translating electrical impulses into mechanical force |
US4680201A (en) | 1985-10-30 | 1987-07-14 | Stellan Hjerten | Coating for electrophoresis tube |
US4690749A (en) | 1985-12-16 | 1987-09-01 | Universities Space Research Association | Polymer-coated surfaces to control surface zeta potential |
US4811218A (en) | 1986-06-02 | 1989-03-07 | Applied Biosystems, Inc. | Real time scanning electrophoresis apparatus for DNA sequencing |
US4874507A (en) | 1986-06-06 | 1989-10-17 | Whitlock David R | Separating constituents of a mixture of particles |
US4911806A (en) | 1987-02-27 | 1990-03-27 | Biotronics | Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields |
US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
US5132012A (en) | 1988-06-24 | 1992-07-21 | Hitachi, Ltd. | Liquid chromatograph |
US4956065A (en) | 1988-11-03 | 1990-09-11 | Kaler Karen V I S | Method and apparatus for three dimensional dynamic dielectric levitation |
DD279984A1 (en) | 1989-02-02 | 1990-06-20 | Univ Berlin Humboldt | DIELECTRIC MICROMECHANICAL ELEMENT |
US5110514A (en) | 1989-05-01 | 1992-05-05 | Soane Technologies, Inc. | Controlled casting of a shrinkable material |
US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
US5275710A (en) * | 1990-05-14 | 1994-01-04 | Labintelligence, Inc. | Gel electrophoresis system including optical stage, sample applicator and sample retriever |
US5569591A (en) | 1990-08-03 | 1996-10-29 | University College Of Wales Aberystwyth | Analytical or monitoring apparatus and method |
US6149789A (en) | 1990-10-31 | 2000-11-21 | Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Process for manipulating microscopic, dielectric particles and a device therefor |
DE59108006D1 (en) | 1991-01-28 | 1996-08-22 | Ciba Geigy Ag | Device for the preparation of samples, in particular for analysis purposes |
JP3104995B2 (en) | 1991-01-31 | 2000-10-30 | ワーナー−ランバート・コンパニー | Substituted heteroaryl analogs of 4,6-di-tert-butyl-5-hydroxy-1,3-pyrimidine useful as anti-inflammatory agents |
DE4127405C2 (en) | 1991-08-19 | 1996-02-29 | Fraunhofer Ges Forschung | Process for the separation of mixtures of microscopic dielectric particles suspended in a liquid or a gel and device for carrying out the process |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
DE59108591D1 (en) | 1991-12-06 | 1997-04-10 | Ciba Geigy Ag | Electrophoretic separation device and electrophoretic separation process |
US5489506A (en) | 1992-10-26 | 1996-02-06 | Biolife Systems, Inc. | Dielectrophoretic cell stream sorter |
AU1254295A (en) | 1993-12-17 | 1995-07-03 | Perkin-Elmer Corporation, The | Uncharged polymers for separation of biomolecules by capillary electrophoresis |
EP0746408B1 (en) | 1994-02-24 | 1998-09-23 | Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. | Shaping of microparticles in electric-field cages |
WO1995023245A1 (en) * | 1994-02-25 | 1995-08-31 | Labintelligence, Inc. | Real time in-gel assay |
JPH07238290A (en) | 1994-03-01 | 1995-09-12 | Nippon Oil Co Ltd | Electroviscous fluid |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US6071394A (en) * | 1996-09-06 | 2000-06-06 | Nanogen, Inc. | Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis |
US5459325A (en) | 1994-07-19 | 1995-10-17 | Molecular Dynamics, Inc. | High-speed fluorescence scanner |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US5630924A (en) * | 1995-04-20 | 1997-05-20 | Perseptive Biosystems, Inc. | Compositions, methods and apparatus for ultrafast electroseparation analysis |
US5626734A (en) * | 1995-08-18 | 1997-05-06 | University Technologies International, Inc. | Filter for perfusion cultures of animal cells and the like |
DE19544127C1 (en) | 1995-11-27 | 1997-03-20 | Gimsa Jan Dr | Suspended particle micro-manipulation |
AU729224B2 (en) | 1996-01-31 | 2001-01-25 | Board Of Regents, The University Of Texas System | Fractionation using dielectrophoresis and field flow fractionation |
DE69709377T2 (en) | 1996-09-04 | 2002-08-14 | Scandinavian Micro Biodevices | MICROFLOWING SYSTEM FOR PARTICLE ANALYSIS AND SEPARATION |
GB9619093D0 (en) | 1996-09-12 | 1996-10-23 | Scient Generics Ltd | Methods of analysis/separation |
DE19653659C1 (en) | 1996-12-20 | 1998-05-20 | Guenter Prof Dr Fuhr | Electrode arrangement for field cages |
WO1998049344A1 (en) * | 1997-04-28 | 1998-11-05 | Lockheed Martin Energy Research Corporation | Method and apparatus for analyzing nucleic acids |
US5869004A (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
WO1999017883A1 (en) | 1997-10-06 | 1999-04-15 | California Institute Of Technology | Electrostatic particle transportation |
DE19815882A1 (en) | 1998-04-08 | 1999-10-14 | Fuhr Guenther | Method and device for manipulating microparticles in fluid flows |
DE19983263T1 (en) * | 1998-05-29 | 2001-05-31 | Ind Res Ltd | Method and device for concentrating and / or positioning particles or cells |
US6093370A (en) * | 1998-06-11 | 2000-07-25 | Hitachi, Ltd. | Polynucleotide separation method and apparatus therefor |
EP1092144A1 (en) | 1998-06-29 | 2001-04-18 | Evotec BioSystems AG | Method and device for manipulating particles in microsystems |
US6132685A (en) * | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US6572830B1 (en) * | 1998-10-09 | 2003-06-03 | Motorola, Inc. | Integrated multilayered microfludic devices and methods for making the same |
US6203683B1 (en) * | 1998-11-09 | 2001-03-20 | Princeton University | Electrodynamically focused thermal cycling device |
DE19859461A1 (en) | 1998-12-22 | 2000-06-29 | Evotec Biosystems Ag | Method and device for the convective movement of liquids in microsystems |
US6352838B1 (en) * | 1999-04-07 | 2002-03-05 | The Regents Of The Universtiy Of California | Microfluidic DNA sample preparation method and device |
US6942776B2 (en) | 1999-05-18 | 2005-09-13 | Silicon Biosystems S.R.L. | Method and apparatus for the manipulation of particles by means of dielectrophoresis |
WO2000073780A1 (en) | 1999-05-28 | 2000-12-07 | Proteologics, Inc. | Methods and apparatus for nonlinear mobility electrophoresis separation |
US6824664B1 (en) | 1999-11-04 | 2004-11-30 | Princeton University | Electrode-less dielectrophorises for polarizable particles |
AU2427301A (en) | 1999-12-01 | 2001-06-12 | Regents Of The University Of California, The | Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells |
US6537433B1 (en) * | 2000-03-10 | 2003-03-25 | Applera Corporation | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
CN1319761A (en) | 2000-03-15 | 2001-10-31 | 清华大学 | Apparatus and method for high-flux electric rotation detection |
AU2001247478A1 (en) | 2000-03-16 | 2001-09-24 | Sri International | Microlaboratory devices and methods |
EP1716926A3 (en) | 2000-04-13 | 2007-08-29 | Wako Pure Chemical Industries Ltd | Electrode for dielectrophoretic apparatus, dielectrophoretic apparatus, method for manufacturing the same, and method for separating substances using the electrode or dielectrophoretic apparatus |
AU2001252973A1 (en) | 2000-04-17 | 2001-10-30 | Purdue Research Foundation | Biosensor and related method |
US6780584B1 (en) | 2000-09-27 | 2004-08-24 | Nanogen, Inc. | Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics |
CN1325909C (en) | 2000-09-27 | 2007-07-11 | 清华大学 | Apparatus for particle operation and guide and use method thereof |
CN100495030C (en) | 2000-09-30 | 2009-06-03 | 清华大学 | Multi-force operator and use thereof |
US6833542B2 (en) | 2000-11-13 | 2004-12-21 | Genoptix, Inc. | Method for sorting particles |
US6784420B2 (en) | 2000-11-13 | 2004-08-31 | Genoptix, Inc. | Method of separating particles using an optical gradient |
US6936811B2 (en) | 2000-11-13 | 2005-08-30 | Genoptix, Inc. | Method for separating micro-particles |
US6744038B2 (en) | 2000-11-13 | 2004-06-01 | Genoptix, Inc. | Methods of separating particles using an optical gradient |
US20030007894A1 (en) | 2001-04-27 | 2003-01-09 | Genoptix | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
US6787018B1 (en) | 2000-12-08 | 2004-09-07 | The Regents Of The University Of California | Dielectrophoretic concentration of particles under electrokinetic flow |
US6764583B2 (en) | 2000-12-13 | 2004-07-20 | The Regents Of The University Of California | Using impedance measurements for detecting pathogens trapped in an electric field |
US6685812B2 (en) | 2001-01-09 | 2004-02-03 | The Regents Of The University Of California | Movement of particles using sequentially activated dielectrophoretic particle trapping |
US6949176B2 (en) | 2001-02-28 | 2005-09-27 | Lightwave Microsystems Corporation | Microfluidic control using dielectric pumping |
US6706163B2 (en) | 2001-03-21 | 2004-03-16 | Michael Seul | On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces |
US6761811B2 (en) | 2001-03-27 | 2004-07-13 | The Regents Of The University Of California | Multi-stage separations based on dielectrophoresis |
US6730204B2 (en) | 2001-03-27 | 2004-05-04 | The Regents Of The University Of California | Three dimensional separation trap based on dielectrophoresis and use thereof |
US6660493B2 (en) | 2001-03-28 | 2003-12-09 | The Regents Of The University Of California | Hydrodynamic enhanced dielectrophoretic particle trapping |
EP1335198B1 (en) | 2002-02-01 | 2004-03-03 | Leister Process Technologies | Microfluidic component and procedure for sorting particles in a fluid |
US6887362B2 (en) | 2002-02-06 | 2005-05-03 | Nanogen, Inc. | Dielectrophoretic separation and immunoassay methods on active electronic matrix devices |
-
2000
- 2000-03-10 US US09/522,638 patent/US6537433B1/en not_active Expired - Lifetime
-
2001
- 2001-03-08 EP EP01918488A patent/EP1261863B1/en not_active Expired - Lifetime
- 2001-03-08 AU AU2001245558A patent/AU2001245558A1/en not_active Abandoned
- 2001-03-08 DE DE60108848T patent/DE60108848T2/en not_active Expired - Lifetime
- 2001-03-08 WO PCT/US2001/007576 patent/WO2001069230A2/en active IP Right Grant
- 2001-03-08 JP JP2001568062A patent/JP2003527601A/en not_active Withdrawn
- 2001-03-08 CA CA002402189A patent/CA2402189A1/en not_active Abandoned
- 2001-03-08 AT AT01918488T patent/ATE289065T1/en not_active IP Right Cessation
-
2002
- 2002-10-27 US US10/281,770 patent/US6969454B2/en not_active Expired - Lifetime
-
2005
- 2005-11-28 US US11/288,664 patent/US7704363B2/en not_active Expired - Lifetime
-
2010
- 2010-04-26 US US12/767,644 patent/US8083917B2/en not_active Expired - Fee Related
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5059294A (en) * | 1985-12-26 | 1991-10-22 | The University Of Puerto Rico | Method for separating nucleic acids and nucleic acid probes |
US5344535A (en) * | 1989-11-27 | 1994-09-06 | British Technology Group Limited | Dielectrophoretic characterization of micro-organisms and other particles |
WO1993005390A1 (en) * | 1991-08-28 | 1993-03-18 | Guzman Norberto A | Automated capillary electrophoresis apparatus |
GB2266153A (en) * | 1992-04-16 | 1993-10-20 | British Tech Group | Dielectrophoretic separating of a mixture of particles |
DE19500683A1 (en) * | 1994-12-10 | 1996-06-13 | Guenter Prof Dr Fuhr | Trapping or movement of micro-particles in micro-structures generating electromagnetic cage field |
WO1996042013A1 (en) * | 1995-06-08 | 1996-12-27 | Visible Genetics Inc. | Microelectrophoresis chip for moving and separating nucleic acids and other charged molecules |
US6007690A (en) * | 1996-07-30 | 1999-12-28 | Aclara Biosciences, Inc. | Integrated microfluidic devices |
WO1999063332A1 (en) * | 1998-06-05 | 1999-12-09 | Sarnoff Corporation | Apparatus for separating molecules |
Non-Patent Citations (1)
Title |
---|
FUHR G ET AL: "POSITIONING AND MANIPULATION OF CELLS AND MICROPARTICLES USING MINIATURIZED ELECTRIC FIELD TRAPS AND TRAVELLING WAVES" SENSORS AND MATERIALS, SCIENTIFIC PUBLISHING DIVISION OF MYU, TOKYO, JP, vol. 7, no. 2, 1995, pages 131-146, XP000617698 ISSN: 0914-4935 * |
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Also Published As
Publication number | Publication date |
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AU2001245558A1 (en) | 2001-09-24 |
DE60108848T2 (en) | 2006-02-09 |
EP1261863B1 (en) | 2005-02-09 |
US6969454B2 (en) | 2005-11-29 |
WO2001069230A3 (en) | 2002-06-20 |
US20060081474A1 (en) | 2006-04-20 |
JP2003527601A (en) | 2003-09-16 |
US20030057094A1 (en) | 2003-03-27 |
US8083917B2 (en) | 2011-12-27 |
CA2402189A1 (en) | 2001-09-20 |
ATE289065T1 (en) | 2005-02-15 |
DE60108848D1 (en) | 2005-03-17 |
EP1261863A2 (en) | 2002-12-04 |
US6537433B1 (en) | 2003-03-25 |
US20100203580A1 (en) | 2010-08-12 |
US7704363B2 (en) | 2010-04-27 |
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