WO2001051917A3 - An apparatus for and method of discriminating against unwanted ionized species in mass spectrometry with collision and reaction devices - Google Patents

An apparatus for and method of discriminating against unwanted ionized species in mass spectrometry with collision and reaction devices Download PDF

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Publication number
WO2001051917A3
WO2001051917A3 PCT/CA2000/001405 CA0001405W WO0151917A3 WO 2001051917 A3 WO2001051917 A3 WO 2001051917A3 CA 0001405 W CA0001405 W CA 0001405W WO 0151917 A3 WO0151917 A3 WO 0151917A3
Authority
WO
WIPO (PCT)
Prior art keywords
ions
collision
mass spectrometry
cell
against unwanted
Prior art date
Application number
PCT/CA2000/001405
Other languages
French (fr)
Other versions
WO2001051917A2 (en
Inventor
Dmitry R Bandura
Scott D Tanner
Vladimir I Baranov
Original Assignee
Mds Inc
Dmitry R Bandura
Scott D Tanner
Vladimir I Baranov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mds Inc, Dmitry R Bandura, Scott D Tanner, Vladimir I Baranov filed Critical Mds Inc
Priority to AU18466/01A priority Critical patent/AU1846601A/en
Priority to JP2001552079A priority patent/JP2003519899A/en
Priority to CA002396925A priority patent/CA2396925A1/en
Priority to EP00981104A priority patent/EP1252648A2/en
Publication of WO2001051917A2 publication Critical patent/WO2001051917A2/en
Publication of WO2001051917A3 publication Critical patent/WO2001051917A3/en

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/061—Ion deflecting means, e.g. ion gates

Abstract

A spectrometer apparatus and method provides a modulated stream of ions which can be from the source that is inherently modulated, or a continuous source that is subject to some modulation or gating technique. The ions are then delivered as a pulse or a series of pulses of ions into a pressurized reaction cell, in which reaction and/or collision with gas in the cell occurs. The ions are then passed from the pressurized cell into a mass analyzer for detection. The mass analyzer, ion detector or ion induced signal processing system are operated in such a manner that only ions that arrive at the detector in a period of time set relatively to the time of release of pulses of ions are used for analysis. It has been found that by careful selection of this period, enhanced specificity can be achieved and the effect of interference ions can be reduced.
PCT/CA2000/001405 2000-01-10 2000-11-24 An apparatus for and method of discriminating against unwanted ionized species in mass spectrometry with collision and reaction devices WO2001051917A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU18466/01A AU1846601A (en) 2000-01-10 2000-11-24 An apparatus for and method of discriminating against unwanted ionized species in mass spectrometry with collision and reaction devices
JP2001552079A JP2003519899A (en) 2000-01-10 2000-11-24 Apparatus and method for discriminating unwanted ionized species in mass spectrometry by collision and reactor
CA002396925A CA2396925A1 (en) 2000-01-10 2000-11-24 An apparatus for and method of discriminating against unwanted ionized species in mass spectrometry with collision and reaction devices
EP00981104A EP1252648A2 (en) 2000-01-10 2000-11-24 An apparatus for and method of discriminating against unwanted ionized species in mass spectrometry with collision and reaction devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17530500P 2000-01-10 2000-01-10
US60/175,305 2000-01-10

Publications (2)

Publication Number Publication Date
WO2001051917A2 WO2001051917A2 (en) 2001-07-19
WO2001051917A3 true WO2001051917A3 (en) 2002-04-04

Family

ID=22639771

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/001405 WO2001051917A2 (en) 2000-01-10 2000-11-24 An apparatus for and method of discriminating against unwanted ionized species in mass spectrometry with collision and reaction devices

Country Status (5)

Country Link
EP (1) EP1252648A2 (en)
JP (1) JP2003519899A (en)
AU (1) AU1846601A (en)
CA (2) CA2326514A1 (en)
WO (1) WO2001051917A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006045200A1 (en) * 2004-10-28 2006-05-04 Albert Edward Litherland Method and apparatus for separation of isobaric interferences
JP4925797B2 (en) * 2006-11-28 2012-05-09 独立行政法人農業環境技術研究所 Iodine analysis method and apparatus
DE102009048063A1 (en) 2009-09-30 2011-03-31 Eads Deutschland Gmbh Ionization method, ion generating device and use thereof in ion mobility spectrometry
GB2561142B (en) 2016-12-19 2019-05-08 Thermo Fisher Scient Bremen Gmbh Determination of isobaric interferences in a mass spectrometer

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0813228A1 (en) * 1996-06-10 1997-12-17 Micromass Limited Plasma mass spectrometer
US5753909A (en) * 1995-11-17 1998-05-19 Bruker Analytical Systems, Inc. High resolution postselector for time-of-flight mass spectrometery
EP0860859A1 (en) * 1996-08-29 1998-08-26 Nkk Corporation Laser ionization mass spectroscope and mass spectrometric analysis method
US5847386A (en) * 1995-08-11 1998-12-08 Mds Inc. Spectrometer with axial field
WO1998056030A1 (en) * 1997-06-04 1998-12-10 Mds Inc. Bandpass reactive collison cell
WO1999062101A1 (en) * 1998-05-29 1999-12-02 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guides

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5847386A (en) * 1995-08-11 1998-12-08 Mds Inc. Spectrometer with axial field
US5753909A (en) * 1995-11-17 1998-05-19 Bruker Analytical Systems, Inc. High resolution postselector for time-of-flight mass spectrometery
EP0813228A1 (en) * 1996-06-10 1997-12-17 Micromass Limited Plasma mass spectrometer
EP0860859A1 (en) * 1996-08-29 1998-08-26 Nkk Corporation Laser ionization mass spectroscope and mass spectrometric analysis method
WO1998056030A1 (en) * 1997-06-04 1998-12-10 Mds Inc. Bandpass reactive collison cell
WO1999062101A1 (en) * 1998-05-29 1999-12-02 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOUGLAS D J ET AL: "COLLISIONAL FOCUSING EFFECTS IN RADIO FREQUENCY QUADRUPOLES", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, ELSEVIER SCIENCE INC., NEW YORK, NY, US, vol. 2, 1992, pages 398 - 408, XP002041216, ISSN: 1044-0305 *
ROWAN J T ET AL: "Attenuation of polyatomic ion interferences in inductively coupled plasma mass spectrometry by gas-phase collisions", APPLIED SPECTROSCOPY, THE SOCIETY FOR APPLIED SPECTROSCOPY. BALTIMORE, US, vol. 43, no. 6, 1989, pages 976 - 980, XP000032932, ISSN: 0003-7028 *
TANNER S D ET AL: "A dynamic reaction cell for inductively coupled plasma mass spectrometry (ICP-DRC-MS). II. Reduction of interferences produced within the cell", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, ELSEVIER SCIENCE INC., NEW YORK, NY, US, vol. 10, no. 11, November 1999 (1999-11-01), pages 1083 - 1094, XP004264742, ISSN: 1044-0305 *

Also Published As

Publication number Publication date
WO2001051917A2 (en) 2001-07-19
EP1252648A2 (en) 2002-10-30
CA2396925A1 (en) 2001-07-19
CA2326514A1 (en) 2001-07-10
AU1846601A (en) 2001-07-24
JP2003519899A (en) 2003-06-24

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