WO2001045675A3 - Valve for osmotic devices - Google Patents

Valve for osmotic devices Download PDF

Info

Publication number
WO2001045675A3
WO2001045675A3 PCT/US2000/034314 US0034314W WO0145675A3 WO 2001045675 A3 WO2001045675 A3 WO 2001045675A3 US 0034314 W US0034314 W US 0034314W WO 0145675 A3 WO0145675 A3 WO 0145675A3
Authority
WO
WIPO (PCT)
Prior art keywords
valve
osmotic
agent
beneficial agent
reservoir
Prior art date
Application number
PCT/US2000/034314
Other languages
French (fr)
Other versions
WO2001045675A8 (en
WO2001045675A2 (en
Inventor
John P Carr
James B Di Eckenhoff
Original Assignee
Alza Corp
Dennis Bonnie Burdett Lf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp, Dennis Bonnie Burdett Lf filed Critical Alza Corp
Priority to EP00984483A priority Critical patent/EP1328256B1/en
Priority to KR1020027008287A priority patent/KR100734187B1/en
Priority to AU21095/01A priority patent/AU773354B2/en
Priority to AT00984483T priority patent/ATE306908T1/en
Priority to CA002402637A priority patent/CA2402637C/en
Priority to DE60023361T priority patent/DE60023361T2/en
Publication of WO2001045675A2 publication Critical patent/WO2001045675A2/en
Publication of WO2001045675A3 publication Critical patent/WO2001045675A3/en
Publication of WO2001045675A8 publication Critical patent/WO2001045675A8/en
Priority to HK03107967A priority patent/HK1055680A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule having a beneficial agent reservoir, an osmotic agent which expands on contact with fluid imbibed through a permeable membrane retained by the implant capsule, a delivery port, and a valve for opening and closing the delivery port. When the osmotic agent expands, a pressure is exerted against a separating member positioned between the beneficial agent reservoir and the osmotic agent. The separating member moves within the capsule, thereby forcing the valve to move a distance such that the beneficial agent can exit the reservoir through the delivery port.
PCT/US2000/034314 1999-12-21 2000-12-13 Valve for osmotic devices WO2001045675A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP00984483A EP1328256B1 (en) 1999-12-21 2000-12-13 Valve for osmotic devices
KR1020027008287A KR100734187B1 (en) 1999-12-21 2000-12-13 Valve for osmotic device
AU21095/01A AU773354B2 (en) 1999-12-21 2000-12-13 Valve for osmotic devices
AT00984483T ATE306908T1 (en) 1999-12-21 2000-12-13 VALVE FOR OSMOTIC DEVICES
CA002402637A CA2402637C (en) 1999-12-21 2000-12-13 Valve for osmotic devices
DE60023361T DE60023361T2 (en) 1999-12-21 2000-12-13 VALVE FOR OSMOTIC DEVICES
HK03107967A HK1055680A1 (en) 1999-12-21 2003-11-05 Valve for osmotic devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17130599P 1999-12-21 1999-12-21
US60/171,305 1999-12-21

Publications (3)

Publication Number Publication Date
WO2001045675A2 WO2001045675A2 (en) 2001-06-28
WO2001045675A3 true WO2001045675A3 (en) 2002-01-03
WO2001045675A8 WO2001045675A8 (en) 2003-05-22

Family

ID=22623268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/034314 WO2001045675A2 (en) 1999-12-21 2000-12-13 Valve for osmotic devices

Country Status (11)

Country Link
US (2) US6508808B1 (en)
EP (1) EP1328256B1 (en)
KR (1) KR100734187B1 (en)
AT (1) ATE306908T1 (en)
AU (1) AU773354B2 (en)
CA (1) CA2402637C (en)
DE (1) DE60023361T2 (en)
DK (1) DK1328256T3 (en)
ES (1) ES2248156T3 (en)
HK (1) HK1055680A1 (en)
WO (1) WO2001045675A2 (en)

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US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
ES2248156T3 (en) * 1999-12-21 2006-03-16 Alza Corporation VALVE FOR OSMOTIC DEVICES.
US6929636B1 (en) * 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
DE60315474T2 (en) * 2002-06-17 2008-04-24 Alza Corp., Mountain View OSMOTIC DISTRIBUTION SYSTEMS WITH OSMOTIC DRIVE AND METHOD FOR PRODUCING BOTH THE OSMOTIC DRIVE AND THE OSMOTIC DELIVERY SYSTEM
US7014636B2 (en) * 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US20040224903A1 (en) * 2002-12-19 2004-11-11 Stephen Berry Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device
AR043810A1 (en) * 2003-03-31 2005-08-17 Alza Corp OSMOTIC SYSTEM OF ADMINISTRATION AND METHOD TO DECREASE TIMES OF ARRIVAL IN THE OPERATING REGIME IN OSMOTIC SYSTEMS OF ADMINISTRATION
CA2520775A1 (en) * 2003-03-31 2004-10-21 Alza Corporation Non-aqueous single phase vehicles and formulations utilizing such vehicles
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US20050175701A1 (en) * 2004-02-10 2005-08-11 Alza Corporation Capillary moderator for osmotic delivery system
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
EP2361630A1 (en) * 2005-02-03 2011-08-31 Intarcia Therapeutics, Inc Implantable drug delivery device comprising particles and an osmotic pump
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US7959938B2 (en) 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
DE602007009377D1 (en) 2006-05-30 2010-11-04 Intarcia Therapeutics Inc SECONDARY FLOW MODULATOR WITH AN INTERNAL CHANNEL FOR AN OSMOTIC OUTPUT SYSTEM
CN102274557B (en) 2006-08-09 2014-12-03 精达制药公司 Osmotic delivery systems and piston assemblies
US7538652B2 (en) * 2006-08-29 2009-05-26 International Business Machines Corporation Electrical component tuned by conductive layer deletion
DK2157967T3 (en) 2007-04-23 2013-04-08 Intarcia Therapeutics Inc Suspension formulations of insulinotropic peptides and applications thereof
FI7960U1 (en) * 2007-04-27 2008-07-28 Bayer Schering Pharma Oy Membrane shell for an implantable dosing system
US8343140B2 (en) * 2008-02-13 2013-01-01 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US8028743B2 (en) * 2008-04-17 2011-10-04 Hewlett-Packard Development Company, L.P. Passive cooling in response to ambient environmental properties
NZ592113A (en) * 2008-10-15 2012-04-27 Intarcia Therapeutics Inc Highly concentrated drug particles, formulations, suspensions and uses thereof
CA2979355C (en) * 2009-05-18 2023-02-21 Dose Medical Corporation Drug eluting ocular implant
LT2462246T (en) 2009-09-28 2017-11-27 Intarcia Therapeutics, Inc Rapid establishment and/or termination of substantial steady-state drug delivery
US20110311606A1 (en) * 2010-06-18 2011-12-22 Coldren Bret A Punctal plugs with continuous or pulsatile drug release mechanism
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US20130090633A1 (en) * 2011-10-07 2013-04-11 University Of Southern California Osmotic patch pump
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
CN113598842A (en) 2015-06-03 2021-11-05 因塔西亚制药公司 Implant placement and removal system
WO2017027376A1 (en) 2015-08-07 2017-02-16 Massachusetts Institute Of Technology Subcutaneous drug delivery device with manual activation and deactivation of drug release
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
IL258904B (en) 2015-11-05 2022-09-01 Massachusetts Gen Hospital Intrathecal delivery of nucleic acid sequences encoding abcd1 for treatment of adrenomyeloneuropathy
EP3458084B1 (en) 2016-05-16 2020-04-01 Intarcia Therapeutics, Inc Glucagon-receptor selective polypeptides and methods of use thereof
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
US10406336B2 (en) * 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
CA3040906A1 (en) 2016-10-20 2018-04-26 Peptron, Inc. Methods of delivering a neuroprotective polypeptide to the central nervous system
EP3565580B1 (en) 2017-01-03 2024-03-06 i2o Therapeutics, Inc. Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel
MX2019010651A (en) 2017-03-08 2020-01-13 Intarcia Therapeutics Inc Apparatus and methods for administration of a nauseogenic compound from a drug delivery device.
CN115568457A (en) * 2018-03-16 2023-01-06 诺埃尔·埃尔曼 Controlled release device and method for integrating an active ingredient into a matrix
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
CN113195524A (en) 2018-10-11 2021-07-30 因塔西亚治疗公司 Human amylin analog polypeptides and methods of use
BR112022013784A2 (en) 2020-01-13 2022-10-11 Durect Corp DISTRIBUTION SYSTEMS FOR PROLONGED RELEASE DRUGS WITH REDUCED IMPURITIES AND RELATED METHODS

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US5498255A (en) * 1993-08-17 1996-03-12 Alza Corporation Osmotic device for protracted pulsatile delivery of agent
WO1998042317A2 (en) * 1997-03-24 1998-10-01 Alza Corporation Implantable delivery device with self adjustable exit port

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Publication number Priority date Publication date Assignee Title
EP0627231A2 (en) * 1993-05-05 1994-12-07 Alza Corporation Delivery devices with pulsatile effect
US5498255A (en) * 1993-08-17 1996-03-12 Alza Corporation Osmotic device for protracted pulsatile delivery of agent
WO1998042317A2 (en) * 1997-03-24 1998-10-01 Alza Corporation Implantable delivery device with self adjustable exit port

Also Published As

Publication number Publication date
WO2001045675A8 (en) 2003-05-22
US6508808B1 (en) 2003-01-21
CA2402637C (en) 2007-04-10
AU2109501A (en) 2001-07-03
EP1328256B1 (en) 2005-10-19
DE60023361T2 (en) 2006-04-27
ATE306908T1 (en) 2005-11-15
US20030093063A1 (en) 2003-05-15
ES2248156T3 (en) 2006-03-16
EP1328256A2 (en) 2003-07-23
KR100734187B1 (en) 2007-07-02
DK1328256T3 (en) 2006-02-20
DE60023361D1 (en) 2005-11-24
KR20030009336A (en) 2003-01-29
US6682522B2 (en) 2004-01-27
WO2001045675A2 (en) 2001-06-28
AU773354B2 (en) 2004-05-20
HK1055680A1 (en) 2004-01-21
CA2402637A1 (en) 2001-06-28

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