WO2001043722A3 - Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces - Google Patents

Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces Download PDF

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Publication number
WO2001043722A3
WO2001043722A3 PCT/US2000/033814 US0033814W WO0143722A3 WO 2001043722 A3 WO2001043722 A3 WO 2001043722A3 US 0033814 W US0033814 W US 0033814W WO 0143722 A3 WO0143722 A3 WO 0143722A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulations
methods
pharmaceutical
skin
administer
Prior art date
Application number
PCT/US2000/033814
Other languages
French (fr)
Other versions
WO2001043722A2 (en
Inventor
David W Osborne
Russell J Mumper
Original Assignee
Atrix Lab Inc
David W Osborne
Russell J Mumper
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atrix Lab Inc, David W Osborne, Russell J Mumper filed Critical Atrix Lab Inc
Priority to EP00984328A priority Critical patent/EP1237540A2/en
Priority to AU20964/01A priority patent/AU784676B2/en
Priority to JP2001544661A priority patent/JP2003516958A/en
Priority to CA002394569A priority patent/CA2394569A1/en
Publication of WO2001043722A2 publication Critical patent/WO2001043722A2/en
Publication of WO2001043722A3 publication Critical patent/WO2001043722A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams

Abstract

Bioadhesive formulations to deliver, for both local and systemic effects, a wide variety of drugs of varying degrees of solubility are described. These formulations can be gels or aerosols and comprise a water-insoluble, pharmaceutically acceptable alkyl cellulose, a solvent system comprising a volatile solvent and water, a solubilizing agent or a dispersing agent, or a mixture thereof, and a pharmaceutical. These formulations can be made bioerodible and release the pharmaceutical in a controlled manner. Formulations further comprising a propellant such as 1,1-difluoroethane are also provided. The delivery can be made to a skin surface or to a mucosal surface. Methods for preparing and administering these formulations are also provided. Several specific examples using the anti-ulcer medication 2-amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano-[2,3-b]-pyridine-3-carboxylic acid are provided.
PCT/US2000/033814 1999-12-17 2000-12-13 Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces WO2001043722A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00984328A EP1237540A2 (en) 1999-12-17 2000-12-13 Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces
AU20964/01A AU784676B2 (en) 1999-12-17 2000-12-13 Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces
JP2001544661A JP2003516958A (en) 1999-12-17 2000-12-13 Pharmaceutical gel and aerosol formulation and method for administering the formulation to skin and mucosal surfaces
CA002394569A CA2394569A1 (en) 1999-12-17 2000-12-13 Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/466,380 1999-12-17
US09/466,380 US6432415B1 (en) 1999-12-17 1999-12-17 Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces

Publications (2)

Publication Number Publication Date
WO2001043722A2 WO2001043722A2 (en) 2001-06-21
WO2001043722A3 true WO2001043722A3 (en) 2002-01-17

Family

ID=23851536

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/033814 WO2001043722A2 (en) 1999-12-17 2000-12-13 Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces

Country Status (6)

Country Link
US (1) US6432415B1 (en)
EP (1) EP1237540A2 (en)
JP (1) JP2003516958A (en)
AU (1) AU784676B2 (en)
CA (1) CA2394569A1 (en)
WO (1) WO2001043722A2 (en)

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Also Published As

Publication number Publication date
AU784676B2 (en) 2006-05-25
US6432415B1 (en) 2002-08-13
JP2003516958A (en) 2003-05-20
EP1237540A2 (en) 2002-09-11
WO2001043722A2 (en) 2001-06-21
CA2394569A1 (en) 2001-06-21
AU2096401A (en) 2001-06-25

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