WO2001042781A3 - Supracolonic aerodigestive neoplasm detection - Google Patents

Supracolonic aerodigestive neoplasm detection Download PDF

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Publication number
WO2001042781A3
WO2001042781A3 PCT/US2000/042683 US0042683W WO0142781A3 WO 2001042781 A3 WO2001042781 A3 WO 2001042781A3 US 0042683 W US0042683 W US 0042683W WO 0142781 A3 WO0142781 A3 WO 0142781A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
neoplasm
supracolonic aerodigestive
supracolonic
materials
Prior art date
Application number
PCT/US2000/042683
Other languages
French (fr)
Other versions
WO2001042781A9 (en
WO2001042781A2 (en
Inventor
Anthony P Shuber
David A Ahlquist
Original Assignee
Exact Sciences Corp
Mayo Clinic
Anthony P Shuber
David A Ahlquist
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exact Sciences Corp, Mayo Clinic, Anthony P Shuber, David A Ahlquist filed Critical Exact Sciences Corp
Priority to JP2001544020A priority Critical patent/JP2003516138A/en
Priority to EP00992876A priority patent/EP1238113B1/en
Priority to AU47142/01A priority patent/AU4714201A/en
Priority to AT00992876T priority patent/ATE458831T1/en
Priority to US10/149,464 priority patent/US7368233B2/en
Priority to DE60043896T priority patent/DE60043896D1/en
Priority to CA002394921A priority patent/CA2394921A1/en
Publication of WO2001042781A2 publication Critical patent/WO2001042781A2/en
Publication of WO2001042781A9 publication Critical patent/WO2001042781A9/en
Publication of WO2001042781A3 publication Critical patent/WO2001042781A3/en
Priority to US12/042,988 priority patent/US7981612B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

The invention provides methods and materials for detecting supracolonic aerodigestive premalignant and malignant neoplasms. Specifically, the invention provides methods and materials for determining whether a stool sample from a mammal contains a neoplasm-specific marker from a neoplasm located in the supracolonic aerodigestive tissue of a mammal. These neoplasm-specific markers are selected from the group consisting of nucleic acids having a point mutation (K-ras, APC, p53), nucleic acids that reflect microsatellite instability (BAT-26), and high integrity nucleic acids (DNA longer than 200 bp).
PCT/US2000/042683 1999-12-07 2000-12-07 Supracolonic aerodigestive neoplasm detection WO2001042781A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2001544020A JP2003516138A (en) 1999-12-07 2000-12-07 Detection of aerobic digestive neoplasms in the colon
EP00992876A EP1238113B1 (en) 1999-12-07 2000-12-07 Detection of lung neoplasms in stool
AU47142/01A AU4714201A (en) 1999-12-07 2000-12-07 Supracolonic aerodigestive neoplasm detection
AT00992876T ATE458831T1 (en) 1999-12-07 2000-12-07 METHOD FOR DETECTING LUNG NEOPLASMS IN FECAL SAMPLES
US10/149,464 US7368233B2 (en) 1999-12-07 2000-12-07 Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm
DE60043896T DE60043896D1 (en) 1999-12-07 2000-12-07 PROCESS FOR DETECTING LUNG NEOPLASMS IN FAKAL SAMPLES
CA002394921A CA2394921A1 (en) 1999-12-07 2000-12-07 Supracolonic aerodigestive neoplasm detection
US12/042,988 US7981612B2 (en) 1999-12-07 2008-03-05 Methods of screening for supracolonic neoplasms based on stool samples containing a nucleic acid marker indicative of a neoplasm

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16945799P 1999-12-07 1999-12-07
US60/169,457 1999-12-07
US19607400P 2000-04-10 2000-04-10
US60/196,074 2000-04-10

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10149464 A-371-Of-International 2000-12-07
US12/042,988 Continuation US7981612B2 (en) 1999-12-07 2008-03-05 Methods of screening for supracolonic neoplasms based on stool samples containing a nucleic acid marker indicative of a neoplasm

Publications (3)

Publication Number Publication Date
WO2001042781A2 WO2001042781A2 (en) 2001-06-14
WO2001042781A9 WO2001042781A9 (en) 2001-10-11
WO2001042781A3 true WO2001042781A3 (en) 2002-05-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/042683 WO2001042781A2 (en) 1999-12-07 2000-12-07 Supracolonic aerodigestive neoplasm detection

Country Status (8)

Country Link
US (2) US7368233B2 (en)
EP (1) EP1238113B1 (en)
JP (1) JP2003516138A (en)
AT (1) ATE458831T1 (en)
AU (1) AU4714201A (en)
CA (1) CA2394921A1 (en)
DE (1) DE60043896D1 (en)
WO (1) WO2001042781A2 (en)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
AU767983B2 (en) * 1999-04-09 2003-11-27 Esoterix Genetic Laboratories, Llc Methods for detecting nucleic acids indicative of cancer
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6919174B1 (en) * 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
JP2003516138A (en) 1999-12-07 2003-05-13 エグザクト サイエンシーズ コーポレイション Detection of aerobic digestive neoplasms in the colon
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
AU2003213107A1 (en) * 2002-02-15 2003-09-09 Exact Sciences Corporation Methods for analysis of molecular events
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US20040259101A1 (en) * 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
US20050014165A1 (en) * 2003-07-18 2005-01-20 California Pacific Medical Center Biomarker panel for colorectal cancer
WO2005113769A1 (en) * 2004-05-14 2005-12-01 Exact Sciences Corporation Method for stabilizing biological samples for nucleic acid analysis
WO2006047787A2 (en) 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
WO2006094149A2 (en) * 2005-03-01 2006-09-08 Exact Sciences Corporation Methods and compositions for detecting adenoma
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
WO2008008515A2 (en) * 2006-07-14 2008-01-17 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
AU2008260075A1 (en) 2007-05-31 2008-12-11 California Pacific Medical Center Method to predict or diagnose a gastrointestinal disorder or disease
WO2009015299A1 (en) 2007-07-26 2009-01-29 California Pacific Medical Center Method to predict or diagnose a gastrointestinal disorder or disease
EP2474626B1 (en) 2008-02-15 2014-08-13 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
WO2011120024A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US8663920B2 (en) 2011-07-29 2014-03-04 Bio-Rad Laboratories, Inc. Library characterization by digital assay
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
EP2940153B1 (en) 2009-09-02 2020-05-13 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
US8399198B2 (en) * 2010-03-02 2013-03-19 Bio-Rad Laboratories, Inc. Assays with droplets transformed into capsules
JP6155419B2 (en) 2010-03-25 2017-07-05 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド Droplet transport system for detection
EP2550351A4 (en) 2010-03-25 2014-07-09 Quantalife Inc Detection system for droplet-based assays
EP2553463B1 (en) * 2010-03-26 2017-05-03 Hongzhi Zou Methods and materials for detecting colorectal neoplasm
CN103429331B (en) 2010-11-01 2016-09-28 伯乐生命医学产品有限公司 For forming the system of emulsion
JP2014509865A (en) 2011-03-18 2014-04-24 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド Multiplexed digital assay using a combination of signals
JP2014512826A (en) 2011-04-25 2014-05-29 バイオ−ラド ラボラトリーズ インコーポレイテッド Methods and compositions for nucleic acid analysis
CA2848162C (en) * 2011-09-12 2023-03-14 Creatics Llc Non-invasive methods of detecting target molecules
US8751261B2 (en) 2011-11-15 2014-06-10 Robert Bosch Gmbh Method and system for selection of patients to receive a medical device
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
MX367963B (en) 2012-09-04 2019-09-11 Guardant Health Inc Systems and methods to detect rare mutations and copy number variation.
US9994911B2 (en) 2013-03-14 2018-06-12 Mayo Foundation For Medical Education And Research Detecting neoplasm
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
WO2015095689A1 (en) 2013-12-19 2015-06-25 Exact Sciences Corporation Synthetic nucleic acid control molecules
EP3087204B1 (en) 2013-12-28 2018-02-14 Guardant Health, Inc. Methods and systems for detecting genetic variants
WO2015153284A1 (en) 2014-03-31 2015-10-08 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN107532124B (en) 2015-03-27 2022-08-09 精密科学公司 Detection of esophageal disorders
CN108138235B (en) 2015-08-31 2022-04-15 梅约医药教育及研究基金会 Detection of gastric tumors
CA3008651A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
EP3443089A4 (en) 2016-04-14 2020-04-22 Mayo Foundation for Medical Education and Research Detecting pancreatic high-grade dysplasia
CA3029838A1 (en) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Nucleic acid control molecules from non-human organisms
EP3978624A1 (en) 2016-07-19 2022-04-06 Exact Sciences Corporation Methylated control dna
CN109642250A (en) 2016-09-30 2019-04-16 夸登特健康公司 The method of multiresolution analysis for cell-free nucleic acid
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
EP3530257B1 (en) * 2016-10-21 2021-09-08 Kuraray Noritake Dental Inc. Self-adhesive dental composite resin
JP7356349B2 (en) 2017-02-28 2023-10-04 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ prostate cancer detection
EP3717644A4 (en) 2017-11-30 2021-12-29 Mayo Foundation for Medical Education and Research Detecting breast cancer
CN113661249A (en) 2019-01-31 2021-11-16 夸登特健康公司 Compositions and methods for isolating cell-free DNA

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020235A1 (en) * 1992-04-01 1993-10-14 The Johns Hopkins University School Of Medicine Methods of detecting mammalian nucleic acids isolated from stool specimen and reagents therefor
US5352775A (en) * 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
US5527676A (en) * 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
WO1997009600A2 (en) * 1995-09-06 1997-03-13 Medical Research Council Method of isolating cells
WO1997019191A1 (en) * 1995-11-17 1997-05-29 Oegreid Dagfinn Method for detection of ki-ras mutations and kit to perform it
DE19712332A1 (en) * 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Method for the detection of microsatellite instability for tumor diagnosis
GB2327497A (en) * 1997-07-18 1999-01-27 Zeneca Ltd Diagnostic assay for cancer
WO1999053316A1 (en) * 1998-04-13 1999-10-21 Exact Laboratories, Inc. Methods for disease diagnosis from stool samples

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US433734A (en) * 1890-08-05 Device for carrying and affixing stamps
US485730A (en) * 1892-11-08 Peocess of treating oxidized or corroded lead
US3413464A (en) 1965-04-29 1968-11-26 Ibm Method for measuring the nucleic acid in biological cells after enhancement in an acidic solution
US4101279A (en) 1977-04-06 1978-07-18 Muhammed Javed Aslam Device for the collection and processing of stool specimens
US4333734A (en) 1980-01-18 1982-06-08 Sloan-Kettering Institute For Cancer Research Diagnostic device for fecal occult blood and method of use
US4535058A (en) 1982-10-01 1985-08-13 Massachusetts Institute Of Technology Characterization of oncogenes and assays based thereon
US4309782A (en) 1980-09-11 1982-01-12 Esteban Paulin Device for collecting fecal specimens
US4358535A (en) 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US5482834A (en) 1982-05-17 1996-01-09 Hahnemann University Evaluation of nucleic acids in a biological sample hybridization in a solution of chaotrophic salt solubilized cells
US4445235A (en) 1982-09-13 1984-05-01 Pearl Slover Stool specimen collector
US4578358A (en) 1983-05-03 1986-03-25 Warner-Lambert Company Collection of specimens and detection of occult blood therein
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4871838A (en) 1985-07-23 1989-10-03 The Board Of Rijks Universiteit Leiden Probes and methods for detecting activated ras oncogenes
US4705050A (en) 1985-10-02 1987-11-10 Markham Charles W Moisture-activated floatation device
US5348855A (en) 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
CA1341576C (en) 1986-08-11 2008-07-08 Thaddeus P. Dryja Diagnosis of retinoblastoma
US4735905A (en) 1986-08-15 1988-04-05 V-Tech, Inc. Specimen-gathering apparatus and method
US4935342A (en) 1986-12-01 1990-06-19 Syngene, Inc. Method of isolating and purifying nucleic acids from biological samples
AU625169B2 (en) 1987-03-23 1992-07-02 Imperial Chemical Industries Plc Molecular markers
US4857300A (en) 1987-07-27 1989-08-15 Cytocorp, Inc. Cytological and histological fixative formulation and methods for using same
AU631788B2 (en) 1988-04-15 1992-12-10 Montefiore Medical Center Method for determining state of malignant and pre-malignant progression
FR2630000A1 (en) 1988-04-18 1989-10-20 Sultan Bernard BOTTLE FOR COLLECTING AN URINARY BIOLOGICAL SAMPLE FOR CYTOBACTERIOLOGICAL EXAMINATION
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5087617A (en) 1989-02-15 1992-02-11 Board Of Regents, The University Of Texas System Methods and compositions for treatment of cancer using oligonucleotides
US5248671A (en) 1989-02-15 1993-09-28 Board Of Regents, The University Of Texas System Methods and compositions for treatment of cancer using oligonucleotides
US5380645A (en) 1989-03-16 1995-01-10 The Johns Hopkins University Generalized method for assessment of colorectal carcinoma
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
DE69032864T3 (en) 1989-03-29 2013-01-31 The Johns Hopkins University Evidence of failure of the wild-type p53 gene
US5192501A (en) 1989-04-04 1993-03-09 Helena Laboratories Corporation Method of formulating a test ink for a fecal occult blood test product
US5196167A (en) 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5589335A (en) 1989-04-05 1996-12-31 Amoco Corporation Hybridization promotion reagents
ES2059895T3 (en) 1989-06-23 1994-11-16 Canon Kk METHOD FOR THE DETECTION OF NUCLEIC ACID.
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
CA2029219A1 (en) 1989-11-08 1991-05-09 Mary K. Estes Methods and reagents to detect and characterize norwalk and related viruses
US5641628A (en) 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
US5137806A (en) 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
JPH05508307A (en) 1990-01-04 1993-11-25 ザ・ジョーンズ・ホプキンス・ユニバーシティ Genes deleted in human colorectal cancer
US5126239A (en) 1990-03-14 1992-06-30 E. I. Du Pont De Nemours And Company Process for detecting polymorphisms on the basis of nucleotide differences
US5200314A (en) 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
EP0489149B1 (en) 1990-06-27 2001-10-17 Princeton University Probes for detecting mutant p53
JPH06510363A (en) 1990-10-29 1994-11-17 ディカルブ　プラント　ジェネティクス Isolation of biological materials using magnetic particles
US5846710A (en) 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
EP0570497B1 (en) 1991-02-05 1996-05-08 Lifecodes Corporation Molecular genetic identification using probes that recognize polymorphic loci
CA2101943A1 (en) 1991-02-05 1992-08-06 Kamal Bahar Simple test for detecting carcinoembryonic antigen
US5330892A (en) 1991-03-13 1994-07-19 The Johns Hopkins University MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans
US5468610A (en) 1991-05-29 1995-11-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Three highly informative microsatellite repeat polymorphic DNA markers
US5378602A (en) 1991-05-29 1995-01-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six
US5149506A (en) 1991-08-09 1992-09-22 Sage Products, Inc. Stool collection and transport device
US5506105A (en) 1991-12-10 1996-04-09 Dade International Inc. In situ assay of amplified intracellular mRNA targets
US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5710028A (en) 1992-07-02 1998-01-20 Eyal; Nurit Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
US5409586A (en) 1992-08-26 1995-04-25 Hitachi, Ltd. Method for analyzing nucleic acid or protein and apparatus therefor
US5331973A (en) 1993-03-15 1994-07-26 Fiedler Paul N Method for obtaining stool samples for gastrointestinal cancer testing
CA2092115C (en) 1993-03-22 1998-12-15 Janet L. Taylor Testing for infestation of rapeseed and other cruciferae by the fungus leptosphaeria maculans (blackleg infestation)
US5492808A (en) 1993-05-05 1996-02-20 The Johns Hopkins University Means for detecting familial colon cancer (FCC)
US5466576A (en) 1993-07-02 1995-11-14 Fred Hutchinson Cancer Research Center Modulation of PIF-1-type helicases
EP0648845B1 (en) 1993-07-08 2002-10-09 Johnson & Johnson Clinical Diagnostics, Inc. Method for coamplification of two different nucleic acid sequences using polymerase chain reaction
US5688643A (en) 1993-07-09 1997-11-18 Wakunaga Seiyaku Kabushiki Kaisha Method of nucleic acid-differentiation and assay kit for nucleic acid differentiation
US5416025A (en) 1993-11-29 1995-05-16 Krepinsky; Jiri J. Screening test for early detection of colorectal cancer
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5709998A (en) 1993-12-15 1998-01-20 The Johns Hopkins University Molecular diagnosis of familial adenomatous polyposis
US5538851A (en) 1993-12-22 1996-07-23 Institut Pasteur And Cneva Primers for the amplification of genes coding for the enterotoxin and the lecithinase of Clostridium perfringens and their application to the determination of the presence and numeration of these bacteriae
US5496470A (en) 1994-05-27 1996-03-05 Barnes International, Inc. Magnetic separator
US6037465A (en) 1994-06-14 2000-03-14 Invitek Gmbh Universal process for isolating and purifying nucleic acids from extremely small amounts of highly contaminated various starting materials
US5512441A (en) 1994-11-15 1996-04-30 American Health Foundation Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
US5463782A (en) 1994-11-21 1995-11-07 Eric V. Carlson Foldable stool sample collection device
US5599662A (en) 1995-02-17 1997-02-04 Hoffmann-La Roche Inc. Oliconucleotide primers and probes for the detection of HIV-1
DE19530132C2 (en) 1995-08-16 1998-07-16 Max Planck Gesellschaft Process for the purification, stabilization or isolation of nucleic acids from biological materials
AU711754B2 (en) 1995-12-22 1999-10-21 Esoterix Genetic Laboratories, Llc Methods for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5612473A (en) 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
AU720489B2 (en) 1996-01-30 2000-06-01 Exact Sciences Corporation Methods for detecting colon cancer from stool samples
US5897999A (en) 1996-03-22 1999-04-27 The Johns Hopkins University Cancer drug screen based on cell cycle uncoupling
US5645995A (en) 1996-04-12 1997-07-08 Baylor College Of Medicine Methods for diagnosing an increased risk for breast or ovarian cancer
US5976800A (en) 1996-06-28 1999-11-02 The Regents Of The University Of California Enhancement of cancer cell death
US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6143529A (en) 1996-08-14 2000-11-07 Exact Laboratories, Inc. Methods for improving sensitivity and specificity of screening assays
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6100029A (en) 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US6146828A (en) 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
ATE378422T1 (en) 1996-08-26 2007-11-15 Invitek Biotechnik & Biodesign METHOD FOR DETECTING CLINICALLY RELEVANT CHANGES IN THE DNA SEQUENCE OF THE KI-RAS ONCOGENE, ITS USE AND TEST KIT FOR EARLY DETECTION OF TUMORS
US5856104A (en) 1996-10-28 1999-01-05 Affymetrix, Inc. Polymorphisms in the glucose-6 phosphate dehydrogenase locus
US6235474B1 (en) * 1996-12-30 2001-05-22 The Johns Hopkins University Methods and kits for diagnosing and determination of the predisposition for diseases
US5830665A (en) 1997-03-03 1998-11-03 Exact Laboratories, Inc. Contiguous genomic sequence scanning
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
US6268136B1 (en) 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
US5888778A (en) 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
US5942396A (en) 1997-08-19 1999-08-24 The Rockefeller University Method for identifying individuals at risk for colorectal neoplasia by quantifying normal colonic mucosal epithelial cell apoptosis
DE19736691A1 (en) 1997-08-22 1999-02-25 Michael Prof Dr Med Giesing Characterising and identifying disseminated metastatic cancer cells
CA2307177C (en) 1997-10-23 2004-06-29 Exact Laboratories, Inc. Methods for detecting contamination in molecular diagnostics using pcr
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US6251660B1 (en) 1997-11-25 2001-06-26 Mosaic Technologies, Inc. Devices and methods for detecting target molecules in biological samples
CA2331767A1 (en) 1998-06-18 1999-12-23 Mosaic Technologies Denaturing gradient affinity electrophoresis and methods of use thereof
AU6412799A (en) 1998-10-05 2000-04-26 Mosaic Technologies Reverse displacement assay for detection of nucleic acid sequences
AU2473900A (en) 1998-11-23 2000-06-13 Exact Sciences Corporation Primer extension methods utilizing donor and acceptor molecules for detecting nucleic acids
EP1179092A2 (en) 1999-01-10 2002-02-13 Exact Sciences Corporation Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
CA2362251C (en) 1999-02-25 2008-06-17 Exact Sciences Corporation Methods for preserving dna integrity
AU767983B2 (en) 1999-04-09 2003-11-27 Esoterix Genetic Laboratories, Llc Methods for detecting nucleic acids indicative of cancer
US20020004206A1 (en) 1999-04-09 2002-01-10 Berger Barry M. Methods of screening for disease
WO2000066005A1 (en) 1999-05-03 2000-11-09 Exact Laboratories, Inc. Stool specimen collector
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
EP1238106A2 (en) 1999-12-07 2002-09-11 Exact Sciences Corporation Apparatus and methods for drug screening based 0on nucleic acid analysis
JP2003516138A (en) 1999-12-07 2003-05-13 エグザクト サイエンシーズ コーポレイション Detection of aerobic digestive neoplasms in the colon
WO2001064950A2 (en) 2000-02-28 2001-09-07 Exact Sciences Corporation Device and method for preparing a sample for analysis
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
JP2004521630A (en) 2001-03-15 2004-07-22 エグザクト サイエンシーズ コーポレイション Methods for change detection
US20030049659A1 (en) 2001-05-29 2003-03-13 Lapidus Stanley N. Devices and methods for isolating samples into subsamples for analysis

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527676A (en) * 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US5352775A (en) * 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
WO1993020235A1 (en) * 1992-04-01 1993-10-14 The Johns Hopkins University School Of Medicine Methods of detecting mammalian nucleic acids isolated from stool specimen and reagents therefor
WO1997009600A2 (en) * 1995-09-06 1997-03-13 Medical Research Council Method of isolating cells
WO1997019191A1 (en) * 1995-11-17 1997-05-29 Oegreid Dagfinn Method for detection of ki-ras mutations and kit to perform it
DE19712332A1 (en) * 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Method for the detection of microsatellite instability for tumor diagnosis
GB2327497A (en) * 1997-07-18 1999-01-27 Zeneca Ltd Diagnostic assay for cancer
WO1999053316A1 (en) * 1998-04-13 1999-10-21 Exact Laboratories, Inc. Methods for disease diagnosis from stool samples

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GIACONA MARY BETH ET AL: "Cell-free DNA in human blood plasma: Length measurements in patients with pancreatic cancer and healthy controls.", PANCREAS, vol. 17, no. 1, July 1998 (1998-07-01), pages 89 - 97, XP000992791, ISSN: 0885-3177 *

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