WO2001038552A3 - Excipient system that contains coating substances with enzymatically removable side-groups - Google Patents

Excipient system that contains coating substances with enzymatically removable side-groups Download PDF

Info

Publication number
WO2001038552A3
WO2001038552A3 PCT/EP2000/011055 EP0011055W WO0138552A3 WO 2001038552 A3 WO2001038552 A3 WO 2001038552A3 EP 0011055 W EP0011055 W EP 0011055W WO 0138552 A3 WO0138552 A3 WO 0138552A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding structure
component
excipient system
groups
contain
Prior art date
Application number
PCT/EP2000/011055
Other languages
German (de)
French (fr)
Other versions
WO2001038552A2 (en
Inventor
Hans-Harald Sedlacek
Thomas Kissel
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Priority to EP00977515A priority Critical patent/EP1235922A2/en
Priority to JP2001539894A priority patent/JP2003514895A/en
Priority to AU15202/01A priority patent/AU1520201A/en
Priority to CA002391922A priority patent/CA2391922A1/en
Priority to MXPA02004532A priority patent/MXPA02004532A/en
Publication of WO2001038552A2 publication Critical patent/WO2001038552A2/en
Publication of WO2001038552A3 publication Critical patent/WO2001038552A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The invention relates to an excipient system that can be obtained by (1) optionally mixing a component a2) with a component a1) in a molar ratio [a2):a1)] of 1:1 to 1000:1, preferably between 10:1 and 100:1, (2) mixing the complex resulting from step (1) or the complex a1) alone with a component b1), preferably in a molar ratio b1):a1) + optionally a2) of 1:1 to 1:1000, said mixing ratio being adjusted in such a manner that the net charge of the resulting total complex is preferably neutral or anionic. Component a1) comprises an active substance a1), a binding structure a1) for the binding structures b1) or a2), wherein the active substance a1) may contain the binding structure a1). Component a2) comprises a binding structure a2) for the binding structure a1) and a carrier a2) which may contain the binding structure a2). Component b1) may comprise a binding structure b1) for the binding structure a1), for the active substance a1), for the binding structure a2) or for the carrier a2), a coating substance that may contain the binding structure b1), an enzymatically removable connector, and an anionic side-group. The invention further relates to the production and to the use of the inventive excipient system.
PCT/EP2000/011055 1999-11-22 2000-11-09 Excipient system that contains coating substances with enzymatically removable side-groups WO2001038552A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP00977515A EP1235922A2 (en) 1999-11-22 2000-11-09 Excipient system that contains coating substances with enzymatically removable side-groups
JP2001539894A JP2003514895A (en) 1999-11-22 2000-11-09 Carrier system comprising a coating substance having enzymatically removable side groups
AU15202/01A AU1520201A (en) 1999-11-22 2000-11-09 Excipient system that contains coating substances with enzymatically removable side-groups
CA002391922A CA2391922A1 (en) 1999-11-22 2000-11-09 Excipient system that contains coating substances with enzymatically removable side-groups
MXPA02004532A MXPA02004532A (en) 1999-11-22 2000-11-09 Excipient system that contains coating substances with enzymatically removable side-groups.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19956029.3 1999-11-22
DE19956029A DE19956029A1 (en) 1999-11-22 1999-11-22 Active substance carrier system based on coating a substance with enzymatically cleavable side groups, useful for gene therapy especially of cancer and inflammation

Publications (2)

Publication Number Publication Date
WO2001038552A2 WO2001038552A2 (en) 2001-05-31
WO2001038552A3 true WO2001038552A3 (en) 2002-03-28

Family

ID=7929842

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/011055 WO2001038552A2 (en) 1999-11-22 2000-11-09 Excipient system that contains coating substances with enzymatically removable side-groups

Country Status (7)

Country Link
EP (1) EP1235922A2 (en)
JP (1) JP2003514895A (en)
AU (1) AU1520201A (en)
CA (1) CA2391922A1 (en)
DE (1) DE19956029A1 (en)
MX (1) MXPA02004532A (en)
WO (1) WO2001038552A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166320A (en) * 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
WO1997000965A2 (en) * 1995-06-23 1997-01-09 University Of Pittsburgh A lipidic vector for nucleic acid delivery
US5630996A (en) * 1992-06-09 1997-05-20 Neorx Corporation Two-step pretargeting methods using improved biotin-active agent conjugates
EP0905254A2 (en) * 1997-09-30 1999-03-31 Hoechst Marion Roussel Deutschland GmbH DNA vector associated with biocompatible low molecular weight polyethyleneimines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166320A (en) * 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
US5630996A (en) * 1992-06-09 1997-05-20 Neorx Corporation Two-step pretargeting methods using improved biotin-active agent conjugates
WO1997000965A2 (en) * 1995-06-23 1997-01-09 University Of Pittsburgh A lipidic vector for nucleic acid delivery
EP0905254A2 (en) * 1997-09-30 1999-03-31 Hoechst Marion Roussel Deutschland GmbH DNA vector associated with biocompatible low molecular weight polyethyleneimines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DUNLA D.D. ET AL.: "Nanoscopic structure of DNA condensed for gene delivery.", NUCL. ACIDS RES., vol. 25, no. 15, 1997, pages 3095 - 3101, XP002164446 *
OLIVIER J -C ET AL: "Stability of orosomucoid-coated polyisobutylcyanoacrylate nanoparticles in the presence of serum", JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, vol. 40, no. 3, 1 July 1996 (1996-07-01), pages 157 - 168, XP004037361, ISSN: 0168-3659 *

Also Published As

Publication number Publication date
CA2391922A1 (en) 2001-05-31
JP2003514895A (en) 2003-04-22
EP1235922A2 (en) 2002-09-04
WO2001038552A2 (en) 2001-05-31
DE19956029A1 (en) 2001-05-23
MXPA02004532A (en) 2002-09-02
AU1520201A (en) 2001-06-04

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