WO2001035932A3 - Sustained drug delivery from structural matrices - Google Patents

Sustained drug delivery from structural matrices Download PDF

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Publication number
WO2001035932A3
WO2001035932A3 PCT/US2000/031754 US0031754W WO0135932A3 WO 2001035932 A3 WO2001035932 A3 WO 2001035932A3 US 0031754 W US0031754 W US 0031754W WO 0135932 A3 WO0135932 A3 WO 0135932A3
Authority
WO
WIPO (PCT)
Prior art keywords
drugs
control over
drug delivery
matrices
vivo
Prior art date
Application number
PCT/US2000/031754
Other languages
French (fr)
Other versions
WO2001035932A2 (en
Inventor
David J Mooney
Lonnie D Shea
Martin C Peters
Elly Liao
Thomas P Richardson
Original Assignee
Univ Michigan
David J Mooney
Lonnie D Shea
Martin C Peters
Elly Liao
Thomas P Richardson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan, David J Mooney, Lonnie D Shea, Martin C Peters, Elly Liao, Thomas P Richardson filed Critical Univ Michigan
Priority to AU16228/01A priority Critical patent/AU1622801A/en
Publication of WO2001035932A2 publication Critical patent/WO2001035932A2/en
Publication of WO2001035932A3 publication Critical patent/WO2001035932A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Abstract

Disclosed are pre-fabrication methods for preparing particular 3-dimensional structural matrices containing proteins and/or drugs, the resultant compositions and in vitro and in vivo methods for the prolonged release of proteins and/or drugs in various biological environments. The pre-fabrication processes provide protein- and/or drug-matrix materials with both high incorporation efficiencies and control over sustained protein and/or drug release. The resultant matrices are thus particularly useful in vivo biodelivery embodiments, providing control over spatial delivery and differential release kinetics of multiple biological components.
PCT/US2000/031754 1999-11-18 2000-11-17 Sustained drug delivery from structural matrices WO2001035932A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16228/01A AU1622801A (en) 1999-11-18 2000-11-17 Sustained drug delivery from structural matrices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16619199P 1999-11-18 1999-11-18
US60/166,191 1999-11-18

Publications (2)

Publication Number Publication Date
WO2001035932A2 WO2001035932A2 (en) 2001-05-25
WO2001035932A3 true WO2001035932A3 (en) 2002-03-07

Family

ID=22602185

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/031754 WO2001035932A2 (en) 1999-11-18 2000-11-17 Sustained drug delivery from structural matrices

Country Status (2)

Country Link
AU (1) AU1622801A (en)
WO (1) WO2001035932A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column

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JP2002542183A (en) 1999-04-16 2002-12-10 ノボ ノルディスク アクティーゼルスカブ Moldable dry pharmaceutical formulation
AUPR289601A0 (en) * 2001-02-05 2001-03-01 Commonwealth Scientific And Industrial Research Organisation Method of tissue repair
AU2002227792B2 (en) * 2001-02-05 2007-12-13 Industrial Technology Research Institute Methods and devices for tissue repair
GB0115320D0 (en) 2001-06-22 2001-08-15 Univ Nottingham Matrix
WO2004108810A1 (en) * 2003-06-06 2004-12-16 Humanautocell Gmbh Matrix, cell implantation and method for their production and use
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
AU2005323062A1 (en) * 2005-01-04 2006-07-13 The Brigham And Women's Hospital, Inc. Sustained delivery of PDGF using self-assembling peptide nanofibers
SI2347775T1 (en) 2005-12-13 2020-10-30 President And Fellows Of Harvard College Scaffolds for cell transplantation
EP1991282B1 (en) 2006-02-09 2013-06-19 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
JP5484047B2 (en) 2006-06-30 2014-05-07 バイオミメティック セラピューティクス， エルエルシー PDGF-biomatrix composition and method for treating rotator cuff injury
US9770535B2 (en) 2007-06-21 2017-09-26 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
ES2358703B1 (en) * 2007-11-14 2012-03-21 Universidad Del Pais Vasco EMPLOYMENT OF MICROPART�? CULAS FOR USE AS VACCINES AND THE RELEASE OF BIOLOGICALLY ACTIVE MOLECULES.
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
AU2009215188B2 (en) 2008-02-13 2014-09-18 Dana-Farber Cancer Institute, Inc. Continuous cell programming devices
WO2009146456A1 (en) * 2008-05-30 2009-12-03 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
WO2010120749A2 (en) 2009-04-13 2010-10-21 President And Fellow Of Harvard College Harnessing cell dynamics to engineer materials
EP2461828B1 (en) 2009-07-31 2017-06-21 President and Fellows of Harvard College Programming of cells for tolerogenic therapies
US8492339B2 (en) * 2009-10-26 2013-07-23 Empire Technology Development Llc Angiogenesis promoted by caged growth factors
NZ601559A (en) 2010-02-22 2014-10-31 Biomimetic Therapeutics Llc Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
EP2542230A4 (en) 2010-03-05 2013-08-28 Harvard College Enhancement of skeletal muscle stem cell engrafment by dual delivery of vegf and igf-1
US9693954B2 (en) * 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
PT2624873T (en) 2010-10-06 2020-03-04 Harvard College Injectable, pore-forming hydrogels for materials-based cell therapies
WO2012064697A2 (en) 2010-11-08 2012-05-18 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
EP2701753B1 (en) 2011-04-27 2018-12-26 President and Fellows of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
EP3417876B1 (en) 2011-04-28 2021-03-31 President and Fellows of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
JP6062426B2 (en) 2011-06-03 2017-01-18 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ In situ antigen-producing cancer vaccine
US8753309B2 (en) 2011-06-24 2014-06-17 The Invention Science Fund I, Llc Device, system, and method including micro-patterned cell treatment array
WO2013158673A1 (en) 2012-04-16 2013-10-24 President And Fellows Of Harvard College Mesoporous silica compositions for modulating immune responses
EP3137105A4 (en) 2014-04-30 2017-12-27 President and Fellows of Harvard College Combination vaccine devices and methods of killing cancer cells
WO2016123573A1 (en) 2015-01-30 2016-08-04 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
JP7094533B2 (en) 2015-04-10 2022-07-04 プレジデント アンド フェローズ オブ ハーバード カレッジ Immune cell capture device and its manufacture and use
US11752238B2 (en) 2016-02-06 2023-09-12 President And Fellows Of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
US11555177B2 (en) 2016-07-13 2023-01-17 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044027A1 (en) * 1997-03-31 1998-10-08 The Regents Of The University Of Michigan Open pore biodegradable matrices
WO1999058656A2 (en) * 1998-05-13 1999-11-18 The Regents Of The University Of Michigan Sustained dna delivery from structural matrices
WO2000056375A2 (en) * 1999-03-19 2000-09-28 The Regents Of The University Of Michigan Mineralization and cellular patterning on biomaterial surfaces

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044027A1 (en) * 1997-03-31 1998-10-08 The Regents Of The University Of Michigan Open pore biodegradable matrices
WO1999058656A2 (en) * 1998-05-13 1999-11-18 The Regents Of The University Of Michigan Sustained dna delivery from structural matrices
WO2000056375A2 (en) * 1999-03-19 2000-09-28 The Regents Of The University Of Michigan Mineralization and cellular patterning on biomaterial surfaces

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOPFERICH A: "Bioerodible implants with programmable drug release", JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, vol. 44, no. 2, 17 February 1997 (1997-02-17), pages 271 - 281, XP004015255, ISSN: 0168-3659 *
SHEA L D: "DNA delivery from polymer matrices for tissue engineering", NATURE BIOTECHNOLOGY,US,NATURE PUBLISHING, vol. 17, no. 6, June 1999 (1999-06-01), pages 551 - 554, XP002121278, ISSN: 1087-0156 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries

Also Published As

Publication number Publication date
AU1622801A (en) 2001-05-30
WO2001035932A2 (en) 2001-05-25

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