WO2001035074A1 - Apparatus and method for calibration of a microarray scanning system - Google Patents
Apparatus and method for calibration of a microarray scanning system Download PDFInfo
- Publication number
- WO2001035074A1 WO2001035074A1 PCT/US2000/041170 US0041170W WO0135074A1 WO 2001035074 A1 WO2001035074 A1 WO 2001035074A1 US 0041170 W US0041170 W US 0041170W WO 0135074 A1 WO0135074 A1 WO 0135074A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- spots
- microarray
- dilution
- fluorophore
- scanning system
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Mathematical Physics (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Theoretical Computer Science (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Facsimile Scanning Arrangements (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00989657A EP1228354B1 (en) | 1999-11-09 | 2000-10-12 | Apparatus and method for calibration of a microarray scanning system |
DE60025400T DE60025400T2 (en) | 1999-11-09 | 2000-10-12 | DEVICE AND METHOD FOR CALIBRATING A SCANNING SYSTEM FOR MICROARRAYS |
CA002390651A CA2390651A1 (en) | 1999-11-09 | 2000-10-12 | Apparatus and method for calibration of a microarray scanning system |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/437,039 US6471916B1 (en) | 1999-11-09 | 1999-11-09 | Apparatus and method for calibration of a microarray scanning system |
US09/437,039 | 1999-11-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001035074A1 true WO2001035074A1 (en) | 2001-05-17 |
WO2001035074A9 WO2001035074A9 (en) | 2002-08-01 |
Family
ID=23734812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/041170 WO2001035074A1 (en) | 1999-11-09 | 2000-10-12 | Apparatus and method for calibration of a microarray scanning system |
Country Status (6)
Country | Link |
---|---|
US (1) | US6471916B1 (en) |
EP (1) | EP1228354B1 (en) |
AT (1) | ATE315222T1 (en) |
CA (1) | CA2390651A1 (en) |
DE (1) | DE60025400T2 (en) |
WO (1) | WO2001035074A1 (en) |
Cited By (11)
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WO2003083127A2 (en) * | 2002-03-28 | 2003-10-09 | Deutsches Krebsforschungszentrum | Method and system for determining absolute mrna quantities |
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DE102005036149A1 (en) * | 2005-07-28 | 2007-02-08 | Gesellschaft zur Förderung von Medizin-, Bio- und Umwelttechnologien e.V. | Biochip fluorescence analysis arrangement for use in, e.g. biotechnology, comprises spectrograph and camera, whose combination with optical components enables fluorescence detection of spot array with specific fluorescence labeled biospots |
US7585463B2 (en) | 2003-10-24 | 2009-09-08 | Aushon Biosystems, Inc. | Apparatus and method for dispensing fluid, semi-solid and solid samples |
WO2010105802A3 (en) * | 2009-03-16 | 2011-03-10 | Clondiag Gmbh | Assay methods using array of test zones |
WO2014100626A1 (en) * | 2012-12-21 | 2014-06-26 | Hutman Diagnostics AG | Microarrays |
EP2881725A1 (en) * | 2013-12-06 | 2015-06-10 | Starna Scientific Limited | PCR validation tubes |
WO2015090534A1 (en) * | 2013-12-18 | 2015-06-25 | Euroimmun Medizinische Labordiagnostika Ag | Calibration standard for a device for image-based representation of biological material |
WO2018189370A1 (en) * | 2017-04-13 | 2018-10-18 | F. Hoffmann-La Roche Ag | Target molecule density determination in a fluorescence image |
CN113227765A (en) * | 2018-12-18 | 2021-08-06 | 惠普发展公司,有限责任合伙企业 | Ordered microspot arrays |
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JP3469504B2 (en) * | 1999-06-01 | 2003-11-25 | 日立ソフトウエアエンジニアリング株式会社 | Microarray chip and indexing method thereof |
US6789040B2 (en) | 2000-08-22 | 2004-09-07 | Affymetrix, Inc. | System, method, and computer software product for specifying a scanning area of a substrate |
JP3596868B2 (en) * | 2000-11-24 | 2004-12-02 | キヤノン株式会社 | Method for evaluating the amount of probe in end-labeled probe array, and method for evaluating amount of target substance using labeled probe array |
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WO2003083127A3 (en) * | 2002-03-28 | 2004-04-29 | Deutsches Krebsforsch | Method and system for determining absolute mrna quantities |
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US7585463B2 (en) | 2003-10-24 | 2009-09-08 | Aushon Biosystems, Inc. | Apparatus and method for dispensing fluid, semi-solid and solid samples |
US9527085B2 (en) | 2003-10-24 | 2016-12-27 | Aushon Biosystems, Inc. | Apparatus and method for dispensing fluid, semi-solid and solid samples |
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JP2017502280A (en) * | 2013-12-18 | 2017-01-19 | オイロイムーン メディツィニシェ ラボルディアグノスティカ アーゲー | Calibration standards for devices for image-based representation of biological materials |
WO2018189370A1 (en) * | 2017-04-13 | 2018-10-18 | F. Hoffmann-La Roche Ag | Target molecule density determination in a fluorescence image |
JP2020519852A (en) * | 2017-04-13 | 2020-07-02 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Target molecule density determination in fluorescence images |
US11385179B2 (en) | 2017-04-13 | 2022-07-12 | Hoffmann-La Roche, Inc. | Target molecule density determination in a fluorescence image |
CN113227765A (en) * | 2018-12-18 | 2021-08-06 | 惠普发展公司,有限责任合伙企业 | Ordered microspot arrays |
Also Published As
Publication number | Publication date |
---|---|
DE60025400D1 (en) | 2006-03-30 |
US6471916B1 (en) | 2002-10-29 |
CA2390651A1 (en) | 2001-05-17 |
EP1228354A1 (en) | 2002-08-07 |
ATE315222T1 (en) | 2006-02-15 |
WO2001035074A9 (en) | 2002-08-01 |
DE60025400T2 (en) | 2006-08-31 |
EP1228354B1 (en) | 2006-01-04 |
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