WO2001032211A3 - Conjugate compounds for treating atheroma and other diseases - Google Patents

Conjugate compounds for treating atheroma and other diseases Download PDF

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Publication number
WO2001032211A3
WO2001032211A3 PCT/US2000/029524 US0029524W WO0132211A3 WO 2001032211 A3 WO2001032211 A3 WO 2001032211A3 US 0029524 W US0029524 W US 0029524W WO 0132211 A3 WO0132211 A3 WO 0132211A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
atheroma
conjugate compounds
treating
compounds
Prior art date
Application number
PCT/US2000/029524
Other languages
French (fr)
Other versions
WO2001032211A2 (en
Inventor
Jonathan L Sessler
Darren Madga
Original Assignee
Pharmacyclics Inc
Univ Texas
Jonathan L Sessler
Darren Madga
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Inc, Univ Texas, Jonathan L Sessler, Darren Madga filed Critical Pharmacyclics Inc
Priority to AU12340/01A priority Critical patent/AU1234001A/en
Priority to EP00973891A priority patent/EP1223982A2/en
Publication of WO2001032211A2 publication Critical patent/WO2001032211A2/en
Publication of WO2001032211A3 publication Critical patent/WO2001032211A3/en
Priority to US10/160,205 priority patent/US20030031676A1/en
Priority to HK03100643.8A priority patent/HK1050315A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines

Abstract

Disclosed are compounds which are conjugates of (a) a moiety capable of localizing in the cells of a tumor or atheroma and (b) a moiety capable of catalyzing the production of reactive oxygen species from a cellular metabolite. The disclosed compounds which are useful for treating atheroma, tumors and other neoplastic tissue.
PCT/US2000/029524 1999-10-29 2000-10-27 Conjugate compounds for treating atheroma and other diseases WO2001032211A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU12340/01A AU1234001A (en) 1999-10-29 2000-10-27 Conjugate compounds for treating atheroma, tumors and other neoplastic tissue
EP00973891A EP1223982A2 (en) 1999-10-29 2000-10-27 Conjugate for treating atheroma and other diseases
US10/160,205 US20030031676A1 (en) 1999-10-29 2002-05-30 Conjugate compounds for treating atheroma and other diseases
HK03100643.8A HK1050315A1 (en) 1999-10-29 2003-01-24 Conjugate for treating atheroma and other diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43129899A 1999-10-29 1999-10-29
US09/431,298 1999-10-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/160,205 Continuation US20030031676A1 (en) 1999-10-29 2002-05-30 Conjugate compounds for treating atheroma and other diseases

Publications (2)

Publication Number Publication Date
WO2001032211A2 WO2001032211A2 (en) 2001-05-10
WO2001032211A3 true WO2001032211A3 (en) 2002-03-07

Family

ID=23711325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/029524 WO2001032211A2 (en) 1999-10-29 2000-10-27 Conjugate compounds for treating atheroma and other diseases

Country Status (4)

Country Link
EP (1) EP1223982A2 (en)
AU (1) AU1234001A (en)
HK (1) HK1050315A1 (en)
WO (1) WO2001032211A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201610306RA (en) * 2014-06-11 2017-01-27 Univ Texas Texaphyrin-pt(iv) conjugates and compositions for use in overcoming platinum resistance

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587371A (en) * 1992-01-21 1996-12-24 Pharmacyclics, Inc. Texaphyrin-oligonucleotide conjugates
US5888997A (en) * 1994-04-14 1999-03-30 Pharmacyclics, Inc. Radiation sensitization using texaphyrins
WO1999062551A1 (en) * 1998-06-05 1999-12-09 Board Of Regents, The University Of Texas System Texaphyrin conjugates and uses thereof
WO2001032210A2 (en) * 1999-10-29 2001-05-10 Pharmacyclics, Inc. Compositions for treating atheroma and neoplastic tissue

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587371A (en) * 1992-01-21 1996-12-24 Pharmacyclics, Inc. Texaphyrin-oligonucleotide conjugates
US5888997A (en) * 1994-04-14 1999-03-30 Pharmacyclics, Inc. Radiation sensitization using texaphyrins
WO1999062551A1 (en) * 1998-06-05 1999-12-09 Board Of Regents, The University Of Texas System Texaphyrin conjugates and uses thereof
WO2001032210A2 (en) * 1999-10-29 2001-05-10 Pharmacyclics, Inc. Compositions for treating atheroma and neoplastic tissue

Also Published As

Publication number Publication date
AU1234001A (en) 2001-05-14
WO2001032211A2 (en) 2001-05-10
EP1223982A2 (en) 2002-07-24
HK1050315A1 (en) 2003-06-20

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