WO2001030419A2 - Disposable jet injector - Google Patents
Disposable jet injector Download PDFInfo
- Publication number
- WO2001030419A2 WO2001030419A2 PCT/GB2000/004152 GB0004152W WO0130419A2 WO 2001030419 A2 WO2001030419 A2 WO 2001030419A2 GB 0004152 W GB0004152 W GB 0004152W WO 0130419 A2 WO0130419 A2 WO 0130419A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- jet injector
- skin
- nozzle
- drug
- delivery tube
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
- A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
Definitions
- Jet injectors have been in use for a long time. In the main, they require a significant amount of drive energy and deliver the dose so rapidly that it causes subcutaneous damage.
- jet injector which is energised by pressing the device against the skin of the patient.
- the pressure deforms a biaxially curved spring which may relax by reversibly buckling.
- the fast moving relaxing spring may impact on a crimp in a drug delivery tube to generate a high pressure at the nozzle end.
- the nozzle end of the drug delivery tube may be flared to form a small piston within a cylinder comprising the exit nozzle.
- the exit nozzle may be in the form of a slit or non circular cross section.
- the device may clip onto the ampoule in such a manner that removal will cause such damage that the system becomes inoperable.
- a point contact of the nozzle on the skin may provide not only a good hydraulic seal but also generate a radially decreasing stress distribution within the soft tissue which will ensure that the drug is delivered to the full depth of the track.
- the biaxially curved spring may be so formed as to provide a high mechanical advantage leverage system to reduce the forces applied to the skin of the patient.
- Jet injectors have been in use for over half a century.
- a high velocity droplet of fluid may pierce the skin and cut a track through the soft subcutaneous tissue.
- a problem of the earlier injectors was that a jet of fluid fast enough to cut the toughest of skins would also penetrate too deeply, especially for drugs like insulin that must be deposited in the subcutaneous fat layer.
- viscous forces attenuate it rapidly, so providing aggressive cutting at the dermis but ensuring controllable range. This effect may be enhanced by use of a planar jet from a slit like nozzle.
- the main dose may be delivered manually from the ampoule in the usual manner, by depressing the piston. This may be done very slowly to minimise soft tissue damage.
- a silicone non return valve may be fitted at the nozzle. This will inhibit back flow of material that might cause cross infection. It will also inhibit inflow of air due to thermal contraction of the fluid in the ampoule. Air in the delivery tube would inhibit the pump operation.
- FIG. 1 An embodiment is shown in section in figure 1, with an enlarged view of the nozzle and valve for clarity.
- an ampoule 1, with liquid drug, 2, rubber piston, 3, and rubber septum, 4, disposed in the usual configuration.
- a drug delivery tube 5, which pierces the septum, 4.
- This has a crimp, 6, midway along its length and a flare, 7 at the outlet end.
- a injection moulded end cap, 8, which comprises, a cylinder, 9, and nozzle, 10.
- the holder clips onto the ampoule as the drug delivery tube pierces the ampoule.
- the holder, 14, and end cap, 8, may clip together or be the same moulding with a bayonet fitting to accept a somewhat rectangular shaped spring together with a flexible connection to permit compression of the spring.
- the ampoule piston is advanced with the system held vertically to expel any air.
- the end cap is then pressed against the skin of the patient which in turn flattens the biaxially curved spring. This then pops through the maximum strain configuration and accelerates toward impact with the drug delivery tube.
- the impact is conducted along the tube to the flared end and the drug in the cylinder, 9, is subject to a very high pressure.
- This high pressure ejects a droplet of drug through the nozzle, the elastomeric non return valve and the skin of the patient.
- a pressure wave will also propagate up the delivery tube into the ampoule.
- the constriction associated with the crimp will attenuate this.
- the change in internal diameters of the crimp and ampoule will ensure that the pressures transmitted to the ampoule will be very small indeed.
- the biaxially curved spring may be any desired shape. It may also be cut or formed in such a fashion that the end cap may exert a small force over a large distance to complete compression, so reducing the loading on the skin of the patient.
- the zone around the hole may be formed in a conical shape to more effectively spread the load on impact. If the spring has a rectangular planform, it may be fitted to an integral holder, 14, and end cap, 8, assembly by insertion and rotation by 90°. In addition, the raising of the angled tips about the pressure point of the holder will provide a significant amount of travel, so reducing the load at the injector skin interface required to cock the device.
- the holder 14 may have a number of radially disposed clips, as shown, engineered so that clipping to the ampoule takes the root of the cantilever clip close to its failure strain. It will be difficult to splay a number of such clips simultaneously to remove the injector. Any effort to splay them is likely to exceed the strength of the carefully engineered cantilevers, causing them to snap off. In this manner, the injector cannot be re-used. This will reduce the risk of infection and will also prevent use with a rival manufacturers ampoules.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU11537/01A AU1153701A (en) | 1999-10-28 | 2000-10-30 | Disposable jet injector |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9925483.1A GB9925483D0 (en) | 1999-10-28 | 1999-10-28 | Low energy injector |
GB9925483.1 | 1999-10-28 | ||
GB0018056.2 | 2000-07-24 | ||
GB0018056A GB0018056D0 (en) | 1999-10-28 | 2000-07-24 | Impact jet injector |
GB0026310.3 | 2000-10-27 | ||
GB0026310A GB0026310D0 (en) | 1999-10-28 | 2000-10-27 | Disposable jet injector |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001030419A2 true WO2001030419A2 (en) | 2001-05-03 |
WO2001030419A3 WO2001030419A3 (en) | 2001-09-20 |
Family
ID=27255815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2000/004152 WO2001030419A2 (en) | 1999-10-28 | 2000-10-30 | Disposable jet injector |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU1153701A (en) |
WO (1) | WO2001030419A2 (en) |
Cited By (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003000320A1 (en) * | 2001-06-20 | 2003-01-03 | William Denne | A low cost disposable jet injector |
WO2004039438A1 (en) * | 2002-11-01 | 2004-05-13 | Novo Nordisk A/S | Jet injector with a bi-stable spring |
FR2853837A1 (en) * | 2003-04-16 | 2004-10-22 | Crossject | Medication injector with or without needle has tube of active liquid connected to nozzle by projections with inclined surfaces and shoulders |
WO2005070482A1 (en) * | 2004-01-26 | 2005-08-04 | Novo Nordisk A/S | Impulse chamber for jet delivery device |
WO2007094833A1 (en) * | 2006-02-14 | 2007-08-23 | Battelle Memorial Institute | Accurate metering system |
US7648494B2 (en) | 2004-03-26 | 2010-01-19 | Unomedical A/S | Infusion set and injector device for infusion set |
US7654484B2 (en) | 2002-09-02 | 2010-02-02 | Unomedical A/S | Apparatus for and a method of adjusting the length of an infusion tube |
US7802824B2 (en) | 2002-11-26 | 2010-09-28 | Unomedical A/S | Connecting piece for a tubing |
US7867200B2 (en) | 2004-12-10 | 2011-01-11 | Unomedical A/S | Inserter |
US7985199B2 (en) | 2005-03-17 | 2011-07-26 | Unomedical A/S | Gateway system |
US8012126B2 (en) | 2006-10-31 | 2011-09-06 | Unomedical A/S | Infusion set |
US8062250B2 (en) | 2004-08-10 | 2011-11-22 | Unomedical A/S | Cannula device |
USD655807S1 (en) | 2005-12-09 | 2012-03-13 | Unomedical A/S | Medical device |
US8152771B2 (en) | 2001-09-27 | 2012-04-10 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US8246588B2 (en) | 2007-07-18 | 2012-08-21 | Unomedical A/S | Insertion device with pivoting action |
US8303549B2 (en) | 2005-12-23 | 2012-11-06 | Unomedical A/S | Injection device |
US8430850B2 (en) | 2007-07-03 | 2013-04-30 | Unomedical A/S | Inserter having bistable equilibrium states |
US8439838B2 (en) | 2006-06-07 | 2013-05-14 | Unomedical A/S | Inserter for transcutaneous sensor |
US8486003B2 (en) | 2007-07-10 | 2013-07-16 | Unomedical A/S | Inserter having two springs |
US8562567B2 (en) | 2009-07-30 | 2013-10-22 | Unomedical A/S | Inserter device with horizontal moving part |
US8608684B2 (en) | 2003-11-27 | 2013-12-17 | Novo Nordisk A/S | Impulse chamber for jet delivery device |
US8790311B2 (en) | 2006-06-09 | 2014-07-29 | Unomedical A/S | Mounting pad |
CN104189969A (en) * | 2014-05-24 | 2014-12-10 | 戎静华 | Automatic liquid-stopping infusion apparatus with novel exhaust liquid-storage tube |
US8945057B2 (en) | 2006-08-02 | 2015-02-03 | Unomedical A/S | Cannula and delivery device |
US9084566B2 (en) | 2006-07-07 | 2015-07-21 | Proteus Digital Health, Inc. | Smart parenteral administration system |
US9186480B2 (en) | 2007-06-20 | 2015-11-17 | Unomedical A/S | Apparatus for making a catheter |
US9211379B2 (en) | 2006-02-28 | 2015-12-15 | Unomedical A/S | Inserter for infusion part and infusion part provided with needle protector |
US9254373B2 (en) | 2008-12-22 | 2016-02-09 | Unomedical A/S | Medical device comprising adhesive pad |
US9415159B2 (en) | 2010-03-30 | 2016-08-16 | Unomedical A/S | Medical device |
US9440051B2 (en) | 2011-10-27 | 2016-09-13 | Unomedical A/S | Inserter for a multiplicity of subcutaneous parts |
US9533092B2 (en) | 2009-08-07 | 2017-01-03 | Unomedical A/S | Base part for a medication delivery device |
US9566384B2 (en) | 2008-02-20 | 2017-02-14 | Unomedical A/S | Insertion device with horizontally moving part |
US9724127B2 (en) | 2010-09-27 | 2017-08-08 | Unomedical A/S | Insertion system and insertion kit |
US10369277B2 (en) | 2005-09-12 | 2019-08-06 | Unomedical A/S | Invisible needle |
US10376218B2 (en) | 2010-02-01 | 2019-08-13 | Proteus Digital Health, Inc. | Data gathering system |
CN110248689A (en) * | 2016-12-07 | 2019-09-17 | 赛诺菲-安万特德国有限公司 | Cap for injection device |
US10898643B2 (en) | 2008-02-13 | 2021-01-26 | Unomedical A/S | Sealing between a cannula part and a fluid path |
US11020526B2 (en) | 2010-10-04 | 2021-06-01 | Unomedical A/S | Sprinkler cannula |
US11110261B2 (en) | 2011-10-19 | 2021-09-07 | Unomedical A/S | Infusion tube system and method for manufacture |
US11197689B2 (en) | 2011-10-05 | 2021-12-14 | Unomedical A/S | Inserter for simultaneous insertion of multiple transcutaneous parts |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5243548B2 (en) | 2007-10-25 | 2013-07-24 | プロテウス デジタル ヘルス, インコーポレイテッド | Fluid communication port for information systems |
MY169700A (en) | 2010-02-01 | 2019-05-13 | Proteus Digital Health Inc | Data gathering system |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4677600A (en) * | 1984-12-11 | 1987-06-30 | Alps Electric Co., Ltd. | Keyboard apparatus |
WO1996018425A1 (en) * | 1994-12-17 | 1996-06-20 | Bailey, William, John | Injector |
-
2000
- 2000-10-30 AU AU11537/01A patent/AU1153701A/en not_active Abandoned
- 2000-10-30 WO PCT/GB2000/004152 patent/WO2001030419A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4677600A (en) * | 1984-12-11 | 1987-06-30 | Alps Electric Co., Ltd. | Keyboard apparatus |
WO1996018425A1 (en) * | 1994-12-17 | 1996-06-20 | Bailey, William, John | Injector |
Cited By (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003000320A1 (en) * | 2001-06-20 | 2003-01-03 | William Denne | A low cost disposable jet injector |
US8152771B2 (en) | 2001-09-27 | 2012-04-10 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US8172805B2 (en) | 2001-09-27 | 2012-05-08 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US8162892B2 (en) | 2001-09-27 | 2012-04-24 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US7654484B2 (en) | 2002-09-02 | 2010-02-02 | Unomedical A/S | Apparatus for and a method of adjusting the length of an infusion tube |
WO2004039438A1 (en) * | 2002-11-01 | 2004-05-13 | Novo Nordisk A/S | Jet injector with a bi-stable spring |
US7802824B2 (en) | 2002-11-26 | 2010-09-28 | Unomedical A/S | Connecting piece for a tubing |
US7559920B2 (en) | 2003-04-16 | 2009-07-14 | Crossject | Device for connecting an active substance container to an injection nozzle in a device used to inject said active substance |
FR2853837A1 (en) * | 2003-04-16 | 2004-10-22 | Crossject | Medication injector with or without needle has tube of active liquid connected to nozzle by projections with inclined surfaces and shoulders |
WO2004093947A1 (en) * | 2003-04-16 | 2004-11-04 | Crossject | Device for connecting an active substance container to an injection nozzle in a device used to inject said active substance |
US8608684B2 (en) | 2003-11-27 | 2013-12-17 | Novo Nordisk A/S | Impulse chamber for jet delivery device |
WO2005070482A1 (en) * | 2004-01-26 | 2005-08-04 | Novo Nordisk A/S | Impulse chamber for jet delivery device |
US8221355B2 (en) | 2004-03-26 | 2012-07-17 | Unomedical A/S | Injection device for infusion set |
US8287516B2 (en) | 2004-03-26 | 2012-10-16 | Unomedical A/S | Infusion set |
US7648494B2 (en) | 2004-03-26 | 2010-01-19 | Unomedical A/S | Infusion set and injector device for infusion set |
US8062250B2 (en) | 2004-08-10 | 2011-11-22 | Unomedical A/S | Cannula device |
US7867200B2 (en) | 2004-12-10 | 2011-01-11 | Unomedical A/S | Inserter |
US7867199B2 (en) | 2004-12-10 | 2011-01-11 | Unomedical A/S | Inserter |
US7985199B2 (en) | 2005-03-17 | 2011-07-26 | Unomedical A/S | Gateway system |
US10369277B2 (en) | 2005-09-12 | 2019-08-06 | Unomedical A/S | Invisible needle |
USD682415S1 (en) | 2005-12-09 | 2013-05-14 | Unomedical A/S | Medical device |
USD655807S1 (en) | 2005-12-09 | 2012-03-13 | Unomedical A/S | Medical device |
US8303549B2 (en) | 2005-12-23 | 2012-11-06 | Unomedical A/S | Injection device |
US9278173B2 (en) | 2005-12-23 | 2016-03-08 | Unomedical A/S | Device for administration |
WO2007094833A1 (en) * | 2006-02-14 | 2007-08-23 | Battelle Memorial Institute | Accurate metering system |
US9211379B2 (en) | 2006-02-28 | 2015-12-15 | Unomedical A/S | Inserter for infusion part and infusion part provided with needle protector |
US8439838B2 (en) | 2006-06-07 | 2013-05-14 | Unomedical A/S | Inserter for transcutaneous sensor |
US8790311B2 (en) | 2006-06-09 | 2014-07-29 | Unomedical A/S | Mounting pad |
US9084566B2 (en) | 2006-07-07 | 2015-07-21 | Proteus Digital Health, Inc. | Smart parenteral administration system |
US8945057B2 (en) | 2006-08-02 | 2015-02-03 | Unomedical A/S | Cannula and delivery device |
US8012126B2 (en) | 2006-10-31 | 2011-09-06 | Unomedical A/S | Infusion set |
US9320869B2 (en) | 2007-06-20 | 2016-04-26 | Unomedical A/S | Apparatus for making a catheter |
US9186480B2 (en) | 2007-06-20 | 2015-11-17 | Unomedical A/S | Apparatus for making a catheter |
US8430850B2 (en) | 2007-07-03 | 2013-04-30 | Unomedical A/S | Inserter having bistable equilibrium states |
US8486003B2 (en) | 2007-07-10 | 2013-07-16 | Unomedical A/S | Inserter having two springs |
US8246588B2 (en) | 2007-07-18 | 2012-08-21 | Unomedical A/S | Insertion device with pivoting action |
US10898643B2 (en) | 2008-02-13 | 2021-01-26 | Unomedical A/S | Sealing between a cannula part and a fluid path |
US9566384B2 (en) | 2008-02-20 | 2017-02-14 | Unomedical A/S | Insertion device with horizontally moving part |
US10376637B2 (en) | 2008-02-20 | 2019-08-13 | Unomedical A/S | Insertion device with horizontally moving part |
US9254373B2 (en) | 2008-12-22 | 2016-02-09 | Unomedical A/S | Medical device comprising adhesive pad |
US8562567B2 (en) | 2009-07-30 | 2013-10-22 | Unomedical A/S | Inserter device with horizontal moving part |
US9533092B2 (en) | 2009-08-07 | 2017-01-03 | Unomedical A/S | Base part for a medication delivery device |
US10376218B2 (en) | 2010-02-01 | 2019-08-13 | Proteus Digital Health, Inc. | Data gathering system |
US11786653B2 (en) | 2010-03-30 | 2023-10-17 | Unomedical A/S | Insertion device |
US9415159B2 (en) | 2010-03-30 | 2016-08-16 | Unomedical A/S | Medical device |
US9724127B2 (en) | 2010-09-27 | 2017-08-08 | Unomedical A/S | Insertion system and insertion kit |
US11020526B2 (en) | 2010-10-04 | 2021-06-01 | Unomedical A/S | Sprinkler cannula |
US11197689B2 (en) | 2011-10-05 | 2021-12-14 | Unomedical A/S | Inserter for simultaneous insertion of multiple transcutaneous parts |
US11110261B2 (en) | 2011-10-19 | 2021-09-07 | Unomedical A/S | Infusion tube system and method for manufacture |
US11684767B2 (en) | 2011-10-19 | 2023-06-27 | Unomedical A/S | Infusion tube system and method for manufacture |
US9440051B2 (en) | 2011-10-27 | 2016-09-13 | Unomedical A/S | Inserter for a multiplicity of subcutaneous parts |
CN104189969A (en) * | 2014-05-24 | 2014-12-10 | 戎静华 | Automatic liquid-stopping infusion apparatus with novel exhaust liquid-storage tube |
CN110248689A (en) * | 2016-12-07 | 2019-09-17 | 赛诺菲-安万特德国有限公司 | Cap for injection device |
CN110248689B (en) * | 2016-12-07 | 2021-11-30 | 赛诺菲-安万特德国有限公司 | Cap for an injection device |
US11191907B2 (en) | 2016-12-07 | 2021-12-07 | Sanofi-Aventis Deutschland Gmbh | Cap for an injection device |
Also Published As
Publication number | Publication date |
---|---|
WO2001030419A3 (en) | 2001-09-20 |
AU1153701A (en) | 2001-05-08 |
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