WO2001028574A3 - Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain - Google Patents

Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain Download PDF

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Publication number
WO2001028574A3
WO2001028574A3 PCT/US2000/041365 US0041365W WO0128574A3 WO 2001028574 A3 WO2001028574 A3 WO 2001028574A3 US 0041365 W US0041365 W US 0041365W WO 0128574 A3 WO0128574 A3 WO 0128574A3
Authority
WO
WIPO (PCT)
Prior art keywords
brain
inducing
progenitor cells
migration
methods
Prior art date
Application number
PCT/US2000/041365
Other languages
French (fr)
Other versions
WO2001028574A2 (en
Inventor
Rosemary A Fricker
Original Assignee
Stem Cells Inc
Rosemary A Fricker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stem Cells Inc, Rosemary A Fricker filed Critical Stem Cells Inc
Priority to JP2001531403A priority Critical patent/JP2003512333A/en
Priority to EP00984586A priority patent/EP1227823A2/en
Priority to CA002387748A priority patent/CA2387748A1/en
Priority to AU21185/01A priority patent/AU2118501A/en
Publication of WO2001028574A2 publication Critical patent/WO2001028574A2/en
Publication of WO2001028574A3 publication Critical patent/WO2001028574A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Abstract

The present invention provides methods of inducing in vivo migration and proliferation of progenitor cells transplanted to the brain. Isolation, characterization, proliferation, differentiation and transplantation of mammalian neural stem cells are also disclosed.
PCT/US2000/041365 1999-10-20 2000-10-20 Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain WO2001028574A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001531403A JP2003512333A (en) 1999-10-20 2000-10-20 Methods for inducing the in vivo proliferation and migration of transplanted precursor cells in the brain
EP00984586A EP1227823A2 (en) 1999-10-20 2000-10-20 Methods for inducing (in vivo) proliferation and migration of transplanted progenitor cells in the brain
CA002387748A CA2387748A1 (en) 1999-10-20 2000-10-20 Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain
AU21185/01A AU2118501A (en) 1999-10-20 2000-10-20 Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16055399P 1999-10-20 1999-10-20
US60/160,553 1999-10-20

Publications (2)

Publication Number Publication Date
WO2001028574A2 WO2001028574A2 (en) 2001-04-26
WO2001028574A3 true WO2001028574A3 (en) 2001-11-08

Family

ID=22577363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041365 WO2001028574A2 (en) 1999-10-20 2000-10-20 Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain

Country Status (5)

Country Link
EP (1) EP1227823A2 (en)
JP (1) JP2003512333A (en)
AU (1) AU2118501A (en)
CA (1) CA2387748A1 (en)
WO (1) WO2001028574A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1423509A2 (en) 2001-08-30 2004-06-02 Stem Cell Therapeutics Inc. Differentiation of neural stem cells and therapeutic use thereof
WO2004011021A1 (en) * 2002-07-31 2004-02-05 Stem Cell Therapeutics Inc. Method of enhancing and/or inducing neuronal migration using erythropoietin
GB0222846D0 (en) * 2002-10-03 2002-11-06 Choo Yen Cell culture
JP4990634B2 (en) 2004-02-13 2012-08-01 ステム セル セラピューティクス コーポレイション Use of luteinizing hormone (LH) and chorionic gonadotropin (hCG) for neural stem cell proliferation and neurogenesis
CA2664629A1 (en) 2005-09-27 2007-04-05 Christopher Gregg Oligodendrocyte precursor cell proliferation regulated by prolactin
EP2283116B1 (en) * 2008-05-08 2016-09-28 University Of Rochester Treating myelin diseases with optimized cell preparations
CN110713982A (en) * 2019-11-25 2020-01-21 深圳科学之门生物工程有限公司 Culture medium for rapid amplification of neural stem cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
WO1999006060A1 (en) * 1997-08-04 1999-02-11 The Regents Of The University Of California Methods for treating neurological deficits
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
WO1999006060A1 (en) * 1997-08-04 1999-02-11 The Regents Of The University Of California Methods for treating neurological deficits
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CRAIG CONSTANCE G ET AL: "In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain.", JOURNAL OF NEUROSCIENCE, vol. 16, no. 8, 1996, pages 2649 - 2658, XP001002077, ISSN: 0270-6474 *
FRICKER-GATES ROSEMARY A ET AL: "EGF infusion stimulates the proliferation and migration of embryonic progenitor cells transplanted in the adult rat striatum.", EXPERIMENTAL NEUROLOGY, vol. 165, no. 2, October 2000 (2000-10-01), pages 237 - 247, XP002167679, ISSN: 0014-4886 *
WINKLER C ET AL: "Effects of intraventricular EGF-delivery on transplants of EGF-responsive neural progenitor cells.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 23, no. 1-2, 1997, 27th Annual Meeting of the Society for Neuroscience, Part 1;New Orleans, Louisiana, USA; October 25-30, 1997, pages 593, XP001002082, ISSN: 0190-5295 *

Also Published As

Publication number Publication date
WO2001028574A2 (en) 2001-04-26
CA2387748A1 (en) 2001-04-26
AU2118501A (en) 2001-04-30
EP1227823A2 (en) 2002-08-07
JP2003512333A (en) 2003-04-02

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