WO2001028474A1 - Ophthalmic drug delivery device - Google Patents
Ophthalmic drug delivery device Download PDFInfo
- Publication number
- WO2001028474A1 WO2001028474A1 PCT/US2000/028187 US0028187W WO0128474A1 WO 2001028474 A1 WO2001028474 A1 WO 2001028474A1 US 0028187 W US0028187 W US 0028187W WO 0128474 A1 WO0128474 A1 WO 0128474A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drug delivery
- delivery device
- pharmaceutically active
- active agent
- sclera
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00885—Methods or devices for eye surgery using laser for treating a particular disease
- A61F2009/00891—Glaucoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT00972099T ATE289500T1 (en) | 1999-10-21 | 2000-10-12 | OPHTHALMOLOGICAL DRUG DELIVERY DEVICE |
JP2001531071A JP4685311B2 (en) | 1999-10-21 | 2000-10-12 | Ophthalmic drug delivery device |
AU10812/01A AU764226B2 (en) | 1999-10-21 | 2000-10-12 | Ophthalmic drug delivery device |
CA2384255A CA2384255C (en) | 1999-10-21 | 2000-10-12 | Ophthalmic drug delivery device |
BRPI0014928-4A BR0014928B1 (en) | 1999-10-21 | 2000-10-12 | device for dispensing medicine to a human eye. |
DK00972099T DK1221919T3 (en) | 1999-10-21 | 2000-10-12 | Ophthalmic drug administration device |
EP00972099A EP1221919B1 (en) | 1999-10-21 | 2000-10-12 | Ophthalmic drug delivery device |
PL355970A PL196539B1 (en) | 1999-10-21 | 2000-10-12 | Ophthalmic drug delivery device |
DE60018298T DE60018298T2 (en) | 1999-10-21 | 2000-10-12 | OPHTHALMOLOGICAL MEDICAMENT FEEDING DEVICE |
HK02108314.0A HK1048428B (en) | 1999-10-21 | 2002-11-15 | Ophthalmic drug delivery device |
AU2003262099A AU2003262099B2 (en) | 1999-10-21 | 2003-11-12 | Ophthalmic drug delivery device |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16067399P | 1999-10-21 | 1999-10-21 | |
US60/160,673 | 1999-10-21 | ||
US09/664,790 US6416777B1 (en) | 1999-10-21 | 2000-09-19 | Ophthalmic drug delivery device |
US09/664,790 | 2000-09-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001028474A1 true WO2001028474A1 (en) | 2001-04-26 |
Family
ID=26857116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/028187 WO2001028474A1 (en) | 1999-10-21 | 2000-10-12 | Ophthalmic drug delivery device |
Country Status (19)
Country | Link |
---|---|
US (4) | US6416777B1 (en) |
EP (1) | EP1221919B1 (en) |
JP (1) | JP4685311B2 (en) |
KR (1) | KR100752821B1 (en) |
CN (1) | CN100341470C (en) |
AR (2) | AR026183A1 (en) |
AT (1) | ATE289500T1 (en) |
AU (2) | AU764226B2 (en) |
BR (1) | BR0014928B1 (en) |
CA (1) | CA2384255C (en) |
DE (1) | DE60018298T2 (en) |
DK (1) | DK1221919T3 (en) |
ES (1) | ES2237463T3 (en) |
HK (1) | HK1048428B (en) |
PL (1) | PL196539B1 (en) |
PT (1) | PT1221919E (en) |
TR (1) | TR200201046T2 (en) |
TW (1) | TW539560B (en) |
WO (1) | WO2001028474A1 (en) |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002013805A2 (en) * | 2000-08-14 | 2002-02-21 | Alcon, Inc. | Method of treating neurodegenerative disorders of the retina and optic nerve head |
WO2002013804A2 (en) * | 2000-08-14 | 2002-02-21 | Alcon, Inc. | Method of treating angiogenesis-related disorders using benzoyl phenylacetic acid |
EP1684669A1 (en) * | 2003-07-10 | 2006-08-02 | Alcon, Inc | Ophthalmic drug delivery device |
CN100349562C (en) * | 2001-07-23 | 2007-11-21 | 爱尔康公司 | Ophthalmic drug delivery device |
JP2010063904A (en) * | 2002-03-11 | 2010-03-25 | Alcon Inc | Implantable drug delivery system |
WO2010147653A1 (en) | 2009-06-16 | 2010-12-23 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
EP2374451A2 (en) | 2005-07-27 | 2011-10-12 | University of Florida Research Foundation, Inc. | Histone deacetylase inhibitors (HDAC) that correct protein misfolding and uses thereof |
WO2012174064A1 (en) | 2011-06-14 | 2012-12-20 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
US8377000B2 (en) | 2010-10-01 | 2013-02-19 | Abbott Laboratories | Enteral feeding apparatus having a feeding set |
US8377001B2 (en) | 2010-10-01 | 2013-02-19 | Abbott Laboratories | Feeding set for a peristaltic pump system |
WO2013058809A1 (en) | 2011-10-19 | 2013-04-25 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
WO2013081642A1 (en) | 2011-12-01 | 2013-06-06 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
US8689439B2 (en) | 2010-08-06 | 2014-04-08 | Abbott Laboratories | Method for forming a tube for use with a pump delivery system |
EP2944628A1 (en) | 2011-11-30 | 2015-11-18 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
US9492432B2 (en) | 2010-04-23 | 2016-11-15 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells |
US9549895B2 (en) | 2004-04-23 | 2017-01-24 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving the viability of photoreceptor cells |
US9724357B2 (en) | 2011-08-15 | 2017-08-08 | Massachusetts Eye & Ear Infirmary | Methods for preserving photoreceptor cell viability following retinal detachment |
US9834791B2 (en) | 2013-11-07 | 2017-12-05 | Editas Medicine, Inc. | CRISPR-related methods and compositions with governing gRNAS |
US9914782B2 (en) | 2006-11-21 | 2018-03-13 | Massachusetts Eye And Ear Infirmary | Methods for preserving the viability of retinal ganglion cells in patients with glaucoma by an anti-TNF receptor 2 (anti-TNFR2) antibody |
US9938521B2 (en) | 2014-03-10 | 2018-04-10 | Editas Medicine, Inc. | CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10) |
US9993517B2 (en) | 2010-11-01 | 2018-06-12 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving retinal ganglion cells |
US10022419B2 (en) | 2011-10-21 | 2018-07-17 | Massachusetts Eye And Ear Infirmary | Methods for treating spinal cord injury |
US10842806B2 (en) | 2011-06-27 | 2020-11-24 | Massachusetts Eye And Ear Infirmary | Methods for treating ocular inflammatory disorders |
US11028388B2 (en) | 2014-03-05 | 2021-06-08 | Editas Medicine, Inc. | CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa |
US11141493B2 (en) | 2014-03-10 | 2021-10-12 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
US11339437B2 (en) | 2014-03-10 | 2022-05-24 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
US11390861B2 (en) | 2016-10-28 | 2022-07-19 | Editas Medicine, Inc. | CRISPR/cas-related methods and compositions for treating herpes simplex virus |
US11566263B2 (en) | 2016-08-02 | 2023-01-31 | Editas Medicine, Inc. | Compositions and methods for treating CEP290 associated disease |
US11638724B2 (en) | 2017-05-05 | 2023-05-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Ocular applications of matrix bound vesicles (MBVs) |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1040837A3 (en) * | 1999-02-26 | 2002-01-02 | Erasmus Universiteit Rotterdam | Medicaments for the treatment of a choroidal neovascularization (CNV) related disorder |
AU767526B2 (en) | 1999-04-26 | 2003-11-13 | Gmp Vision Solutions, Inc. | Trabeculotomy device and method for treating glaucoma |
US6416777B1 (en) * | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
US7943162B2 (en) * | 1999-10-21 | 2011-05-17 | Alcon, Inc. | Drug delivery device |
US20050119737A1 (en) * | 2000-01-12 | 2005-06-02 | Bene Eric A. | Ocular implant and methods for making and using same |
US7708711B2 (en) | 2000-04-14 | 2010-05-04 | Glaukos Corporation | Ocular implant with therapeutic agents and methods thereof |
US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
US20020143284A1 (en) * | 2001-04-03 | 2002-10-03 | Hosheng Tu | Drug-releasing trabecular implant for glaucoma treatment |
US6638239B1 (en) | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
US7181287B2 (en) * | 2001-02-13 | 2007-02-20 | Second Sight Medical Products, Inc. | Implantable drug delivery device |
WO2002078681A2 (en) * | 2001-04-02 | 2002-10-10 | Alcon, Inc. | Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac |
US7488303B1 (en) * | 2002-09-21 | 2009-02-10 | Glaukos Corporation | Ocular implant with anchor and multiple openings |
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
EP1418868B1 (en) | 2001-04-07 | 2008-03-26 | Glaukos Corporation | Glaucoma stent for glaucoma treatment |
US7678065B2 (en) | 2001-05-02 | 2010-03-16 | Glaukos Corporation | Implant with intraocular pressure sensor for glaucoma treatment |
AU2002305400A1 (en) | 2001-05-03 | 2002-11-18 | Glaukos Corporation | Medical device and methods of use for glaucoma treatment |
EP1404297B1 (en) | 2001-06-12 | 2011-04-27 | The Johns Hopkins University School Of Medicine | Reservoir device for intraocular drug delivery |
EP1409065B1 (en) | 2001-07-23 | 2007-01-17 | Alcon, Inc. | Ophthalmic drug delivery device |
US7331984B2 (en) | 2001-08-28 | 2008-02-19 | Glaukos Corporation | Glaucoma stent for treating glaucoma and methods of use |
US7749528B2 (en) * | 2001-08-29 | 2010-07-06 | Ricardo Azevedo Pontes De Carvalho | Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues |
RU2311892C2 (en) * | 2001-08-29 | 2007-12-10 | КАРВАЛХО Рикардо А. П. ДЕ | Implantable sealable system for one-way delivery of therapeutic preparations to tissues |
US7186232B1 (en) | 2002-03-07 | 2007-03-06 | Glaukoa Corporation | Fluid infusion methods for glaucoma treatment |
US7951155B2 (en) | 2002-03-15 | 2011-05-31 | Glaukos Corporation | Combined treatment for cataract and glaucoma treatment |
US9301875B2 (en) | 2002-04-08 | 2016-04-05 | Glaukos Corporation | Ocular disorder treatment implants with multiple opening |
KR20040101499A (en) * | 2002-05-03 | 2004-12-02 | 알콘, 인코퍼레이티드 | Method of treating vascular endothelial growth factor mediated vascular disorders using amfenac or nepafenac |
BR0313546A (en) * | 2002-08-05 | 2005-07-12 | Alcon Inc | Use of anacortave acetate to protect visual acuity in patients with age-related macular degeneration |
DE10238310A1 (en) * | 2002-08-21 | 2004-03-04 | Erich Jaeger Gmbh | electrode assembly |
US20050143363A1 (en) * | 2002-09-29 | 2005-06-30 | Innorx, Inc. | Method for subretinal administration of therapeutics including steroids; method for localizing pharmacodynamic action at the choroid of the retina; and related methods for treatment and/or prevention of retinal diseases |
US20030187072A1 (en) * | 2003-02-14 | 2003-10-02 | Kapin Michael A. | Method of treating angiogenesis-related disorders |
JP2006518383A (en) * | 2003-02-20 | 2006-08-10 | アルコン,インコーポレイテッド | Glucocorticoid formulations for treating pathological ocular angiogenesis |
PL378210A1 (en) * | 2003-02-20 | 2006-03-20 | Alcon, Inc. | Use of steroids to treat ocular disorders |
US20040236343A1 (en) * | 2003-05-23 | 2004-11-25 | Taylor Jon B. | Insertion tool for ocular implant and method for using same |
JP2007500250A (en) * | 2003-06-13 | 2007-01-11 | アルコン,インコーポレイテッド | Nonsteroidal anti-inflammatory drug formulations for treating pathological ocular angiogenesis |
EP1635842A4 (en) * | 2003-06-20 | 2007-04-04 | Alcon Inc | Treatment of amd with combination of ingredients |
US20050009910A1 (en) * | 2003-07-10 | 2005-01-13 | Allergan, Inc. | Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug |
JP4869930B2 (en) | 2003-08-26 | 2012-02-08 | ヴィスタ サイエンティフィック エルエルシー | Ophthalmic drug supply device |
AU2004274026A1 (en) | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
US20050158365A1 (en) * | 2003-12-22 | 2005-07-21 | David Watson | Drug delivery device with mechanical locking mechanism |
US7276050B2 (en) * | 2004-03-02 | 2007-10-02 | Alan Franklin | Trans-scleral drug delivery method and apparatus |
US20060110428A1 (en) | 2004-07-02 | 2006-05-25 | Eugene Dejuan | Methods and devices for the treatment of ocular conditions |
US7722669B2 (en) * | 2004-08-13 | 2010-05-25 | Richard Foulkes | Method and insert for modifying eye color |
US8246569B1 (en) | 2004-08-17 | 2012-08-21 | California Institute Of Technology | Implantable intraocular pressure drain |
CN100428958C (en) * | 2004-09-06 | 2008-10-29 | 段亚东 | Implant agent for treating ophthalmopathy |
KR101387456B1 (en) | 2005-02-09 | 2014-04-21 | 산텐 세이야꾸 가부시키가이샤 | Liquid formulations for treatment of diseases or conditions |
US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
KR20070121754A (en) * | 2005-03-21 | 2007-12-27 | 마커사이트, 인코포레이티드 | Drug delivery systems for treatment of diseases or conditions |
WO2006110487A1 (en) | 2005-04-08 | 2006-10-19 | Surmodics, Inc. | Sustained release implants for subretinal delivery |
US20060258994A1 (en) * | 2005-05-12 | 2006-11-16 | Avery Robert L | Implantable delivery device for administering pharmacological agents to an internal portion of a body |
US20070212397A1 (en) * | 2005-09-15 | 2007-09-13 | Roth Daniel B | Pharmaceutical delivery device and method for providing ocular treatment |
WO2007047626A1 (en) * | 2005-10-14 | 2007-04-26 | Alcon, Inc. | Combination treatment with anecortave acetate and bevacizumab or ranibizumab for pathologic ocular angiogenesis |
MX2008006379A (en) | 2005-11-29 | 2009-03-03 | Smithkline Beecham Corp | Treatment method. |
EP2001438A2 (en) | 2006-02-09 | 2008-12-17 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
EP1998829B1 (en) | 2006-03-14 | 2011-02-09 | University Of Southern California | Mems device for delivery of therapeutic agents |
DK2001466T3 (en) | 2006-03-23 | 2016-02-29 | Santen Pharmaceutical Co Ltd | LOW-DOSAGE RAPAMYCINE FOR TREATMENT OF VASCULAR PERMEABILITY-RELATED DISEASES |
US20070293807A1 (en) * | 2006-05-01 | 2007-12-20 | Lynch Mary G | Dual drainage pathway shunt device and method for treating glaucoma |
JP4829345B2 (en) * | 2006-05-04 | 2011-12-07 | カフマン、ハーバート | Methods, devices, and systems for administering therapeutic agents to the eye |
US8506515B2 (en) | 2006-11-10 | 2013-08-13 | Glaukos Corporation | Uveoscleral shunt and methods for implanting same |
WO2008076544A2 (en) * | 2006-12-18 | 2008-06-26 | Alcon Research, Ltd. | Devices and methods for ophthalmic drug delivery |
DE102007024642A1 (en) | 2007-05-24 | 2008-11-27 | Eyesense Ag | Hydrogel implant for sensor of metabolites on the eye |
EP2666510B1 (en) | 2007-12-20 | 2017-10-18 | University Of Southern California | Apparatus for controlled delivery of therapeutic agents |
US20090192493A1 (en) * | 2008-01-03 | 2009-07-30 | University Of Southern California | Implantable drug-delivery devices, and apparatus and methods for refilling the devices |
CN104353150A (en) * | 2008-05-08 | 2015-02-18 | 迷你泵有限责任公司 | Implantable pums and cannulas therefor |
US8231609B2 (en) * | 2008-05-08 | 2012-07-31 | Minipumps, Llc | Drug-delivery pumps and methods of manufacture |
US9333297B2 (en) | 2008-05-08 | 2016-05-10 | Minipumps, Llc | Drug-delivery pump with intelligent control |
CN103394142B (en) | 2008-05-08 | 2015-08-19 | 迷你泵有限责任公司 | Implantable drug delivery devices with for filling equipment and the method for this device |
US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
EP2276439A4 (en) | 2008-05-12 | 2013-11-27 | Univ Utah Res Found | Intraocular drug delivery device and associated methods |
US9095404B2 (en) | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
US8664182B2 (en) | 2008-11-12 | 2014-03-04 | Duke University | Methods of inhibiting cancer cell growth with HDAC inhibitors and methods of screening for HDAC10 inhibitors |
PL2391419T3 (en) | 2009-01-29 | 2019-12-31 | Forsight Vision4, Inc. | Posterior segment drug delivery |
US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
US8372036B2 (en) | 2009-05-06 | 2013-02-12 | Alcon Research, Ltd. | Multi-layer heat assembly for a drug delivery device |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
ES2921527T3 (en) | 2009-06-03 | 2022-08-29 | Forsight Vision5 Inc | Anterior segment drug delivery |
EP2467797B1 (en) * | 2009-08-18 | 2017-07-19 | MiniPumps, LLC | Electrolytic drug-delivery pump with adaptive control |
US20120232102A1 (en) | 2009-09-30 | 2012-09-13 | Chun-Fang Xu | Methods Of Administration And Treatment |
US8177747B2 (en) | 2009-12-22 | 2012-05-15 | Alcon Research, Ltd. | Method and apparatus for drug delivery |
US10166142B2 (en) | 2010-01-29 | 2019-01-01 | Forsight Vision4, Inc. | Small molecule delivery with implantable therapeutic device |
WO2011146483A1 (en) | 2010-05-17 | 2011-11-24 | Aerie Pharmaceuticals, Inc. | Drug delivery devices for delivery of ocular therapeutic agents |
SI2600812T1 (en) | 2010-08-05 | 2021-12-31 | ForSight Vision4, Inc., | Apparatus to treat an eye |
EP3861969A1 (en) | 2010-08-05 | 2021-08-11 | ForSight Vision4, Inc. | Injector apparatus for drug delivery |
WO2012019139A1 (en) | 2010-08-05 | 2012-02-09 | Forsight Vision4, Inc. | Combined drug delivery methods and apparatus |
US20120109054A1 (en) * | 2010-10-29 | 2012-05-03 | Vista Scientific Llc | Devices with an erodible surface for delivering at least one active agent to tissue over a prolonged period of time |
CA2818612C (en) | 2010-11-19 | 2020-12-29 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
US9919099B2 (en) | 2011-03-14 | 2018-03-20 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
US9603997B2 (en) | 2011-03-14 | 2017-03-28 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
US10286146B2 (en) | 2011-03-14 | 2019-05-14 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
EP4249059A3 (en) | 2011-06-28 | 2023-11-29 | ForSight Vision4, Inc. | An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye |
WO2013040238A2 (en) | 2011-09-13 | 2013-03-21 | Vista Scientific Llc | Sustained release ocular drug delivery devices and methods of manufacture |
EP3659495B1 (en) | 2011-09-13 | 2022-12-14 | Dose Medical Corporation | Intraocular physiological sensor |
RU2740680C2 (en) | 2011-09-14 | 2021-01-19 | Форсайт Вижн5, Инк. | Eye inserter device and methods |
SI2755600T1 (en) | 2011-09-16 | 2021-08-31 | Forsight Vision4, Inc. | Fluid exchange apparatus |
US10010448B2 (en) | 2012-02-03 | 2018-07-03 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
PT2911623T (en) | 2012-10-26 | 2019-11-21 | Forsight Vision5 Inc | Ophthalmic system for sustained release of drug to eye |
US9730638B2 (en) | 2013-03-13 | 2017-08-15 | Glaukos Corporation | Intraocular physiological sensor |
AU2014236455B2 (en) | 2013-03-14 | 2018-07-12 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
US9592151B2 (en) | 2013-03-15 | 2017-03-14 | Glaukos Corporation | Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye |
EP4302736A3 (en) | 2013-03-28 | 2024-04-03 | ForSight Vision4, Inc. | Ophthalmic implant for delivering therapeutic substances |
US10098836B2 (en) | 2013-05-02 | 2018-10-16 | Retina Foundation Of The Southwest | Method for forming a molded two-layer ocular implant |
EP3089748A4 (en) | 2014-01-02 | 2017-09-27 | Massachusetts Eye & Ear Infirmary | Treating ocular neovascularization |
AU2015266850B2 (en) | 2014-05-29 | 2019-12-05 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
US10258503B2 (en) | 2014-07-15 | 2019-04-16 | Forsight Vision4, Inc. | Ocular implant delivery device and method |
MY182793A (en) | 2014-08-08 | 2021-02-05 | Forsight Vision4 Inc | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
US10500091B2 (en) | 2014-11-10 | 2019-12-10 | Forsight Vision4, Inc. | Expandable drug delivery devices and methods of use |
EP3283004A4 (en) | 2015-04-13 | 2018-12-05 | Forsight Vision5, Inc. | Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent |
WO2016187426A1 (en) | 2015-05-19 | 2016-11-24 | Amorphex Therapeutics Llc | A device that delivers a sustained low-dose of a myopia-suppressing drug |
US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
CN109312338B (en) | 2015-10-30 | 2022-09-27 | 爱迪塔斯医药公司 | CRISPR/CAS related methods and compositions for treating herpes simplex virus |
CN108430405B (en) | 2015-11-20 | 2021-04-13 | 弗赛特影像4股份有限公司 | Porous structures for sustained release drug delivery devices |
CN105997338B (en) * | 2016-03-09 | 2019-04-26 | 泰山医学院 | Through vitreum nano material drug delivery system |
US11617680B2 (en) | 2016-04-05 | 2023-04-04 | Forsight Vision4, Inc. | Implantable ocular drug delivery devices |
AU2017252294B2 (en) | 2016-04-20 | 2021-12-02 | Dose Medical Corporation | Bioresorbable ocular drug delivery device |
CA3032153A1 (en) | 2016-08-19 | 2018-02-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selective estrogen-receptor modulators (serms) confer protection against photoreceptor degeneration |
CN110944634A (en) | 2017-06-30 | 2020-03-31 | 加利福尼亚大学董事会 | Compositions and methods for regulating hair growth |
WO2019103906A1 (en) | 2017-11-21 | 2019-05-31 | Forsight Vision4, Inc. | Fluid exchange apparatus for expandable port delivery system and methods of use |
EP3758736B1 (en) | 2018-03-02 | 2024-05-01 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Il-34 for use in a method of treating retinal inflammation and neurodegeneration |
JPWO2019203310A1 (en) * | 2018-04-18 | 2021-04-22 | 株式会社ニコン | Image processing methods, programs, and image processing equipment |
US20220079899A1 (en) * | 2019-01-14 | 2022-03-17 | The Regents Of The University Of California | Compositions and methods for treating ocular conditions |
KR20210133993A (en) | 2019-02-25 | 2021-11-08 | 에디타스 메디신, 인코포레이티드 | CRISPR/RNA-guided nuclease-related methods and compositions for treating RHO-associated autosomal-dominant retinitis pigmentosa (ADRP) |
EP4090381A1 (en) | 2020-01-17 | 2022-11-23 | The United States of America, as represented by the Secretary, Department of Health and Human Services | <smallcaps/>? ? ?crx-? ? ? ? ?gene therapy for treatment ofautosomal dominant retinopathies |
AU2021300425A1 (en) | 2020-07-02 | 2023-02-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cyclic compounds for use in treating retinal degeneration |
WO2022221741A1 (en) | 2021-04-16 | 2022-10-20 | Editas Medicine, Inc. | Crispr/rna-guided nuclease-related methods and compositions for treating rho-associated autosomal-dominant retinitis pigmentosa (adrp) |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4022553A1 (en) * | 1990-07-16 | 1992-01-23 | Hund Helmut Gmbh | Medical contact lens - with recess contg. therapeutically or diagnostically active substance |
US5476511A (en) | 1992-05-04 | 1995-12-19 | Allergan, Inc. | Subconjunctival implants for ocular drug delivery |
US5679666A (en) | 1991-11-22 | 1997-10-21 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids |
US5725493A (en) * | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
US5743274A (en) * | 1996-03-18 | 1998-04-28 | Peyman; Gholam A. | Macular bandage for use in the treatment of subretinal neovascular members |
US5770592A (en) | 1991-11-22 | 1998-06-23 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization using angiostatic steroids |
US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
US5824073A (en) | 1996-03-18 | 1998-10-20 | Peyman; Gholam A. | Macular indentor for use in the treatment of subretinal neovascular membranes |
US5824072A (en) | 1993-11-15 | 1998-10-20 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3416530A (en) | 1966-03-02 | 1968-12-17 | Richard A. Ness | Eyeball medication dispensing tablet |
US3756478A (en) * | 1971-02-03 | 1973-09-04 | D Podell | Eye drop dispenser with liquid metering device |
US3828777A (en) | 1971-11-08 | 1974-08-13 | Alza Corp | Microporous ocular device |
US4014335A (en) | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
US4300557A (en) | 1980-01-07 | 1981-11-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating intraocular malignancies |
US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
US5322691A (en) | 1986-10-02 | 1994-06-21 | Sohrab Darougar | Ocular insert with anchoring protrusions |
US5147647A (en) | 1986-10-02 | 1992-09-15 | Sohrab Darougar | Ocular insert for the fornix |
US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
DE3905050A1 (en) | 1989-02-18 | 1990-08-30 | Lohmann Therapie Syst Lts | THERAPEUTIC SYSTEM FOR DELAYED AND CONTROLLED TRANSDERMAL OR TRANSMUCOSAL ADMINISTRATION OF ACTIVE SUBSTANCES (II) |
US4946450A (en) | 1989-04-18 | 1990-08-07 | Biosource Genetics Corporation | Glucan/collagen therapeutic eye shields |
DE69032100T2 (en) * | 1989-08-14 | 1998-10-29 | Photogenesis Inc | SURGICAL INSTRUMENT AND CELL INSULATION |
US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
US5290892A (en) | 1990-11-07 | 1994-03-01 | Nestle S.A. | Flexible intraocular lenses made from high refractive index polymers |
US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
WO1993020785A1 (en) * | 1992-04-20 | 1993-10-28 | Basilice Vincent P | Improvements in dispensing eye drops |
FR2690846B1 (en) | 1992-05-05 | 1995-07-07 | Aiache Jean Marc | GALENIC FORM FOR EYE ADMINISTRATION AND METHOD OF PREPARATION. |
US5387202A (en) * | 1992-07-20 | 1995-02-07 | Aaron Medical Industries | Eye drop dispensing device |
WO1994005257A1 (en) | 1992-09-08 | 1994-03-17 | Allergan, Inc. | Sustained release of ophthalmic drugs from a soluble polymer drug delivery vehicle |
US5707643A (en) * | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
CA2158443C (en) * | 1993-03-16 | 2003-11-25 | Stephen E. Hughes | Method for preparation and transplantation of volute grafts and surgical instrument therefor |
WO1995003009A1 (en) | 1993-07-22 | 1995-02-02 | Oculex Pharmaceuticals, Inc. | Method of treatment of macular degeneration |
US5516522A (en) | 1994-03-14 | 1996-05-14 | Board Of Supervisors Of Louisiana State University | Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same |
JPH09511507A (en) | 1994-04-04 | 1997-11-18 | フリーマン,ウイリアム・アール | Use of phosphonyl methoxyalkyl nucleosides to treat elevated intraocular pressure |
US5466233A (en) | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
US5710165A (en) * | 1994-07-06 | 1998-01-20 | Synthelabo | Use of polyamine antagonists for the treatment of glaucoma |
AUPM897594A0 (en) | 1994-10-25 | 1994-11-17 | Daratech Pty Ltd | Controlled release container |
AU708529B2 (en) | 1994-11-10 | 1999-08-05 | University Of Kentucky Research Foundation, The | Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body |
CN1283324C (en) | 1995-05-14 | 2006-11-08 | 奥普通诺尔有限公司 | Intraocular implant, delivery device, and method of implantation |
AUPN605795A0 (en) | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
US5904144A (en) * | 1996-03-22 | 1999-05-18 | Cytotherapeutics, Inc. | Method for treating ophthalmic diseases |
JP3309175B2 (en) | 1996-03-25 | 2002-07-29 | 参天製薬株式会社 | Scleral plug containing proteinaceous drug |
US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
US6120460A (en) * | 1996-09-04 | 2000-09-19 | Abreu; Marcio Marc | Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions |
US5941250A (en) * | 1996-11-21 | 1999-08-24 | University Of Louisville Research Foundation Inc. | Retinal tissue implantation method |
ZA9710342B (en) | 1996-11-25 | 1998-06-10 | Alza Corp | Directional drug delivery stent and method of use. |
DK0973499T3 (en) | 1997-03-31 | 2003-11-17 | Alza Corp | Implantable diffusion delivery system |
JPH1170138A (en) * | 1997-07-02 | 1999-03-16 | Santen Pharmaceut Co Ltd | Polylactic acid scleral plug |
ES2232005T3 (en) | 1997-08-11 | 2005-05-16 | Allergan, Inc. | BIODEGRADABLE STERILE IMPLANT DEVICE CONTAINING RETINOID WITH IMPROVED BIOCOMPATIBILITY AND PREPARATION METHOD. |
US5902598A (en) | 1997-08-28 | 1999-05-11 | Control Delivery Systems, Inc. | Sustained release drug delivery devices |
US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
EP1061913B1 (en) | 1998-03-13 | 2007-06-27 | The Johns Hopkins University School Of Medicine | The use of a protein tyrosine inhibitor such as genistein in the treatment of diabetic retinopathy |
US6146366A (en) | 1998-11-03 | 2000-11-14 | Ras Holding Corp | Device for the treatment of macular degeneration and other eye disorders |
US6399655B1 (en) | 1998-12-22 | 2002-06-04 | Johns Hopkins University, School Of Medicine | Method for the prophylactic treatment of cataracts |
US6217895B1 (en) | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
US6416777B1 (en) * | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
ATE283013T1 (en) * | 1999-10-21 | 2004-12-15 | Alcon Inc | MEDICATION DELIVERY DEVICE |
RU2149615C1 (en) | 1999-11-10 | 2000-05-27 | Нестеров Аркадий Павлович | Method for introducing drugs in treating posterior eye segment diseases |
US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
ATE547080T1 (en) * | 2000-08-30 | 2012-03-15 | Univ Johns Hopkins | DEVICES FOR INTRAOCULAR DRUG DELIVERY |
-
2000
- 2000-09-19 US US09/664,790 patent/US6416777B1/en not_active Expired - Lifetime
- 2000-10-12 CA CA2384255A patent/CA2384255C/en not_active Expired - Fee Related
- 2000-10-12 JP JP2001531071A patent/JP4685311B2/en not_active Expired - Fee Related
- 2000-10-12 PT PT00972099T patent/PT1221919E/en unknown
- 2000-10-12 EP EP00972099A patent/EP1221919B1/en not_active Expired - Lifetime
- 2000-10-12 BR BRPI0014928-4A patent/BR0014928B1/en not_active IP Right Cessation
- 2000-10-12 WO PCT/US2000/028187 patent/WO2001028474A1/en active IP Right Grant
- 2000-10-12 CN CNB008131929A patent/CN100341470C/en not_active Expired - Fee Related
- 2000-10-12 AT AT00972099T patent/ATE289500T1/en active
- 2000-10-12 KR KR1020027005022A patent/KR100752821B1/en not_active IP Right Cessation
- 2000-10-12 AU AU10812/01A patent/AU764226B2/en not_active Ceased
- 2000-10-12 TR TR2002/01046T patent/TR200201046T2/en unknown
- 2000-10-12 PL PL355970A patent/PL196539B1/en not_active IP Right Cessation
- 2000-10-12 DE DE60018298T patent/DE60018298T2/en not_active Expired - Lifetime
- 2000-10-12 DK DK00972099T patent/DK1221919T3/en active
- 2000-10-12 ES ES00972099T patent/ES2237463T3/en not_active Expired - Lifetime
- 2000-10-19 AR ARP000105517A patent/AR026183A1/en active IP Right Grant
- 2000-10-20 TW TW089122134A patent/TW539560B/en not_active IP Right Cessation
-
2002
- 2002-07-01 US US10/187,006 patent/US6669950B2/en not_active Expired - Lifetime
- 2002-11-15 HK HK02108314.0A patent/HK1048428B/en not_active IP Right Cessation
-
2003
- 2003-03-25 AR ARP030101033A patent/AR039130A2/en unknown
- 2003-10-30 US US10/697,423 patent/US20040131655A1/en not_active Abandoned
- 2003-10-30 US US10/697,141 patent/US20040131654A1/en not_active Abandoned
- 2003-11-12 AU AU2003262099A patent/AU2003262099B2/en not_active Ceased
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4022553A1 (en) * | 1990-07-16 | 1992-01-23 | Hund Helmut Gmbh | Medical contact lens - with recess contg. therapeutically or diagnostically active substance |
US5679666A (en) | 1991-11-22 | 1997-10-21 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids |
US5770592A (en) | 1991-11-22 | 1998-06-23 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization using angiostatic steroids |
US5476511A (en) | 1992-05-04 | 1995-12-19 | Allergan, Inc. | Subconjunctival implants for ocular drug delivery |
US5824072A (en) | 1993-11-15 | 1998-10-20 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US5725493A (en) * | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
US5743274A (en) * | 1996-03-18 | 1998-04-28 | Peyman; Gholam A. | Macular bandage for use in the treatment of subretinal neovascular members |
US5824073A (en) | 1996-03-18 | 1998-10-20 | Peyman; Gholam A. | Macular indentor for use in the treatment of subretinal neovascular membranes |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002013804A2 (en) * | 2000-08-14 | 2002-02-21 | Alcon, Inc. | Method of treating angiogenesis-related disorders using benzoyl phenylacetic acid |
WO2002013805A3 (en) * | 2000-08-14 | 2002-05-30 | Alcon Inc | Method of treating neurodegenerative disorders of the retina and optic nerve head |
WO2002013804A3 (en) * | 2000-08-14 | 2002-06-06 | Alcon Universal Ltd | Method of treating angiogenesis-related disorders using benzoyl phenylacetic acid |
US6638976B2 (en) | 2000-08-14 | 2003-10-28 | Alcon, Inc. | Method of treating neurodegenerative disorders of the retina and optic nerve head |
WO2002013805A2 (en) * | 2000-08-14 | 2002-02-21 | Alcon, Inc. | Method of treating neurodegenerative disorders of the retina and optic nerve head |
CN100349562C (en) * | 2001-07-23 | 2007-11-21 | 爱尔康公司 | Ophthalmic drug delivery device |
JP2010063904A (en) * | 2002-03-11 | 2010-03-25 | Alcon Inc | Implantable drug delivery system |
KR101127502B1 (en) * | 2002-03-11 | 2012-03-23 | 알콘, 인코퍼레이티드 | Implantable drug delivery system |
KR101173497B1 (en) | 2002-03-11 | 2012-08-14 | 알콘, 인코퍼레이티드 | Implantable drug delivery system |
KR101191254B1 (en) * | 2002-03-11 | 2012-10-16 | 알콘, 인코퍼레이티드 | Implantable drug delivery system |
JP2013063308A (en) * | 2002-03-11 | 2013-04-11 | Alcon Inc | Implantable drug delivery system |
EP1684669A4 (en) * | 2003-07-10 | 2008-01-02 | Alcon Inc | Ophthalmic drug delivery device |
EP1684669A1 (en) * | 2003-07-10 | 2006-08-02 | Alcon, Inc | Ophthalmic drug delivery device |
US9549895B2 (en) | 2004-04-23 | 2017-01-24 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving the viability of photoreceptor cells |
EP2374451A2 (en) | 2005-07-27 | 2011-10-12 | University of Florida Research Foundation, Inc. | Histone deacetylase inhibitors (HDAC) that correct protein misfolding and uses thereof |
US9914782B2 (en) | 2006-11-21 | 2018-03-13 | Massachusetts Eye And Ear Infirmary | Methods for preserving the viability of retinal ganglion cells in patients with glaucoma by an anti-TNF receptor 2 (anti-TNFR2) antibody |
WO2010147653A1 (en) | 2009-06-16 | 2010-12-23 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
EP3100723A1 (en) | 2009-06-16 | 2016-12-07 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
US9492432B2 (en) | 2010-04-23 | 2016-11-15 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells |
US10639345B2 (en) | 2010-04-23 | 2020-05-05 | Massachusetts Eye And Ear Infirmary | Compositions for preserving photoreceptor cells, retinal pigment epithelial cells, or visual function |
US10149884B2 (en) | 2010-04-23 | 2018-12-11 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells |
US8689439B2 (en) | 2010-08-06 | 2014-04-08 | Abbott Laboratories | Method for forming a tube for use with a pump delivery system |
US8377000B2 (en) | 2010-10-01 | 2013-02-19 | Abbott Laboratories | Enteral feeding apparatus having a feeding set |
US8377001B2 (en) | 2010-10-01 | 2013-02-19 | Abbott Laboratories | Feeding set for a peristaltic pump system |
US9993517B2 (en) | 2010-11-01 | 2018-06-12 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving retinal ganglion cells |
US10617735B2 (en) | 2010-11-01 | 2020-04-14 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving retinal ganglion cells |
WO2012174064A1 (en) | 2011-06-14 | 2012-12-20 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
US10842806B2 (en) | 2011-06-27 | 2020-11-24 | Massachusetts Eye And Ear Infirmary | Methods for treating ocular inflammatory disorders |
US9724357B2 (en) | 2011-08-15 | 2017-08-08 | Massachusetts Eye & Ear Infirmary | Methods for preserving photoreceptor cell viability following retinal detachment |
WO2013058809A1 (en) | 2011-10-19 | 2013-04-25 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
US10022419B2 (en) | 2011-10-21 | 2018-07-17 | Massachusetts Eye And Ear Infirmary | Methods for treating spinal cord injury |
US10799552B2 (en) | 2011-10-21 | 2020-10-13 | Massachusetts Eye And Ear Infirmary | Methods for treating diabetic neurotherapy |
EP2944628A1 (en) | 2011-11-30 | 2015-11-18 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
WO2013081642A1 (en) | 2011-12-01 | 2013-06-06 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
US10190137B2 (en) | 2013-11-07 | 2019-01-29 | Editas Medicine, Inc. | CRISPR-related methods and compositions with governing gRNAS |
US11390887B2 (en) | 2013-11-07 | 2022-07-19 | Editas Medicine, Inc. | CRISPR-related methods and compositions with governing gRNAS |
US10640788B2 (en) | 2013-11-07 | 2020-05-05 | Editas Medicine, Inc. | CRISPR-related methods and compositions with governing gRNAs |
US9834791B2 (en) | 2013-11-07 | 2017-12-05 | Editas Medicine, Inc. | CRISPR-related methods and compositions with governing gRNAS |
US11028388B2 (en) | 2014-03-05 | 2021-06-08 | Editas Medicine, Inc. | CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa |
US10253312B2 (en) | 2014-03-10 | 2019-04-09 | Editas Medicine, Inc. | CRISPR/CAS-related methods and compositions for treating Leber's Congenital Amaurosis 10 (LCA10) |
US11141493B2 (en) | 2014-03-10 | 2021-10-12 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
US11268086B2 (en) | 2014-03-10 | 2022-03-08 | Editas Medicine, Inc. | CRISPR/CAS-related methods and compositions for treating Leber's Congenital Amaurosis 10 (LCA10) |
US11339437B2 (en) | 2014-03-10 | 2022-05-24 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
US9938521B2 (en) | 2014-03-10 | 2018-04-10 | Editas Medicine, Inc. | CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10) |
US11566263B2 (en) | 2016-08-02 | 2023-01-31 | Editas Medicine, Inc. | Compositions and methods for treating CEP290 associated disease |
US11390861B2 (en) | 2016-10-28 | 2022-07-19 | Editas Medicine, Inc. | CRISPR/cas-related methods and compositions for treating herpes simplex virus |
US11638724B2 (en) | 2017-05-05 | 2023-05-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Ocular applications of matrix bound vesicles (MBVs) |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6416777B1 (en) | Ophthalmic drug delivery device | |
US6413540B1 (en) | Drug delivery device | |
AU2002319606B2 (en) | Ophthalmic drug delivery device | |
US7943162B2 (en) | Drug delivery device | |
US20060039952A1 (en) | Ophthalmic drug delivery device | |
AU2002319606A1 (en) | Ophthalmic drug delivery device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU BR CA CN JP KR MX PL TR US ZA |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2002/01189 Country of ref document: ZA Ref document number: 200201189 Country of ref document: ZA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2000972099 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10812/01 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2384255 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2002/002925 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 008131929 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002/01046 Country of ref document: TR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020027005022 Country of ref document: KR |
|
ENP | Entry into the national phase |
Ref document number: 2001 531071 Country of ref document: JP Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 1020027005022 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 2000972099 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 10812/01 Country of ref document: AU |
|
WWG | Wipo information: grant in national office |
Ref document number: 2000972099 Country of ref document: EP |