WO2001026709A3 - Apparatus and method for blood oxygenation - Google Patents

Apparatus and method for blood oxygenation Download PDF

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Publication number
WO2001026709A3
WO2001026709A3 PCT/US2000/026521 US0026521W WO0126709A3 WO 2001026709 A3 WO2001026709 A3 WO 2001026709A3 US 0026521 W US0026521 W US 0026521W WO 0126709 A3 WO0126709 A3 WO 0126709A3
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
gas
fluid
blood
inlet
Prior art date
Application number
PCT/US2000/026521
Other languages
French (fr)
Other versions
WO2001026709A2 (en
WO2001026709A9 (en
Inventor
Vincent Divino Jr
William R Patterson
Jeffrey L Creech
Stephen E Myrick
Mark S Buhr
James E Benedict Iv
Paul J Zakesky
Original Assignee
Therox Inc
Vincent Divino Jr
William R Patterson
Jeffrey L Creech
Stephen E Myrick
Mark S Buhr
James E Benedict Iv
Paul J Zakesky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/409,952 external-priority patent/US6387324B1/en
Priority claimed from US09/410,343 external-priority patent/US6576191B1/en
Priority claimed from US09/410,344 external-priority patent/US6602467B1/en
Priority claimed from US09/410,179 external-priority patent/US6759008B1/en
Application filed by Therox Inc, Vincent Divino Jr, William R Patterson, Jeffrey L Creech, Stephen E Myrick, Mark S Buhr, James E Benedict Iv, Paul J Zakesky filed Critical Therox Inc
Priority to DE60031706T priority Critical patent/DE60031706T2/en
Priority to EP00965476A priority patent/EP1220695B1/en
Priority to AU76189/00A priority patent/AU7618900A/en
Priority to JP2001529770A priority patent/JP4448640B2/en
Publication of WO2001026709A2 publication Critical patent/WO2001026709A2/en
Publication of WO2001026709A3 publication Critical patent/WO2001026709A3/en
Publication of WO2001026709A9 publication Critical patent/WO2001026709A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3613—Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/21—Mixing gases with liquids by introducing liquids into gaseous media
    • B01F23/213—Mixing gases with liquids by introducing liquids into gaseous media by spraying or atomising of the liquids
    • B01F23/2132—Mixing gases with liquids by introducing liquids into gaseous media by spraying or atomising of the liquids using nozzles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A61M2202/0476—Oxygenated solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Abstract

An apparatus and method for blood oxygenation is provided, comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vertical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient a catheter, or other interventional fluid delivery device. Alternatively, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator.
PCT/US2000/026521 1999-09-30 2000-09-27 Apparatus and method for blood oxygenation WO2001026709A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE60031706T DE60031706T2 (en) 1999-09-30 2000-09-27 DEVICE FOR BLOOD OXYGENATION
EP00965476A EP1220695B1 (en) 1999-09-30 2000-09-27 Apparatus for blood oxygenation
AU76189/00A AU7618900A (en) 1999-09-30 2000-09-27 Apparatus and method for blood oxygenation
JP2001529770A JP4448640B2 (en) 1999-09-30 2000-09-27 Fluid mixing device

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US41013499A 1999-09-30 1999-09-30
US40923599A 1999-09-30 1999-09-30
US09/409,952 US6387324B1 (en) 1999-09-30 1999-09-30 Apparatus and method for blood oxygenation
US09/410,343 US6576191B1 (en) 1999-09-30 1999-09-30 Apparatus for blood oxygenation
US09/410,344 1999-09-30
US09/409,235 1999-09-30
US09/410,134 1999-09-30
US09/410,344 US6602467B1 (en) 1998-07-24 1999-09-30 Apparatus and method for blood oxygenation
US09/410,179 US6759008B1 (en) 1999-09-30 1999-09-30 Apparatus and method for blood oxygenation
US09/409,952 1999-09-30
US09/410,343 1999-09-30
US09/410,179 1999-09-30

Publications (3)

Publication Number Publication Date
WO2001026709A2 WO2001026709A2 (en) 2001-04-19
WO2001026709A3 true WO2001026709A3 (en) 2001-11-29
WO2001026709A9 WO2001026709A9 (en) 2002-11-21

Family

ID=27559946

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/026521 WO2001026709A2 (en) 1999-09-30 2000-09-27 Apparatus and method for blood oxygenation

Country Status (7)

Country Link
EP (5) EP1762256B1 (en)
JP (4) JP4448640B2 (en)
AT (2) ATE450279T1 (en)
AU (1) AU7618900A (en)
DE (2) DE60043467D1 (en)
ES (2) ES2273731T3 (en)
WO (1) WO2001026709A2 (en)

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US6582387B2 (en) * 2001-03-20 2003-06-24 Therox, Inc. System for enriching a bodily fluid with a gas
US9078964B2 (en) * 2008-08-21 2015-07-14 Sur-Real Industries, Inc. Pump device, tube device and method for movement and collection of fluid
JP4926257B2 (en) 2010-03-03 2012-05-09 株式会社エヌ・ティ・ティ・ドコモ Positioning terminal and server
DE102011052188A1 (en) * 2011-07-27 2013-01-31 Maquet Vertrieb Und Service Deutschland Gmbh Arrangement for removing carbon dioxide from blood flow or for enriching blood flow with oxygen, has filter, which has membrane, where membrane separates blood region, through which blood flow is guided
DE102011052187A1 (en) 2011-07-27 2013-01-31 Maquet Vertrieb Und Service Deutschland Gmbh Arrangement for removing carbon dioxide from an extracorporeal blood stream by means of inert gases
DE102011052189A1 (en) * 2011-07-27 2013-01-31 Maquet Vertrieb Und Service Deutschland Gmbh Electronically controlled gas mixing unit for supplying a purge gas to an oxygenator
ITMO20120052A1 (en) * 2012-03-01 2013-09-02 Cardionova S R L EQUIPMENT CONNECTED TO A DEVICE FOR EXTRACORPROUS BLOOD OXYGENATION
JP7007044B2 (en) * 2015-08-11 2022-01-24 モキタ メディカル ゲーエムベーハー Methods, kits and systems for removing air from medical devices
DE102016010398A1 (en) * 2016-06-10 2017-12-14 Hemovent Gmbh Gas exchange unit, method for manufacturing a gas exchange unit and set with a gas exchange unit and a humidifying and heating device
DE102016009534A1 (en) 2016-08-08 2018-02-08 Xenios Ag Oxygenator with a housing wall
DE102016011946A1 (en) * 2016-08-09 2018-02-15 Xenios Ag Oxygenator with a housing wall
US11759558B2 (en) * 2017-04-03 2023-09-19 United States Government As Represented By The Department Of Veterans Affairs Microfluidic diffusion devices and systems, and methods of manufacturing and using same
RU2750524C1 (en) * 2020-02-14 2021-06-29 Общество с ограниченной ответственностью "Салютарис" Membrane hollow fiber blood oxygenator
EP4126103A1 (en) * 2020-03-31 2023-02-08 ZOLL Circulation, Inc. System and method for controlling supersaturated oxygen therapy based on patient parameter feedback
EP4126098A1 (en) * 2020-04-07 2023-02-08 Gis Ventures Inc. Infusing dissolved oxygen into i.v. fluids to provide short term emergency oxygenation of venous blood for compromised or trauma patients

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GB1506555A (en) * 1974-05-24 1978-04-05 Johnson & Johnson Blood reservoir
US4239729A (en) * 1978-06-06 1980-12-16 Terumo Corporation Oxygenator
US4297318A (en) * 1975-06-06 1981-10-27 Bentley Laboratories, Inc. Blood oxygenator
US4596210A (en) * 1982-09-04 1986-06-24 Kohlensaurewerke C. G. Rommenholler Gmbh Method and device for dissolving gas, especially carbon dioxide, in liquid fuel and for distributing the fuel in a supersaturated state through the combustion air
US4735750A (en) * 1985-01-16 1988-04-05 Damann Franz Josef Process and device for the dissolution of gas in liquid
US4804358A (en) * 1985-02-20 1989-02-14 Medicorp Research Laboratories Corporation Coronary perfusion pump
US4917667A (en) * 1988-02-11 1990-04-17 Retroperfusion Systems, Inc. Retroperfusion balloon catheter and method
US5261875A (en) * 1991-02-14 1993-11-16 Wayne State University Method and apparatus for injection of gas hydrates
US5380307A (en) * 1992-09-30 1995-01-10 Target Therapeutics, Inc. Catheter with atraumatic drug delivery tip
US5382407A (en) * 1988-12-14 1995-01-17 Minnesota Mining And Manufacturing Company Membrane blood oxygenator
US5573505A (en) * 1993-03-04 1996-11-12 Johnson; Gilbert H. Variable ratio blood-additive solution device and delivery system
US5599296A (en) * 1991-02-14 1997-02-04 Wayne State University Apparatus and method of delivery of gas-supersaturated liquids
US5730935A (en) * 1984-07-12 1998-03-24 Wayne State University High pressure gas exchanger
WO1999008733A1 (en) * 1997-08-15 1999-02-25 Therox, Inc. System and method for generalized extracorporeal support
US5888611A (en) * 1995-11-30 1999-03-30 Leonard; Ronald J. Multilayer hollow fiber body and method of making
US5893838A (en) * 1997-08-15 1999-04-13 Therox, Inc. System and method for high pressure delivery of gas-supersaturated fluids

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Publication number Priority date Publication date Assignee Title
GB1506555A (en) * 1974-05-24 1978-04-05 Johnson & Johnson Blood reservoir
US4297318A (en) * 1975-06-06 1981-10-27 Bentley Laboratories, Inc. Blood oxygenator
US4239729A (en) * 1978-06-06 1980-12-16 Terumo Corporation Oxygenator
US4596210A (en) * 1982-09-04 1986-06-24 Kohlensaurewerke C. G. Rommenholler Gmbh Method and device for dissolving gas, especially carbon dioxide, in liquid fuel and for distributing the fuel in a supersaturated state through the combustion air
US5730935A (en) * 1984-07-12 1998-03-24 Wayne State University High pressure gas exchanger
US4735750A (en) * 1985-01-16 1988-04-05 Damann Franz Josef Process and device for the dissolution of gas in liquid
US4804358A (en) * 1985-02-20 1989-02-14 Medicorp Research Laboratories Corporation Coronary perfusion pump
US4917667A (en) * 1988-02-11 1990-04-17 Retroperfusion Systems, Inc. Retroperfusion balloon catheter and method
US5382407A (en) * 1988-12-14 1995-01-17 Minnesota Mining And Manufacturing Company Membrane blood oxygenator
US5261875A (en) * 1991-02-14 1993-11-16 Wayne State University Method and apparatus for injection of gas hydrates
US5599296A (en) * 1991-02-14 1997-02-04 Wayne State University Apparatus and method of delivery of gas-supersaturated liquids
US5380307A (en) * 1992-09-30 1995-01-10 Target Therapeutics, Inc. Catheter with atraumatic drug delivery tip
US5573505A (en) * 1993-03-04 1996-11-12 Johnson; Gilbert H. Variable ratio blood-additive solution device and delivery system
US5888611A (en) * 1995-11-30 1999-03-30 Leonard; Ronald J. Multilayer hollow fiber body and method of making
WO1999008733A1 (en) * 1997-08-15 1999-02-25 Therox, Inc. System and method for generalized extracorporeal support
US5893838A (en) * 1997-08-15 1999-04-13 Therox, Inc. System and method for high pressure delivery of gas-supersaturated fluids

Also Published As

Publication number Publication date
EP2143453A3 (en) 2010-02-17
ATE450279T1 (en) 2009-12-15
ES2335680T3 (en) 2010-03-31
DE60031706T2 (en) 2007-09-06
JP5502927B2 (en) 2014-05-28
DE60031706D1 (en) 2006-12-14
EP1220695B1 (en) 2006-11-02
JP5066156B2 (en) 2012-11-07
JP2003532448A (en) 2003-11-05
EP2143453A2 (en) 2010-01-13
WO2001026709A2 (en) 2001-04-19
JP2012152572A (en) 2012-08-16
ATE344066T1 (en) 2006-11-15
ES2273731T3 (en) 2007-05-16
JP2009172393A (en) 2009-08-06
EP1767230A2 (en) 2007-03-28
EP1767231A1 (en) 2007-03-28
AU7618900A (en) 2001-04-23
EP2143453B1 (en) 2013-08-14
EP1762256A1 (en) 2007-03-14
DE60043467D1 (en) 2010-01-14
WO2001026709A9 (en) 2002-11-21
EP1767231B1 (en) 2009-12-02
JP2010046506A (en) 2010-03-04
EP1220695A2 (en) 2002-07-10
JP4448640B2 (en) 2010-04-14
EP1767230A3 (en) 2007-07-11
EP1762256B1 (en) 2011-12-21
EP1767230B1 (en) 2011-11-16

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