WO2001025403A3 - Bio-artificial substrate for the production of animal and, in particular, human tissues and organs - Google Patents

Bio-artificial substrate for the production of animal and, in particular, human tissues and organs Download PDF

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Publication number
WO2001025403A3
WO2001025403A3 PCT/IT2000/000382 IT0000382W WO0125403A3 WO 2001025403 A3 WO2001025403 A3 WO 2001025403A3 IT 0000382 W IT0000382 W IT 0000382W WO 0125403 A3 WO0125403 A3 WO 0125403A3
Authority
WO
WIPO (PCT)
Prior art keywords
bio
animal
organs
production
human tissues
Prior art date
Application number
PCT/IT2000/000382
Other languages
French (fr)
Other versions
WO2001025403A2 (en
Inventor
Ubaldo Armato
Claudio Migliaresi
Antonella Motta
Original Assignee
Consorzio Per Gli Studi Uni
Ubaldo Armato
Claudio Migliaresi
Antonella Motta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consorzio Per Gli Studi Uni, Ubaldo Armato, Claudio Migliaresi, Antonella Motta filed Critical Consorzio Per Gli Studi Uni
Priority to EP00969802A priority Critical patent/EP1218490A2/en
Priority to AU79447/00A priority patent/AU7944700A/en
Publication of WO2001025403A2 publication Critical patent/WO2001025403A2/en
Publication of WO2001025403A3 publication Critical patent/WO2001025403A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Abstract

A substrate suitable for the survival, the proliferation and the correct differentiation and functioning of specialised tissue cells of the human and animal body, consisting of a material that is bio-compatible and bio-resorbable in pre-determinable times, which can be transplanted or implanted onto or connected with the body in order to achieve a complete integration of the transplanted, implanted or connected tissue with the other cell systems and their functions in the organism onto which the transplant or the implant or with which the connection has been made, and comprising a mixture and/or combination of natural and/or synthetic polymers in which fibroin is present.
PCT/IT2000/000382 1999-10-01 2000-09-28 Bio-artificial substrate for the production of animal and, in particular, human tissues and organs WO2001025403A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00969802A EP1218490A2 (en) 1999-10-01 2000-09-28 Bio-artificial substrate for the production of animal and, in particular, human tissues and organs
AU79447/00A AU7944700A (en) 1999-10-01 2000-09-28 Bio-artificial substrate for the production of animal and, in particular, human tissues and organs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999VR000082A IT1309453B1 (en) 1999-10-01 1999-10-01 BIOARTIFICIAL SUBSTRATE FOR THE REALIZATION OF FABRICS AND ORGANIANIMALS, IN PARTICULAR HUMAN.
ITVR99A000082 1999-10-01

Publications (2)

Publication Number Publication Date
WO2001025403A2 WO2001025403A2 (en) 2001-04-12
WO2001025403A3 true WO2001025403A3 (en) 2001-11-08

Family

ID=11428788

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2000/000382 WO2001025403A2 (en) 1999-10-01 2000-09-28 Bio-artificial substrate for the production of animal and, in particular, human tissues and organs

Country Status (4)

Country Link
EP (1) EP1218490A2 (en)
AU (1) AU7944700A (en)
IT (1) IT1309453B1 (en)
WO (1) WO2001025403A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2466001C (en) * 2001-10-25 2012-01-03 University Of Connecticut Bioactive materials, methods of making bioactive materials and method of use thereof
US6902932B2 (en) * 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
CN100382772C (en) * 2005-09-28 2008-04-23 南通大学 Medical nerve transplant containing silk element and preparing method
US20080038236A1 (en) * 2006-03-06 2008-02-14 Artecel Sciences, Inc. Biocompatible scaffolds and adipose-derived stem cells
ITMO20060404A1 (en) * 2006-12-12 2008-06-13 Eurocoating S P A METHOD OF COVERING AND / OR IMPREGNATION
EP2129772B1 (en) 2007-02-27 2016-07-27 Trustees Of Tufts College Tissue-engineered silk organs
US9730964B2 (en) * 2011-03-15 2017-08-15 Cell Ideas Pty Ltd. Pharmaceutical compositions and topical use thereof
CN103923200A (en) * 2014-03-27 2014-07-16 苏州丝美特生物技术有限公司 Silk fibroin freeze-dried powder with large molecular weight

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996025961A1 (en) * 1995-02-22 1996-08-29 Ed Geistlich Söhne Ag Für Chemische Industrie Resorbable extracellular matrix for reconstruction of cartilage tissue
US5606019A (en) * 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5606019A (en) * 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
WO1996025961A1 (en) * 1995-02-22 1996-08-29 Ed Geistlich Söhne Ag Für Chemische Industrie Resorbable extracellular matrix for reconstruction of cartilage tissue

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOTOH YOHKO ET AL: "Effect of the chemical modification of the arginyl residue in Bombyx mori silk fibroin on the attachment and growth of fibroblast cells.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 39, no. 3, 5 May 1998 (1998-05-05), pages 351 - 357, XP002166764, ISSN: 0021-9304 *
SANTIN MATTEO ET AL: "In vitro evaluation of the inflammatory potential of the silk fibroin.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 46, no. 3, pages 382 - 389, XP002166763, ISSN: 0021-9304 *

Also Published As

Publication number Publication date
WO2001025403A2 (en) 2001-04-12
IT1309453B1 (en) 2002-01-23
EP1218490A2 (en) 2002-07-03
ITVR990082A1 (en) 2001-04-01
AU7944700A (en) 2001-05-10

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