WO2001023913A3 - Optical confocal device having a common light directing means - Google Patents

Optical confocal device having a common light directing means Download PDF

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Publication number
WO2001023913A3
WO2001023913A3 PCT/US2000/026713 US0026713W WO0123913A3 WO 2001023913 A3 WO2001023913 A3 WO 2001023913A3 US 0026713 W US0026713 W US 0026713W WO 0123913 A3 WO0123913 A3 WO 0123913A3
Authority
WO
WIPO (PCT)
Prior art keywords
microlasers
array
detectors
light
microlaser
Prior art date
Application number
PCT/US2000/026713
Other languages
French (fr)
Other versions
WO2001023913A2 (en
Inventor
Zhijiang Hang
Victor Lazarev
Robert H Webb
Original Assignee
New Dimension Res & Instr Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New Dimension Res & Instr Inc filed Critical New Dimension Res & Instr Inc
Priority to AU76212/00A priority Critical patent/AU7621200A/en
Publication of WO2001023913A2 publication Critical patent/WO2001023913A2/en
Publication of WO2001023913A3 publication Critical patent/WO2001023913A3/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0056—Optical details of the image generation based on optical coherence, e.g. phase-contrast arrangements, interference arrangements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/004—Scanning details, e.g. scanning stages fixed arrays, e.g. switchable aperture arrays
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0072—Optical details of the image generation details concerning resolution or correction, including general design of CSOM objectives
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A61B3/1225—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation

Abstract

A confocal scanning imaging device for viewing an object includes an array of independently addressable microlasers and an array of detectors for detecting light from an object to which light from the microlasers has been directed. The array of microlasers and the array of detectors are combined into a single array, such as on a single chip, and in a pattern constructed and arranged so that different detectors are adjacent to each microlaser so that light from an illuminated object may be directed back to the vicinity of the illuminating microlaser and be detected by the adjacent detector(s). An optical arrangement directs light generated by the microlasers onto an object and directs light from an object so illuminated onto detectors adjacent to the illuminating microlaser. The optical arrangement includes a bilens and a matching lens system including two objective lenses. A microlens collimates light generated by the microlasers.
PCT/US2000/026713 1999-09-28 2000-09-28 Optical confocal device having a common light directing means WO2001023913A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU76212/00A AU7621200A (en) 1999-09-28 2000-09-28 Optical confocal device having a common light directing means

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/407,458 1999-09-28
US09/407,458 US6399936B1 (en) 1997-12-01 1999-09-28 Optical confocal device having a common light directing means

Publications (2)

Publication Number Publication Date
WO2001023913A2 WO2001023913A2 (en) 2001-04-05
WO2001023913A3 true WO2001023913A3 (en) 2008-03-06

Family

ID=23612186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/026713 WO2001023913A2 (en) 1999-09-28 2000-09-28 Optical confocal device having a common light directing means

Country Status (3)

Country Link
US (1) US6399936B1 (en)
AU (1) AU7621200A (en)
WO (1) WO2001023913A2 (en)

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US7410793B2 (en) * 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US7088650B1 (en) * 1999-08-23 2006-08-08 Worthington Mark O Methods and apparatus for optical disc data acquisition using physical synchronization markers
EP1232678A4 (en) * 2000-07-26 2004-08-25 Univ California Manipulation of live cells and inorganic objects with optical micro beam arrays
US6695493B2 (en) * 2000-10-06 2004-02-24 Bae Systems Information And Electronic Systems Integration Inc Optical fiber utilization for VCSEL driven communications
JP2005526253A (en) 2002-05-17 2005-09-02 アプレラ コーポレイション Apparatus and method for differentiating multiple fluorescent signals by excitation wavelength
US7193775B2 (en) * 2002-05-30 2007-03-20 Dmetrix, Inc. EPI-illumination system for an array microscope
US6865208B1 (en) 2002-06-10 2005-03-08 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Ultrafast laser beam switching and pulse train generation by using coupled vertical-cavity, surface-emitting lasers (VCSELS)
FR2849215B1 (en) * 2002-12-20 2005-03-11 Mauna Kea Technologies PARALLEL CONFOCAL LASER MICROSCOPY SYSTEM BASED ON VCSEL TECHNOLOGY
US20050142608A1 (en) * 2003-09-22 2005-06-30 Yokogawa Electric Corporation Screening method and device, and new drug screening method and device
US7099528B2 (en) * 2004-01-07 2006-08-29 International Business Machines Corporation Methods and devices for coupling electromagnetic radiation using diffractive optical elements
DE102005037889A1 (en) * 2005-08-10 2007-02-22 Carl Zeiss Jena Gmbh Microscope and microscopy method
SE530730C2 (en) * 2005-12-30 2008-08-26 Ericsson Telefon Ab L M Alignment of optical fibers in their jointing
SE530854C2 (en) * 2005-12-30 2008-09-30 Ericsson Telefon Ab L M Alignment of optical fibers in their jointing
GB0606788D0 (en) * 2006-04-03 2006-05-10 Ind Co Ltd Confocal microscopy
JPWO2008099778A1 (en) * 2007-02-14 2010-05-27 株式会社ニコン Slit scanning confocal microscope
WO2009005748A1 (en) * 2007-06-29 2009-01-08 The Trustees Of Columbia University In The City Ofnew York Optical imaging or spectroscopy systems and methods
US8998511B2 (en) * 2008-07-08 2015-04-07 Telefonaktiebolaget L M Ericsson (Publ) Cladding alignment for fusion splicing optical fibers
US8619237B2 (en) 2009-12-04 2013-12-31 The Trustees Of Columbia University In The City Of New York Laser-scanning intersecting plane tomography such as for high speed volumetric optical imaging
DE102011013195A1 (en) * 2011-03-02 2012-09-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Sensor, particularly inverted confocal sensor for position and distance measurement, has light source for emitting light, where optical medium is provided for focusing light in focal plane
US8237835B1 (en) * 2011-05-19 2012-08-07 Aeon Imaging, LLC Confocal imaging device using spatially modulated illumination with electronic rolling shutter detection
US9117149B2 (en) 2011-10-07 2015-08-25 Industrial Technology Research Institute Optical registration carrier
WO2013151622A1 (en) 2012-04-03 2013-10-10 Illumina, Inc. Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
DE102013113511A1 (en) * 2013-12-05 2015-06-11 Karl Storz Gmbh & Co. Kg Endoscope, exoscope or microscope and method for illuminating an operating area of an endoscope, exoscope or microscope
WO2018176972A1 (en) * 2017-04-01 2018-10-04 北科天绘（苏州）激光技术有限公司 Laser radar device and channel gating method thereof
DE102017115739A1 (en) 2017-07-13 2019-01-17 Karl Storz Se & Co. Kg Imaging medical instrument such as an endoscope, an exoscope or a microscope
US10323929B1 (en) * 2017-12-19 2019-06-18 Datamax-O'neil Corporation Width detecting media hanger
CN111258046A (en) * 2020-02-26 2020-06-09 清华大学 Light field microscope system and method based on front microlens array

Citations (4)

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Publication number Priority date Publication date Assignee Title
US3819938A (en) * 1973-02-01 1974-06-25 Gen Electric Opto-electronic transducers for object detection
US4988153A (en) * 1989-12-22 1991-01-29 Bell Communications Research, Inc. Holographic memory read by a laser array
US5028802A (en) * 1990-01-11 1991-07-02 Eye Research Institute Of Retina Foundation Imaging apparatus and methods utilizing scannable microlaser source
US5563710A (en) * 1994-10-28 1996-10-08 The Schepens Eye Research Institute, Inc. Imaging system with confocally self-detecting laser

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121603A (en) * 1997-12-01 2000-09-19 Hang; Zhijiang Optical confocal device having a common light directing means

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819938A (en) * 1973-02-01 1974-06-25 Gen Electric Opto-electronic transducers for object detection
US4988153A (en) * 1989-12-22 1991-01-29 Bell Communications Research, Inc. Holographic memory read by a laser array
US5028802A (en) * 1990-01-11 1991-07-02 Eye Research Institute Of Retina Foundation Imaging apparatus and methods utilizing scannable microlaser source
US5563710A (en) * 1994-10-28 1996-10-08 The Schepens Eye Research Institute, Inc. Imaging system with confocally self-detecting laser

Also Published As

Publication number Publication date
US6399936B1 (en) 2002-06-04
AU7621200A (en) 2001-04-30
WO2001023913A2 (en) 2001-04-05

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