WO2001021833A3 - Assay for detection of human cftr allele variants using specific diagnostic primers - Google Patents
Assay for detection of human cftr allele variants using specific diagnostic primers Download PDFInfo
- Publication number
- WO2001021833A3 WO2001021833A3 PCT/GB2000/003597 GB0003597W WO0121833A3 WO 2001021833 A3 WO2001021833 A3 WO 2001021833A3 GB 0003597 W GB0003597 W GB 0003597W WO 0121833 A3 WO0121833 A3 WO 0121833A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- primer
- variant
- diagnostic
- detection
- human cftr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00960854A EP1242619A2 (en) | 1999-09-24 | 2000-09-19 | Assay for detection of human cftr allele variants using specific diagnostic primers |
CA002385920A CA2385920A1 (en) | 1999-09-24 | 2000-09-19 | Assay |
AU73022/00A AU7302200A (en) | 1999-09-24 | 2000-09-19 | Assay |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9922527.8 | 1999-09-24 | ||
GBGB9922527.8A GB9922527D0 (en) | 1999-09-24 | 1999-09-24 | Assay |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001021833A2 WO2001021833A2 (en) | 2001-03-29 |
WO2001021833A3 true WO2001021833A3 (en) | 2002-07-25 |
Family
ID=10861465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2000/003597 WO2001021833A2 (en) | 1999-09-24 | 2000-09-19 | Assay for detection of human cftr allele variants using specific diagnostic primers |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1242619A2 (en) |
AU (1) | AU7302200A (en) |
CA (1) | CA2385920A1 (en) |
GB (1) | GB9922527D0 (en) |
WO (1) | WO2001021833A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008016334A1 (en) * | 2006-08-03 | 2008-02-07 | National University Of Singapore | Multiplex analysis of nucleic acids |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0497527A1 (en) * | 1991-01-31 | 1992-08-05 | Zeneca Limited | Detection method for nucleotide sequences |
WO1993018177A1 (en) * | 1992-03-13 | 1993-09-16 | The Children's Hospital Of Philadelphia | Diagnosis of cystic fibrosis using allele specific multiplex polymerase chain reactions |
WO1997042345A1 (en) * | 1996-05-04 | 1997-11-13 | Zeneca Limited | Method for detecting a nucleic acid base sequence |
US5853989A (en) * | 1991-08-27 | 1998-12-29 | Zeneca Limited | Method of characterisation of genomic DNA |
EP0928832A2 (en) * | 1998-01-13 | 1999-07-14 | Zeneca Limited | Cystic fibrosis test based on the detection of mutations in the CFRE gene by ARMS |
-
1999
- 1999-09-24 GB GBGB9922527.8A patent/GB9922527D0/en not_active Ceased
-
2000
- 2000-09-19 EP EP00960854A patent/EP1242619A2/en not_active Withdrawn
- 2000-09-19 AU AU73022/00A patent/AU7302200A/en not_active Abandoned
- 2000-09-19 CA CA002385920A patent/CA2385920A1/en not_active Abandoned
- 2000-09-19 WO PCT/GB2000/003597 patent/WO2001021833A2/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0497527A1 (en) * | 1991-01-31 | 1992-08-05 | Zeneca Limited | Detection method for nucleotide sequences |
US5853989A (en) * | 1991-08-27 | 1998-12-29 | Zeneca Limited | Method of characterisation of genomic DNA |
WO1993018177A1 (en) * | 1992-03-13 | 1993-09-16 | The Children's Hospital Of Philadelphia | Diagnosis of cystic fibrosis using allele specific multiplex polymerase chain reactions |
WO1997042345A1 (en) * | 1996-05-04 | 1997-11-13 | Zeneca Limited | Method for detecting a nucleic acid base sequence |
EP0928832A2 (en) * | 1998-01-13 | 1999-07-14 | Zeneca Limited | Cystic fibrosis test based on the detection of mutations in the CFRE gene by ARMS |
Non-Patent Citations (8)
Title |
---|
BRAUN A ET AL: "DETECTING CFTR GENE MUTATIONS BY USING PRIMER OLIGO BASE EXTENSION AND MASS SPECTROMETRY", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY. WINSTON, US, vol. 43, no. 7, 1997, pages 1151 - 1158, XP001019094, ISSN: 0009-9147 * |
COHEN J ET AL: "Relation between mutations of the Cystic Fibrosis Gene and idiopathic pancreatitis", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 339, no. 10, September 1998 (1998-09-01), pages 653 - 58, XP001053192 * |
FRIEDMAM K ET AL: "Cystic fibrosis syndrome: A new paradigm for inherited disorders and implications for molecular diagnosis", CLINICAL CHEMISTRY, vol. 45, no. 7, 1999, pages 92931, XP002188789 * |
FRIEDMAN K ET AL: "Rapid characterization of the variable length Polythymidine Tract in the Cystic Fibrosis gene (CFTR)", HUMAN MUTATION, vol. 10, no. 2, 1997, pages 108 - 15, XP001053200 * |
GELFI C ET AL: "Rapid capillary zone electrophoresis in isoelectric histidine buffer: high resolution of the poly-T tract allelic variants in intron 8 of the CFTR gene", CLINICAL CHEMISTRY, vol. 44, no. 5, 1998, pages 906 - 13, XP002188788 * |
HABER P ET AL: "Alcoholic Pancreatitis and polymorphisms of the variable length tract in the cystic fibrosis gene", ALCOHOLISM: CLINICAL AND EXPERIMENTAL RESEARCH, vol. 23, no. 3, March 1999 (1999-03-01), pages 509 - 12, XP001053196 * |
MAK V ET AL: "Proportion of cystic fibrosis gene mutations not detected by routine testing in men with Obstructive Azoospermia", JAMA, vol. 281, no. 23, June 1999 (1999-06-01), pages 2217 - 24, XP001053208 * |
SHARER N ET AL: "Mutations of the cystic fibrosis gene in patients with chronic pancreatitis", THE NEW JOURNAL OF ENGLAND MEDICINE, vol. 339, no. 10, 3 September 1998 (1998-09-03), pages 645 - 52, XP001053194 * |
Also Published As
Publication number | Publication date |
---|---|
CA2385920A1 (en) | 2001-03-29 |
WO2001021833A2 (en) | 2001-03-29 |
AU7302200A (en) | 2001-04-24 |
EP1242619A2 (en) | 2002-09-25 |
GB9922527D0 (en) | 1999-11-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2000056916A3 (en) | Detection of mutations in genes by specific lna primers | |
EP1061135A3 (en) | Methods and oligonucleotides for detecting nucleic acid sequence variations | |
WO1999040226A3 (en) | Determination of a genotype of an amplification product at multiple allelic sites | |
EP1241266A4 (en) | Method of detecting nucleotide polymorphism | |
EP1591541A3 (en) | Method of nucleic acid sequencing | |
WO2002061133A3 (en) | Nucleic acid detection using structured probes | |
CA2254111A1 (en) | Artificial mismatch hybridization | |
GB9821989D0 (en) | Detection of nucleic acid polymorphism | |
WO2003016565A3 (en) | Dna sequence analysis | |
KR910006497A (en) | Diagnostic and amplification method overcoming primer-target mismatch at primer 3 'end | |
KR930004477A (en) | Mycobacterial Primers and Probes | |
CA2149257A1 (en) | Methods and reagents for the detection of herpes simplex virus, treponema pallidum and haemophilus ducreyi | |
WO2000061801A3 (en) | METHOD FOR THE DETECTION AND/OR ANALYSIS, BY MEANS OF PRIMER EXTENSION TECHNIQUES, OF SINGLE NUCLEOTIDE POLYMORPHISMS IN RESTRICTION FRAGMENTS, IN PARTICULAR IN AMPLIFIED RESTRICTION FRAGMENTS GENERATED USING AFLP$m(3) | |
AU2002218129A1 (en) | Method for the detection of cytosine methylations | |
WO2002063049A3 (en) | Methods for determining a nucleotide at a specific location within a nucleic acid molecule | |
AU4766000A (en) | Method for analysing a patient's genetic predisposition to at least a disease and amplification adapted to such a method | |
WO2002006523A3 (en) | Method for detecting pre-disposition to hepatotoxicity | |
WO2001029262A3 (en) | Genotyping reagents, kits and methods of use thereof | |
WO2001021833A3 (en) | Assay for detection of human cftr allele variants using specific diagnostic primers | |
EP0787806A2 (en) | Abo glycosyltransferase sequence polymorphism | |
WO2001046472A3 (en) | Analysis of nucleotide polymorphisms at a site | |
WO2003002721A3 (en) | Compositions and methods for inferring a response to a statin | |
EP0872561A3 (en) | Neisseria gonorrhoae-specific oligonucleotides | |
WO1999005313A3 (en) | Method for typing of minor histocompatibility antigen ha-1 | |
WO1998051791A1 (en) | Gene causative of rheumatoid arthritis, method for the diagnosis of rheumatoid arthritis, and method for the determination of factors causing rheumatoid arthritis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2385920 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2000960854 Country of ref document: EP |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 2000960854 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2000960854 Country of ref document: EP |