WO2001016598A3 - High throughput chemical profiling - Google Patents

High throughput chemical profiling Download PDF

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Publication number
WO2001016598A3
WO2001016598A3 PCT/US2000/024093 US0024093W WO0116598A3 WO 2001016598 A3 WO2001016598 A3 WO 2001016598A3 US 0024093 W US0024093 W US 0024093W WO 0116598 A3 WO0116598 A3 WO 0116598A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemical compounds
high throughput
chemical
throughput chemical
methods
Prior art date
Application number
PCT/US2000/024093
Other languages
French (fr)
Other versions
WO2001016598A2 (en
Inventor
Dennis Brown
Lev Leytes
Original Assignee
Medalys Corp
Dennis Brown
Lev Leytes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medalys Corp, Dennis Brown, Lev Leytes filed Critical Medalys Corp
Priority to AU71035/00A priority Critical patent/AU7103500A/en
Publication of WO2001016598A2 publication Critical patent/WO2001016598A2/en
Publication of WO2001016598A3 publication Critical patent/WO2001016598A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44782Apparatus specially adapted therefor of a plurality of samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • B01J2219/00707Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/38Flow patterns
    • G01N30/46Flow patterns using more than one column
    • G01N30/466Flow patterns using more than one column with separation columns in parallel
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90Plate chromatography, e.g. thin layer or paper chromatography

Abstract

Methods are described for rapid profiling of characteristics of chemical compounds that are useful indicators of the potential efficacy of individual chemical compounds for a particular intended use and/or desired route of administration, as well as information relative to potential chemical and physical stability. The methods use small (<10 mg) amounts of a chemical compound to obtain a complete profile of characteristics. A database generated from the profiles can be searched to identify chemical compounds having a desired set of characteristics.
PCT/US2000/024093 1999-09-01 2000-09-01 High throughput chemical profiling WO2001016598A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU71035/00A AU7103500A (en) 1999-09-01 2000-09-01 High throughput chemical profiling

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38826299A 1999-09-01 1999-09-01
US09/388,262 1999-09-01

Publications (2)

Publication Number Publication Date
WO2001016598A2 WO2001016598A2 (en) 2001-03-08
WO2001016598A3 true WO2001016598A3 (en) 2001-11-22

Family

ID=23533377

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/024093 WO2001016598A2 (en) 1999-09-01 2000-09-01 High throughput chemical profiling

Country Status (2)

Country Link
AU (1) AU7103500A (en)
WO (1) WO2001016598A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0217551D0 (en) * 2002-07-30 2002-09-11 Amersham Biosciences Uk Ltd Perturbation effect recognition
CN103411893B (en) * 2013-07-29 2015-06-10 陕西步长制药有限公司 Detection method for near infrared spectrum of Naoxintong capsule

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056359A (en) * 1973-04-10 1977-11-01 American Home Products Corporation Profile recognition apparatus for identifying bacteria
US4671870A (en) * 1985-04-04 1987-06-09 Tompa Ildiko F Apparatus for overpressured thin-layer chromatographic technique
US4752562A (en) * 1981-01-23 1988-06-21 Baxter Travenol Laboratories, Inc. Detection of serum antibody and surface antigen by radial partition immunoassay
WO1989003430A1 (en) * 1987-10-13 1989-04-20 Terrapin Diagnostics, Ltd. Method to produce immunodiagnostic reagents
GB2281122A (en) * 1993-08-18 1995-02-22 Zeneca Ltd Complementary binding of receptor and ligand or test compound involving capillary action
WO1997007245A1 (en) * 1995-08-14 1997-02-27 Ely Michael Rabani Methods and devices for parallel multiplex polynucleotide sequencing
WO1998059360A1 (en) * 1997-06-20 1998-12-30 Ciphergen Biosystems, Inc. Retentate chromatography and protein chip arrays with applications in biology and medicine
WO1999014368A2 (en) * 1997-09-15 1999-03-25 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
WO1999015888A1 (en) * 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Capillary electroflow apparatus and method

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056359A (en) * 1973-04-10 1977-11-01 American Home Products Corporation Profile recognition apparatus for identifying bacteria
US4752562A (en) * 1981-01-23 1988-06-21 Baxter Travenol Laboratories, Inc. Detection of serum antibody and surface antigen by radial partition immunoassay
US4671870A (en) * 1985-04-04 1987-06-09 Tompa Ildiko F Apparatus for overpressured thin-layer chromatographic technique
WO1989003430A1 (en) * 1987-10-13 1989-04-20 Terrapin Diagnostics, Ltd. Method to produce immunodiagnostic reagents
GB2281122A (en) * 1993-08-18 1995-02-22 Zeneca Ltd Complementary binding of receptor and ligand or test compound involving capillary action
WO1997007245A1 (en) * 1995-08-14 1997-02-27 Ely Michael Rabani Methods and devices for parallel multiplex polynucleotide sequencing
WO1998059360A1 (en) * 1997-06-20 1998-12-30 Ciphergen Biosystems, Inc. Retentate chromatography and protein chip arrays with applications in biology and medicine
WO1999014368A2 (en) * 1997-09-15 1999-03-25 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
WO1999015888A1 (en) * 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Capillary electroflow apparatus and method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STAN H -J ET AL: "On-line coupling of liquid chromatography with thin-layer chromatography", JOURNAL OF CHROMATOGRAPHY A,NL,ELSEVIER SCIENCE, vol. 819, no. 1-2, 11 September 1998 (1998-09-11), pages 35 - 44, XP004145895, ISSN: 0021-9673 *

Also Published As

Publication number Publication date
WO2001016598A2 (en) 2001-03-08
AU7103500A (en) 2001-03-26

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