WO2001012851A3 - Identification of genetic markers of biological age and metabolism - Google Patents

Identification of genetic markers of biological age and metabolism Download PDF

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Publication number
WO2001012851A3
WO2001012851A3 PCT/US2000/021603 US0021603W WO0112851A3 WO 2001012851 A3 WO2001012851 A3 WO 2001012851A3 US 0021603 W US0021603 W US 0021603W WO 0112851 A3 WO0112851 A3 WO 0112851A3
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WO
WIPO (PCT)
Prior art keywords
organ
tissue
cell
subject
gene expression
Prior art date
Application number
PCT/US2000/021603
Other languages
French (fr)
Other versions
WO2001012851A2 (en
Inventor
Richard H Weindruch
Tomas A Prolla
Cheol-Koo Lee
Original Assignee
Wisconsin Alumni Res Found
Weindruch, Richard, H.
Prolla, Tomas, A.
Cheol-Koo Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found, Weindruch, Richard, H., Prolla, Tomas, A., Cheol-Koo Lee filed Critical Wisconsin Alumni Res Found
Priority to AU65289/00A priority Critical patent/AU782102B2/en
Priority to EP00952626A priority patent/EP1200629B1/en
Priority to CA2381777A priority patent/CA2381777C/en
Priority to DE60037817T priority patent/DE60037817D1/en
Publication of WO2001012851A2 publication Critical patent/WO2001012851A2/en
Publication of WO2001012851A3 publication Critical patent/WO2001012851A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment this method comprises the steps of obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell and determining the expression pattern of a panel of sequences within the nucleic acid that have been predetermined by either increase or decrease in response to biological aging of the organ, tissue or cell. A method of obtaining biomarkers of aging is also disclosed. This method comprises the step of comparing a gene expression profile of a young multicellular organism subject's organ, tissue or cells; a gene expression profile from a chronologically aged subject's organ, tissue or cell; and a gene expression profile from a chronologically aged but biologically younger subject's organ, tissue or cell and identifying gene expression alterations that are observed when comparing the young subjects and the chronologically aged subjects and are not observed or reduced in magnitude when comparing the young subject and the chronologically aged but biologically younger subjects.
PCT/US2000/021603 1999-08-12 2000-08-08 Identification of genetic markers of biological age and metabolism WO2001012851A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU65289/00A AU782102B2 (en) 1999-08-12 2000-08-08 Identification of genetic markers of biological age and metabolism
EP00952626A EP1200629B1 (en) 1999-08-12 2000-08-08 Identification of genetic markers of biological age and metabolism
CA2381777A CA2381777C (en) 1999-08-12 2000-08-08 Identification of genetic markers of biological age and metabolism
DE60037817T DE60037817D1 (en) 1999-08-12 2000-08-08 IDENTIFICATION OF GENETIC MARKERS OF BIOLOGICAL AGE AND METABOLISM

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14854099P 1999-08-12 1999-08-12
US60/148,540 1999-08-12
US17823200P 2000-01-26 2000-01-26
US60/178,232 2000-01-26
US21192300P 2000-06-16 2000-06-16
US60/211,923 2000-06-16

Publications (2)

Publication Number Publication Date
WO2001012851A2 WO2001012851A2 (en) 2001-02-22
WO2001012851A3 true WO2001012851A3 (en) 2001-08-23

Family

ID=27386702

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/021603 WO2001012851A2 (en) 1999-08-12 2000-08-08 Identification of genetic markers of biological age and metabolism

Country Status (7)

Country Link
US (3) US6569624B1 (en)
EP (1) EP1200629B1 (en)
AT (1) ATE384137T1 (en)
AU (1) AU782102B2 (en)
CA (1) CA2381777C (en)
DE (1) DE60037817D1 (en)
WO (1) WO2001012851A2 (en)

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US6406853B1 (en) 1999-12-23 2002-06-18 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction
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US7572575B2 (en) 2000-12-13 2009-08-11 Massachusetts Institute Of Technology SIR2 activity
US7041449B2 (en) * 2001-03-19 2006-05-09 Wisconsin Alumni Research Foundation Methods of screening for compounds that inhibit expression of biomarker sequences differentially expressed with age in mice
CA2451247A1 (en) 2001-06-22 2003-01-03 The Regents Of The University Of California Eukaryotic genes involved in adult lifespan regulation
US20030036079A1 (en) * 2001-06-26 2003-02-20 Weindruch Richard H. Gene expression alterations underlying the retardation of aging by caloric restriction in mammals
AU2002313737A1 (en) * 2001-08-13 2003-04-01 University Of Kentucky Research Foundation Gene expression profile biomarkers and therapeutic targets for brain aging and age-related cognitive impairment
WO2003016573A1 (en) * 2001-08-15 2003-02-27 Elixir Pharmaceuticals, Inc. Age-associated markers
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WO2003099781A2 (en) * 2002-05-24 2003-12-04 Boehringer Ingelheim Pharmaceuticals, Inc. METHODS FOR THE IDENTIFICATION OF IKKα FUNCTION AND OTHER GENES USEFUL FOR TREATMENT OF INFLAMMATORY DISEASES
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EP2308968A1 (en) * 2002-11-26 2011-04-13 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20040191775A1 (en) * 2003-03-12 2004-09-30 Spindler Stephen R. Methods of analyzing genes affected by caloric restriction or caloric restriction mimetics
WO2005042795A2 (en) * 2003-10-31 2005-05-12 Queststar Medical, Inc. Plasma polymerization of atomically modified surfaces
US20070275108A1 (en) * 2003-12-19 2007-11-29 Geesamen Bard J Life Span Managment
WO2005089436A2 (en) * 2004-03-16 2005-09-29 The Regents Of The University Of California Genetic networks regulated by attenuated gh/igf1 signaling and caloric restriction
US20050228237A1 (en) * 2004-04-12 2005-10-13 Frank Shallenberger Method for analyzing the biological age of a subject
US7273453B2 (en) * 2004-04-12 2007-09-25 Frank Shallenberger Method for analyzing the biological age of a subject
WO2005123955A2 (en) * 2004-06-09 2005-12-29 Children's Medical Center Corporation Methods and compositions for modifying gene regulation and dna damage in ageing
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US7960605B2 (en) * 2006-03-17 2011-06-14 BioMaker Pharmaceuticals, Inc. Methods for testing for caloric restriction (CR) mimetics
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US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
US7666137B2 (en) * 2008-04-10 2010-02-23 Frank Shallenberger Method for analyzing mitochondrial function
AU2009246180B2 (en) 2008-05-14 2015-11-05 Dermtech International Diagnosis of melanoma and solar lentigo by nucleic acid analysis
CA2734521A1 (en) * 2008-08-28 2010-03-04 Dermtech International Determining age ranges of skin samples
US20120040855A1 (en) * 2009-03-11 2012-02-16 Yuanlong Pan Tissue-specific aging biomarkers
US20110091081A1 (en) * 2009-10-16 2011-04-21 General Electric Company Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin
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Also Published As

Publication number Publication date
WO2001012851A2 (en) 2001-02-22
AU6528900A (en) 2001-03-13
AU782102B2 (en) 2005-07-07
US6569624B1 (en) 2003-05-27
ATE384137T1 (en) 2008-02-15
DE60037817D1 (en) 2008-03-06
US20030157526A1 (en) 2003-08-21
EP1200629B1 (en) 2008-01-16
CA2381777A1 (en) 2001-02-22
EP1200629A2 (en) 2002-05-02
CA2381777C (en) 2011-10-04
US20080254464A1 (en) 2008-10-16

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