WO2001009607A8 - Microarrays and their manufacture - Google Patents

Microarrays and their manufacture

Info

Publication number
WO2001009607A8
WO2001009607A8 PCT/US2000/020695 US0020695W WO0109607A8 WO 2001009607 A8 WO2001009607 A8 WO 2001009607A8 US 0020695 W US0020695 W US 0020695W WO 0109607 A8 WO0109607 A8 WO 0109607A8
Authority
WO
WIPO (PCT)
Prior art keywords
arrays
microarrays
manufacture
tubules
rods
Prior art date
Application number
PCT/US2000/020695
Other languages
French (fr)
Other versions
WO2001009607A1 (en
Inventor
Norman G Anderson
N Leigh Anderson
James A Braatz
Original Assignee
Large Scale Proteomics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Large Scale Proteomics Corp filed Critical Large Scale Proteomics Corp
Priority to MXPA02000992A priority Critical patent/MXPA02000992A/en
Priority to EP00955276A priority patent/EP1204867A4/en
Priority to CA 2376489 priority patent/CA2376489A1/en
Priority to AU67502/00A priority patent/AU6750200A/en
Priority to IL14768300A priority patent/IL147683A0/en
Priority to JP2001514567A priority patent/JP2003527569A/en
Priority to KR1020027001337A priority patent/KR20020042632A/en
Publication of WO2001009607A1 publication Critical patent/WO2001009607A1/en
Publication of WO2001009607A8 publication Critical patent/WO2001009607A8/en

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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50857—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using arrays or bundles of open capillaries for holding samples
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer

Abstract

The instant invention relates to micro arrays containing bioreactive molecules, uses thereby, and methods for manufacturing thereof. The arrays are constructed by sectioning bundles of tubules or rods, each containing unique reactants to produce large numbers of identical arrays.
PCT/US2000/020695 1999-07-30 2000-07-28 Microarrays and their manufacture WO2001009607A1 (en)

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CA 2376489 CA2376489A1 (en) 1999-07-30 2000-07-28 Microarrays and their manufacture
AU67502/00A AU6750200A (en) 1999-07-30 2000-07-28 Microarrays and their manufacture
IL14768300A IL147683A0 (en) 1999-07-30 2000-07-28 Microarrays and their manufacture
JP2001514567A JP2003527569A (en) 1999-07-30 2000-07-28 Microarray and its manufacture
KR1020027001337A KR20020042632A (en) 1999-07-30 2000-07-28 Microarrays and their manufacture

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Families Citing this family (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794127B1 (en) * 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
DE69737883T2 (en) 1996-04-25 2008-03-06 Bioarray Solutions Ltd. LIGHT-REGULATED, ELECTROKINETIC COMPOSITION OF PARTICLES TO SURFACES
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
EP1714699B1 (en) * 1998-01-12 2010-08-18 Massachusetts Institute of Technology System for analyzing a plurality of samples
US7132247B1 (en) * 1998-09-17 2006-11-07 Regents Of The University Of Minnesota Composite devices incorporating biological material and methods
AU2830400A (en) * 1999-03-05 2000-09-28 Mitsubishi Rayon Company Limited Carriers having biological substance
CA2367912A1 (en) * 1999-03-19 2000-09-28 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
US6824987B1 (en) * 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
US6713309B1 (en) * 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
US6406840B1 (en) 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
WO2001061054A2 (en) 2000-02-18 2001-08-23 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US20010031495A1 (en) * 2000-03-13 2001-10-18 Hideji Tajima Integrated support, integrated minute vessels and permeable membrane and method of making and using same
DE10023505A1 (en) * 2000-05-13 2001-11-22 Fraunhofer Ges Forschung Reactor module for use in artificial organs contains ceramic hollow fibers on which cells are immobilized
AU2001274571B2 (en) * 2000-06-20 2007-02-08 Mitsubishi Chemical Corporation Micro-array of organism-associated substance
JP4744778B2 (en) 2000-06-21 2011-08-10 バイオアレイ ソルーションズ リミテッド Method for analyzing multiple analyte molecules using a specific random particle array
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
GB0024276D0 (en) * 2000-10-04 2000-11-15 Univ Cranfield Substrate specific materials
US20020051995A1 (en) * 2000-10-30 2002-05-02 Rajan Kumar Stacked arrays
DE60111906D1 (en) * 2000-11-07 2005-08-18 Advanced Gene Technology Corp Method of screening plant extracts for active ingredients
DE10110511C1 (en) * 2001-02-28 2002-10-10 Attomol Gmbh Molekulare Diagno Method for producing an array for the detection of components from a biological sample
US20020129889A1 (en) * 2001-03-15 2002-09-19 Anderson Norman G. Method and apparatus for making fibers for sectioned arrays
JP3937742B2 (en) * 2001-03-28 2007-06-27 キヤノン株式会社 Probe carrier and method for producing the same
DE10117135A1 (en) * 2001-04-05 2002-10-17 Biotechnolog Forschung Gmbh Method for making a plurality of identical copies of a planar test assembly of probe molecules
DE10117275B4 (en) * 2001-04-06 2005-02-24 Hte Ag The High Throughput Experimentation Company Device for archiving and analyzing materials
JP2004536290A (en) * 2001-04-19 2004-12-02 ゲゼルシャフト　フュア　バイオテクノロギッシェ　フォーシュンク　エム　ベー　ハー（ゲー　ベー　エフ） Methods for producing stable and reproducible antibody arrays
US6872320B2 (en) * 2001-04-19 2005-03-29 Xerox Corporation Method for printing etch masks using phase-change materials
US6742884B2 (en) 2001-04-19 2004-06-01 Xerox Corporation Apparatus for printing etch masks using phase-change materials
DE10122836A1 (en) * 2001-05-11 2002-11-28 November Ag Molekulare Medizin Security thread for forgery-proof marking of objects comprises a fiber to which a string of nucleic acid molecules is attached, such that they can be verified using a string of complementary molecules
CN100404692C (en) * 2001-05-11 2008-07-23 松下电器产业株式会社 Biomolecular substrate and method and apparatus for examination and diagnosis using the same
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
JP2003014746A (en) * 2001-06-27 2003-01-15 Fuji Photo Film Co Ltd Biological material-fixed structure and its manufacturing method
EP1281966A3 (en) * 2001-07-30 2003-06-18 Fuji Photo Film Co., Ltd. Method and apparatus for conducting a receptor-ligand reaction
CN1537229A (en) * 2001-07-31 2004-10-13 ���ְ�˹��ʽ���� Gene inspection apparatus and target nucleic acid extraction method using the same
JP3883539B2 (en) * 2001-09-01 2007-02-21 サムスン エレクトロニクス カンパニー リミテッド Method for producing hydrogel biochip using radial polyethylene glycol derivative having epoxy group
US20040259091A1 (en) * 2001-09-28 2004-12-23 Kenji Yasuda Luminescence detecting device and luminescence detecting microarray plate
GB0124338D0 (en) * 2001-10-10 2001-11-28 Randox Lab Ltd Biochips
US7085404B2 (en) * 2001-10-11 2006-08-01 Industry-University Cooperation Foundation, Hangyang University Image analysis system and method of biochip
JP4377689B2 (en) 2001-10-15 2009-12-02 バイオアレイ ソリューションズ リミテッド Combined analysis of polymorphic loci with simultaneous interrogation and enzyme-mediated detection
US6797393B2 (en) * 2001-11-30 2004-09-28 Eastman Kodak Company Method for making biochip substrate
WO2003053998A1 (en) * 2001-12-11 2003-07-03 Mitsubishi Rayon Co., Ltd. Array for crystallizing protein, device for crystallizing protein and method of screening protein crystallization using the same
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
WO2003062824A1 (en) * 2002-01-23 2003-07-31 Boditech Inc. Lateral flow quantitative assay method and strip and laser-induced fluoerescence detection device therefor
EP1333281A3 (en) * 2002-01-31 2004-01-14 Fuji Photo Film Co., Ltd. Method and reactor for conducting receptor-ligand association reactions
JP3933058B2 (en) * 2002-02-25 2007-06-20 日立化成工業株式会社 Support unit for microfluidic system and method for manufacturing the same
WO2003078621A1 (en) * 2002-03-13 2003-09-25 Genomics Usa Inc. Method for manufacturing microarrays based on the immobilization of porous substrates on thermally modifiable surfaces
US20040052412A1 (en) * 2002-05-10 2004-03-18 Large Scale Biology Corporation Satellite image enhancement and feature identification using information theory radial-basis bio-marker filter
JP2003337117A (en) * 2002-05-17 2003-11-28 Hitachi High-Technologies Corp Capillary array and method for manufacturing the same
US7011971B2 (en) * 2002-06-03 2006-03-14 Eastman Kodak Company Method of making random array of microspheres using enzyme digestion
US8277753B2 (en) * 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
EP1561109A1 (en) * 2002-09-03 2005-08-10 Zeptosens AG Analytical platform and detection method with analytes which are to be detected in a sample in the form of immobilized specific binding partners
US7364896B2 (en) * 2002-10-31 2008-04-29 Agilent Technologies, Inc. Test strips including flexible array substrates and method of hybridization
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US7682565B2 (en) * 2002-12-20 2010-03-23 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
GB0304515D0 (en) * 2003-02-27 2003-04-02 Dakocytomation Denmark As Standard
DE10316689A1 (en) * 2003-04-10 2004-10-28 Dimitrij Dr. Plachov Three-dimensional chip
WO2004101414A1 (en) * 2003-05-19 2004-11-25 Mitsubishi Rayon Co., Ltd. Yarn arrangement device and method for yarn arrangement using the device, yarn arrangement tool, method of manufacturing yarn arranged body, and method of manufacturing living body-related substance immobilizing micro array
US7556660B2 (en) 2003-06-11 2009-07-07 James Kevin Shurtleff Apparatus and system for promoting a substantially complete reaction of an anhydrous hydride reactant
GB0315991D0 (en) * 2003-07-08 2003-08-13 Dakocytomation Denmark As Standard
WO2005014805A1 (en) * 2003-08-08 2005-02-17 Regents Of The University Of Minnesota A structured material for the production of hydrogen
US20090052850A1 (en) * 2003-09-05 2009-02-26 Loic Barbedette Micro-well plates and methods of fabricating and selectively blackening the same
US7280727B1 (en) * 2003-09-05 2007-10-09 Schott Corporation Micro-well and methods of fabricating and selectively blackening the same
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
NZ546072A (en) 2003-09-22 2009-08-28 Bioarray Solutions Ltd Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
WO2005042763A2 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
EP1694859B1 (en) 2003-10-29 2015-01-07 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
EP1712912A1 (en) * 2003-12-30 2006-10-18 Universal Bio Research Co., Ltd. Reaction vessel utilizing article having three-dimensionally arranged particles and reaction apparatus
CN100571860C (en) * 2004-02-18 2009-12-23 日立化成工业株式会社 Micro fluid system support unit
US20080026950A1 (en) * 2004-02-24 2008-01-31 Mitsubishi Rayon Co., Ltd. Gene Relating to Estimation of Postoperative Prognosis for Breast Cancer
CA2559171A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
RU2252411C1 (en) * 2004-04-09 2005-05-20 Общество с ограниченной ответственностью "Институт рентгеновской оптики" Fluorescent sensor on basis of multichannel structures
US20060030037A1 (en) 2004-05-28 2006-02-09 Victor Joseph Thermo-controllable high-density chips for multiplex analyses
US20090054255A1 (en) * 2004-07-01 2009-02-26 The Regents Of The University Of California Microfluidic devices and methods
US20070045777A1 (en) * 2004-07-08 2007-03-01 Jennifer Gillies Micronized semiconductor nanocrystal complexes and methods of making and using same
US7697808B2 (en) * 2004-07-27 2010-04-13 Ut-Battelle, Llc Multi-tipped optical component
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060105453A1 (en) * 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
US7595157B2 (en) * 2004-08-19 2009-09-29 Biocept, Inc. Microarrays utilizing hydrogels
CN100348324C (en) * 2004-11-10 2007-11-14 厦门大学 Multichannel array micro liquid transferrer
JP4006002B2 (en) * 2004-11-26 2007-11-14 キヤノン株式会社 DNA-carrying fiber, DNA-carrying fiber sheet, and production method thereof
EP1832861B1 (en) * 2004-11-30 2020-04-29 Hitachi Chemical Company, Ltd. Analytical pretreatment device
CN101072635A (en) * 2004-12-09 2007-11-14 日立化成工业株式会社 Support unit for micro fluid system and process for producing the same
US20060194215A1 (en) * 2005-02-28 2006-08-31 Kronick Mel N Methods, reagents and kits for reusing arrays
US7189522B2 (en) 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
WO2006098804A2 (en) * 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
AU2006273702A1 (en) * 2005-07-28 2007-02-01 Biosystems International Sas Normalization of complex analyte mixtures
JP2009503548A (en) * 2005-08-02 2009-01-29 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション Biosensors containing metal nanocavities
US20080020260A1 (en) * 2005-11-12 2008-01-24 Brydon Chris A Apparatus, system, and method for manifolded integration of a humidification chamber for input gas for a proton exchange membrane fuel cell
US20070148677A1 (en) * 2005-12-02 2007-06-28 Chagovetz Alexander M Methods and systems for acquiring real-time quantitative melt data
US20070134814A1 (en) * 2005-12-09 2007-06-14 Kajander E O Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease
CN101384757A (en) * 2006-01-03 2009-03-11 哈佛大学校长及研究员协会 Small molecule printing
US7657070B2 (en) * 2006-01-20 2010-02-02 Sakura Finetek U.S.A., Inc. Automated system of processing biological specimens and method
US8460878B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for detecting cells and cellular components in small defined volumes
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
CA2650886A1 (en) * 2006-05-10 2007-11-22 Armark Authentication Technologies, Inc. Extruded filament having high definition cross-sectional indicia/coding, microscopic tagging system formed therefrom, and method of use thereof for anti-counterfeiting and productauthentication
US7651542B2 (en) 2006-07-27 2010-01-26 Thulite, Inc System for generating hydrogen from a chemical hydride
US7648786B2 (en) 2006-07-27 2010-01-19 Trulite, Inc System for generating electricity from a chemical hydride
CN101578520B (en) 2006-10-18 2015-09-16 哈佛学院院长等 Based on formed pattern porous medium cross flow and through biometric apparatus, and preparation method thereof and using method
JP2010516281A (en) * 2007-01-22 2010-05-20 ウェハージェン，インコーポレイテッド High-throughput chemical reaction equipment
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
US8357214B2 (en) 2007-04-26 2013-01-22 Trulite, Inc. Apparatus, system, and method for generating a gas from solid reactant pouches
US20090025293A1 (en) * 2007-07-25 2009-01-29 John Patton Apparatus, system, and method for processing hydrogen gas
US8364287B2 (en) 2007-07-25 2013-01-29 Trulite, Inc. Apparatus, system, and method to manage the generation and use of hybrid electric power
EP2201374B1 (en) * 2007-08-30 2015-10-07 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
US8340913B2 (en) * 2008-03-03 2012-12-25 Schlumberger Technology Corporation Phase behavior analysis using a microfluidic platform
US7812318B1 (en) 2008-03-14 2010-10-12 Advanced Technology Applications, Llc Electromagnetic biosensor
US8735846B1 (en) 2008-03-14 2014-05-27 Advanced Technology Applications, Llc Electromagnetic biosensor
WO2009121043A2 (en) * 2008-03-27 2009-10-01 President And Fellows Of Harvard College Cotton thread as a low-cost multi-assay diagnostic platform
CN102016595B (en) 2008-03-27 2014-08-06 哈佛学院院长等 Three-dimensional microfluidic devices
WO2009121041A2 (en) * 2008-03-27 2009-10-01 President And Fellows Of Harvard College Paper-based microfluidic systems
US9829488B2 (en) * 2008-03-27 2017-11-28 President And Fellows Of Havard College Paper-based cellular arrays
US9518288B2 (en) 2008-04-11 2016-12-13 University Of Utah Research Foundation Methods and compositions related to quantitative, array based methylation analysis
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
US8715590B2 (en) * 2008-08-15 2014-05-06 Prognosys LLC Multiplexed lateral flow assay arrays
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
BRPI1006958B1 (en) 2009-01-22 2019-11-19 Biopath Automation Llc histological tissue specimen support and guidance devices and methods of preparing one or more elongated biopsy tissue samples for histological examination
PL2403645T3 (en) 2009-03-06 2017-05-31 President And Fellows Of Harvard College Microfluidic, electrochemical devices
WO2011015359A1 (en) * 2009-08-05 2011-02-10 Eth Zurich Bioanalytical device
JP2012231678A (en) * 2009-09-11 2012-11-29 Espinex:Kk Method for detecting microorganism
EP2531300A1 (en) 2010-02-03 2012-12-12 President and Fellows of Harvard College Devices and methods for multiplexed assays
DE102010001714A1 (en) * 2010-02-09 2011-08-11 Robert Bosch GmbH, 70469 Apparatus and method for the optical parallel analysis of a sample arrangement and corresponding production method
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
ES2544635T3 (en) 2010-03-01 2015-09-02 Quanterix Corporation Methods to extend the dynamic range in assays for the detection of molecules or particles
KR101273453B1 (en) * 2010-05-20 2013-06-11 고려대학교 산학협력단 Quantitative Analysis Using Minute Tube with Accumulated Enzyme
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US8603835B2 (en) 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
JP5609700B2 (en) * 2011-02-17 2014-10-22 ソニー株式会社 Electrophoretic element and display device
JP5660468B2 (en) * 2011-03-15 2015-01-28 三菱レイヨン株式会社 Method for producing gel microarray for detecting bio-related substances
JP5673269B2 (en) * 2011-03-22 2015-02-18 ソニー株式会社 Electrophoretic element, display device and electronic device
JP2012198417A (en) * 2011-03-22 2012-10-18 Sony Corp Electrophoretic element, display device, and electronic apparatus
JP5741122B2 (en) * 2011-03-28 2015-07-01 ソニー株式会社 Electrophoretic element, display device and electronic device
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
US20120275753A1 (en) * 2011-04-28 2012-11-01 Reinhardt Sherrh C Fiber assembly with tray feature
JP6075799B2 (en) * 2011-06-09 2017-02-08 ジェン−プローブ・インコーポレイテッドＧｅｎ−Ｐｒｏｂｅ Ｉｎｃｏｒｐｏｒａｔｅｄ Diagnostic device, method and system for detecting platelet factor 4 (PF4) / heparin antibody
JP2013045074A (en) * 2011-08-26 2013-03-04 Sony Corp Electrophoretic element and method of manufacturing the same, display device, display substrate and electronic apparatus
CA2848608A1 (en) * 2011-09-16 2013-03-21 The Governors Of The University Of Alberta Method and system for amplification of nucleic acids in microfluidic volume hydrogels
JP5870605B2 (en) * 2011-10-13 2016-03-01 ソニー株式会社 Display device, driving method thereof, and electronic apparatus
JP5942394B2 (en) * 2011-11-22 2016-06-29 ソニー株式会社 Electrophoretic element and display device
CN103135309B (en) * 2011-11-22 2017-11-17 索尼公司 Electrophoretic apparatus, the manufacture method of electrophoretic apparatus and display
CN103975053A (en) * 2011-12-01 2014-08-06 三菱丽阳株式会社 Base for use in amplification of nucleic acid, and nucleic acid amplification method
JP5953128B2 (en) * 2012-06-01 2016-07-20 秀明 久本 Method for producing capillary array for assay
JP5884659B2 (en) * 2012-06-29 2016-03-15 ソニー株式会社 Electrophoretic element and display device
TWI622845B (en) * 2012-09-05 2018-05-01 Sony Corp Electrophoresis element, display device and electronic device
JP2014106333A (en) * 2012-11-27 2014-06-09 Sony Corp Electrophoretic element, display device, and electronic apparatus
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
EP3489644A1 (en) * 2013-02-19 2019-05-29 Abbott Point Of Care, Inc. Biologic fluid sample analysis cartridge with non-reflective beads
JP6230091B2 (en) * 2013-03-13 2017-11-15 国立研究開発法人産業技術総合研究所 Microarray, manufacturing method thereof, and use thereof
US9828284B2 (en) 2014-03-28 2017-11-28 Ut-Battelle, Llc Thermal history-based etching
GB2548653A (en) 2014-04-02 2017-09-27 Chembio Diagnostic Systems Inc Immunoassay utilizing trapping conjugate
US9442074B2 (en) 2014-06-27 2016-09-13 Eastman Chemical Company Fibers with surface markings used for coding
US9863920B2 (en) 2014-06-27 2018-01-09 Eastman Chemical Company Fibers with chemical markers and physical features used for coding
US9358486B2 (en) 2014-06-27 2016-06-07 Eastman Chemical Company Method for characterizing fibers with shape and size used for coding
US20160116466A1 (en) 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
CN107407685B (en) 2015-02-20 2021-08-03 宝生物工程（美国)有限公司 Method for rapid and accurate dispensing, visualization and analysis of individual cells
WO2016152702A1 (en) * 2015-03-24 2016-09-29 国立大学法人名古屋大学 Analytical device
JP6631771B2 (en) * 2015-05-11 2020-01-15 国立研究開発法人情報通信研究機構 Microorganism analyzer and microorganism analysis method
JP7075394B2 (en) 2016-07-21 2022-05-25 タカラ バイオ ユーエスエー， インコーポレイテッド Multi-Z imaging and dispensing using a multi-well device
JP7261481B2 (en) * 2017-12-23 2023-04-20 国立大学法人 東京大学 Arrays and their uses
CA3095292A1 (en) 2018-04-02 2019-10-10 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
GB2582906B (en) * 2019-04-01 2022-09-07 Ip2Ipo Innovations Ltd Electrochemical sensor cable
EP3947718A4 (en) 2019-04-02 2022-12-21 Enumera Molecular, Inc. Methods, systems, and compositions for counting nucleic acid molecules
CN114181804A (en) * 2022-02-15 2022-03-15 深圳市研元生物科技有限公司 Gene chip and preparation and use method thereof

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238757A (en) 1976-03-19 1980-12-09 General Electric Company Field effect transistor for detection of biological reactions
US4459360A (en) 1981-10-05 1984-07-10 Mast Medical Industries, Ltd. Multiple-component binding assay system and method of making and using it
US4623355A (en) 1984-03-16 1986-11-18 Sawruk Stephen D Prosthetic axon
US4708931A (en) 1984-06-01 1987-11-24 Regents Of University Of California Laminated rod having alternating detection and spacer layers for binding assays
US4859538A (en) 1986-11-20 1989-08-22 Ribi Hans O Novel lipid-protein compositions and articles and methods for their preparation
US4896363A (en) 1987-05-28 1990-01-23 Thumbscan, Inc. Apparatus and method for matching image characteristics such as fingerprint minutiae
US5540828A (en) 1987-06-08 1996-07-30 Yacynych; Alexander Method for making electrochemical sensors and biosensors having a polymer modified surface
US4914022A (en) 1987-10-21 1990-04-03 Amc Cancer Research Center Method for preparing multiple tissue samples for microscopic investigation and testing
US4981653A (en) 1988-10-06 1991-01-01 Miles Inc. Self-indicating strip
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
DE4024545A1 (en) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Metered delivery of biochemical analytical soln., esp. reagent
US5264565A (en) 1991-01-22 1993-11-23 Affymax Technologies, N.V. Nucleic acid encoding the D2 /Ml chimeric receptor
GB2262163B (en) 1991-03-09 1995-12-20 Flor Henry Michel Whole cell sheet photometer
US5186824A (en) 1991-09-04 1993-02-16 Large Scale Biology Corporation System for solid phase reactions
US5273656A (en) 1991-09-04 1993-12-28 Large Scale Biology Corporation System for solid phase reactions
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
CA2124087C (en) 1991-11-22 2002-10-01 James L. Winkler Combinatorial strategies for polymer synthesis
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5302707A (en) 1992-03-26 1994-04-12 Affymax Technologies N.V. 5-fluorouridine nucleoside phosphate compounds
US5648458A (en) 1992-05-06 1997-07-15 Affymax Technologies N.V. Peptides and compounds that bind to ELAM-1
US5728802A (en) 1992-05-06 1998-03-17 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1)
US5622944A (en) 1992-06-12 1997-04-22 Affymax Technologies N.V. Testosterone prodrugs for improved drug delivery
US5607691A (en) 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5585275A (en) 1992-09-02 1996-12-17 Arris Pharmaceutical Corporation Pilot apparatus for peptide synthesis and screening
US5420328A (en) 1992-09-11 1995-05-30 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5491074A (en) 1993-04-01 1996-02-13 Affymax Technologies Nv Association peptides
US5484639A (en) * 1993-04-15 1996-01-16 Shaw Industires, Inc. Carpet and carpet backing with directional guide
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6027880A (en) 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US20020048749A1 (en) 1998-04-15 2002-04-25 Robert J. Lipshutz Methods for polymorphism identifcation and profiling
US5874239A (en) 1993-07-30 1999-02-23 Affymax Technologies N.V. Biotinylation of proteins
US5362899A (en) 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
DK0725682T3 (en) 1993-10-28 2002-07-15 Houston Advanced Res Ct Micro-made, porous pass-through apparatus for discrete detection of bonding reactions
US5922545A (en) 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5608035A (en) 1994-02-02 1997-03-04 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5786331A (en) 1994-02-02 1998-07-28 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5880096A (en) 1994-02-02 1999-03-09 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5635597A (en) 1994-05-27 1997-06-03 Affymax Technologies, N.V. Peptides that bind IL-2 receptors
DE69527585T2 (en) 1994-06-08 2003-04-03 Affymetrix Inc Method and device for packaging chips
US5990112A (en) 1996-06-18 1999-11-23 Affymax Technologies N.V. Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use
US5817751A (en) 1994-06-23 1998-10-06 Affymax Technologies N.V. Method for synthesis of diketopiperazine and diketomorpholine derivatives
AU689924B2 (en) 1994-06-23 1998-04-09 Affymax Technologies N.V. Photolabile compounds and methods for their use
US6060288A (en) 1994-08-03 2000-05-09 Mosaic Technologies Method for performing amplification of nucleic acid on supports
US5506420A (en) 1994-09-14 1996-04-09 The Regents Of The University Of California Semiconductor bio-electronic devices incorporating biochemical stabilization layers
US5710000A (en) 1994-09-16 1998-01-20 Affymetrix, Inc. Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping
JP3342590B2 (en) 1994-10-20 2002-11-11 株式会社サンギ Semiconductor integrated circuit
US6600996B2 (en) 1994-10-21 2003-07-29 Affymetrix, Inc. Computer-aided techniques for analyzing biological sequences
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
SE9404166D0 (en) 1994-11-30 1994-11-30 Pharmacia Biotech Ab Multifunctional surfaces
US5655560A (en) 1994-12-16 1997-08-12 Affymax Technologies N.V. Clog-free valving system
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5925562A (en) 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6025129A (en) 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
US5961923A (en) 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5654276A (en) 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5668110A (en) 1995-06-07 1997-09-16 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US5759779A (en) 1995-08-29 1998-06-02 Dehlinger; Peter J. Polynucleotide-array assay and methods
US5733729A (en) 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US5814524A (en) * 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
JPH1099085A (en) 1996-05-16 1998-04-21 Affymetrix Inc Polymorphism of human mitochondrial dna
AU3568897A (en) * 1996-06-07 1998-01-05 Eos Biotechnology, Inc. Immobilised linear oligonucleotide arrays
US5932579A (en) 1996-06-18 1999-08-03 Affymax Technologies N.V. Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use
CA2259395C (en) 1996-07-15 2002-03-05 Sumitomo Metal Industries, Ltd. Equipment for crystal growth and crystal-growing method using the same
AU5505498A (en) 1996-12-19 1998-07-15 Telefonaktiebolaget Lm Ericsson (Publ) Flip-chip type connection with elastic contacts
US5993627A (en) 1997-06-24 1999-11-30 Large Scale Biology Corporation Automated system for two-dimensional electrophoresis
US6037186A (en) * 1997-07-16 2000-03-14 Stimpson; Don Parallel production of high density arrays
US6177282B1 (en) 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
CN100337106C (en) * 1997-09-11 2007-09-12 生物风险公司 Method of making high density arrays
EP0926260A3 (en) 1997-12-12 2001-04-11 Matsushita Electric Industrial Co., Ltd. Using antibody - antigen interaction for formation of a patterened metal film
US5945522A (en) 1997-12-22 1999-08-31 Genset Prostate cancer gene
US6093302A (en) 1998-01-05 2000-07-25 Combimatrix Corporation Electrochemical solid phase synthesis
US20020006604A1 (en) * 1998-02-21 2002-01-17 Alan W Schwabacher One dimensional compound arrays and a method for assaying them
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6130046A (en) 1998-05-04 2000-10-10 Affymetrix, Inc. Techniques for synthesis integrity evaluation utilizing cycle fidelity probes
US6525185B1 (en) 1998-05-07 2003-02-25 Affymetrix, Inc. Polymorphisms associated with hypertension
DE19823454A1 (en) 1998-05-18 1999-11-25 Epigenomics Gmbh Photolithographic production of oligonucleotide array for manufacture of DNA chips
US6271957B1 (en) 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
ATE313548T1 (en) 1998-06-22 2006-01-15 Affymetrix Inc REAGENT AND METHOD FOR SOLID PHASE SYNTHESIS
US6129896A (en) * 1998-12-17 2000-10-10 Drawn Optical Components, Inc. Biosensor chip and manufacturing method
US6103518A (en) 1999-03-05 2000-08-15 Beecher Instruments Instrument for constructing tissue arrays
US6713309B1 (en) * 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture

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