WO2001009389A3 - Methods and apparatus for template capture and normalization for submicroliter reaction - Google Patents
Methods and apparatus for template capture and normalization for submicroliter reaction Download PDFInfo
- Publication number
- WO2001009389A3 WO2001009389A3 PCT/US2000/021182 US0021182W WO0109389A3 WO 2001009389 A3 WO2001009389 A3 WO 2001009389A3 US 0021182 W US0021182 W US 0021182W WO 0109389 A3 WO0109389 A3 WO 0109389A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- nucleic acid
- reaction
- normalization
- capillary
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00367—Pipettes capillary
- B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00511—Walls of reactor vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00691—Automatic using robots
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0838—Capillaries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
- B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/809—Incubators or racks or holders for culture plates or containers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001513644A JP2003505110A (en) | 1999-08-02 | 2000-08-02 | Methods and apparatus for template capture and normalization for sub-microliter reactions |
AU65147/00A AU6514700A (en) | 1999-08-02 | 2000-08-02 | Methods and apparatus for template capture and normalization for submicroliter reaction |
EP00952450A EP1203099A2 (en) | 1999-08-02 | 2000-08-02 | Methods and apparatus for template capture and normalization for submicroliter reaction |
CA002380794A CA2380794A1 (en) | 1999-08-02 | 2000-08-02 | Methods and apparatus for template capture and normalization for submicroliter reaction |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14673299P | 1999-08-02 | 1999-08-02 | |
US60/146,732 | 1999-08-02 | ||
US09/577,199 | 2000-05-23 | ||
US09/577,199 US6423536B1 (en) | 1999-08-02 | 2000-05-23 | Low volume chemical and biochemical reaction system |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001009389A2 WO2001009389A2 (en) | 2001-02-08 |
WO2001009389A3 true WO2001009389A3 (en) | 2001-08-16 |
Family
ID=26844248
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/021182 WO2001009389A2 (en) | 1999-08-02 | 2000-08-02 | Methods and apparatus for template capture and normalization for submicroliter reaction |
PCT/US2000/021116 WO2001008802A1 (en) | 1999-08-02 | 2000-08-02 | Low volume chemical and biochemical reaction system |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/021116 WO2001008802A1 (en) | 1999-08-02 | 2000-08-02 | Low volume chemical and biochemical reaction system |
Country Status (9)
Country | Link |
---|---|
US (4) | US6423536B1 (en) |
EP (2) | EP1200191A1 (en) |
JP (2) | JP2003505110A (en) |
CN (2) | CN1560267A (en) |
AU (2) | AU6512700A (en) |
CA (2) | CA2379969A1 (en) |
DE (1) | DE20022783U1 (en) |
GB (1) | GB2368032B (en) |
WO (2) | WO2001009389A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9132427B2 (en) | 2007-01-22 | 2015-09-15 | Wafergen, Inc. | Apparatus for high throughput chemical reactions |
Families Citing this family (229)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6893877B2 (en) | 1998-01-12 | 2005-05-17 | Massachusetts Institute Of Technology | Methods for screening substances in a microwell array |
ATE363339T1 (en) | 1998-05-01 | 2007-06-15 | Gen Probe Inc | STIRRING DEVICE FOR THE FLUID CONTENTS OF A CONTAINER |
US8337753B2 (en) | 1998-05-01 | 2012-12-25 | Gen-Probe Incorporated | Temperature-controlled incubator having a receptacle mixing mechanism |
US6689323B2 (en) * | 1998-10-30 | 2004-02-10 | Agilent Technologies | Method and apparatus for liquid transfer |
US6887431B1 (en) * | 1999-02-16 | 2005-05-03 | Applera Corporation | Bead dispensing system |
US6306578B1 (en) | 1999-03-19 | 2001-10-23 | Genencor International, Inc. | Multi-through hole testing plate for high throughput screening |
US20030022383A1 (en) * | 1999-04-06 | 2003-01-30 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
US7247490B2 (en) * | 1999-04-06 | 2007-07-24 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
US7244396B2 (en) * | 1999-04-06 | 2007-07-17 | Uab Research Foundation | Method for preparation of microarrays for screening of crystal growth conditions |
US7250305B2 (en) * | 2001-07-30 | 2007-07-31 | Uab Research Foundation | Use of dye to distinguish salt and protein crystals under microcrystallization conditions |
US7214540B2 (en) * | 1999-04-06 | 2007-05-08 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
ATE357656T1 (en) * | 1999-04-06 | 2007-04-15 | Univ Alabama Res Found | DEVICE FOR SCREENING CRYSTALIZATION CONDITIONS IN CRYSTAL GROWING SOLUTIONS |
US6423536B1 (en) * | 1999-08-02 | 2002-07-23 | Molecular Dynamics, Inc. | Low volume chemical and biochemical reaction system |
US7138254B2 (en) * | 1999-08-02 | 2006-11-21 | Ge Healthcare (Sv) Corp. | Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins |
JP2003507715A (en) * | 1999-08-13 | 2003-02-25 | カーティージャン テクノロジーズ、 インコーポレイテッド | Liquid sample handling equipment |
JP3865107B2 (en) * | 2000-05-26 | 2007-01-10 | 横河電機株式会社 | Biochip manufacturing method and biochip manufacturing apparatus using the same |
US20030027204A1 (en) * | 1999-09-03 | 2003-02-06 | Yokogawa Electric Corporation, A Japan Corporation | Method and apparatus for producing biochips |
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
CA2290731A1 (en) | 1999-11-26 | 2001-05-26 | D. Jed Harrison | Apparatus and method for trapping bead based reagents within microfluidic analysis system |
US7390459B2 (en) * | 1999-12-13 | 2008-06-24 | Illumina, Inc. | Oligonucleotide synthesizer |
US20020151040A1 (en) | 2000-02-18 | 2002-10-17 | Matthew O' Keefe | Apparatus and methods for parallel processing of microvolume liquid reactions |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
DE10032730A1 (en) * | 2000-07-05 | 2002-01-24 | Nmi Univ Tuebingen | Microtiter plate for carrying out tests on biological cells, e.g. using pharmaceuticals, has array of projections which act as test sites and have binding agents on their surfaces to which cells can be bound |
US6640891B1 (en) * | 2000-09-05 | 2003-11-04 | Kevin R. Oldenburg | Rapid thermal cycling device |
US20020100582A1 (en) * | 2000-09-05 | 2002-08-01 | Oldenburg Kevin R. | Rapid thermal cycling device |
US7025120B2 (en) * | 2000-09-05 | 2006-04-11 | Oldenburg Kevin R | Rapid thermal cycling device |
US20040050836A1 (en) * | 2000-09-29 | 2004-03-18 | Nesbitt Geoffrey John | Assembly of an integrated vessel transporter and at least one reaction vessel and integrated vessel transporter for transporting a chemical substance |
DE10104025B4 (en) * | 2001-01-31 | 2008-07-10 | Qiagen North American Holdings, Inc. | Process for the purification and subsequent amplification of double-stranded DNA |
JP2002228669A (en) * | 2001-01-31 | 2002-08-14 | Shimadzu Corp | Liquid transport device and reaction container |
US20030091473A1 (en) * | 2001-02-08 | 2003-05-15 | Downs Robert Charles | Automated centrifuge and method of using same |
DE50212958D1 (en) * | 2001-02-14 | 2008-12-11 | Evotec Ag | dispensing device |
US7670429B2 (en) * | 2001-04-05 | 2010-03-02 | The California Institute Of Technology | High throughput screening of crystallization of materials |
US20030119193A1 (en) * | 2001-04-25 | 2003-06-26 | Robert Hess | System and method for high throughput screening of droplets |
US20050123970A1 (en) * | 2001-04-25 | 2005-06-09 | Can Ozbal | High throughput autosampler |
US7588725B2 (en) * | 2001-04-25 | 2009-09-15 | Biotrove, Inc. | High throughput autosampler |
US8414774B2 (en) * | 2001-04-25 | 2013-04-09 | Agilent Technologies, Inc. | Systems and methods for high-throughput screening of fluidic samples |
DK1389955T3 (en) * | 2001-05-10 | 2010-03-01 | Chempaq As | Device for sampling small and precise fluid volumes |
US6811752B2 (en) * | 2001-05-15 | 2004-11-02 | Biocrystal, Ltd. | Device having microchambers and microfluidics |
US20030073230A1 (en) * | 2001-06-01 | 2003-04-17 | Akyuz Can D. | Liquid handling system and method |
US6855538B2 (en) * | 2001-06-27 | 2005-02-15 | The Regents Of The University Of California | High-efficiency microarray printing device |
US7402286B2 (en) * | 2001-06-27 | 2008-07-22 | The Regents Of The University Of California | Capillary pins for high-efficiency microarray printing device |
KR100414157B1 (en) * | 2001-09-28 | 2004-01-13 | 삼성전자주식회사 | Apparatus for sampling a fluid sample and fluid analyzer having the same |
US20030108664A1 (en) * | 2001-10-05 | 2003-06-12 | Kodas Toivo T. | Methods and compositions for the formation of recessed electrical features on a substrate |
US7614444B2 (en) | 2002-01-08 | 2009-11-10 | Oldenburg Kevin R | Rapid thermal cycling device |
US7373968B2 (en) * | 2002-01-08 | 2008-05-20 | Kevin R. Oldenburg | Method and apparatus for manipulating an organic liquid sample |
JP3740528B2 (en) * | 2002-02-05 | 2006-02-01 | 独立行政法人産業技術総合研究所 | Fine particle manufacturing method |
EP1567656A2 (en) * | 2002-02-08 | 2005-08-31 | Amersham Biosciences SV Corp. | Method and apparatus for performing submicroliter reactions with nucleic acids or proteins |
JP3933058B2 (en) | 2002-02-25 | 2007-06-20 | 日立化成工業株式会社 | Support unit for microfluidic system and method for manufacturing the same |
FR2839979B1 (en) * | 2002-05-21 | 2004-08-20 | Agronomique Inst Nat Rech | CELL CULTURE DEVICE |
US20030217923A1 (en) * | 2002-05-24 | 2003-11-27 | Harrison D. Jed | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
US7273589B2 (en) * | 2002-05-28 | 2007-09-25 | Pss Bio Instruments, Inc. | Samples delivering device, method of manufacturing samples applicator, method of delivering samples, and base activation device |
US20070026528A1 (en) * | 2002-05-30 | 2007-02-01 | Delucas Lawrence J | Method for screening crystallization conditions in solution crystal growth |
US20040224329A1 (en) * | 2003-05-08 | 2004-11-11 | Gjerde Douglas T. | Three-dimensional solid phase extraction surfaces |
US20040007672A1 (en) * | 2002-07-10 | 2004-01-15 | Delucas Lawrence J. | Method for distinguishing between biomolecule and non-biomolecule crystals |
US7452712B2 (en) | 2002-07-30 | 2008-11-18 | Applied Biosystems Inc. | Sample block apparatus and method of maintaining a microcard on a sample block |
US6997066B2 (en) * | 2002-08-07 | 2006-02-14 | Perkinelmer Las, Inc. | Dispensing apparatus |
US8277753B2 (en) | 2002-08-23 | 2012-10-02 | Life Technologies Corporation | Microfluidic transfer pin |
WO2004020673A1 (en) * | 2002-08-28 | 2004-03-11 | Millipore Corporation | Compositions of solution for sequencing reaction clean-up |
AU2003236461B2 (en) | 2002-08-29 | 2009-05-28 | Epigenomics Ag | Improved method for bisulfite treatment |
US7217542B2 (en) * | 2002-10-31 | 2007-05-15 | Hewlett-Packard Development Company, L.P. | Microfluidic system for analyzing nucleic acids |
US20060211055A1 (en) * | 2002-11-12 | 2006-09-21 | Caliper Life Sciences, Inc. | Capture and release assay system and method |
WO2004061100A1 (en) * | 2002-12-10 | 2004-07-22 | Olympus Corporation | Method of analyzing nucleic acid mutation and method of analyzing gene expression |
US7879580B2 (en) * | 2002-12-10 | 2011-02-01 | Massachusetts Institute Of Technology | Methods for high fidelity production of long nucleic acid molecules |
CA2521999A1 (en) * | 2002-12-20 | 2004-09-02 | Biotrove, Inc. | Assay apparatus and method using microfluidic arrays |
US7195026B2 (en) | 2002-12-27 | 2007-03-27 | American Air Liquide, Inc. | Micro electromechanical systems for delivering high purity fluids in a chemical delivery system |
US7445926B2 (en) | 2002-12-30 | 2008-11-04 | The Regents Of The University Of California | Fluid control structures in microfluidic devices |
GB0303524D0 (en) * | 2003-02-15 | 2003-03-19 | Sec Dep For The Home Departmen | Improvements in and relating to the handling of dna |
US7435601B2 (en) * | 2003-02-19 | 2008-10-14 | Fitzco Incorporated | Biological specimen handling method |
US20040241872A1 (en) * | 2003-03-17 | 2004-12-02 | Qiagen Operon, Inc. | Optical detection liquid handling robot system |
EP2390352A1 (en) | 2003-03-18 | 2011-11-30 | Quantum Genetics Ireland Limited | Systems and methods for improving protein and milk production of dairy herds |
US7553455B1 (en) * | 2003-04-02 | 2009-06-30 | Sandia Corporation | Micromanifold assembly |
CA2521539A1 (en) * | 2003-04-08 | 2004-10-28 | Irm, Llc | Material removal and dispensing devices, systems, and methods |
WO2004099788A1 (en) * | 2003-04-30 | 2004-11-18 | Riken | Method for producing microarray, and head and apparatus for producing microarray |
CA2527338A1 (en) * | 2003-06-05 | 2004-12-16 | Bioprocessors Corp. | Apparatus and method for manipulating substrates |
WO2004108270A2 (en) * | 2003-06-05 | 2004-12-16 | Bioprocessors Corp. | System and method for process automation |
JP3818277B2 (en) | 2003-07-14 | 2006-09-06 | 株式会社日立製作所 | Chemical reaction device, chemical reaction system, and chemical reaction method |
EP2354253A3 (en) * | 2003-09-05 | 2011-11-16 | Trustees of Boston University | Method for non-invasive prenatal diagnosis |
US20050226779A1 (en) * | 2003-09-19 | 2005-10-13 | Oldham Mark F | Vacuum assist for a microplate |
US20050221358A1 (en) * | 2003-09-19 | 2005-10-06 | Carrillo Albert L | Pressure chamber clamp mechanism |
EP3246093A1 (en) | 2003-10-24 | 2017-11-22 | Aushon Biosystems, Inc. | Apparatus and method for dispensing fluid, semi-solid and solid samples |
JP2007516449A (en) * | 2003-12-23 | 2007-06-21 | イージーン,インコーポレイティド | Bioanalytical cartridge recording and protection mechanism |
DE502004010672D1 (en) | 2004-01-06 | 2010-03-11 | Thermo Electron Led Gmbh | Air conditioner with germ-proof separated areas |
US8592219B2 (en) * | 2005-01-17 | 2013-11-26 | Gyros Patent Ab | Protecting agent |
US20050196790A1 (en) * | 2004-02-05 | 2005-09-08 | U.S. Genomics, Inc. | Methods for detection and quantitation of minimum length polymers |
CA2556911C (en) | 2004-02-19 | 2013-07-30 | The Governors Of The University Of Alberta | Leptin promoter polymorphisms and uses thereof |
CA2559171A1 (en) | 2004-03-12 | 2005-09-29 | Biotrove, Inc. | Nanoliter array loading |
US7223949B2 (en) * | 2004-04-21 | 2007-05-29 | Beckman Coulter, Inc. | Analysis apparatus having improved temperature control unit |
US7833709B2 (en) | 2004-05-28 | 2010-11-16 | Wafergen, Inc. | Thermo-controllable chips for multiplex analyses |
US7799553B2 (en) | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
US20050268943A1 (en) * | 2004-06-08 | 2005-12-08 | Arthur Schleifer | Microarray washing apparatus and method |
US20050282270A1 (en) * | 2004-06-21 | 2005-12-22 | Applera Corporation | System for thermally cycling biological samples with heated lid and pneumatic actuator |
US8536661B1 (en) | 2004-06-25 | 2013-09-17 | University Of Hawaii | Biosensor chip sensor protection methods |
US20060292558A1 (en) * | 2004-07-19 | 2006-12-28 | Cell Biosciences Inc. | Methods and apparatus for protein assay diagnostics |
US20060292649A1 (en) * | 2004-07-19 | 2006-12-28 | Cell Biosciences Inc. | Methods and apparatus for reference lab diagnostics |
EP1776581B1 (en) * | 2004-07-19 | 2015-05-06 | ProteinSimple | Method for protein detection |
US7846676B2 (en) * | 2004-07-19 | 2010-12-07 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
US7935479B2 (en) | 2004-07-19 | 2011-05-03 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
US20060024204A1 (en) * | 2004-08-02 | 2006-02-02 | Oldenburg Kevin R | Well plate sealing apparatus and method |
EP1794581A2 (en) | 2004-09-15 | 2007-06-13 | Microchip Biotechnologies, Inc. | Microfluidic devices |
US20060110764A1 (en) * | 2004-10-25 | 2006-05-25 | Tom Tang | Large-scale parallelized DNA sequencing |
US7785785B2 (en) | 2004-11-12 | 2010-08-31 | The Board Of Trustees Of The Leland Stanford Junior University | Charge perturbation detection system for DNA and other molecules |
WO2006059649A1 (en) | 2004-11-30 | 2006-06-08 | Hitachi Chemical Co., Ltd. | Component for preanalytical treatment |
WO2006075965A1 (en) * | 2005-01-17 | 2006-07-20 | Gyros Patent Ab | A method for detecting an at least bivalent analyte using two affinity reactants |
US20060166223A1 (en) * | 2005-01-26 | 2006-07-27 | Reed Michael W | DNA purification and analysis on nanoengineered surfaces |
WO2006086673A2 (en) * | 2005-02-09 | 2006-08-17 | Pacific Biosciences Of California, Inc. | Nucleotide compositions and uses thereof |
US20060228734A1 (en) * | 2005-03-18 | 2006-10-12 | Applera Corporation | Fluid processing device with captured reagent beads |
US8021611B2 (en) * | 2005-04-09 | 2011-09-20 | ProteinSimple | Automated micro-volume assay system |
US20060286378A1 (en) * | 2005-05-23 | 2006-12-21 | Shivkumar Chiruvolu | Nanostructured composite particles and corresponding processes |
JP2006329716A (en) * | 2005-05-24 | 2006-12-07 | Ushio Inc | Microchip measuring apparatus |
EP1893770B1 (en) * | 2005-05-30 | 2012-03-14 | Qiagen GmbH | Device and method for standardizing nucleic acid concentrations |
WO2007035864A2 (en) * | 2005-09-20 | 2007-03-29 | Cell Biosciences, Inc. | Electrophoresis standards, methods and kits |
US7749365B2 (en) | 2006-02-01 | 2010-07-06 | IntegenX, Inc. | Optimized sample injection structures in microfluidic separations |
JP5063616B2 (en) | 2006-02-03 | 2012-10-31 | インテジェニックス インコーポレイテッド | Microfluidic device |
US7766033B2 (en) * | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
WO2007130434A2 (en) * | 2006-05-02 | 2007-11-15 | Applera Corporation | Variable volume dispenser and method |
KR100785016B1 (en) * | 2006-05-22 | 2007-12-12 | 삼성전자주식회사 | Method and apparatus for the concentration and amplification of nucleic acids in a single micro chamber |
EP2041318A2 (en) * | 2006-06-26 | 2009-04-01 | Blood Cell Storage, Inc. | Device and method for extraction and analysis of nucleic acids from biological samples |
US8163535B2 (en) * | 2006-06-26 | 2012-04-24 | Blood Cell Storage, Inc. | Devices and processes for nucleic acid extraction |
DE102006033875A1 (en) * | 2006-07-21 | 2008-01-31 | Siemens Ag | Analysis system based on porous material for highly parallel single cell detection |
US20080017512A1 (en) * | 2006-07-24 | 2008-01-24 | Bordunov Andrei V | Coatings for capillaries capable of capturing analytes |
US20080075635A1 (en) * | 2006-09-27 | 2008-03-27 | Hongjun Wang | Pipette Holder |
US8841116B2 (en) * | 2006-10-25 | 2014-09-23 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated DNA analysis system using same |
US11339430B2 (en) | 2007-07-10 | 2022-05-24 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
CA2672315A1 (en) | 2006-12-14 | 2008-06-26 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes using large scale fet arrays |
US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
US8262900B2 (en) * | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US8999636B2 (en) | 2007-01-08 | 2015-04-07 | Toxic Report Llc | Reaction chamber |
US20080175757A1 (en) * | 2007-01-19 | 2008-07-24 | Andrew Powell | Microarray device with elastomeric well structure |
CN101715483A (en) | 2007-02-05 | 2010-05-26 | 微芯片生物工艺学股份有限公司 | microfluidic and nanofluidic devices, systems, and applications |
US20090023156A1 (en) * | 2007-07-20 | 2009-01-22 | Voss Karl O | Methods and reagents for quantifying analytes |
WO2009015296A1 (en) | 2007-07-24 | 2009-01-29 | The Regents Of The University Of California | Microfabricated dropley generator |
US20090055243A1 (en) | 2007-08-21 | 2009-02-26 | Jayson Lee Lusk | Systems and methods for predicting a livestock marketing method |
AU2008308686B2 (en) * | 2007-10-02 | 2015-01-22 | Labrador Diagnostics Llc | Modular point-of-care devices and uses thereof |
US8677808B2 (en) * | 2007-11-02 | 2014-03-25 | Agilent Technologies, Inc. | Sample injection system |
WO2009108260A2 (en) | 2008-01-22 | 2009-09-03 | Microchip Biotechnologies, Inc. | Universal sample preparation system and use in an integrated analysis system |
US10107782B2 (en) | 2008-01-25 | 2018-10-23 | ProteinSimple | Method to perform limited two dimensional separation of proteins and other biologicals |
EP2250479A2 (en) * | 2008-02-15 | 2010-11-17 | 3M Innovative Properties Company | Sample acquisition device |
US8247217B2 (en) * | 2008-02-15 | 2012-08-21 | Bio-Rad Laboratories, Inc. | Thermal cycler with self-adjusting lid |
US20110141465A1 (en) * | 2008-05-22 | 2011-06-16 | Waters Technologies Corporation | Light-Guiding Flow Cells And Analytical Devices Using The Same |
US8470164B2 (en) | 2008-06-25 | 2013-06-25 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US20100035252A1 (en) * | 2008-08-08 | 2010-02-11 | Ion Torrent Systems Incorporated | Methods for sequencing individual nucleic acids under tension |
US20100055733A1 (en) * | 2008-09-04 | 2010-03-04 | Lutolf Matthias P | Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels |
DE102008047790A1 (en) * | 2008-09-17 | 2010-04-15 | Qiagen Gmbh | Method for normalizing the content of biomolecules in a sample |
US8361716B2 (en) | 2008-10-03 | 2013-01-29 | Pathogenetix, Inc. | Focusing chamber |
US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US20100119454A1 (en) * | 2008-11-03 | 2010-05-13 | Ping Shen | Use of the conserved Drosophila NPFR1 system for uncovering interacting genes and pathways important in nociception and stress response |
WO2010054004A2 (en) * | 2008-11-04 | 2010-05-14 | Blood Cell Storage, Inc. | Nucleic acid extraction on curved glass surfaces |
US9103782B2 (en) | 2008-12-02 | 2015-08-11 | Malvern Instruments Incorporated | Automatic isothermal titration microcalorimeter apparatus and method of use |
US8672532B2 (en) | 2008-12-31 | 2014-03-18 | Integenx Inc. | Microfluidic methods |
WO2010114842A1 (en) * | 2009-03-30 | 2010-10-07 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
US20120261274A1 (en) | 2009-05-29 | 2012-10-18 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US8673627B2 (en) | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
US8776573B2 (en) | 2009-05-29 | 2014-07-15 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
CN102459565A (en) | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | Fluidic devices with diaphragm valves |
JP2012529268A (en) | 2009-06-05 | 2012-11-22 | インテジェンクス,インコーポレイテッド | Use of universal sample preparation system and integrated analysis system |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
EP2525905B1 (en) | 2010-01-19 | 2020-11-04 | Illumina, Inc. | Methods and compositions for processing chemical reactions |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
JP5952813B2 (en) | 2010-06-30 | 2016-07-13 | ライフ テクノロジーズ コーポレーション | Method and apparatus for testing ISFET arrays |
AU2011226767B1 (en) | 2010-06-30 | 2011-11-10 | Life Technologies Corporation | Ion-sensing charge-accumulation circuits and methods |
US8731847B2 (en) | 2010-06-30 | 2014-05-20 | Life Technologies Corporation | Array configuration and readout scheme |
US11307166B2 (en) | 2010-07-01 | 2022-04-19 | Life Technologies Corporation | Column ADC |
EP2589065B1 (en) | 2010-07-03 | 2015-08-19 | Life Technologies Corporation | Chemically sensitive sensor with lightly doped drains |
US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
US9121058B2 (en) | 2010-08-20 | 2015-09-01 | Integenx Inc. | Linear valve arrays |
WO2012036679A1 (en) | 2010-09-15 | 2012-03-22 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
EP2619564B1 (en) | 2010-09-24 | 2016-03-16 | Life Technologies Corporation | Matched pair transistor circuits |
JP5616309B2 (en) | 2010-12-01 | 2014-10-29 | アークレイ株式会社 | Device and manufacturing method thereof |
US9289764B2 (en) | 2010-12-20 | 2016-03-22 | Boehringer Ingelheim Microparts Gmbh | Method for mixing at least one sample solution having at least one reagent, and device |
US8629264B2 (en) | 2011-05-19 | 2014-01-14 | Blood Cell Storage, Inc. | Gravity flow fluidic device for nucleic acid extraction |
US9012375B2 (en) | 2011-07-25 | 2015-04-21 | Csir | Array printing |
EP2736631B1 (en) * | 2011-07-25 | 2015-03-04 | Csir | Array printing |
US9029297B2 (en) | 2011-07-25 | 2015-05-12 | Csir | Array printing |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
DK2756101T3 (en) | 2011-09-15 | 2018-08-27 | David A Shafer | PROBLEMS: ANTISON DETAIL COMPOSITIONS FOR DETECTING HIGH OR SPECIFIC DNA OR RNA |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
US9970984B2 (en) | 2011-12-01 | 2018-05-15 | Life Technologies Corporation | Method and apparatus for identifying defects in a chemical sensor array |
US8747748B2 (en) | 2012-01-19 | 2014-06-10 | Life Technologies Corporation | Chemical sensor with conductive cup-shaped sensor surface |
US8821798B2 (en) | 2012-01-19 | 2014-09-02 | Life Technologies Corporation | Titanium nitride as sensing layer for microwell structure |
JP6014865B2 (en) * | 2012-03-22 | 2016-10-26 | 株式会社エンプラス | Liquid dividing method and liquid dividing kit |
US8685708B2 (en) | 2012-04-18 | 2014-04-01 | Pathogenetix, Inc. | Device for preparing a sample |
WO2013155634A1 (en) | 2012-04-19 | 2013-10-24 | Jiaqi Wu | Dual wavelength isoelectric focusing for determining drug load in antibody drug conjugates |
CN103421676B (en) * | 2012-05-25 | 2016-04-20 | 国家纳米科学中心 | A kind of nucleic acid isothermal amplification reactive system and its preparation method and application |
US8786331B2 (en) | 2012-05-29 | 2014-07-22 | Life Technologies Corporation | System for reducing noise in a chemical sensor array |
US20140100102A1 (en) * | 2012-10-10 | 2014-04-10 | California Institute Of Technology | Devices and methods for cell lysis and sample preparation through centrifugation |
US9776182B2 (en) * | 2012-11-27 | 2017-10-03 | Gencell Biosystems Ltd. | Handling liquid samples |
US9080968B2 (en) | 2013-01-04 | 2015-07-14 | Life Technologies Corporation | Methods and systems for point of use removal of sacrificial material |
US9841398B2 (en) | 2013-01-08 | 2017-12-12 | Life Technologies Corporation | Methods for manufacturing well structures for low-noise chemical sensors |
US8962366B2 (en) | 2013-01-28 | 2015-02-24 | Life Technologies Corporation | Self-aligned well structures for low-noise chemical sensors |
US8841217B1 (en) | 2013-03-13 | 2014-09-23 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
US8963216B2 (en) | 2013-03-13 | 2015-02-24 | Life Technologies Corporation | Chemical sensor with sidewall spacer sensor surface |
US9116117B2 (en) | 2013-03-15 | 2015-08-25 | Life Technologies Corporation | Chemical sensor with sidewall sensor surface |
CN105051525B (en) | 2013-03-15 | 2019-07-26 | 生命科技公司 | Chemical device with thin conducting element |
CN105264366B (en) | 2013-03-15 | 2019-04-16 | 生命科技公司 | Chemical sensor with consistent sensor surface area |
CN105283758B (en) | 2013-03-15 | 2018-06-05 | 生命科技公司 | Chemical sensor with consistent sensor surface area |
MX2015013421A (en) | 2013-03-19 | 2016-07-05 | Life Technologies Corp | Thermal cycler cover. |
US20140336063A1 (en) | 2013-05-09 | 2014-11-13 | Life Technologies Corporation | Windowed Sequencing |
US10458942B2 (en) | 2013-06-10 | 2019-10-29 | Life Technologies Corporation | Chemical sensor array having multiple sensors per well |
WO2015008281A1 (en) * | 2013-07-16 | 2015-01-22 | Technion Research And Development Foundation Ltd. | Sample recording device and system |
US9766206B2 (en) | 2013-09-27 | 2017-09-19 | ProteinSimple | Apparatus, systems, and methods for capillary electrophoresis |
WO2015073999A1 (en) | 2013-11-18 | 2015-05-21 | Integenx Inc. | Cartridges and instruments for sample analysis |
GB201401584D0 (en) * | 2014-01-29 | 2014-03-19 | Bg Res Ltd | Intelligent detection of biological entities |
GB201403522D0 (en) * | 2014-02-28 | 2014-04-16 | Ge Healthcare Uk Ltd | Improvements in and relating to processed biological sample storage |
GB2544198B (en) | 2014-05-21 | 2021-01-13 | Integenx Inc | Fluidic cartridge with valve mechanism |
CN107106983B (en) | 2014-10-22 | 2021-04-16 | 尹特根埃克斯有限公司 | Systems and methods for sample preparation, processing, and analysis |
KR102593647B1 (en) | 2014-12-18 | 2023-10-26 | 라이프 테크놀로지스 코포레이션 | High data rate integrated circuit with transmitter configuration |
US10077472B2 (en) | 2014-12-18 | 2018-09-18 | Life Technologies Corporation | High data rate integrated circuit with power management |
EP3234575B1 (en) | 2014-12-18 | 2023-01-25 | Life Technologies Corporation | Apparatus for measuring analytes using large scale fet arrays |
EP3822361A1 (en) | 2015-02-20 | 2021-05-19 | Takara Bio USA, Inc. | Method for rapid accurate dispensing, visualization and analysis of single cells |
BR112018073378A2 (en) * | 2016-05-20 | 2019-03-06 | Quantum-Si Incorporated | labeled nucleotide compositions and methods for nucleic acid sequencing |
CA3020629A1 (en) | 2016-07-21 | 2018-01-25 | Takara Bio Usa, Inc. | Multi-z imaging and dispensing with multi-well devices |
JP6828049B2 (en) * | 2016-10-20 | 2021-02-10 | 株式会社日立ハイテク | Biomolecule processing and analysis methods |
DE102016015700A1 (en) | 2016-12-21 | 2018-06-21 | Bayer Pharma Aktiengesellschaft | metering |
CN106591107B (en) * | 2017-01-12 | 2019-04-12 | 武汉菲思特生物科技有限公司 | Sample adding device for pyrosequencing |
WO2018175715A1 (en) | 2017-03-24 | 2018-09-27 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Herpes simplex virus type-1(hsv-1) vaccine strain vc2 generating an anti-ehv-1 immune response |
JP7287942B2 (en) | 2017-07-24 | 2023-06-06 | クアンタム-エスアイ インコーポレイテッド | High Intensity Labeling Reactant Compositions and Methods for Sequencing |
CN112930223B (en) * | 2018-09-28 | 2022-09-27 | 合成燃料美国公司 | Production system including subsystems for forming filter tubes and methods of use thereof |
WO2020154546A1 (en) | 2019-01-23 | 2020-07-30 | Quantum-Si Incorporated | High intensity labeled reactant compositions and methods for sequencing |
JP7168074B2 (en) * | 2019-04-12 | 2022-11-09 | 株式会社島津製作所 | microfluidic system |
JP7360552B2 (en) * | 2019-12-20 | 2023-10-12 | ベックマン コールター, インコーポレイテッド | Thermal circulator for robotic liquid handling systems |
US20230098565A1 (en) * | 2020-01-31 | 2023-03-30 | Western Connecticut Health Network, Inc. | Apparatus and method for collecting liquid samples |
WO2023105419A1 (en) * | 2021-12-08 | 2023-06-15 | Dh Technologies Development Pte. Ltd. | Capillary electrophoresis methods for characterizing genome integrity |
GB202212732D0 (en) * | 2022-09-01 | 2022-10-19 | Remedy Biologics Ltd | Methods and systems of material recovery |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0649853A1 (en) * | 1993-09-27 | 1995-04-26 | Becton, Dickinson and Company | Modified glass fiber membranes useful for DNA purification by solid phase extraction |
EP0671626A1 (en) * | 1994-03-08 | 1995-09-13 | Ciba-Geigy Ag | Device and method for combined bioaffinity assay and electrophoretic separation |
WO1996001836A1 (en) * | 1994-07-07 | 1996-01-25 | Nanogen, Inc. | Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics |
WO1997010331A1 (en) * | 1995-09-15 | 1997-03-20 | Beckman Instruments, Inc. | Method for purifying nucleic acids from homogeneous mixtures |
WO1997040939A1 (en) * | 1996-05-01 | 1997-11-06 | Visible Genetics Inc. | Method and apparatus for thermal cycling and for automated sample preparation with thermal cycling |
US5720923A (en) * | 1993-07-28 | 1998-02-24 | The Perkin-Elmer Corporation | Nucleic acid amplification reaction apparatus |
US5785926A (en) * | 1995-09-19 | 1998-07-28 | University Of Washington | Precision small volume fluid processing apparatus |
US5846727A (en) * | 1996-06-06 | 1998-12-08 | Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College | Microsystem for rapid DNA sequencing |
DE19746874A1 (en) * | 1997-10-23 | 1999-04-29 | Qiagen Gmbh | Isolation of nucleic acids |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3915652A (en) | 1973-08-16 | 1975-10-28 | Samuel Natelson | Means for transferring a liquid in a capillary open at both ends to an analyzing system |
CA1289856C (en) * | 1986-09-11 | 1991-10-01 | Ei Mochida | Chemical reaction apparatus |
US5234809A (en) * | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
US5455175A (en) | 1990-06-04 | 1995-10-03 | University Of Utah Research Foundation | Rapid thermal cycling device |
SE9002579D0 (en) * | 1990-08-07 | 1990-08-07 | Pharmacia Ab | METHOD AND APPARATUS FOR CARRYING OUT BIOCHEMICAL REACTIONS |
WO1992020778A1 (en) | 1991-05-24 | 1992-11-26 | Kindconi Pty Limited | Biochemical reaction control |
US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
US5840573A (en) | 1994-02-01 | 1998-11-24 | Fields; Robert E. | Molecular analyzer and method of use |
JP3434914B2 (en) * | 1994-11-11 | 2003-08-11 | 株式会社日立製作所 | Electrophoresis device sample holding device, electrophoresis device, and method for injecting sample into electrophoresis device |
US5560811A (en) | 1995-03-21 | 1996-10-01 | Seurat Analytical Systems Incorporated | Capillary electrophoresis apparatus and method |
US5759779A (en) * | 1995-08-29 | 1998-06-02 | Dehlinger; Peter J. | Polynucleotide-array assay and methods |
CA2192262C (en) * | 1995-12-08 | 2011-03-15 | Yoshihide Hayashizaki | Method for purification and transfer to separation/detection systems of dna sequencing samples and plates used therefor |
US5830657A (en) | 1996-05-01 | 1998-11-03 | Visible Genetics Inc. | Method for single-tube sequencing of nucleic acid polymers |
EP0880537B1 (en) * | 1996-02-14 | 2004-12-15 | bioMerieux B.V. | Isolation of single stranded nucleic acids |
US5958342A (en) * | 1996-05-17 | 1999-09-28 | Incyte Pharmaceuticals, Inc. | Jet droplet device |
US6083762A (en) | 1996-05-31 | 2000-07-04 | Packard Instruments Company | Microvolume liquid handling system |
US6083761A (en) * | 1996-12-02 | 2000-07-04 | Glaxo Wellcome Inc. | Method and apparatus for transferring and combining reagents |
SE9702005D0 (en) | 1997-05-28 | 1997-05-28 | Alphahelix Ab | New reaction vessel and method for its use |
EP1027159B1 (en) * | 1997-10-31 | 2002-04-03 | PE Corporation (NY) | Method and apparatus for making arrays of samples |
US6225061B1 (en) * | 1999-03-10 | 2001-05-01 | Sequenom, Inc. | Systems and methods for performing reactions in an unsealed environment |
US6423536B1 (en) * | 1999-08-02 | 2002-07-23 | Molecular Dynamics, Inc. | Low volume chemical and biochemical reaction system |
DE10006214A1 (en) * | 2000-02-11 | 2001-08-16 | Roche Diagnostics Gmbh | System for simple nucleic acid analysis |
-
2000
- 2000-05-23 US US09/577,199 patent/US6423536B1/en not_active Expired - Lifetime
- 2000-08-02 JP JP2001513644A patent/JP2003505110A/en not_active Withdrawn
- 2000-08-02 CA CA002379969A patent/CA2379969A1/en not_active Abandoned
- 2000-08-02 CN CNA2004100431615A patent/CN1560267A/en active Pending
- 2000-08-02 US US09/632,094 patent/US6489112B1/en not_active Expired - Fee Related
- 2000-08-02 EP EP00952424A patent/EP1200191A1/en not_active Withdrawn
- 2000-08-02 AU AU65127/00A patent/AU6512700A/en not_active Abandoned
- 2000-08-02 GB GB0201920A patent/GB2368032B/en not_active Expired - Fee Related
- 2000-08-02 WO PCT/US2000/021182 patent/WO2001009389A2/en not_active Application Discontinuation
- 2000-08-02 DE DE20022783U patent/DE20022783U1/en not_active Expired - Lifetime
- 2000-08-02 JP JP2001513520A patent/JP2003505711A/en active Pending
- 2000-08-02 CN CNB008128707A patent/CN1156584C/en not_active Expired - Fee Related
- 2000-08-02 WO PCT/US2000/021116 patent/WO2001008802A1/en not_active Application Discontinuation
- 2000-08-02 EP EP00952450A patent/EP1203099A2/en not_active Withdrawn
- 2000-08-02 CA CA002380794A patent/CA2380794A1/en not_active Abandoned
- 2000-08-02 AU AU65147/00A patent/AU6514700A/en not_active Abandoned
-
2002
- 2002-04-18 US US10/125,045 patent/US20020110900A1/en not_active Abandoned
- 2002-09-30 US US10/262,476 patent/US6927045B2/en not_active Expired - Fee Related
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5720923A (en) * | 1993-07-28 | 1998-02-24 | The Perkin-Elmer Corporation | Nucleic acid amplification reaction apparatus |
EP0649853A1 (en) * | 1993-09-27 | 1995-04-26 | Becton, Dickinson and Company | Modified glass fiber membranes useful for DNA purification by solid phase extraction |
EP0671626A1 (en) * | 1994-03-08 | 1995-09-13 | Ciba-Geigy Ag | Device and method for combined bioaffinity assay and electrophoretic separation |
WO1996001836A1 (en) * | 1994-07-07 | 1996-01-25 | Nanogen, Inc. | Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics |
WO1997010331A1 (en) * | 1995-09-15 | 1997-03-20 | Beckman Instruments, Inc. | Method for purifying nucleic acids from homogeneous mixtures |
US5785926A (en) * | 1995-09-19 | 1998-07-28 | University Of Washington | Precision small volume fluid processing apparatus |
WO1997040939A1 (en) * | 1996-05-01 | 1997-11-06 | Visible Genetics Inc. | Method and apparatus for thermal cycling and for automated sample preparation with thermal cycling |
US5846727A (en) * | 1996-06-06 | 1998-12-08 | Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College | Microsystem for rapid DNA sequencing |
DE19746874A1 (en) * | 1997-10-23 | 1999-04-29 | Qiagen Gmbh | Isolation of nucleic acids |
Non-Patent Citations (2)
Title |
---|
HADD ANDREW G ET AL: "Sub-microliter DNA sequencing for capillary array electrophoresis.", JOURNAL OF CHROMATOGRAPHY A, vol. 894, no. 1-2, October 2000 (2000-10-01), pages 191 - 201, XP000982717, ISSN: 0021-9673 * |
SWERDLOW H ET AL: "FULLY AUTOMATED DNA REACTION AND ANALYSIS IN A FLUIDIC CAPILLARY INSTRUMENT", ANALYTICAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. COLUMBUS, vol. 69, no. 5, 1 March 1997 (1997-03-01), pages 848 - 855, XP000197684, ISSN: 0003-2700 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9132427B2 (en) | 2007-01-22 | 2015-09-15 | Wafergen, Inc. | Apparatus for high throughput chemical reactions |
Also Published As
Publication number | Publication date |
---|---|
GB0201920D0 (en) | 2002-03-13 |
CA2380794A1 (en) | 2001-02-08 |
WO2001008802A1 (en) | 2001-02-08 |
AU6514700A (en) | 2001-02-19 |
JP2003505711A (en) | 2003-02-12 |
CN1156584C (en) | 2004-07-07 |
EP1200191A1 (en) | 2002-05-02 |
JP2003505110A (en) | 2003-02-12 |
US6927045B2 (en) | 2005-08-09 |
US6423536B1 (en) | 2002-07-23 |
EP1203099A2 (en) | 2002-05-08 |
GB2368032B (en) | 2003-01-08 |
US20020110900A1 (en) | 2002-08-15 |
CA2379969A1 (en) | 2001-02-08 |
US20030032052A1 (en) | 2003-02-13 |
CN1373813A (en) | 2002-10-09 |
AU6512700A (en) | 2001-02-19 |
GB2368032A (en) | 2002-04-24 |
DE20022783U1 (en) | 2002-08-14 |
WO2001009389A2 (en) | 2001-02-08 |
CN1560267A (en) | 2005-01-05 |
US6489112B1 (en) | 2002-12-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2001009389A3 (en) | Methods and apparatus for template capture and normalization for submicroliter reaction | |
Li et al. | N‐Halocarbamate Salts Lead to More Efficient Catalytic Asymmetric Aminohydroxylation. | |
WO2005054441A3 (en) | Device for immobilizing chemical and biomedical species and methods of using same | |
WO2000070088A3 (en) | Immobilization of unmodified biopolymers to acyl fluoride activated substrates | |
AU2001273370A1 (en) | Method and apparatus for the automated generation of nucleic acid ligands | |
HUP0000615A3 (en) | Process for producing transdermal pharmaceutical compositions containing penetration increasing substance | |
WO1999005308A3 (en) | Apparatus and methods for arraying solution onto a solid support | |
EP1304665A3 (en) | Apparatus and method for controlling a card device | |
AU2001259290A1 (en) | Apparatus, method, and computer program product for quantitative analysis of a nucleic acid amplification reaction | |
EP0790216A3 (en) | Sol-gel process for obtaining pure and mixed oxide zirconia washcoats, useful as catalysts or catalyst supports | |
DE60029913D1 (en) | Improved Thermal Gradient DNA Chip (ATGC), its Production Process, and Method for Performing Biochemical Reactions | |
EP1630227A4 (en) | Immobilization support, process for producing the same, electrode, process for producing the same, electrode reaction utilizing apparatus and process for producing the same | |
ZA200603707B (en) | Device for recovering feedstock liquid, device for supplying a feedstock liquid, device for solidifying the surface of drops, and apparatus for producing ammonium diuranate particles | |
EP1724018A3 (en) | Substrate and device for bioassay and method for making the substrate | |
EP1144669A4 (en) | Method and apparatus for the automated generation of nucleic acid ligands | |
WO2001044515A3 (en) | Apparatus for performing biological reactions | |
AU2001245390A1 (en) | Ammonia synthesis process and apparatus for use therein | |
GB0006174D0 (en) | Method for the preparation of a probe for nucleic acid hybridization | |
EP1138629A3 (en) | Microchip for aqueous distribution and method of aqueous distribution using the same | |
EP1157737A3 (en) | Methods and apparatus for producing biochips | |
AU2135901A (en) | Apparatus and process for purifying a liquid by thermoelectric peltier means | |
AU1977901A (en) | Process for metering hydrogen permeated in a metallurgical structure, and apparatus thereof | |
WO2003066667A3 (en) | Method and apparatus for performing submicroliter reactions with nucleic acids or proteins | |
IL74492A0 (en) | Non-aqueous and mixed non-aqueous/aqueous solutions of nucleotides and polynucleotides,their preparation and their use | |
WO2000049557A3 (en) | Computer-implemented nucleic acid isolation method and apparatus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2380794 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2000952450 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 008128707 Country of ref document: CN |
|
WWP | Wipo information: published in national office |
Ref document number: 2000952450 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2000952450 Country of ref document: EP |