WO2001004634B1 - Antigen recovery and/or staining apparatus and method - Google Patents

Antigen recovery and/or staining apparatus and method

Info

Publication number
WO2001004634B1
WO2001004634B1 PCT/US2000/018686 US0018686W WO0104634B1 WO 2001004634 B1 WO2001004634 B1 WO 2001004634B1 US 0018686 W US0018686 W US 0018686W WO 0104634 B1 WO0104634 B1 WO 0104634B1
Authority
WO
WIPO (PCT)
Prior art keywords
reagent
independently
operate
reaction compartment
slide
Prior art date
Application number
PCT/US2000/018686
Other languages
French (fr)
Other versions
WO2001004634A1 (en
Inventor
Lee Angros
Original Assignee
Lee Angros
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22501286&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2001004634(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lee Angros filed Critical Lee Angros
Priority to AU60795/00A priority Critical patent/AU6079500A/en
Priority to CA2379410A priority patent/CA2379410C/en
Priority to EP00947135.0A priority patent/EP1208378B9/en
Publication of WO2001004634A1 publication Critical patent/WO2001004634A1/en
Publication of WO2001004634B1 publication Critical patent/WO2001004634B1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00138—Slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/110833—Utilizing a moving indicator strip or tape
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/111666—Utilizing a centrifuge or compartmented rotor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/112499—Automated chemical analysis with sample on test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114165—Automated chemical analysis with conveyance of sample along a test line in a container or rack with step of insertion or removal from test line
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

An automated in situ heat induced antigen recovery and staining method and apparatus (10) for treating a plurality of microscope slides (44).

Claims

AMENDED CLAIMS
[received by the International Bureau on 15 January 2001 (15.01.01); original claims 18-23 amended; remaining claims unchanged (2 pages)]
16. The apparatus of claim 15 further comprising: a drive mechanism for advancing each reagent dispensing strip into a dispensing position; a press assembly comprising a plurality of pressing mechanisms for puncturing a reagent capsule on the reagent dispensing strip for delivering a reagent from the reagent capsule through the upper opening of the reaction compartment into the reaction compartment below the reagent dispensing strip; a dispenser, for dispensing a quantity of a rinse solution into each reaction compartment; and a nozzle for delivering a stream of pressurized air into each reaction compartment.
17. The apparatus of claim 16 further comprising a port for dispensing an antigen recovery buffer into the reaction compartment .
18. The apparatus of claim 16 wherein the drive mechanism can operate to independently or simultaneously advance each reagent dispensing strip.
19. The apparatus of claim 15 wherein the heating element can operate to independently or simultaneously heat each microscope slide disposed on the slide support assembly.
AMENDED SHEET (ARTICLE 19) 30
20. The apparatus of claim 16 wherein the press assembly can operate such that each pressing mechanism can operate independently or simultaneously.
21. The apparatus of claim 15 wherein each slide support element is independently or simultaneously movable.
22. The apparatus of claim 16 wherein each dispenser can operate independently or simultaneously.
23. The apparatus of claim 16 where each nozzle can operate independently or simultaneously.
24. The apparatus of claim 15 wherein each slide support element is movable upwardly and downwardly.
25. A modular treatment apparatus comprising a plurality of the treatment in situ antigen recovery and staining apparatuses of claim 15.
26. A method of treating a microscope slide, comprising:
(a) disposing a microscope slide on a slide support element of a slide support assembly; and
(b) treating the microscope slide by applying a reagent to the microscope slide.
AMENDED SHEET (ARTICLE 19) 31
PCT/US2000/018686 1999-07-08 2000-07-07 Antigen recovery and/or staining apparatus and method WO2001004634A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU60795/00A AU6079500A (en) 1999-07-08 2000-07-07 Antigen recovery and/or staining apparatus and method
CA2379410A CA2379410C (en) 1999-07-08 2000-07-07 Antigen recovery and/or staining apparatus and method
EP00947135.0A EP1208378B9 (en) 1999-07-08 2000-07-07 Antigen recovery and/or staining apparatus and method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14278999P 1999-07-08 1999-07-08
US60/142,789 1999-07-08

Publications (2)

Publication Number Publication Date
WO2001004634A1 WO2001004634A1 (en) 2001-01-18
WO2001004634B1 true WO2001004634B1 (en) 2001-04-19

Family

ID=22501286

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/018686 WO2001004634A1 (en) 1999-07-08 2000-07-07 Antigen recovery and/or staining apparatus and method

Country Status (5)

Country Link
US (25) US6534008B1 (en)
EP (1) EP1208378B9 (en)
AU (1) AU6079500A (en)
CA (1) CA2379410C (en)
WO (1) WO2001004634A1 (en)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010023070A (en) * 1997-08-20 2001-03-26 더 유니버시티 오브 마이애미 A high quality, continuous throughput, tissue fixation-dehydration-fat removal-impregnation method
US7951612B2 (en) * 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US8298485B2 (en) 1999-07-08 2012-10-30 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
WO2001004634A1 (en) * 1999-07-08 2001-01-18 Lee Angros Antigen recovery and/or staining apparatus and method
US7897106B2 (en) 1999-07-08 2011-03-01 Lee Angros Situ heat induced antigen recovery and staining apparatus and method
US7294478B1 (en) * 2001-06-06 2007-11-13 Rosetta Inpharmatics Llc Microarray reaction cartridge
US7297311B2 (en) * 2001-06-29 2007-11-20 Sysmex Corporation Automatic smear preparing apparatus and automatic sample analysis system having the same
AU2002361618A1 (en) * 2001-11-13 2003-05-26 Chromavision Medical Systems, Inc. A system for tracking biological samples
US6773677B2 (en) * 2002-01-09 2004-08-10 Caliper Life Sciences, Inc. Slide cassette for fluidic injection
EP1494808B1 (en) * 2002-04-15 2013-07-03 Ventana Medical Systems, Inc. Automated high volume slide staining system
US11249095B2 (en) 2002-04-15 2022-02-15 Ventana Medical Systems, Inc. Automated high volume slide processing system
US7468161B2 (en) * 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
JP2005530165A (en) * 2002-06-20 2005-10-06 ビジョン・バイオシステムズ・リミテッド Biological reaction device with fluid discharge mechanism
AU2003901871A0 (en) 2003-03-31 2003-05-08 Vision Biosystems Limited A method and apparatus for fluid dispensation, preparation and dilation
DE10239739B4 (en) * 2002-08-29 2006-05-11 Leica Mikrosysteme Gmbh Apparatus and method for performing immunological labeling techniques for tissue thinning
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US7584019B2 (en) * 2003-12-15 2009-09-01 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US7875245B2 (en) * 2003-05-14 2011-01-25 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7850912B2 (en) * 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US9518899B2 (en) 2003-08-11 2016-12-13 Sakura Finetek U.S.A., Inc. Automated reagent dispensing system and method of operation
EP1711590B1 (en) 2004-01-08 2016-12-14 Dako Denmark A/S Apparatus and methods for processing biological samples and a reservoir therefore
CA2556772A1 (en) * 2004-03-02 2005-09-15 Dako Denmark A/S Reagent delivery system, dispensing device and container for a biological staining apparatus
US20050274395A1 (en) * 2004-06-14 2005-12-15 Applera Corporation Microarray wash tray
US7867443B2 (en) * 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
GB0501590D0 (en) * 2005-01-25 2005-03-02 Ceres Power Ltd Processing of enhanced performance LSCF fuel cell cathode microstructure and a fuel cell cathode
CA2623241A1 (en) * 2005-04-21 2006-11-02 Celerus Diagnostics, Inc. Parallel processing fluidic method and apparatus for automated rapid immunohistochemistry
KR100682018B1 (en) 2005-05-18 2007-02-13 제주대학교 산학협력단 Heating apparatus for high temperature and pressure and container thereof
EP1888739B1 (en) 2005-05-24 2021-08-11 Lee H. Angros Automated apparatus and method for treating biological specimens on slides
CA2613203C (en) * 2005-06-28 2013-08-13 The Board Of Regents Of The University Of Oklahoma Methods for growing and harvesting carbon nanotubes
US20080020923A1 (en) * 2005-09-13 2008-01-24 Debe Mark K Multilayered nanostructured films
US9551635B2 (en) * 2006-03-09 2017-01-24 Biogenex Laboratories Inc. Sample processing system
US8459509B2 (en) * 2006-05-25 2013-06-11 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
US20080081368A1 (en) * 2006-10-03 2008-04-03 Anne Marie Bailey Method and apparatus that increases efficiency and reproducibility in immunohistochemistry and immunocytochemistry
US7875242B2 (en) * 2006-10-17 2011-01-25 Preyas Sarabhai Shah Slide stainer with multiple heater stations
CA2976998C (en) * 2007-07-10 2018-09-04 Ventana Medical Systems, Inc. Apparatus and method for biological sample processing
US8549912B2 (en) 2007-12-18 2013-10-08 Teradyne, Inc. Disk drive transport, clamping and testing
US7996174B2 (en) * 2007-12-18 2011-08-09 Teradyne, Inc. Disk drive testing
US20090153993A1 (en) * 2007-12-18 2009-06-18 Teradyne, Inc. Disk Drive Testing
EP2255310B1 (en) 2008-02-29 2019-02-20 Dako Denmark A/S Systems and methods for tracking and providing workflow information
DE102008018982A1 (en) * 2008-04-14 2009-11-05 Merz, Hartmut, Prof. Dr. med. Automatic device for carrying out detection reactions and method for dispensing reagents on microscope slides
US8305751B2 (en) 2008-04-17 2012-11-06 Teradyne, Inc. Vibration isolation within disk drive testing systems
US20110123301A1 (en) * 2008-04-17 2011-05-26 Scott Noble Bulk feeding storage devices to storage device testing systems
US8238099B2 (en) * 2008-04-17 2012-08-07 Teradyne, Inc. Enclosed operating area for disk drive testing systems
US20090262455A1 (en) * 2008-04-17 2009-10-22 Teradyne, Inc. Temperature Control Within Disk Drive Testing Systems
US8095234B2 (en) * 2008-04-17 2012-01-10 Teradyne, Inc. Transferring disk drives within disk drive testing systems
US8117480B2 (en) 2008-04-17 2012-02-14 Teradyne, Inc. Dependent temperature control within disk drive testing systems
US7848106B2 (en) * 2008-04-17 2010-12-07 Teradyne, Inc. Temperature control within disk drive testing systems
US8041449B2 (en) * 2008-04-17 2011-10-18 Teradyne, Inc. Bulk feeding disk drives to disk drive testing systems
US7945424B2 (en) 2008-04-17 2011-05-17 Teradyne, Inc. Disk drive emulator and method of use thereof
US8160739B2 (en) * 2008-04-17 2012-04-17 Teradyne, Inc. Transferring storage devices within storage device testing systems
US8102173B2 (en) * 2008-04-17 2012-01-24 Teradyne, Inc. Thermal control system for test slot of test rack for disk drive testing system with thermoelectric device and a cooling conduit
US9602777B2 (en) * 2008-04-25 2017-03-21 Roche Diagnostics Hematology, Inc. Systems and methods for analyzing body fluids
WO2012030313A1 (en) 2008-04-25 2012-03-08 James Winkelman Method of determining a complete blood count and a white blood cell differential count
WO2009148942A2 (en) * 2008-06-03 2009-12-10 Teradyne, Inc. Processing storage devices
US8975039B2 (en) * 2008-06-09 2015-03-10 SYFR, Inc. Automatic sample staining method
FR2934047B1 (en) * 2008-07-17 2013-04-05 Diagdev METHOD, DEVICE AND CARTRIDGE FOR COLORING CELLS
AU2009285551B2 (en) * 2008-08-29 2015-10-29 Lee H. Angros Multiplexed microscope slide staining apparatus
FR2938062B1 (en) * 2008-11-05 2014-02-28 Biomerieux Sa DEVICE FOR PREPARING AND / OR PROCESSING A BIOLOGICAL SAMPLE
AU2009313985B2 (en) 2008-11-12 2014-07-31 Ventana Medical Systems, Inc. Methods and apparatuses for heating slides carrying specimens
ES2903147T3 (en) * 2009-04-27 2022-03-31 Roche Diagnostics Hematology Inc Systems and procedures for analyzing body fluids
EP2425227B1 (en) * 2009-04-27 2020-10-14 Becton Dickinson and Company Sample preparation device and associated method
US8687356B2 (en) 2010-02-02 2014-04-01 Teradyne, Inc. Storage device testing system cooling
US7920380B2 (en) * 2009-07-15 2011-04-05 Teradyne, Inc. Test slot cooling system for a storage device testing system
US7995349B2 (en) 2009-07-15 2011-08-09 Teradyne, Inc. Storage device temperature sensing
US8466699B2 (en) 2009-07-15 2013-06-18 Teradyne, Inc. Heating storage devices in a testing system
US8628239B2 (en) 2009-07-15 2014-01-14 Teradyne, Inc. Storage device temperature sensing
US8547123B2 (en) * 2009-07-15 2013-10-01 Teradyne, Inc. Storage device testing system with a conductive heating assembly
US8116079B2 (en) 2009-07-15 2012-02-14 Teradyne, Inc. Storage device testing system cooling
US8067241B2 (en) * 2009-08-26 2011-11-29 General Electric Company Method and apparatus for antigen retrieval process
US9779780B2 (en) 2010-06-17 2017-10-03 Teradyne, Inc. Damping vibrations within storage device testing systems
US8687349B2 (en) 2010-07-21 2014-04-01 Teradyne, Inc. Bulk transfer of storage devices using manual loading
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
US9001456B2 (en) 2010-08-31 2015-04-07 Teradyne, Inc. Engaging test slots
ES2699950T3 (en) 2010-10-06 2019-02-13 Biocare Medical Llc Procedure and system for efficient processing of biological samples
US8454908B2 (en) 2010-11-10 2013-06-04 Constitution Medical, Inc. Automated systems and methods for preparing biological specimens for examination
US9111343B2 (en) 2011-01-18 2015-08-18 Roche Diagnostics Hematology, Inc. Microscope slide coordinate system registration
US8752732B2 (en) 2011-02-01 2014-06-17 Sakura Finetek U.S.A., Inc. Fluid dispensing system
US9945763B1 (en) 2011-02-18 2018-04-17 Biocare Medical, Llc Methods and systems for immunohistochemistry heat retrieval of biological samples
US8580568B2 (en) 2011-09-21 2013-11-12 Sakura Finetek U.S.A., Inc. Traceability for automated staining system
US8932543B2 (en) * 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
CN104321443A (en) 2012-04-18 2015-01-28 霍夫曼-拉罗奇有限公司 HEV assay
ES2774713T3 (en) 2013-04-05 2020-07-22 Roche Diagnostics Hematology Inc Automated systems and procedures to prepare biological samples for examination
US9459312B2 (en) 2013-04-10 2016-10-04 Teradyne, Inc. Electronic assembly test system
DE102014001481A1 (en) 2013-10-28 2015-04-30 Euroimmun Medizinische Labordiagnostika Ag Improved apparatus and method for reactions between a solid and a liquid phase
AU2014363675B2 (en) 2013-12-13 2016-12-22 Ventana Medical Systems, Inc. Automated processing systems and methods of thermally processing microscope slides
EP3080580B1 (en) 2013-12-13 2021-05-05 Ventana Medical Systems, Inc. Staining reagents and other liquids for histological processing of biological specimens and associated technology
EP4095509A1 (en) 2013-12-13 2022-11-30 Ventana Medical Systems, Inc. Automated histological processing of biological specimens and associated technology
US10209166B2 (en) 2014-11-18 2019-02-19 Alfonso Heras System and method for processing biological specimens
EP3306297A4 (en) 2015-05-26 2019-01-30 Olympus Corporation Sample staining device and sample staining method
EP3943911A1 (en) 2016-02-29 2022-01-26 Ventana Medical Systems, Inc. System and method for dispense characterization
WO2017218882A1 (en) 2016-06-16 2017-12-21 Nanocytomics, LLC Automated staining system
US10725091B2 (en) 2017-08-28 2020-07-28 Teradyne, Inc. Automated test system having multiple stages
US11226390B2 (en) 2017-08-28 2022-01-18 Teradyne, Inc. Calibration process for an automated test system
US10845410B2 (en) 2017-08-28 2020-11-24 Teradyne, Inc. Automated test system having orthogonal robots
US10948534B2 (en) 2017-08-28 2021-03-16 Teradyne, Inc. Automated test system employing robotics
US10983145B2 (en) 2018-04-24 2021-04-20 Teradyne, Inc. System for testing devices inside of carriers
US10775408B2 (en) 2018-08-20 2020-09-15 Teradyne, Inc. System for testing devices inside of carriers
CN113785184A (en) * 2019-05-14 2021-12-10 文塔纳医疗系统公司 System comprising a biological sample processing chamber
CN111272992A (en) * 2020-02-28 2020-06-12 百盛(广州)生物制品有限公司 Large flux antigen restoring instrument
US11754596B2 (en) 2020-10-22 2023-09-12 Teradyne, Inc. Test site configuration in an automated test system
US11953519B2 (en) 2020-10-22 2024-04-09 Teradyne, Inc. Modular automated test system
US11899042B2 (en) 2020-10-22 2024-02-13 Teradyne, Inc. Automated test system
US11867749B2 (en) 2020-10-22 2024-01-09 Teradyne, Inc. Vision system for an automated test system
US11754622B2 (en) 2020-10-22 2023-09-12 Teradyne, Inc. Thermal control system for an automated test system

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645690A (en) 1968-01-22 1972-02-29 Beckman Instruments Inc Automated chemical analyzer
US3853092A (en) 1973-10-25 1974-12-10 Corning Glass Works Apparatus for nutating and staining a microscope slide
US4296069A (en) * 1980-06-16 1981-10-20 Eastman Kodak Company Apparatus for processing an analysis slide
US4296070A (en) * 1980-06-16 1981-10-20 Eastman Kodak Company Slide distributor for a chemical analyzer
US4568519A (en) * 1983-06-29 1986-02-04 Eastman Kodak Company Apparatus for processing analysis slides
JPH076992B2 (en) * 1985-06-21 1995-01-30 富士写真フイルム株式会社 Chemical analyzer
EP0231951B1 (en) * 1986-02-07 1993-06-09 Fuji Photo Film Co., Ltd. Chemical analysis apparatus
US5154889A (en) 1986-08-07 1992-10-13 Fuji Photo Film Co., Ltd. Chemical analysis apparatus
US4847208A (en) 1987-07-29 1989-07-11 Bogen Steven A Apparatus for immunohistochemical staining and method of rinsing a plurality of slides
US5089233A (en) * 1989-06-12 1992-02-18 Eastman Kodak Company Processing apparatus for a chemical reaction pack
US5209903A (en) * 1989-09-06 1993-05-11 Toa Medical Electronics, Co., Ltd. Synthetic apparatus for inspection of blood
US5250262A (en) * 1989-11-22 1993-10-05 Vettest S.A. Chemical analyzer
US5225325A (en) 1990-03-02 1993-07-06 Ventana Medical Systems, Inc. Immunohistochemical staining method and reagents therefor
US5595707A (en) 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
US6472217B1 (en) * 1990-03-02 2002-10-29 Ventana Medical Systems, Inc. Slide aqueous volume controlling apparatus
US5075079A (en) * 1990-05-21 1991-12-24 Technicon Instruments Corporation Slide analysis system
US5192503A (en) * 1990-05-23 1993-03-09 Mcgrath Charles M Probe clip in situ assay apparatus
US5425918A (en) 1990-07-18 1995-06-20 Australian Biomedical Corporation Apparatus for automatic tissue staining for immunohistochemistry
US5244787A (en) 1991-01-31 1993-09-14 Biogenex Laboratories Antigen retrieval in formalin-fixed tissues using microwave energy
US5273905A (en) 1991-02-22 1993-12-28 Amoco Corporation Processing of slide mounted material
US5696887A (en) * 1991-08-05 1997-12-09 Biotek Solutions, Incorporated Automated tissue assay using standardized chemicals and packages
US5355439A (en) * 1991-08-05 1994-10-11 Bio Tek Instruments Method and apparatus for automated tissue assay
US5232664A (en) 1991-09-18 1993-08-03 Ventana Medical Systems, Inc. Liquid dispenser
FI915731A0 (en) 1991-12-05 1991-12-05 Derek Henry Potter FOERFARANDE OCH ANORDNING FOER REGLERING AV TEMPERATUREN I ETT FLERTAL PROV.
US5578452A (en) * 1992-01-16 1996-11-26 Biogenex Laboratories Enhancement of immunochemical staining in aldehyde-fixed tissues
US5645114A (en) * 1992-05-11 1997-07-08 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US5947167A (en) 1992-05-11 1999-09-07 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US5316452A (en) 1992-05-11 1994-05-31 Gilbert Corporation Dispensing assembly with interchangeable cartridge pumps
US6180061B1 (en) 1992-05-11 2001-01-30 Cytologix Corporation Moving platform slide stainer with heating elements
US5439649A (en) 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
US6632598B1 (en) * 1994-03-11 2003-10-14 Biogenex Laboratories Deparaffinization compositions and methods for their use
US6451551B1 (en) * 1994-03-11 2002-09-17 Biogenex Laboratories Releasing embedding media from tissue specimens
US5525514A (en) * 1994-04-06 1996-06-11 Johnson & Johnson Clinical Diagnostics, Inc. Wash detection method for dried chemistry test elements
AUPN038995A0 (en) 1995-01-05 1995-01-27 Australian Biomedical Corporation Limited Method and apparatus for human or animal cell sample treatment
US5551487A (en) 1995-03-10 1996-09-03 Hewlett-Packard Company Micro-dispenser for preparing assay plates
DE19524851C2 (en) * 1995-07-07 1998-05-07 Sun Chemical Corp Acetal polymers and use thereof in photosensitive compositions and for lithographic printing plates
US6127188A (en) * 1995-10-06 2000-10-03 Mj Research, Inc. Method and apparatus for controlling evaporation in histological procedures
AUPN923596A0 (en) * 1996-04-12 1996-05-09 Australian Biomedical Corporation Limited Method and apparatus for treatment of human or animal cell samples
WO1998000580A1 (en) 1996-06-28 1998-01-08 E.I. Du Pont De Nemours And Company In-situ halogenation of compounds in an electrochemical cell
US5829091A (en) 1996-09-10 1998-11-03 Ingram; Curt R. Automobile central vacuum cleaning system
US5839091A (en) * 1996-10-07 1998-11-17 Lab Vision Corporation Method and apparatus for automatic tissue staining
US5804141A (en) 1996-10-15 1998-09-08 Chianese; David Reagent strip slide treating apparatus
US5958341A (en) * 1996-12-23 1999-09-28 American Registry Of Pathology Apparatus for efficient processing of tissue samples on slides
US5948359A (en) * 1997-03-21 1999-09-07 Biogenex Laboratories Automated staining apparatus
US6489171B1 (en) * 1997-04-18 2002-12-03 Cell Marque Corporation Chemical dispensing system and method
US5985214A (en) * 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
US5922604A (en) 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
US5882601A (en) 1997-06-18 1999-03-16 Merck & Co., Ltd. Deflected septum seal access port
US6093574A (en) * 1997-08-11 2000-07-25 Ventana Medical Systems Method and apparatus for rinsing a microscope slide
KR20010023070A (en) * 1997-08-20 2001-03-26 더 유니버시티 오브 마이애미 A high quality, continuous throughput, tissue fixation-dehydration-fat removal-impregnation method
US6649368B1 (en) * 1997-10-24 2003-11-18 Cell Marque Corporation Composition and method for treating tissue samples
CA2315809C (en) 1997-12-23 2014-06-03 Dako A/S Cartridge device for processing a sample mounted on a surface of a support member
US6269846B1 (en) * 1998-01-13 2001-08-07 Genetic Microsystems, Inc. Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays
US6428752B1 (en) * 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
US6068648A (en) 1998-01-26 2000-05-30 Orthodyne, Inc. Tissue anchoring system and method
US20030211630A1 (en) * 1998-02-27 2003-11-13 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6183693B1 (en) 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US6096271A (en) * 1998-02-27 2000-08-01 Cytologix Corporation Random access slide stainer with liquid waste segregation
DE69942975D1 (en) 1998-02-27 2011-01-05 Ventana Med Syst Inc AUTOMATED MOLECULAR PATHOLOGY APPARENT WITH INDEPENDENT OBJECT CARRIER WARMERS
US6855559B1 (en) * 1998-09-03 2005-02-15 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6495106B1 (en) * 1998-03-24 2002-12-17 Biogenex Laboratories Automated staining apparatus
ID23331A (en) 1998-03-31 2000-04-05 American Cyanamid Co COMPOSITION OF SPRAY INSECTICIDE WHICH HAS STRONG PROSPERITY
WO2000000417A1 (en) 1998-06-29 2000-01-06 H & P Technologies Limited Stacking device for stacking articles
JP3718430B2 (en) * 1998-06-30 2005-11-24 ラミナ，インコーポレイテッド Cell and tissue fixative compositions and methods of use
EP1112479B1 (en) 1998-09-03 2018-08-15 Ventana Medical Systems, Inc. Automated removal of embedding media from biological samples
WO2000018686A1 (en) 1998-09-28 2000-04-06 Tao Inc. Method for production of amorphous titanium peroxide solution and anatase titanium oxide sol
CN1216050C (en) * 1998-10-23 2005-08-24 东丽株式会社 5,6,7-trino-4,8-inter-m-phenylene PGI2 derivative and drugs containing the same
US6544798B1 (en) * 1999-02-26 2003-04-08 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6673620B1 (en) * 1999-04-20 2004-01-06 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
US7897106B2 (en) * 1999-07-08 2011-03-01 Lee Angros Situ heat induced antigen recovery and staining apparatus and method
US7951612B2 (en) * 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
WO2001004634A1 (en) * 1999-07-08 2001-01-18 Lee Angros Antigen recovery and/or staining apparatus and method
AU5967900A (en) * 1999-07-21 2001-02-13 Dako A/S A method of controlling the temperature of a specimen in or on a solid support member
US6403036B1 (en) * 1999-09-29 2002-06-11 Ventana Medical Systems, Inc. Temperature monitoring system for an automated biological reaction apparatus
US6358473B1 (en) 1999-10-05 2002-03-19 Albert Coello Microscope slide heater
US6403931B1 (en) * 1999-10-07 2002-06-11 Ventana Medical Systems, Inc. Slide heater calibrator and temperature converter apparatus and method
US6943035B1 (en) * 2000-05-19 2005-09-13 Genetix Limited Liquid dispensing apparatus and method
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US7025933B2 (en) * 2000-07-06 2006-04-11 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
EP1494808B1 (en) 2002-04-15 2013-07-03 Ventana Medical Systems, Inc. Automated high volume slide staining system
EP2420814B1 (en) 2002-04-26 2015-08-26 Ventana Medical Systems, Inc. Automatic slide processing apparatus
USD495425S1 (en) * 2003-03-24 2004-08-31 Vision Biosystems, Limited Cover tile
US7875242B2 (en) * 2006-10-17 2011-01-25 Preyas Sarabhai Shah Slide stainer with multiple heater stations
US10036690B2 (en) * 2011-11-16 2018-07-31 Leica Biosystems Melbourne Pty Ltd Biological sample treatment apparatus

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