WO2001004634A1 - Antigen recovery and/or staining apparatus and method - Google Patents
Antigen recovery and/or staining apparatus and method Download PDFInfo
- Publication number
- WO2001004634A1 WO2001004634A1 PCT/US2000/018686 US0018686W WO0104634A1 WO 2001004634 A1 WO2001004634 A1 WO 2001004634A1 US 0018686 W US0018686 W US 0018686W WO 0104634 A1 WO0104634 A1 WO 0104634A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reagent
- slide
- microscope
- microscope slide
- antigen recovery
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title claims abstract description 65
- 102000036639 antigens Human genes 0.000 title claims abstract description 65
- 108091007433 antigens Proteins 0.000 title claims abstract description 65
- 238000011084 recovery Methods 0.000 title claims abstract description 52
- 238000000034 method Methods 0.000 title claims description 41
- 238000010186 staining Methods 0.000 title claims description 22
- 238000011065 in-situ storage Methods 0.000 claims abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 114
- 239000000872 buffer Substances 0.000 claims description 51
- 238000011282 treatment Methods 0.000 claims description 47
- 239000002775 capsule Substances 0.000 claims description 30
- 238000010438 heat treatment Methods 0.000 claims description 23
- 230000007246 mechanism Effects 0.000 claims description 14
- 238000003825 pressing Methods 0.000 claims description 7
- 230000000712 assembly Effects 0.000 claims 1
- 238000000429 assembly Methods 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 238000011221 initial treatment Methods 0.000 claims 1
- 238000007447 staining method Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 14
- 238000009835 boiling Methods 0.000 description 13
- 239000007788 liquid Substances 0.000 description 12
- 239000012472 biological sample Substances 0.000 description 11
- 239000000523 sample Substances 0.000 description 11
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 7
- 239000012620 biological material Substances 0.000 description 7
- 238000001704 evaporation Methods 0.000 description 7
- 230000008020 evaporation Effects 0.000 description 7
- 239000000834 fixative Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000002203 pretreatment Methods 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000012487 rinsing solution Substances 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241001510071 Pyrrhocoridae Species 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
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- 239000012530 fluid Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- HSTOKWSFWGCZMH-UHFFFAOYSA-N 3,3'-diaminobenzidine Chemical compound C1=C(N)C(N)=CC=C1C1=CC=C(N)C(N)=C1 HSTOKWSFWGCZMH-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
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- 239000004793 Polystyrene Substances 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
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- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00138—Slides
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10T436/110833—Utilizing a moving indicator strip or tape
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- Y10T436/111666—Utilizing a centrifuge or compartmented rotor
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
- Y10T436/114165—Automated chemical analysis with conveyance of sample along a test line in a container or rack with step of insertion or removal from test line
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10T436/11—Automated chemical analysis
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- Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU60795/00A AU6079500A (en) | 1999-07-08 | 2000-07-07 | Antigen recovery and/or staining apparatus and method |
CA2379410A CA2379410C (en) | 1999-07-08 | 2000-07-07 | Antigen recovery and/or staining apparatus and method |
EP00947135.0A EP1208378B9 (en) | 1999-07-08 | 2000-07-07 | Antigen recovery and/or staining apparatus and method |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14278999P | 1999-07-08 | 1999-07-08 | |
US60/142,789 | 1999-07-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001004634A1 true WO2001004634A1 (en) | 2001-01-18 |
WO2001004634B1 WO2001004634B1 (en) | 2001-04-19 |
Family
ID=22501286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/018686 WO2001004634A1 (en) | 1999-07-08 | 2000-07-07 | Antigen recovery and/or staining apparatus and method |
Country Status (5)
Country | Link |
---|---|
US (25) | US6534008B1 (en) |
EP (1) | EP1208378B9 (en) |
AU (1) | AU6079500A (en) |
CA (1) | CA2379410C (en) |
WO (1) | WO2001004634A1 (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004001390A1 (en) * | 2002-06-20 | 2003-12-31 | Vision Biosystems Limited | Biological reaction apparatus with draining mechanism |
WO2004025273A1 (en) * | 2002-08-29 | 2004-03-25 | Leica Mikrosysteme Gmbh | Device and method for carrying out immunological marking techniques for thin-sectioned tissue |
EP1463940A1 (en) * | 2002-01-09 | 2004-10-06 | Zymark Corporation | Slide cassette for fluidic injection |
US7250301B2 (en) | 1999-07-08 | 2007-07-31 | Lee Angros | In situ heat induced antigen recovery and staining method |
US7897106B2 (en) | 1999-07-08 | 2011-03-01 | Lee Angros | Situ heat induced antigen recovery and staining apparatus and method |
CN102202791A (en) * | 2008-11-05 | 2011-09-28 | 生物梅里埃公司 | Device for preparing and/or treating a biological sample |
US8298485B2 (en) | 1999-07-08 | 2012-10-30 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
WO2015062715A1 (en) * | 2013-10-28 | 2015-05-07 | Euroimmun Medizinische Labordiagnostika Ag | Improved device and method for reactions between a solid and a liquid phase |
US9346053B2 (en) | 2003-03-31 | 2016-05-24 | Leica Biosystems Melbourne Pty Ltd | Method and apparatus for fluid dispensation, preparation and dilution |
EP2573542A3 (en) * | 2011-09-21 | 2017-12-20 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
CN111272992A (en) * | 2020-02-28 | 2020-06-12 | 百盛(广州)生物制品有限公司 | Large flux antigen restoring instrument |
Families Citing this family (93)
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WO1999009390A1 (en) * | 1997-08-20 | 1999-02-25 | The University Of Miami | A high quality, continuous throughput, tissue fixation-dehydration-fat removal-impregnation method |
US7951612B2 (en) * | 1999-07-08 | 2011-05-31 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
US7294478B1 (en) * | 2001-06-06 | 2007-11-13 | Rosetta Inpharmatics Llc | Microarray reaction cartridge |
US7297311B2 (en) * | 2001-06-29 | 2007-11-20 | Sysmex Corporation | Automatic smear preparing apparatus and automatic sample analysis system having the same |
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US7468161B2 (en) * | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
US11249095B2 (en) | 2002-04-15 | 2022-02-15 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
US7303725B2 (en) * | 2002-04-15 | 2007-12-04 | Ventana Medical Systems, Inc. | Automated high volume slide staining system |
US7875245B2 (en) * | 2003-05-14 | 2011-01-25 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US7850912B2 (en) * | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
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US20050274395A1 (en) * | 2004-06-14 | 2005-12-15 | Applera Corporation | Microarray wash tray |
US7867443B2 (en) * | 2004-07-23 | 2011-01-11 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
GB0501590D0 (en) * | 2005-01-25 | 2005-03-02 | Ceres Power Ltd | Processing of enhanced performance LSCF fuel cell cathode microstructure and a fuel cell cathode |
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KR100682018B1 (en) | 2005-05-18 | 2007-02-13 | 제주대학교 산학협력단 | Heating apparatus for high temperature and pressure and container thereof |
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US7875242B2 (en) * | 2006-10-17 | 2011-01-25 | Preyas Sarabhai Shah | Slide stainer with multiple heater stations |
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