WO2001003821A1 - Method of particle formation - Google Patents
Method of particle formation Download PDFInfo
- Publication number
- WO2001003821A1 WO2001003821A1 PCT/GB2000/002606 GB0002606W WO0103821A1 WO 2001003821 A1 WO2001003821 A1 WO 2001003821A1 GB 0002606 W GB0002606 W GB 0002606W WO 0103821 A1 WO0103821 A1 WO 0103821A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vehicle
- fluid
- solvent
- suspension
- vehicles
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0488—Flow sheets
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Extraction Or Liquid Replacement (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Glass Compositions (AREA)
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60001944T DE60001944T2 (en) | 1999-07-07 | 2000-07-07 | METHOD FOR PRODUCING PARTICLES |
US10/030,392 US6860907B1 (en) | 1999-07-07 | 2000-07-07 | Method of particle formation |
JP2001509286A JP4490016B2 (en) | 1999-07-07 | 2000-07-07 | Particle formation method |
AU56990/00A AU773548B2 (en) | 1999-07-07 | 2000-07-07 | Method of particle formation |
CA002376593A CA2376593C (en) | 1999-07-07 | 2000-07-07 | Method of particle formation |
EP00942295A EP1191999B1 (en) | 1999-07-07 | 2000-07-07 | Method of particle formation |
DK00942295T DK1191999T3 (en) | 1999-07-07 | 2000-07-07 | Process for manufacturing particles |
AT00942295T ATE235956T1 (en) | 1999-07-07 | 2000-07-07 | METHOD FOR PRODUCING PARTICLES |
MXPA01013259A MXPA01013259A (en) | 1999-07-07 | 2000-07-07 | Method of particle formation. |
US11/006,464 US7150766B2 (en) | 1999-07-07 | 2004-12-07 | Method of particle formation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9915975.8 | 1999-07-07 | ||
GBGB9915975.8A GB9915975D0 (en) | 1999-07-07 | 1999-07-07 | Method for the formation of particles |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10030392 A-371-Of-International | 2000-07-07 | ||
US11/006,464 Continuation US7150766B2 (en) | 1999-07-07 | 2004-12-07 | Method of particle formation |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001003821A1 true WO2001003821A1 (en) | 2001-01-18 |
Family
ID=10856857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2000/002606 WO2001003821A1 (en) | 1999-07-07 | 2000-07-07 | Method of particle formation |
Country Status (12)
Country | Link |
---|---|
US (2) | US6860907B1 (en) |
EP (1) | EP1191999B1 (en) |
JP (1) | JP4490016B2 (en) |
AT (1) | ATE235956T1 (en) |
AU (1) | AU773548B2 (en) |
CA (1) | CA2376593C (en) |
DE (1) | DE60001944T2 (en) |
DK (1) | DK1191999T3 (en) |
ES (1) | ES2195908T3 (en) |
GB (2) | GB9915975D0 (en) |
MX (1) | MXPA01013259A (en) |
WO (1) | WO2001003821A1 (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001015664A2 (en) * | 1999-08-31 | 2001-03-08 | Bradford Particle Design Limited | Coformulation methods and their products |
WO2002038127A2 (en) * | 2000-11-09 | 2002-05-16 | Nektar Therapeutics Uk Limited | Particle formation methods and their products |
EP1232002A1 (en) | 1999-11-16 | 2002-08-21 | Advanced Phytonics Limited | Method for the production of particles |
WO2003039729A1 (en) * | 2001-11-07 | 2003-05-15 | Advanced Phytonics Limited | Method for the production of particles |
WO2004009672A1 (en) * | 2002-07-19 | 2004-01-29 | Nektar Therapeutics Uk Ltd | Polyalkylene glycols, derivatives and conjugates thereof in particulate form |
WO2005061090A1 (en) * | 2003-12-22 | 2005-07-07 | Censdelivery Ab | Device, method and use for the formation of small particles |
WO2006018644A1 (en) * | 2004-08-19 | 2006-02-23 | Advanced Phytonics Limited | Process for preparing particles and apparatus |
JP2006516958A (en) * | 2002-12-19 | 2006-07-13 | バクスター・インターナショナル・インコーポレイテッド | Process for preparing combination pharmaceutical formulations using supercritical fluids |
US7108867B2 (en) | 2001-01-26 | 2006-09-19 | Astrazeneca Ab | Process for preparing particles |
WO2007009164A1 (en) | 2005-07-15 | 2007-01-25 | Eiffel Technologies Limited | Method of particle formation |
US7250152B2 (en) | 2001-10-22 | 2007-07-31 | Dompé Pha.R.Ma S.P.A. | Supercritical fluids processing: preparation of protein microparticles and their stablilisation |
US7332111B2 (en) | 2001-07-10 | 2008-02-19 | The Regents Of The University Of Colorado | Devices and methods for the production of particles |
US7354601B2 (en) | 2003-05-08 | 2008-04-08 | Walker Stephen E | Particulate materials |
US7507823B2 (en) | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
EP1330266B2 (en) † | 2000-10-19 | 2009-08-26 | Separex | Method for making very fine particles consisting of a principle inserted in a host molecule |
CZ301857B6 (en) * | 2001-02-26 | 2010-07-14 | Dompé Pha.R.Ma S.P.A. | Device and method for forming micron or submicron particles and a nozzle for forming such particles |
US8241371B2 (en) | 2007-02-08 | 2012-08-14 | Thar Pharmaceuticals, Inc. | Method of creating crystalline substances |
EP2612703A2 (en) | 2002-04-17 | 2013-07-10 | Nektar Therapeutics | Particulate materials |
EP3106217A1 (en) * | 2015-06-12 | 2016-12-21 | Messer France S.A.S. | Device and method for cooling and atomizing liquid or paste-like substances |
WO2017013498A2 (en) | 2015-07-22 | 2017-01-26 | Anavex Life Sciences Corp. | Crystal forms of tetra-hydro-n, n-dimethyl-2, 2-diphenyl-3-furanmethanamine hydrochloride, processes for making such forms, and their pharmaceutical compositions |
US9700529B2 (en) | 2002-05-03 | 2017-07-11 | Nektar Therapeutics | Particulate materials |
US9808030B2 (en) | 2011-02-11 | 2017-11-07 | Grain Processing Corporation | Salt composition |
US9833451B2 (en) | 2007-02-11 | 2017-12-05 | Map Pharmaceuticals, Inc. | Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile |
CN108969555A (en) * | 2017-09-25 | 2018-12-11 | 太和县三九药业有限公司 | A kind of kidney tonifying, benefiting essence-blood, strengthen immunity Herba Epimedii Chinese medicine composition |
US10806770B2 (en) | 2014-10-31 | 2020-10-20 | Monash University | Powder formulation |
US11351115B2 (en) | 2014-02-13 | 2022-06-07 | Crystec Ltd | Inhalable particles |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9703673D0 (en) * | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
GB9810559D0 (en) * | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
GB9915975D0 (en) * | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
KR20030074693A (en) * | 2000-12-28 | 2003-09-19 | 알투스 바이올로직스 인코포레이티드 | Crystals of whole antibodies and fragments thereof and methods for making and using them |
AU2002322295C1 (en) * | 2001-06-21 | 2008-12-18 | Altus Pharmaceuticals Inc. | Spherical protein particles and methods of making and using them |
GB0117696D0 (en) * | 2001-07-20 | 2001-09-12 | Bradford Particle Design Plc | Particle information |
US7582284B2 (en) * | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
GB0216562D0 (en) * | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
GB0229714D0 (en) * | 2002-12-20 | 2003-01-29 | Glaxo Group Ltd | Novel apparatus and method |
MXPA05007154A (en) | 2002-12-30 | 2005-09-21 | Nektar Therapeutics | Prefilming atomizer. |
JP4545467B2 (en) * | 2004-03-26 | 2010-09-15 | 株式会社大川原製作所 | Supercritical fine particle production equipment |
JP5016785B2 (en) * | 2004-12-28 | 2012-09-05 | 株式会社奈良機械製作所 | Fine particle generator |
EP1866407A4 (en) * | 2005-03-22 | 2010-07-14 | Regeron Inc | Apparatus and method for submicroni zation of proteins using supercritical fluids |
ES2390183T3 (en) * | 2006-10-11 | 2012-11-07 | Crititech, Inc. | Method of precipitation of small particles of medicine in use container |
US7827822B2 (en) * | 2007-07-25 | 2010-11-09 | Schott Corporation | Method and apparatus for spray-forming melts of glass and glass-ceramic compositions |
AU2008331967B2 (en) * | 2007-12-07 | 2012-10-25 | Xspray Microparticles Ab | Method and arrangement for the production of particles |
WO2010151804A1 (en) * | 2009-06-26 | 2010-12-29 | Map Pharmaceuticals, Inc. | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
GB201016436D0 (en) | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Method of making solid beads |
GB201016433D0 (en) * | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Apparatus and method for making solid beads |
US8778181B1 (en) | 2013-03-14 | 2014-07-15 | Crititech, Inc. | Equipment assembly for and method of processing particles |
US9925512B2 (en) | 2013-03-14 | 2018-03-27 | Crititech, Inc. | Equipment assembly for and method of processing particles |
US20170050337A1 (en) * | 2013-05-02 | 2017-02-23 | Melior Innovations, Inc. | Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures |
US10252270B2 (en) * | 2014-09-08 | 2019-04-09 | Arizona Board Of Regents On Behalf Of Arizona State University | Nozzle apparatus and methods for use thereof |
WO2019158932A1 (en) | 2018-02-15 | 2019-08-22 | The Chancellor, Masters And Scholars Of The University Of Cambridge | Constant shear continuous reactor device |
CN112657301A (en) * | 2020-12-01 | 2021-04-16 | 大连理工大学 | Supercritical gas-solid separation device and method |
EP4190437A1 (en) * | 2021-12-03 | 2023-06-07 | SiTec PharmaBio SL | Process and apparatus for the manufacture of solid microparticles |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264536A (en) * | 1990-12-06 | 1993-11-23 | Exxon Research And Engineering Company | Supercritical mixed-solvent separation of polymer mixtures |
WO1996000610A1 (en) * | 1994-06-30 | 1996-01-11 | University Of Bradford | Method and apparatus for the formation of particles |
WO1999044733A1 (en) * | 1998-03-02 | 1999-09-10 | Bradford Particle Design Plc | Method of particle formation |
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DE3787533T2 (en) | 1987-12-21 | 1994-01-20 | Union Carbide Corp | Use of supercritical liquids as a thinner when spraying coatings. |
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GB9703673D0 (en) | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
GB9810559D0 (en) * | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
GB9915975D0 (en) * | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
-
1999
- 1999-07-07 GB GBGB9915975.8A patent/GB9915975D0/en not_active Ceased
-
2000
- 2000-07-07 US US10/030,392 patent/US6860907B1/en not_active Expired - Lifetime
- 2000-07-07 WO PCT/GB2000/002606 patent/WO2001003821A1/en active IP Right Grant
- 2000-07-07 ES ES00942295T patent/ES2195908T3/en not_active Expired - Lifetime
- 2000-07-07 EP EP00942295A patent/EP1191999B1/en not_active Expired - Lifetime
- 2000-07-07 DE DE60001944T patent/DE60001944T2/en not_active Expired - Lifetime
- 2000-07-07 MX MXPA01013259A patent/MXPA01013259A/en active IP Right Grant
- 2000-07-07 AT AT00942295T patent/ATE235956T1/en not_active IP Right Cessation
- 2000-07-07 DK DK00942295T patent/DK1191999T3/en active
- 2000-07-07 GB GB0016618A patent/GB2354968B/en not_active Expired - Lifetime
- 2000-07-07 CA CA002376593A patent/CA2376593C/en not_active Expired - Lifetime
- 2000-07-07 JP JP2001509286A patent/JP4490016B2/en not_active Expired - Lifetime
- 2000-07-07 AU AU56990/00A patent/AU773548B2/en not_active Ceased
-
2004
- 2004-12-07 US US11/006,464 patent/US7150766B2/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264536A (en) * | 1990-12-06 | 1993-11-23 | Exxon Research And Engineering Company | Supercritical mixed-solvent separation of polymer mixtures |
WO1996000610A1 (en) * | 1994-06-30 | 1996-01-11 | University Of Bradford | Method and apparatus for the formation of particles |
WO1999044733A1 (en) * | 1998-03-02 | 1999-09-10 | Bradford Particle Design Plc | Method of particle formation |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001015664A3 (en) * | 1999-08-31 | 2001-09-20 | Bradford Particle Design Plc | Coformulation methods and their products |
WO2001015664A2 (en) * | 1999-08-31 | 2001-03-08 | Bradford Particle Design Limited | Coformulation methods and their products |
EP1232002A1 (en) | 1999-11-16 | 2002-08-21 | Advanced Phytonics Limited | Method for the production of particles |
US7404828B1 (en) | 1999-11-16 | 2008-07-29 | Glaxo Group Limited | Method for the production of particles |
EP1330266B2 (en) † | 2000-10-19 | 2009-08-26 | Separex | Method for making very fine particles consisting of a principle inserted in a host molecule |
US7115280B2 (en) | 2000-11-09 | 2006-10-03 | Nektar Therapeutics Uk, Ltd. | Particle formation methods and their products |
WO2002038127A2 (en) * | 2000-11-09 | 2002-05-16 | Nektar Therapeutics Uk Limited | Particle formation methods and their products |
WO2002038127A3 (en) * | 2000-11-09 | 2003-01-09 | Bradford Particle Design Ltd | Particle formation methods and their products |
US10798955B2 (en) | 2000-11-09 | 2020-10-13 | Nektar Therapeutics | Compositions of particulate coformulation |
US9120031B2 (en) | 2000-11-09 | 2015-09-01 | Nektar Therapeutics | Compositions of particulate coformulation |
US7829123B2 (en) | 2001-01-26 | 2010-11-09 | Astrazeneca Ab | Process |
US7108867B2 (en) | 2001-01-26 | 2006-09-19 | Astrazeneca Ab | Process for preparing particles |
CZ301857B6 (en) * | 2001-02-26 | 2010-07-14 | Dompé Pha.R.Ma S.P.A. | Device and method for forming micron or submicron particles and a nozzle for forming such particles |
US7332111B2 (en) | 2001-07-10 | 2008-02-19 | The Regents Of The University Of Colorado | Devices and methods for the production of particles |
US7250152B2 (en) | 2001-10-22 | 2007-07-31 | Dompé Pha.R.Ma S.P.A. | Supercritical fluids processing: preparation of protein microparticles and their stablilisation |
EP1440082B1 (en) * | 2001-10-22 | 2011-09-28 | Dompé S.P.A. | Supercritical fluids processing: preparation of protein microparticles and their stabilisation |
WO2003039729A1 (en) * | 2001-11-07 | 2003-05-15 | Advanced Phytonics Limited | Method for the production of particles |
EP2612703A2 (en) | 2002-04-17 | 2013-07-10 | Nektar Therapeutics | Particulate materials |
US9616060B2 (en) | 2002-04-17 | 2017-04-11 | Nektar Therapeutics | Particulate materials |
US10251881B2 (en) | 2002-04-17 | 2019-04-09 | Nektar Therapeutics | Particulate materials |
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Publication number | Publication date |
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GB2354968B (en) | 2001-09-12 |
EP1191999A1 (en) | 2002-04-03 |
DE60001944D1 (en) | 2003-05-08 |
DE60001944T2 (en) | 2003-12-24 |
US7150766B2 (en) | 2006-12-19 |
US6860907B1 (en) | 2005-03-01 |
GB9915975D0 (en) | 1999-09-08 |
DK1191999T3 (en) | 2003-07-21 |
ATE235956T1 (en) | 2003-04-15 |
JP4490016B2 (en) | 2010-06-23 |
GB2354968A (en) | 2001-04-11 |
CA2376593A1 (en) | 2001-01-18 |
AU5699000A (en) | 2001-01-30 |
JP2003504178A (en) | 2003-02-04 |
ES2195908T3 (en) | 2003-12-16 |
EP1191999B1 (en) | 2003-04-02 |
US20050206023A1 (en) | 2005-09-22 |
AU773548B2 (en) | 2004-05-27 |
MXPA01013259A (en) | 2002-12-13 |
GB0016618D0 (en) | 2000-08-23 |
CA2376593C (en) | 2009-12-01 |
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