WO2001002030A3 - Scaffold matrix and tissue maintaining systems - Google Patents

Scaffold matrix and tissue maintaining systems Download PDF

Info

Publication number
WO2001002030A3
WO2001002030A3 PCT/IL2000/000386 IL0000386W WO0102030A3 WO 2001002030 A3 WO2001002030 A3 WO 2001002030A3 IL 0000386 W IL0000386 W IL 0000386W WO 0102030 A3 WO0102030 A3 WO 0102030A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
sulfates
scaffold
scaffold matrix
pressure
Prior art date
Application number
PCT/IL2000/000386
Other languages
French (fr)
Other versions
WO2001002030A2 (en
Inventor
Zvi Nevo
Dror Robinson
Original Assignee
Zvi Nevo
Dror Robinson
Univ Ramot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zvi Nevo, Dror Robinson, Univ Ramot filed Critical Zvi Nevo
Priority to AU55619/00A priority Critical patent/AU5561900A/en
Priority to DE60014381T priority patent/DE60014381D1/en
Priority to CA002378209A priority patent/CA2378209A1/en
Priority to JP2001507520A priority patent/JP2003503159A/en
Priority to AT00940721T priority patent/ATE278009T1/en
Priority to EP00940721A priority patent/EP1196540B1/en
Publication of WO2001002030A2 publication Critical patent/WO2001002030A2/en
Publication of WO2001002030A3 publication Critical patent/WO2001002030A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3612—Cartilage, synovial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3629—Intestinal tissue, e.g. small intestinal submucosa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30762—Means for culturing cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30766—Scaffolds for cartilage ingrowth and regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C12N2533/92—Amnion; Decellularised dermis or mucosa

Abstract

The invention concerns a device with a constant perfusion system for maintenance of viable cells, tissues and composite implants, which involves a pressure generator for producing rhythmic pulses of pressure on the biological specimen. All the operative parameters of the system are controllable, easily manipulated. The invention further concerns a scaffold which is used as a growth supportive base for various cells and tissue explants from three-dimensional tissue comprising naturally derived connective or skeletal tissue cross-linked with one of the following: hyaluronic acid, proteoglycans, glycosaminolycans, chondroitin sulfates, heparan sulfates, heparins and dextran sulfates.
PCT/IL2000/000386 1999-07-06 2000-07-04 Scaffold matrix and tissue maintaining systems WO2001002030A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU55619/00A AU5561900A (en) 1999-07-06 2000-07-04 Scaffold matrix and tissue maintaining systems
DE60014381T DE60014381D1 (en) 1999-07-06 2000-07-04 TISSUE MAINTENANCE SYSTEM
CA002378209A CA2378209A1 (en) 1999-07-06 2000-07-04 Scaffold matrix and tissue maintaining systems
JP2001507520A JP2003503159A (en) 1999-07-06 2000-07-04 Scaffold matrix and tissue maintenance system
AT00940721T ATE278009T1 (en) 1999-07-06 2000-07-04 SYSTEM FOR MAINTAINING TISSUE
EP00940721A EP1196540B1 (en) 1999-07-06 2000-07-04 Tissue maintaining system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/345,138 1999-07-06
US09/345,138 US6632651B1 (en) 1999-07-06 1999-07-06 Tissue maintenance system that applies rhythmic pulses of pressure

Publications (2)

Publication Number Publication Date
WO2001002030A2 WO2001002030A2 (en) 2001-01-11
WO2001002030A3 true WO2001002030A3 (en) 2001-08-23

Family

ID=23353693

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2000/000386 WO2001002030A2 (en) 1999-07-06 2000-07-04 Scaffold matrix and tissue maintaining systems

Country Status (8)

Country Link
US (1) US6632651B1 (en)
EP (1) EP1196540B1 (en)
JP (1) JP2003503159A (en)
AT (1) ATE278009T1 (en)
AU (1) AU5561900A (en)
CA (1) CA2378209A1 (en)
DE (1) DE60014381D1 (en)
WO (1) WO2001002030A2 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6652872B2 (en) 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US6528052B1 (en) 2000-09-29 2003-03-04 The Board Of Trustees Of The Leland Stanford Junior University Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling
EP1093854B1 (en) * 2000-08-03 2008-07-02 Koninklijke Philips Electronics N.V. Pressure-variation fluid transport for body-fluid analysis
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
JP4500898B2 (en) * 2001-03-23 2010-07-14 高木産業株式会社 Compositions and methods for producing biological tissues and tissue constructs
US7468192B2 (en) * 2002-03-22 2008-12-23 Histogenics Corporation Method for repair of cartilage lesions
CA2853267C (en) * 2002-04-08 2018-06-26 Octane Biotech Inc. Automated tissue engineering system comprising sensors linked to a microprocessor
US20040170950A1 (en) * 2002-09-12 2004-09-02 Prien Samuel D. Organ preservation apparatus and methods
AU2003900620A0 (en) * 2003-02-12 2003-02-27 Australian Surgical Design And Manufacture Pty Limited Arthroscopic chondrocyte implantation method and device
US7666230B2 (en) 2003-12-08 2010-02-23 Depuy Products, Inc. Implant device for cartilage regeneration in load bearing articulation regions
ES2403357T3 (en) 2003-12-11 2013-05-17 Isto Technologies Inc. Particle Cartilage System
US20050153271A1 (en) * 2004-01-13 2005-07-14 Wenrich Marshall S. Organ preservation apparatus and methods
US8546142B2 (en) 2004-03-05 2013-10-01 Millenium Biologix Technologies Inc. Reverse flow perfusion of three-dimensional scaffolds
US7776392B2 (en) * 2005-04-15 2010-08-17 Siemens Energy, Inc. Composite insulation tape with loaded HTC materials
US7767446B2 (en) * 2004-09-16 2010-08-03 Becton, Dickinson And Company Perfusion bioreactors for culturing cells
US9427496B2 (en) 2005-02-18 2016-08-30 Drexel University Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering
EP1916964A4 (en) 2005-08-26 2015-11-04 Zimmer Inc Implants and methods for repair, replacement and treatment of joint disease
CA2620663A1 (en) * 2005-09-02 2007-03-08 Colbar Lifescience Ltd. Cross-linked polysaccharide and protein matrices and methods for their preparation
AU2006292224B2 (en) 2005-09-19 2013-08-01 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US9944900B2 (en) * 2006-01-18 2018-04-17 Hemacell Perfusion Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells
EP2049159A4 (en) * 2006-08-11 2011-08-17 Univ Queensland Scaffold treatment - device and method
US20080145919A1 (en) * 2006-12-18 2008-06-19 Franklin Thomas D Portable organ and tissue preservation apparatus, kit and methods
US20090012629A1 (en) 2007-04-12 2009-01-08 Isto Technologies, Inc. Compositions and methods for tissue repair
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
WO2009026392A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation A method for improvement of differentiation of mesenchymal stem cells using a double-structured tissue implant
WO2010102059A1 (en) * 2009-03-03 2010-09-10 The Trustees Of Columbia University In The City Of New York Methods, devices, and systems for bone tissue engineering using a bioreactor
US9606035B2 (en) 2011-12-21 2017-03-28 Ta Instruments-Waters Llc System for mechanical stimulation and characterization of biologic samples
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
EP3177708B1 (en) * 2014-08-05 2018-07-25 The Charles Stark Draper Laboratory, Inc. Fluid circulation systems incorporating fluid leveling devices
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
EP3607046A4 (en) 2017-04-07 2020-05-27 Epibone, Inc. System and method for seeding and culturing
KR20230092033A (en) 2017-09-01 2023-06-23 론차 콜로그네 게엠베하 End-to-End Cell Therapy Automation
KR20210108406A (en) 2018-12-21 2021-09-02 론자 워커스빌 아이엔씨. Automated production of viral vectors
CN113366099A (en) 2018-12-21 2021-09-07 奥克泰生物科技股份有限公司 Carousel for modular bio-production units
WO2020132743A1 (en) 2018-12-28 2020-07-02 Octane Biotech Inc. Cell culture and tissue engineering systems with controlled environmental zones
SG11202108473XA (en) 2019-02-08 2021-09-29 Lonza Walkersville Inc Cell concentration methods and devices for use in automated bioreactors
US11896736B2 (en) * 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851354A (en) * 1987-12-07 1989-07-25 Trustees Of The University Of Pennsylvania Apparatus for mechanically stimulating cells
WO1992014419A1 (en) * 1991-02-14 1992-09-03 Baxter International Inc. Pliable biological graft materials and their methods of manufacture
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
WO1997021447A1 (en) * 1995-12-12 1997-06-19 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
WO1997049799A1 (en) * 1996-06-27 1997-12-31 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
WO1998014222A1 (en) * 1996-09-30 1998-04-09 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
DE19808055A1 (en) * 1998-02-27 1999-09-02 Adamietz Tissue engineering procedure extracting and culturing cells with mechanical stimulation to simulate in-vivo growth
WO1999052572A1 (en) * 1998-04-09 1999-10-21 Children's Medical Center Corporation Methods and compositions for tissue regeneration
US6037141A (en) * 1998-06-04 2000-03-14 Banes; Albert J. Culture compression device
WO2000041648A1 (en) * 1999-01-14 2000-07-20 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic, or native vascular grafts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108438A (en) 1989-03-02 1992-04-28 Regen Corporation Prosthetic intervertebral disc
US4880429A (en) 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
JP3080647B2 (en) * 1990-10-09 2000-08-28 エーザイ株式会社 Cell culture device
ATE265191T1 (en) 1994-03-14 2004-05-15 Cryolife Inc PRODUCTION PROCESS OF TISSUE FOR IMPLANTATION
US5928945A (en) 1996-11-20 1999-07-27 Advanced Tissue Sciences, Inc. Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851354A (en) * 1987-12-07 1989-07-25 Trustees Of The University Of Pennsylvania Apparatus for mechanically stimulating cells
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
WO1992014419A1 (en) * 1991-02-14 1992-09-03 Baxter International Inc. Pliable biological graft materials and their methods of manufacture
WO1997021447A1 (en) * 1995-12-12 1997-06-19 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
WO1997049799A1 (en) * 1996-06-27 1997-12-31 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
WO1998014222A1 (en) * 1996-09-30 1998-04-09 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
DE19808055A1 (en) * 1998-02-27 1999-09-02 Adamietz Tissue engineering procedure extracting and culturing cells with mechanical stimulation to simulate in-vivo growth
WO1999052572A1 (en) * 1998-04-09 1999-10-21 Children's Medical Center Corporation Methods and compositions for tissue regeneration
US6037141A (en) * 1998-06-04 2000-03-14 Banes; Albert J. Culture compression device
WO2000041648A1 (en) * 1999-01-14 2000-07-20 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic, or native vascular grafts

Also Published As

Publication number Publication date
CA2378209A1 (en) 2001-01-11
JP2003503159A (en) 2003-01-28
EP1196540B1 (en) 2004-09-29
ATE278009T1 (en) 2004-10-15
DE60014381D1 (en) 2004-11-04
WO2001002030A2 (en) 2001-01-11
US6632651B1 (en) 2003-10-14
EP1196540A2 (en) 2002-04-17
AU5561900A (en) 2001-01-22

Similar Documents

Publication Publication Date Title
WO2001002030A3 (en) Scaffold matrix and tissue maintaining systems
Rubin et al. Functional strains and cortical bone adaptation: epigenetic assurance of skeletal integrity
ATE228021T1 (en) BIOLOGICALLY ACTIVE IMPLANTS
WO2007030752A3 (en) System and method for tissue generation and bone regeneration
CA2435491A1 (en) Crosslinked polysaccharide sponge
WO2006047581A3 (en) Bone plate system and methods
WO2001039795A3 (en) Attenuation of fibroblast proliferation
ITPD910228A1 (en) COMPOSITE MEMBRANES FOR GUIDED REGENERATION OF FABRICS
DE69622575D1 (en) PHOTO-NETWORKED HYALURONIC ACID AND METHOD FOR THE PRODUCTION THEREOF
RU97102352A (en) AGENT STIMULATING SOLID FABRIC
CA2265508A1 (en) Bone morphogenetic protein-16 (bmp-16) compositions
WO1998052619A3 (en) Peptide-coated implants and methods for producing same
IL173488A0 (en) Scaffold-free self-organized 3d synthetic tissue
HUP0001465A2 (en) Implant for subcutaneous or intradermal injection
TW200505514A (en) Composite scaffolds seeded with mammalian cells
EP1087797B1 (en) Three-dimensional prostheses containing hyaluronic acid derivatives
SE9704003L (en) Molds for use as implants in human medicine and a method for making such molds
EP1948258B1 (en) Method and device for synovial cell-charged collagen membrane or gel
US20190314165A1 (en) Method for producing osteosynthesis devices, osteosynthesis devices and implants made of semi-synthetic hybrid material obtained by structural modification of the components of a natural marine biomaterial
DK1715900T3 (en) Composite Structures Containing Hyaluronic Acid Derivatives as New Bone Substitutes and Transplants
GB9902976D0 (en) Composite
CA2521053A1 (en) Self-aligning tissue growth guide
CN2879998Y (en) Nail hole locking structure for bone implanted product
BR9605881A (en) Method for improving the mechanical properties of a fiberglass matrix
CN208999217U (en) A kind of mechanical strength detection device

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 507520

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2378209

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2000940721

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000940721

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 2000940721

Country of ref document: EP