WO2000079285A3 - Devices and methods for the performance of miniaturized homogeneous assays - Google Patents

Devices and methods for the performance of miniaturized homogeneous assays Download PDF

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Publication number
WO2000079285A3
WO2000079285A3 PCT/US2000/016653 US0016653W WO0079285A3 WO 2000079285 A3 WO2000079285 A3 WO 2000079285A3 US 0016653 W US0016653 W US 0016653W WO 0079285 A3 WO0079285 A3 WO 0079285A3
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WO
WIPO (PCT)
Prior art keywords
methods
platform
miniaturized
performance
devices
Prior art date
Application number
PCT/US2000/016653
Other languages
French (fr)
Other versions
WO2000079285A2 (en
WO2000079285A9 (en
Inventor
Gregory J Kellogg
David C Duffy
Original Assignee
Gamera Bioscience Corp
Gregory J Kellogg
David C Duffy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2001505200A priority Critical patent/JP2004529312A/en
Priority to AT00939944T priority patent/ATE272213T1/en
Priority to EP00939944A priority patent/EP1230544B1/en
Priority to DE60012562T priority patent/DE60012562D1/en
Priority to AU54949/00A priority patent/AU5494900A/en
Application filed by Gamera Bioscience Corp, Gregory J Kellogg, David C Duffy filed Critical Gamera Bioscience Corp
Publication of WO2000079285A2 publication Critical patent/WO2000079285A2/en
Priority to PCT/US2001/015743 priority patent/WO2001087485A2/en
Priority to JP2001583935A priority patent/JP2004501360A/en
Priority to AU2001263162A priority patent/AU2001263162A1/en
Priority to EP01937420A priority patent/EP1284819A2/en
Publication of WO2000079285A3 publication Critical patent/WO2000079285A3/en
Publication of WO2000079285A9 publication Critical patent/WO2000079285A9/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/23—Mixing by intersecting jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71725—Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/0072—Organic compounds
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    • G01—MEASURING; TESTING
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    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. These assays may be performed for a variety of purposes, including but not limited to screening of drug candidate compounds, life sciences research, and clinical and molecular diagnostics. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.
PCT/US2000/016653 1999-06-18 2000-06-16 Devices and methods for the performance of miniaturized homogeneous assays WO2000079285A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2001505200A JP2004529312A (en) 1999-06-18 2000-06-16 Devices and methods for miniaturized homogeneous assays
AT00939944T ATE272213T1 (en) 1999-06-18 2000-06-16 DEVICES AND METHODS FOR PERFORMING MINIATURIZED HOMOGENEOUS TESTS
EP00939944A EP1230544B1 (en) 1999-06-18 2000-06-16 Devices and methods for the performance of miniaturized homogeneous assays
DE60012562T DE60012562D1 (en) 1999-06-18 2000-06-16 DEVICES AND METHOD FOR CARRYING OUT MINIATURIZED HOMOGENEOUS TESTS
AU54949/00A AU5494900A (en) 1999-06-18 2000-06-16 Devices and methods for the performance of miniaturized homogeneous assays
PCT/US2001/015743 WO2001087485A2 (en) 2000-05-15 2001-05-15 Microfluidics devices and methods for high throughput screening
EP01937420A EP1284819A2 (en) 2000-05-15 2001-05-15 Microfluidics devices and methods for high throughput screening
JP2001583935A JP2004501360A (en) 2000-05-15 2001-05-15 Microfluidic devices and methods for high-throughput screening
AU2001263162A AU2001263162A1 (en) 2000-05-15 2001-05-15 Microfluidics devices and methods for high throughput screening

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14010599P 1999-06-18 1999-06-18
US60/140,105 1999-06-18

Publications (3)

Publication Number Publication Date
WO2000079285A2 WO2000079285A2 (en) 2000-12-28
WO2000079285A3 true WO2000079285A3 (en) 2002-06-20
WO2000079285A9 WO2000079285A9 (en) 2002-10-03

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Family Applications (1)

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PCT/US2000/016653 WO2000079285A2 (en) 1999-06-18 2000-06-16 Devices and methods for the performance of miniaturized homogeneous assays

Country Status (7)

Country Link
US (2) US6582662B1 (en)
EP (1) EP1230544B1 (en)
JP (1) JP2004529312A (en)
AT (1) ATE272213T1 (en)
AU (1) AU5494900A (en)
DE (1) DE60012562D1 (en)
WO (1) WO2000079285A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7939018B2 (en) 2000-06-28 2011-05-10 3M Innovative Properties Company Multi-format sample processing devices and systems
US8003051B2 (en) 2001-12-28 2011-08-23 3M Innovative Properties Company Thermal structure for sample processing systems

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790684B1 (en) * 1999-03-09 2001-05-11 Biomerieux Sa APPARATUS FOR CAPILLARITY TRANSFER OF LIQUIDS
WO2000079285A2 (en) * 1999-06-18 2000-12-28 Gamera Bioscience Corporation Devices and methods for the performance of miniaturized homogeneous assays
US20020151078A1 (en) * 2000-05-15 2002-10-17 Kellogg Gregory J. Microfluidics devices and methods for high throughput screening
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
EP2045005A3 (en) * 2000-07-03 2011-12-21 Xeotron Corporation Devices and methods for carrying out chemical reactions using photogenerated reagents
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